Anne E Sumner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Glycated Albumin Identifies Prediabetes Not Detected by Hemoglobin A1c: The Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD
    Clin Chem 62:1524-1532. 2016
  2. pmc A1C Combined With Glycated Albumin Improves Detection of Prediabetes in Africans: The Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Diabetes Care 39:271-7. 2016
  3. pmc Detection of abnormal glucose tolerance in Africans is improved by combining A1C with fasting glucose: the Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Diabetes Care 38:213-9. 2015
  4. pmc ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women
    Anne E Sumner
    Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Nutr Metab (Lond) 10:73. 2013
  5. pmc Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study
    Aurelian Bidulescu
    Department of Community Health and Preventive Medicine, Cardiovascular Research Institute, Morehouse School of Medicine, 30310, Atlanta, GA, USA
    BMC Cardiovasc Disord 13:9. 2013
  6. ncbi request reprint Obese premenopausal African-American women with normal and impaired glucose tolerance have a similar degree of insulin resistance but differ in beta-cell function
    A E Sumner
    National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 24:1978-83. 2001
  7. ncbi request reprint Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions
    A E Sumner
    Institute for Women s Health, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA
    Diabetes Care 22:71-7. 1999
  8. pmc Waist circumference, BMI, and visceral adipose tissue in white women and women of African descent
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    Obesity (Silver Spring) 19:671-4. 2011
  9. pmc The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women: an analysis of Jackson Heart Study
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 0892 1612, USA
    Metab Syndr Relat Disord 8:511-4. 2010
  10. pmc Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults
    Anne E Sumner
    Clinical Endocrinology Branch, NIDDK, NIH, Bethesda, MD 20892 1612, USA
    J Pediatr 155:S7.e7-11. 2009

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Glycated Albumin Identifies Prediabetes Not Detected by Hemoglobin A1c: The Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD
    Clin Chem 62:1524-1532. 2016
    ..Therefore, we evaluated the ability of hemoglobin A1c (Hb A1c) and glycated albumin to detect prediabetes in nonobese (BMI <30 kg/m2) and obese (BMI ≥30 kg/m2) African immigrants...
  2. pmc A1C Combined With Glycated Albumin Improves Detection of Prediabetes in Africans: The Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Diabetes Care 39:271-7. 2016
    ..Our goals were to determine the ability of A1C, fructosamine, and GA to detect prediabetes in U.S.-based Africans and the value of combining A1C with either fructosamine or GA...
  3. pmc Detection of abnormal glucose tolerance in Africans is improved by combining A1C with fasting glucose: the Africans in America Study
    Anne E Sumner
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Diabetes Care 38:213-9. 2015
    ..6 mmol/L, 2) A1C ≥ 5.7% (39 mmol/mol), and 3) FPG combined with A1C (FPG ≥5.6 mmol/L and/or A1C ≥5.7% [39 mmol/mol]) for the detection of abnormal glucose tolerance...
  4. pmc ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women
    Anne E Sumner
    Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Nutr Metab (Lond) 10:73. 2013
    ..Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins, B, C-III and E, on race differences in TG content of very low density lipoproteins (VLDL)...
  5. pmc Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study
    Aurelian Bidulescu
    Department of Community Health and Preventive Medicine, Cardiovascular Research Institute, Morehouse School of Medicine, 30310, Atlanta, GA, USA
    BMC Cardiovasc Disord 13:9. 2013
    ....
  6. ncbi request reprint Obese premenopausal African-American women with normal and impaired glucose tolerance have a similar degree of insulin resistance but differ in beta-cell function
    A E Sumner
    National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 24:1978-83. 2001
    ..To determine whether insulin resistance and secretion differ in obese premenopausal African-American women with and without glucose intolerance...
  7. ncbi request reprint Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions
    A E Sumner
    Institute for Women s Health, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA
    Diabetes Care 22:71-7. 1999
    ..The purpose of this study was to determine if there are sex differences in African-Americans regarding the effect of obesity on sensitivity to insulin as a glucoregulatory and antilipolytic hormone...
  8. pmc Waist circumference, BMI, and visceral adipose tissue in white women and women of African descent
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    Obesity (Silver Spring) 19:671-4. 2011
    ..As WC-BMI relationship did not differ by race, the same BMI-based WC guidelines may be appropriate for black and white women. However, if WC is defined by VAT, race-specific WC thresholds are required...
  9. pmc The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women: an analysis of Jackson Heart Study
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 0892 1612, USA
    Metab Syndr Relat Disord 8:511-4. 2010
    ..0 to predict insulin resistance in African Americans. The validity of this recommendation needs examination. Therefore, our aim was to determine the ability of TG/HDL-C ratio to predict insulin resistance in African Americans...
  10. pmc Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults
    Anne E Sumner
    Clinical Endocrinology Branch, NIDDK, NIH, Bethesda, MD 20892 1612, USA
    J Pediatr 155:S7.e7-11. 2009
    ..Overall, we conclude that an ethnic-specific formulation of the lipid criteria in the metabolic syndrome may lead to better identification of blacks at high risk for development of diabetes and cardiovascular disease...
  11. pmc Validity of the reduced-sample insulin modified frequently-sampled intravenous glucose tolerance test using the nonlinear regression approach
    Anne E Sumner
    Clinical Endocrinology Branch, NIDDK, NIH, Bethesda, MD 20892 1612, USA
    Metabolism 58:220-5. 2009
    ..The agreement and maintenance of rank order of S(I) between protocols support the use of the nonlinear regression approach to the minimal model and the Reduced-Sample-IM-FSIGT in clinical studies...
  12. pmc The relationship of body fat to metabolic disease: influence of sex and ethnicity
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1612, USA
    Gend Med 5:361-71. 2008
    ..For central obesity and low HDL, the metabolic syndrome guidelines are sex specific. Diagnostic guidelines should also take ethnic differences into account, particularly in the diagnosis of central obesity and hypertriglyceridemia...
  13. ncbi request reprint Ethnic differences in the ability of triglyceride levels to identify insulin resistance
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Atherosclerosis 196:696-703. 2008
    ..As syndromes are formulated to identify individuals at high risk for conditions such as cardiovascular disease and Type 2 diabetes, ethnic differences in TG levels should be considered...
  14. ncbi request reprint Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans
    Anne E Sumner
    Clincial Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:1395-400. 2005
    ..Our goal was to determine whether TG levels or TG-HDL-C ratio predicted insulin resistance in African Americans with a BMI of 25 kg/m(2) or more...
  15. ncbi request reprint Sex differences in visceral adipose tissue volume among African Americans
    Anne E Sumner
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Am J Clin Nutr 76:975-9. 2002
    ..Men are believed to have more visceral adipose tissue (VAT) than women have, but studies in African Americans that measured VAT from a single computed tomography (CT) slice found no sex difference...
  16. ncbi request reprint Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans
    Marshall K Tulloch-Reid
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Pheonix, AZ, USA
    Obes Res 12:1352-9. 2004
    ..The aim of this study was to determine whether both VAT and SAT contribute to insulin resistance in African Americans and to examine the effects of sex on this relationship...
  17. ncbi request reprint The TG/HDL-C ratio does not predict insulin resistance in overweight women of African descent: a study of South African, African American and West African women
    Michael G Knight
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 1612, USA
    Ethn Dis 21:490-4. 2011
    ..Resources to identify effective markers of insulin resistance are needed to improve cardiometabolic health in women of African descent...
  18. pmc Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women
    Carson C Chow
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:2456-63. 2011
    ..Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential...
  19. pmc Evaluation of quantitative models of the effect of insulin on lipolysis and glucose disposal
    Vipul Periwal
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, Bethesda, Maryland 20892, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1089-96. 2008
    ..In the best model, insulin suppressed lipolysis via a Hill function through a remote compartment that acted on both glucose and FFA simultaneously, and glucose dynamics obeyed the classic MMG...
  20. doi request reprint Determining the waist circumference in african americans which best predicts insulin resistance
    Anne E Sumner
    Clinical Endocrinology Branch, NIDDK, Bethesda, Maryland, USA
    Obesity (Silver Spring) 16:841-6. 2008
    ..In African Americans, insulin resistance (in men) was best predicted by a WC > or =102 cm, and in women by a WC > or =98 cm, or by a BMI value that fell in the obese category (men: > or =30 kg/m(2), women: > or =32 kg/m(2))...
  21. pmc Metabolic syndrome does not detect metabolic risk in African men living in the U.S
    Ugochi J Ukegbu
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 34:2297-9. 2011
    ..S. and African Americans. If MetSyn were an effective predictor of cardiometabolic risk, then the group with a worse metabolic risk profile would have a higher rate of MetSyn...
  22. pmc Postprandial endothelial function does not differ in women by race: an insulin resistance paradox?
    Ranganath Muniyappa
    Diabetes, Endocrinology, and Obesity Branch, Intramural Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 10 Center Drive, Bethesda, MD 20892 0920, USA
    Am J Physiol Endocrinol Metab 302:E218-25. 2012
    ..These results imply that insulin sensitivity may not be an important determinant of racial differences in endothelial function...
  23. pmc Age is positively associated with high-density lipoprotein cholesterol among African Americans in cross-sectional analysis: the Jackson Heart Study
    Jane L Harman
    Program in Prevention and Population Sciences, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Suite 10018, Bethesda, MD 20982 7936, USA
    J Clin Lipidol 5:173-8. 2011
    ..African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities...
  24. pmc Effect of low-dose oral contraceptives on metabolic risk factors in African-American women
    Barbara A Frempong
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:2097-103. 2008
    ..The effect of oral contraceptive pill (OCP) use on cardiovascular risk in African-American women is unknown...
  25. pmc Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test
    Yanjun Li
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, MSC 5621, LBM, NIDDK, NIH, Bethesda, MD, 20892 5621, USA
    Theor Biol Med Model 13:8. 2016
    ..A simple way to calculate the appearance rate (Ra) of glucose and FFA would be especially helpful to evaluate glucose and FFA kinetics for clinical applications...
  26. pmc Sex-associated differences in free fatty acid flux of obese adolescents
    Diane C Adler-Wailes
    Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    J Clin Endocrinol Metab 98:1676-84. 2013
    ..Adult women release more FFA relative to resting energy expenditure (REE) and have greater FFA clearance rates than men. In adolescents, it is unknown whether sex differences in FFA flux occur...
  27. pmc The triglyceride paradox in people of African descent
    Sophia S K Yu
    Diabetes, Endocrinology and Obesity Branch, National Institutes of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892 1612, USA
    Metab Syndr Relat Disord 10:77-82. 2012
    ..Overall, a broader understanding of how TG physiology varies by race could lead to better diagnostic tests and improved health outcomes...
  28. pmc Triglyceride-based screening tests fail to recognize cardiometabolic disease in African immigrant and African-American men
    Sophia S K Yu
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1612, USA
    Metab Syndr Relat Disord 11:15-20. 2013
    ..In Africans, the efficacy of TG-based screening tests is unknown. Our goal was to determine the association between hypertriglyceridemia (TG ≥150 mg/dL) and cardiometabolic disease in African and African-American men...
  29. ncbi request reprint Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase
    Anne E Sumner
    Clinical Endocrinology Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1612, USA
    Metabolism 54:902-9. 2005
    ..The lack of an effect of insulin resistance on PH-LPL could allow LPL to clear TG even in the presence of insulin resistance and explain the coexistence of insulin resistance and normotriglyceridemia in African Americans...
  30. pmc The uncertain significance of low vitamin D levels in African descent populations: a review of the bone and cardiometabolic literature
    Michelle Y O'Connor
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Prog Cardiovasc Dis 56:261-9. 2013
    ..Then data on the relationship of vitamin D to bone and cardiometabolic health in people of African descent are evaluated. ..
  31. pmc Worse cardiometabolic health in African immigrant men than African American men: reconsideration of the healthy immigrant effect
    Michelle Y O'Connor
    1 Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Metab Syndr Relat Disord 12:347-53. 2014
    ..The recent global increase in cardiometabolic diseases raises the possibility that immigrant health may be changing. Therefore, a new assessment of cardiometabolic health in African immigrants is warranted...
  32. pmc Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES
    Michelle T Duong
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10 CRC, Rm 6 5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892 1612, USA
    J Racial Ethn Health Disparities . 2016
    ..In this perspective, we outline the approach taken in 21 different NHANES studies...
  33. pmc The Association between Stress Measured by Allostatic Load Score and Physiologic Dysregulation in African Immigrants: The Africans in America Study
    Brianna A Bingham
    Section on Ethnicity and Health, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health NIH, Bethesda, MD, USA
    Front Public Health 4:265. 2016
    ..Allostatic load score (ALS) summarizes the physiological effect of stress on cardiovascular, metabolic and immune systems. As immigration is stressful, ALS could be affected...
  34. pmc Sickle Cell Trait from a Metabolic, Renal, and Vascular Perspective: Linking History, Knowledge, and Health
    Caroline K Thoreson
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Bld 10 CRC, Rm 6 5940, MSC 1612 9000 Rockville Pike, Bethesda, MD 20892 1612, USA
    J Racial Ethn Health Disparities 2:330-5. 2015
    ....
  35. pmc Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy
    Scott A Soleimanpour
    Islet and Autoimmunity Branch, NIDDK, NIH, Bethesda, MD, USA
    Cell Transplant 21:1297-304. 2012
    ..Furthermore, improved glycemic control achieved via islet transplantation over the diabetic state might be attained, in part, via reduced glucagon secretion...
  36. pmc Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
    Hariom Yadav
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, South Drive and Old Georgetown Road, Bethesda, MD 20892, USA
    Cell Metab 14:67-79. 2011
    ..Together, these results demonstrate that TGF-β signaling regulates glucose tolerance and energy homeostasis and suggest that modulation of TGF-β activity might be an effective treatment strategy for obesity and diabetes...
  37. pmc Neck circumference is a predictor of metabolic syndrome and obstructive sleep apnea in short-sleeping obese men and women
    Giovanni Cizza
    1 Section on Neuroendocrinology of Obesity, Diabetes, Endocrinology, and Obesity Branch National Institute of Diabetes and Digestive and Kidney Diseases DEOB NIDDK, Bethesda, Maryland
    Metab Syndr Relat Disord 12:231-41. 2014
    ..Our goal was to investigate the associations among neck circumference (NC), obstructive sleep apnea syndromes (OSAS), and metabolic syndrome in obese men and women sleeping less than 6.5 hr per night...
  38. pmc Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
    Junghyo Jo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA
    PLoS Comput Biol 5:e1000324. 2009
    ..Additionally, high-fat diet leads to a dramatic spreading of the size distribution of adipose cells in both strains; this implies an increase in size fluctuations of adipose cells through lipid turnover...
  39. pmc Evaluation of hemoglobin A1c measurement by Capillarys 2 electrophoresis for detection of abnormal glucose tolerance in African immigrants to the United States
    Zhen Zhao
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States
    Clin Chim Acta 446:54-60. 2015
    ..An automated liquid-flow capillary electrophoresis method was recently developed to measure HbA1c using the Capillarys 2 Flex Piercing instrument...