Genomes and Genes
Richard L Veech
Affiliation: National Institutes of Health
- The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolismRichard L Veech
Laboratory of Membrane Biochemistry and Biophysics, National Institutes of Alcoholism and Alcohol Abuse, 12501 Washington Ave, Rockville, MD 20850, USA
Prostaglandins Leukot Essent Fatty Acids 70:309-19. 2004..New diets comprised of ketone bodies themselves or their esters may obviate this present difficulty...
- Ketoacids? Good medicine?George F Cahill
Trans Am Clin Climatol Assoc 114:149-61; discussion 162-3. 2003..Efforts are underway to prepare esters of beta-hydroxybutyrate which can be taken orally or parenterally to study its potential therapeutic applications...
- Low doses of alcohol substantially decrease glucose metabolism in the human brainNora D Volkow
National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
Neuroimage 29:295-301. 2006....
- The energetics of ion distribution: the origin of the resting electric potential of cellsRichard L Veech
LMBB NIAAA, 12501 Washington Ave, Rockville, Maryland 20852, USA
IUBMB Life 54:241-52. 2002..We conclude that the energy of ATP was expressed in Na+/K+ ATPase and its linked inorganic ion transporters to create a Gibbs-Donnan near-equilibrium system, an inherent part of which was the electric potential...
- A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesisRichard L Veech
Laboratory of Metabolism and Molecular Biology, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 12501 Washington Avenue, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 100:5578-80. 2003
- The mitochondrial permeability transition pore provides a key to the diagnosis and treatment of traumatic brain injuryRichard L Veech
Laboratory of Metabolic Control, NIAAA, NIH, Rockville, MD 20852, USA
IUBMB Life 64:203-7. 2012..While ketosis has previously been known to prevent damage from TBI, the availability of oral ketone esters presents the first practical modality of achieving therapeutic levels of ketone bodies...
- A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar RatYoshihiro Kashiwaya
Laboratory of Metabolic Control, NIAAA, National Institutes of Health, Rockville, Maryland 20852 9047, USA
J Biol Chem 285:25950-6. 2010..Feeding ketone ester or palm oil supplemented diets decreased brain L-glutamate by 15-20% and GABA by about 34% supporting the view that fatty acids as well as ketone bodies can be metabolized by the brain...
- Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester dietShireesh Srivastava
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
FASEB J 26:2351-62. 2012..The quantitative insulin-sensitivity check index was 73% higher in the KE group. These results identify KE as a potential antiobesity supplement...
- A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in miceShireesh Srivastava
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
IUBMB Life 65:58-66. 2013..5-fold higher, suggesting increased sympathetic system activity. These results demonstrate that a KD can also increase BAT mitochondrial size and protein levels...
- Microwave irradiation decreases ATP, increases free [Mg²⁺], and alters in vivo intracellular reactions in rat brainShireesh Srivastava
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
J Neurochem 123:668-75. 2012..The determinations of some glycolytic and TCA cycle metabolites, the phosphorylation potential, and the ∆G' of ATP hydrolysis do not represent the in vivo state when using microwave-fixed brain tissue...
- Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the ratRobert J Pawlosky
Laboratory of Metabolic Control and Laboratory of Physiological Studies, NIH, DHHS, Bethesda, Maryland 20892 9410, USA
Alcohol Clin Exp Res 34:375-81. 2010..We investigated whether the major metabolite of ethanol, acetate, could account for this observation by providing an alternate to glucose as an energy substrate for brain and the metabolic consequences of that shift...
- Effects of a dietary ketone ester on hippocampal glycolytic and TCA cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's diseaseRobert J Pawlosky
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD, 20892
J Neurochem . 2017..The KE offers a potential therapy to counter fundamental metabolic deficits common to patients and transgenic models. This article is protected by copyright. All rights reserved...
- Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findingsNikoletta Lendvai
Program in Reproductive and Adult Endocrinology N L, P B, K P, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Second Department of Medicine N L, Semmelweis University, Budapest, Hungary 1088 Section on Metabolic Control Analysis R P, R L V, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852 Department of Molecular Medicine P B, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic 84505 Institute of Clinical Chemistry and Laboratory Medicine G E, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany Department of Medicine III G E, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany 01307 Molecular Medicine Research Group A P, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary and Department of Laboratory Medicine Institute A P, Central Isotope Laboratory, Semmelweis University, Budapest, Hungary 1088
Endocrinology 155:27-32. 2014....
- Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the ratRichard L Veech
Laboratory of Metabolic Control, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland
Ann N Y Acad Sci 1302:42-8. 2013....
- A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's diseaseYoshihiro Kashiwaya
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Neurobiol Aging 34:1530-9. 2013..KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model...
- The effect of pH and free Mg2+ on ATP linked enzymes and the calculation of Gibbs free energy of ATP hydrolysisChristian Bergman
Laboratory of Metabolic Control, NIAAA, NIH, DHHS, 5625 Fishers Lane, Bethesda, Maryland 20892, USA
J Phys Chem B 114:16137-46. 2010..Furthermore, a theory linking the ΔG′ value of mitochondrial complex I−II and the cytosolic ΔG′ value of ATP hydrolysis is discussed with evidence from previous publications...
- An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in HumansMartin F Kemper
Laboratory of Metabolic Control, National Institute of Alcohol Abuse and Alcoholism, 5625 Fishers Ln 1S22, Rockville, MD, 20852, USA
Lipids 50:1185-93. 2015..Partial replacement of dietary carbohydrate with KE induced ketosis and altered cholesterol homeostasis in rats. In healthy individuals an elevated plasma βHB correlated with lower plasma mevalonate...
- Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox stateMarcella Fulco
Muscle Gene Expression Group, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell 12:51-62. 2003..In response to exercise, food intake, and starvation, Sir2 may sense modifications of the redox state and promptly modulate gene expression...
- Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liverShawn C Burgess
Department of Biochemistry, Advanced Imaging Research Center, University of Texas Southwestern Medical School and Veterans Affairs, 5323 Harry Hines Blvd, Dallas, TX 75390 8854, USA
J Biol Chem 283:1670-8. 2008..Overall, the shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice...
- Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR studyJames C A Hopkins
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Metab Eng 6:36-43. 2004..5mM and V(max) of 1.4 micromol/g dry weight/min. We conclude that the rates of 2DG6P accumulation do not accurately reflect glucose uptake rates under all physiological conditions in the isolated heart and should be used with caution...
- Simultaneous determination of low free Mg2+ and pH in human sickle cells using 31P NMR spectroscopyJames P Willcocks
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
J Biol Chem 277:49911-20. 2002..8 +/- 1.2 mm) was significantly higher. Because total magnesium was normal in sickle cells, the lower [Mg(2+)](free) could be attributed to increased [DPG] and therefore greater magnesium binding capacity of sickle cells...