Peter D Sun

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors
    Jeffrey C Boyington
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Mol Immunol 38:1007-21. 2002
  2. ncbi request reprint Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases
    Peter D Sun
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1092-8. 2002
  3. ncbi request reprint Generating isomorphous heavy-atom derivatives by a quick-soak method. Part II: phasing of new structures
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1099-103. 2002
  4. ncbi request reprint Mass-spectrometry assisted heavy-atom derivative screening of human Fc gamma RIII crystals
    P D Sun
    Structural Biology Section, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 56:161-8. 2000
  5. ncbi request reprint Structure and function of natural-killer-cell receptors
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Res 27:539-48. 2003
  6. pmc Structural implications of Siglec-5-mediated sialoglycan recognition
    Marina A Zhuravleva
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 375:437-47. 2008
  7. ncbi request reprint Crystal structure of the human myeloid cell activating receptor TREM-1
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Structure 11:1527-35. 2003
  8. pmc Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids
    Zhongcheng Zou
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e24559. 2011
  9. ncbi request reprint The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain
    Christian C Boesen
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Structure 10:913-9. 2002
  10. ncbi request reprint Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG
    Johnson Agniswamy
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Structure 14:225-35. 2006

Collaborators

Detail Information

Publications56

  1. ncbi request reprint A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors
    Jeffrey C Boyington
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Mol Immunol 38:1007-21. 2002
    ..Furthermore, unexpected similarities with T-cell receptor (TCR) recognition of MHC molecules are also observed. The detailed interactions between KIR and HLA-C molecules and their functional implications will be reviewed here...
  2. ncbi request reprint Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases
    Peter D Sun
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1092-8. 2002
    ....
  3. ncbi request reprint Generating isomorphous heavy-atom derivatives by a quick-soak method. Part II: phasing of new structures
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1099-103. 2002
    ....
  4. ncbi request reprint Mass-spectrometry assisted heavy-atom derivative screening of human Fc gamma RIII crystals
    P D Sun
    Structural Biology Section, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 56:161-8. 2000
    ....
  5. ncbi request reprint Structure and function of natural-killer-cell receptors
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Res 27:539-48. 2003
    ....
  6. pmc Structural implications of Siglec-5-mediated sialoglycan recognition
    Marina A Zhuravleva
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 375:437-47. 2008
    ....
  7. ncbi request reprint Crystal structure of the human myeloid cell activating receptor TREM-1
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Structure 11:1527-35. 2003
    ..As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites...
  8. pmc Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids
    Zhongcheng Zou
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e24559. 2011
    ....
  9. ncbi request reprint The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain
    Christian C Boesen
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Structure 10:913-9. 2002
    ..The first finger in the TBRII is significantly longer than in ActRII and BRIA and folds tightly between the second finger and the C terminus. Surface charge distributions and hydrophobic patches predict potential TBRII binding sites...
  10. ncbi request reprint Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG
    Johnson Agniswamy
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Structure 14:225-35. 2006
    ..A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2...
  11. pmc Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 285:14806-14. 2010
    ..Further, extensive hydrogen bonds and salt bridges are present at the high affinity cytokine-receptor interfaces, whereas hydrophobic interactions dominate the low affinity receptor-ligand interfaces...
  12. pmc Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Structure 18:934-43. 2010
    ..These studies provide the first structural model for understanding BCR function...
  13. ncbi request reprint Structure and function of natural killer cell surface receptors
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Biophys Biomol Struct 32:93-114. 2003
    ....
  14. ncbi request reprint The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer
    Greg A Snyder
    Laboratory of Immunogenetics, Structural Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 347:979-89. 2005
    ....
  15. doi request reprint Overview of protein structural and functional folds
    Peter D Sun
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    Curr Protoc Protein Sci . 2004
    ....
  16. pmc Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor
    Greg A Snyder
    Laboratory of Immunogenetics, Structural Immunology Section, NIAID, NIH, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
    J Virol 79:4589-98. 2005
    ..Our work contradicts the function of DC-SIGN as a Trojan horse to facilitate HIV-1 infection; rather, it supports the function of DC-SIGN/R (a designation referring to both DC-SIGN and DC-SIGNR) as an antigen-capturing receptor...
  17. ncbi request reprint A survey of protein-protein complex crystallizations
    Sergei Radaev
    Structural Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 62:605-12. 2006
    ..Based on statistical analysis of the database, a sparse-matrix and a systematic buffer and pH screen were formulated to best represent the crystallization of protein complexes...
  18. ncbi request reprint Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors
    Christine E Foster
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 278:46081-6. 2003
    ..The structural similarity of NKp46 to inhibitory KIR receptors may have implications for how NK cells balance activating and inhibitory signals...
  19. pmc A rational approach to heavy-atom derivative screening
    M Gordon Joyce
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 66:358-65. 2010
    ..Overall, this system streamlines the process of heavy-atom compound identification and minimizes the problem of non-isomorphism in phasing...
  20. pmc Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852
    Proc Natl Acad Sci U S A 111:5189-94. 2014
    ..The combined structural and functional studies provide mechanistic insights into the pathogenic contribution of glycosaminoglycan in SAA1.1-mediated AA amyloid formation. ..
  21. doi request reprint The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Sci Signal 5:pe11. 2012
    ..This work contributes to our current knowledge of TLR function and further demonstrates the ability of TLRs to couple versatile ligand recognition to a conserved receptor signaling mechanism...
  22. pmc A case of structure determination using pseudosymmetry
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 65:1334-40. 2009
    ..The geometrical relationships between the subcell and parental cell can be used to generate a complete molecular representation of the parental asymmetric unit for refinement...
  23. pmc Structural recognition and functional activation of FcgammaR by innate pentraxins
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Nature 456:989-92. 2008
    ..These results establish antibody-like functions for pentraxins in the FcgammaR pathway, suggest an evolutionary overlap between the innate and adaptive immune systems, and have new therapeutic implications for autoimmune diseases...
  24. pmc Towards a rational approach for heavy-atom derivative screening in protein crystallography
    Johnson Agniswamy
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 64:354-67. 2008
    ..The results showed highly consistent heavy-atom reactivities between the peptides and lysozyme...
  25. ncbi request reprint Insight of host immune evasion mediated by two variants of group a Streptococcus Mac protein
    Johnson Agniswamy
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 279:52789-96. 2004
    ..Consequently, these proteins may be potential therapeutic targets...
  26. ncbi request reprint Making sense of the diverse ligand recognition by NKG2D
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 169:6279-85. 2002
    ....
  27. pmc Pentraxins and Fc receptors
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Immunol Rev 250:230-8. 2012
    ..This review summarizes the structural and functional work that bridge the innate pentraxins and the adaptive Fc receptor functions. In many ways, pentraxins can be regarded as innate antibodies...
  28. ncbi request reprint Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy
    Neil Gupta
    Laboratory of Immunoregulation, NIAID, NIH Bldg 10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
    Virology 332:491-7. 2005
    ..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers...
  29. pmc Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland, USA
    J Biol Chem 286:40608-13. 2011
    ....
  30. ncbi request reprint An improved recombinant mammalian cell expression system for human transforming growth factor-beta2 and -beta3 preparations
    Zhongcheng Zou
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Protein Expr Purif 50:9-17. 2006
    ..We further confirmed that latent TGF-beta2 and -beta3 can be activated by proteolysis and glycolysis, which have not been reported before...
  31. ncbi request reprint Crystallization and preliminary crystallographic studies of human TGF-beta type II receptor ligand-binding domain
    Christian C Boesen
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1214-6. 2002
    ..5, b = 40.7, c = 76.2 A. There was one molecule in the asymmetric unit, which corresponds to a solvent content of 42.1%...
  32. pmc Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site
    M Gordon Joyce
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:6223-8. 2011
    ..This study provides insights into NKp30 ligand recognition and a framework for a potential family of unidentified ligands...
  33. pmc Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1
    Ruipeng Wang
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Leukoc Biol 91:299-309. 2012
    ..Their preferential induction in the lysis of insensitive NK target cells suggests that IFN-γ and TNF-α are functionally linked to and should be regarded as an integral part of NK cytolytic function...
  34. pmc The structural basis of ligand recognition by natural killer cell receptors
    M Gordon Joyce
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD 20852, USA
    J Biomed Biotechnol 2011:203628. 2011
    ..This paper collates these structural studies detailing the aspects which directly relate to the natural killer cell function and serves to inform both the specialized structural biologist reader and a more general immunology audience...
  35. pmc The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Sci Signal 5:pe11. 2012
    ..This work contributes to our current knowledge of TLR function and further demonstrates the ability of TLRs to couple versatile ligand recognition to a conserved receptor signaling mechanism...
  36. pmc Influence of the second amino acid on recombinant protein expression
    Louis Bivona
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Protein Expr Purif 74:248-56. 2010
    ..This work suggests a general approach to enhance protein expression by incorporating an Ala or Ser after the initiation codon...
  37. ncbi request reprint Overexpression of human transforming growth factor-beta1 using a recombinant CHO cell expression system
    Zhongcheng Zou
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Protein Expr Purif 37:265-72. 2004
    ....
  38. ncbi request reprint Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors
    J C Boyington
    Structural Biology Section, Office of the Scientific Director, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA
    Immunity 10:75-82. 1999
    ..The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94...
  39. pmc Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 and
    Proc Natl Acad Sci U S A 112:833-8. 2015
    ..These results highlight a unique glycan recognition in FcγRI function and open potential therapeutic avenues based on antibody glycan engineering or small molecular glycan mimics to target FcγRI for certain autoimmune diseases...
  40. pmc Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly
    Kaveh Abdi
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:6028-36. 2014
    ....
  41. pmc αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities
    Anastasia N Tikhonova
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:79-91. 2012
    ..This study demonstrates that, without MHC-specific thymic selection, αβTCRs can resemble antibodies in recognizing conformational epitopes on MHC-independent ligands...
  42. ncbi request reprint Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Immunity 15:1039-49. 2001
    ..Unlike the KIR receptors that recognize a conserved HLA region by a lock-and-key mechanism, NKG2D recognizes diverse ligands by an induced-fit mechanism...
  43. ncbi request reprint The structure of a human type III Fcgamma receptor in complex with Fc
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 276:16469-77. 2001
    ..An antibody-FcgammaRIII model suggests two possible ligand-induced receptor aggregations...
  44. ncbi request reprint Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
    J C Boyington
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Nature 405:537-43. 2000
    ..A second KIR/HLA interface produced an ordered receptor-ligand aggregation in the crystal which may resemble receptor clustering during immune synapse formation...
  45. pmc Development of an improved mammalian overexpression method for human CD62L
    Haley A Brown
    Structural Immunology Section, Lab of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, United States
    Protein Expr Purif 105:8-13. 2015
    ..In addition, we developed a MSX resistance assay as an alternative to utilizing ELISA for evaluating the expression level of stable recombinant CHO cell lines. ..
  46. doi request reprint Structural mechanism of high affinity FcγRI recognition of immunoglobulin G
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Immunol Rev 268:192-200. 2015
    ..This review will focus on the knowledge learned from the high affinity complex structural work and a potential receptor-glycan interaction as an important contribution to the receptor affinity. ..
  47. pmc A rapid and rational approach to generating isomorphous heavy-atom phasing derivatives
    Jinghua Lu
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA
    FEBS J 281:4021-8. 2014
    ..As an example, we applied this rational heavy-atom phasing approach to determine a previously unknown mouse serum amyloid A2 crystal structure. ..
  48. pmc Natural killer cell-mediated shedding of ULBP2
    Ruipeng Wang
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 9:e91133. 2014
    ..Consequently, compounds inhibiting NKG2D ligand shedding may offer therapeutic means to reduce excessive pathogenic NK cell activities. ..
  49. ncbi request reprint Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster
    J C Boyington
    Laboratory of Molecular Structure, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Rockville, MD 20852, USA
    Science 275:1305-8. 1997
    ..These structures suggest a reaction mechanism that directly involves SeCys140 and His141 in proton abstraction and the molybdenum, molybdopterin, Lys44, and the Fe4S4 cluster in electron transfer...
  50. ncbi request reprint Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules
    J C Boyington
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Immunol Rev 181:66-78. 2001
    ..The detailed interactions between KIR2DL2 and HLA-Cw3 and their functional implications will be reviewed here...
  51. ncbi request reprint Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 276:16478-83. 2001
    ..The results of peptide binding illustrate new ways of designing therapeutic compounds to block Fc receptor activation...
  52. ncbi request reprint Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis
    V N Gladyshev
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:8095-100. 1996
    ..These data provide the first example of crystallization of a substrate-reduced form of a Se- and Mo-containing enzyme...
  53. ncbi request reprint Overview of protein folds in the immune system
    P D Sun
    National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland, USA
    Curr Protoc Immunol . 2001
    ..Focus is placed on immunologically relevant proteins such as immunoreceptors and major histocompatibility complexes. Information is also provided regarding protein structure data banks...
  54. ncbi request reprint Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer
    S P Rafferty
    Office of Scientific Directors, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, 20892 1886, USA
    Biochem Biophys Res Commun 257:344-7. 1999
    ..The H4B cofactor content of this species was only one per dimer yet this was sufficient to form two competent arginine binding sites as determined by optical stoichiometric titrations...
  55. ncbi request reprint Conserved in structure but diverse in recognition
    Peter D Sun
    Structure 11:362-3. 2003
  56. pmc Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors
    C Andrew Stewart
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université Méditerranée, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 102:13224-9. 2005
    ..We discuss how our results for KIR2DS1 and parallel studies on KIR2DS2 relate to the association between activating KIR genes and susceptibility to autoimmune disorders...