Joshua H Singer
Affiliation: National Institutes of Health
- Sustained Ca2+ entry elicits transient postsynaptic currents at a retinal ribbon synapseJoshua H Singer
Synaptic Physiology Unit, National Institutes of Health National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 4066, USA
J Neurosci 23:10923-33. 2003..We conclude that the time course of vesicle release from RBCs is inherently transient and, together with the fast kinetics of postsynaptic AMPARs, speeds transmission at this synapse...
- Coordinated multivesicular release at a mammalian ribbon synapseJoshua H Singer
Synaptic Physiology Unit, NIH NINDS, 36 Convent Drive, MSC 4066, Building 36 Room 2C 09, Bethesda, Maryland 20892, USA
Nat Neurosci 7:826-33. 2004..The release synchrony reflected in these multivesicular events suggests that release within an active zone is coordinated during MVR...
- Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapsesBhupesh Mehta
Departments of Cellular and Molecular Physiology and Ophthalmology and Visual Science, Yale University, New Haven, Connecticut 06520, Department of Biology, University of Maryland, College Park, Maryland 20742, and Circuit Dynamics and Connectivity Unit, National Institutes of Health NIH National Institute of Neurological Disorders and Stroke NINDS, Bethesda, Maryland 20892
J Neurosci 34:6233-44. 2014..Our observations support the conclusion that ribbon-independent release provides a read-out of the average behavior of all of the active zones in a rod bipolar cell's terminal. ..
- Vesicle depletion and synaptic depression at a mammalian ribbon synapseJoshua H Singer
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurophysiol 95:3191-8. 2006..The small RRP and very high release probability likely contribute to the transient characteristics of neurotransmission at RBC synapses...
- Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptorsAndres E Chavez
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
Nature 443:705-8. 2006..These results describe a fast synapse that operates independently of VGCCs and membrane depolarization and reveal a previously unknown form of feedback inhibition within a neural circuit...
- Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapsesJoshua H Singer
Departments of Ophthalmology and Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Tarry 5 715, Chicago, IL 60611, USA
J Physiol 580:23-9. 2007..Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR...
- GABA is an endogenous ligand for synaptic glycine receptorsJoshua H Singer
Departments of Ophthalmology and Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 5 715, Chicago, IL 60611, USA
Neuron 57:475-7. 2008..Lu, Rubio, and Trussell, however, demonstrate in this issue of Neuron the first instance of cotransmission in which two neurotransmitters act on the same postsynaptic receptor...