Daniel E Sturdevant

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics
    Daniel E Sturdevant
    Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA
    Future Microbiol 5:205-19. 2010
  2. ncbi request reprint Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus
    Amy M Palazzolo-Ballance
    Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 180:500-9. 2008
  3. ncbi request reprint Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events
    Paul Sumby
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 192:771-82. 2005
  4. ncbi request reprint Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    J Immunol 175:3907-19. 2005
  5. pmc Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
    Damon W Ellison
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 76:542-50. 2008
  6. pmc RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus
    Shu Y Queck
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Cell 32:150-8. 2008
  7. pmc Global changes in Staphylococcus aureus gene expression in human blood
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18617. 2011
  8. ncbi request reprint Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 173:1194-201. 2004
  9. pmc Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis
    Viveka Vadyvaloo
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000783. 2010
  10. pmc Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
    Lihua Song
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:636-44. 2013

Collaborators

Detail Information

Publications38

  1. pmc Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics
    Daniel E Sturdevant
    Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA
    Future Microbiol 5:205-19. 2010
    ..Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease...
  2. ncbi request reprint Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus
    Amy M Palazzolo-Ballance
    Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 180:500-9. 2008
    ..Collectively, the data provide an enhanced view of the mechanisms used by S. aureus to circumvent destruction by the innate immune system...
  3. ncbi request reprint Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events
    Paul Sumby
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 192:771-82. 2005
    ..Multiple horizontal gene transfer events were a crucial factor in the evolutionary origin and emergence of a very abundant contemporary clone of serotype M1 GAS...
  4. ncbi request reprint Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    J Immunol 175:3907-19. 2005
    ..Our studies reveal a gene transcription program in a prominent human pathogen that likely contributes to evasion of innate host defense...
  5. pmc Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
    Damon W Ellison
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 76:542-50. 2008
    ..rickettsii strain R. Although R. rickettsii Iowa does not cause apparent disease, infection of guinea pigs with this strain confers protection against subsequent challenge with the virulent strain R. rickettsii Sheila Smith...
  6. pmc RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus
    Shu Y Queck
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Cell 32:150-8. 2008
    ..By establishing a two-level model of quorum-sensing target gene regulation in S. aureus, our study gives important insight into the evolution of virulence control in this leading human pathogen...
  7. pmc Global changes in Staphylococcus aureus gene expression in human blood
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18617. 2011
    ..These findings, along with a requirement of specific growth conditions for leukotoxin expression, may explain the apparent limited contribution of any single two-component leukotoxin to USA300 immune evasion and virulence...
  8. ncbi request reprint Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 173:1194-201. 2004
    ..Importantly, our studies identify specific genes in the pathogen survival response as potential targets to control human infections...
  9. pmc Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis
    Viveka Vadyvaloo
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000783. 2010
    ..Our results suggest that transit through the flea vector induces a phenotype that enhances survival and dissemination of Y. pestis after transmission to the mammalian host...
  10. pmc Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
    Lihua Song
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:636-44. 2013
    ..Our findings have major implications for understanding the plasmid's role in chlamydial pathogenesis at the molecular level...
  11. ncbi request reprint The antimicrobial peptide-sensing system aps of Staphylococcus aureus
    Min Li
    Laboratory of Human Bacterial Pathogenesis, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, USA
    Mol Microbiol 66:1136-47. 2007
    ..aureus...
  12. pmc Gram-positive three-component antimicrobial peptide-sensing system
    Min Li
    Laboratory of Human Bacterial Pathogenesis and Research and Technology Branch, Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 104:9469-74. 2007
    ..Our study shows that Gram-positive bacteria have developed an efficient and unique way of controlling resistance mechanisms to antimicrobial peptides, which may provide a promising target for antimicrobial drug development...
  13. pmc Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Innate Immun 2:560-75. 2010
    ..aureus pore-forming toxins. We propose that the ability of CA-MRSA strains to induce programmed necrosis of neutrophils is a component of enhanced virulence...
  14. pmc Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT 59840, USA
    Infect Immun 73:1856-60. 2005
    ..Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections...
  15. pmc Limited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli
    Damon W Ellison
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infections Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 4:e5612. 2009
    ..A minimal number of predicted transcriptional regulators in the R. rickettsii genome is consistent with this hypothesis...
  16. pmc Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity
    Shawna F Graves
    Laboratory of Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Leukoc Biol 92:361-74. 2012
    ..We propose that PVL-mediated priming of PMNs enhances the host innate immune response...
  17. pmc Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Gordon Y C Cheung
    Laboratory of Human Bacterial Pathogenesis, NIAID, NIH, Bldg 33, 1W10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Infect Immun 79:1927-35. 2011
    ..Our findings demonstrate that agr functionality is critical for CA-MRSA disease and indicate that an adaptation of the agr regulon contributed to the evolution of highly pathogenic CA-MRSA...
  18. pmc AI-2-dependent gene regulation in Staphylococcus epidermidis
    Min Li
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT 59840, USA
    BMC Microbiol 8:4. 2008
    ..Particularly, we have a lack of knowledge about AI-2 signaling in the important human pathogens Staphylococcus aureus and S. epidermidis...
  19. pmc Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:11766-71. 2006
    ..High NO levels induced during plague may also influence the developing adaptive immune response and contribute to septic shock...
  20. pmc Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague
    Jason E Comer
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:5086-98. 2010
    ..Thus, the ability to counteract a PMN response in the lymph node appears to be a major in vivo function of the Y. pestis virulence plasmid...
  21. ncbi request reprint The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci
    Yuping Lai
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT, USA
    Mol Microbiol 63:497-506. 2007
    ..Our study indicates that staphylococci can react to human AMPs by specific mechanisms of resistance and establishes a crucial role for staphylococcal proteases in the interaction with human innate host defence...
  22. ncbi request reprint Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum-sensing regulation of resistance to human innate host defense
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 193:841-8. 2006
    ....
  23. pmc Host cell-free growth of the Q fever bacterium Coxiella burnetii
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 106:4430-4. 2009
    ..Furthermore, the systematic approach used here may be broadly applicable to development of axenic media that support growth of other medically important obligate intracellular pathogens...
  24. pmc Transcriptional profiling of human epithelial cells infected with plasmid-bearing and plasmid-deficient Chlamydia trachomatis
    Stephen F Porcella
    Genomics Unit Research Technologies Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 83:534-43. 2015
    ..These results provide new insights into the role of the chlamydial plasmid as a chlamydial virulence factor and its contributions to trachoma pathogenesis. ..
  25. pmc Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections
    Stephen B Beres
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:11833-8. 2004
    ..Genome-wide analysis of population-based strain samples cultured from clinically well defined patients is crucial for understanding the molecular events underlying bacterial epidemics...
  26. pmc The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
    ..Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease...
  27. pmc Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro
    J Antonio Ibarra
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 156:1120-33. 2010
    ..These findings show that induction of SPI1 under different pre-invasion growth conditions can affect the ability of Salmonella to interact with eukaryotic host cells...
  28. pmc Transcriptional Profiling of Coxiella burnetii Reveals Extensive Cell Wall Remodeling in the Small Cell Variant Developmental Form
    Kelsi M Sandoz
    Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 11:e0149957. 2016
    ..Collectively, these results indicate the SCV produces a unique transcriptome with a major component directed towards remodeling a PG layer that likely contributes to Coxiella's environmental resistance. ..
  29. pmc Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 100:1996-2001. 2003
    ..The gene regulatory program revealed by our studies identifies previously undescribed potential vaccine antigens and targets for therapeutic interventions designed to control GAS infections...
  30. pmc Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium
    Anders Omsland
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 109:19781-5. 2012
    ..The described axenic culture system will greatly enhance biochemical and physiological analyses of chlamydiae...
  31. ncbi request reprint Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 191:289-98. 2005
    ..The observed physiological characteristics of the biofilm mode of growth--in particular, the contribution of surfactant-like peptides--might serve as a model for a variety of biofilm-forming pathogens...
  32. pmc Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
    Jianbing Mu
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Genet 42:268-71. 2010
    ..Parasite half-maximum inhibitory concentrations for seven antimalarial drugs were obtained and used in GWAS to identify genes associated with drug responses. This study provides valuable tools and insight into the P. falciparum genome...
  33. pmc Insights into the Staphylococcus aureus-host interface: global changes in host and pathogen gene expression in a rabbit skin infection model
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 10:e0117713. 2015
    ..aureus SSTIs, including a temporal component of the host response. These results serve as a springboard for future studies directed to better understand how/why mild or moderate SSTIs progress to invasive disease. ..
  34. pmc Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomatous Disease
    David E Greenberg
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA Departments of Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Infect Immun 83:4277-92. 2015
    ....
  35. pmc Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes
    Michael S Chaussee
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 70:762-70. 2002
    ..The results show that Rgg influences the expression of multiple regulatory networks to coregulate virulence factor expression in S. pyogenes...
  36. pmc Developmental transitions of Coxiella burnetii grown in axenic media
    Kelsi M Sandoz
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, United States
    J Microbiol Methods 96:104-10. 2014
    ..Axenic cultivation of C. burnetii in ACCM-2 and new methods of genetic manipulation now allow investigation of the molecular basis of C. burnetii biphasic development. ..
  37. pmc Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling
    Morag R Graham
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 99:13855-60. 2002
    ....
  38. pmc Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks
    James C Smoot
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 99:4668-73. 2002
    ..Our analysis provides a critical foundation for accelerated research into ARF pathogenesis and a molecular framework to study the plasticity of GAS genomes...