Alan Sher

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
    Alan Sher
    National Institutes of Health, Bethesda, MD 20892 8003, USA
    Immunol Res 27:521-8. 2003
  2. ncbi request reprint Effector and regulatory CD4+ T cell function in a murine model of Helicobacter hepaticus-induced colitis
    Alan Sher
    National Institutes of Health, Bethesda, Maryland, USA
    J Pediatr Gastroenterol Nutr 40:S35-6. 2005
  3. ncbi request reprint Shaping the immune response to parasites: role of dendritic cells
    Alan Sher
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 8003, USA
    Curr Opin Immunol 15:421-9. 2003
  4. ncbi request reprint Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 171:4758-64. 2003
  5. ncbi request reprint Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 174:4185-92. 2005
  6. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
  7. pmc Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome
    Kevin Shenderov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:5722-30. 2013
  8. ncbi request reprint TLR11 activation of dendritic cells by a protozoan profilin-like protein
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Science 308:1626-9. 2005
  9. ncbi request reprint Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:8165-72. 2005
  10. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005

Detail Information

Publications93

  1. ncbi request reprint Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
    Alan Sher
    National Institutes of Health, Bethesda, MD 20892 8003, USA
    Immunol Res 27:521-8. 2003
    ..In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells...
  2. ncbi request reprint Effector and regulatory CD4+ T cell function in a murine model of Helicobacter hepaticus-induced colitis
    Alan Sher
    National Institutes of Health, Bethesda, Maryland, USA
    J Pediatr Gastroenterol Nutr 40:S35-6. 2005
  3. ncbi request reprint Shaping the immune response to parasites: role of dendritic cells
    Alan Sher
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 8003, USA
    Curr Opin Immunol 15:421-9. 2003
    ..This regulation also benefits parasites by protecting their host niche from the potentially lethal consequences of an uncontrolled inflammatory response...
  4. ncbi request reprint Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 171:4758-64. 2003
    ....
  5. ncbi request reprint Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 174:4185-92. 2005
    ..tuberculosis infection and suggest that breakdown of this mechanism could be a contributing factor in reactivated disease...
  6. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  7. pmc Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome
    Kevin Shenderov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:5722-30. 2013
    ..Taken together, these findings suggest a general strategy for the rational design of Th17-skewing adjuvants by combining agonists of the CARD9 pathway with inflammasome activators...
  8. ncbi request reprint TLR11 activation of dendritic cells by a protozoan profilin-like protein
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Science 308:1626-9. 2005
    ..Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens...
  9. ncbi request reprint Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:8165-72. 2005
    ..Together, these data establish that LRG-47 can influence pathogen control by simultaneously regulating macrophage-microbicidal activity and hemopoietic function...
  10. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005
    ..These findings reveal a previously unappreciated role for TLR9 in the host response to M. tuberculosis and illustrate TLR collaboration in host resistance to a major human pathogen...
  11. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  12. ncbi request reprint Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 6148, Building 50, 50 South Drive, Bethesda, MD 20892, USA
    J Immunol 172:1163-8. 2004
    ..These findings establish a role for LRG-47 in host control of mycobacteria and demonstrate that in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival...
  13. ncbi request reprint Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 279:53635-42. 2004
    ..These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent...
  14. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
    ..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...
  15. ncbi request reprint NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis
    Carl G Feng
    Immunobiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8003, USA
    J Immunol 177:7086-93. 2006
    ..tuberculosis infection and suggest that this response could serve as an important barrier in AIDS patients or other individuals with compromised CD4+ T cell function...
  16. ncbi request reprint Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 25:655-64. 2006
    ..These findings support a major influence of TLR recognition in antigen presentation by DC in vivo and establish a mechanism by which TLR ligand association regulates the immunogenicity of microbial antigens...
  17. pmc TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production
    Romina S Goldszmid
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 204:2591-602. 2007
    ....
  18. pmc NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection
    Romina S Goldszmid
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Immunity 36:1047-59. 2012
    ....
  19. ncbi request reprint Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:3515-9. 2006
    ..Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi...
  20. ncbi request reprint The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5514-22. 2007
    ..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter...
  21. pmc MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression
    Charles A Scanga
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 72:2400-4. 2004
    ..These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs...
  22. pmc Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections
    Mark S Wilson
    Immunopathogensis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4378-90. 2010
    ..The IL-22 pathway has emerged as a possible target for control of inflammation in certain autoimmune diseases. Our findings suggest that few if any infectious complications would be expected with the suppression of IL-22 signaling...
  23. pmc Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 116:3485-93. 2010
    ..Instead, our findings suggest that mycobacterial-associated IRIS results from a heightened sensitivity of infected lymphopenic hosts to the detrimental effects of Ag-driven CD4 T-cell responses...
  24. pmc Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:1601-6. 2005
    ..tuberculosis...
  25. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  26. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
    ..Together our findings reveal a major role for IL-1beta in host resistance to M. tuberculosis and indicate that during this infection the cytokine can be generated by a mechanism that does not require TLR signaling or caspase-1...
  27. ncbi request reprint Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2
    Andre Bafica
    Immunobiology Section, National Institute of Allergy and Infectious Diseases and Chemical Immunology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:1123-7. 2003
    ..Together, these results argue that TLR2 plays a crucial role in the activation of HIV-1 expression by mycobacterial coinfections...
  28. ncbi request reprint Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent
    Li Yun Huang
    Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 171:1441-6. 2003
    ..Taken together, our data demonstrate that MyD88-dependent pathways are crucial for activation by HKBA and that TLR2 plays a role in TNF, but not IL-12p40 pathways activated by this microbial product...
  29. pmc The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stem Cell 2:83-9. 2008
    ..Our results establish a link between the response to infection and HSC activation and demonstrate a novel function for a member of the p47 GTPase family...
  30. ncbi request reprint Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
    Charles A Scanga
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5997-6001. 2002
    ..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways...
  31. pmc In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli
    Antonio Gigliotti Rothfuchs
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:6915-25. 2009
    ....
  32. ncbi request reprint The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA
    J Leukoc Biol 75:460-6. 2004
    ....
  33. ncbi request reprint Viral gene expression in HIV transgenic mice is activated by Mycobacterium tuberculosis and suppressed after antimycobacterial chemotherapy
    Charles A Scanga
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 195:246-54. 2007
    ..tuberculosis on latent HIV expression and for testing therapeutic regimens for reducing the disease burden in patients with acquired immunodeficiency syndrome-associated tuberculosis...
  34. ncbi request reprint Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:2419-27. 2004
    ..Together, these findings suggest that the emergence of IL-4-producing CD4(+) lymphocytes results from a suppression in DC function leading to a temporary delay in initial T cell cycling...
  35. pmc Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo
    Atfa Sassi
    Section of Intercellular Interactions, Program of Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Microbes Infect 11:1106-13. 2009
    ..These ex vivo findings raise the possibility that, in addition to being a co-factor in HIV disease, T. gondii may influence the outcome of viral infection by preferentially suppressing R5 variants...
  36. pmc Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
    Lis R V Antonelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 120:1674-82. 2010
    ..tuberculosis infection, by promoting the accumulation of a permissive myeloid population in the lung. In addition, these data suggest that agents that stimulate type I IFN should be used with caution in patients exposed to this pathogen...
  37. pmc Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:271-84. 2008
    ..By characterizing the migration of both innate and adaptive immune cells throughout the process of granuloma development, these studies provide a new perspective on the cellular events involved in mycobacterial containment and escape...
  38. pmc Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome
    Lis R V Antonelli
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:3818-27. 2010
    ..These studies are registered online at http://clinicaltrials.gov as NCT00557570 and NCT00286767...
  39. ncbi request reprint Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 4:485-90. 2003
    ..The ability to generate this strong protective response may benefit parasite transmission by preventing the protozoan from overwhelming its intermediate hosts...
  40. ncbi request reprint Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells
    Antonio Gigliotti Rothfuchs
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:3463-71. 2007
    ..tuberculosis-induced IL-12p40 production by DC in which the receptor augments bacterial-host cell interaction and enhances the subsequent cytokine response through an unknown mechanism involving Syk signaling...
  41. ncbi request reprint Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5349-53. 2003
    ..Our data thus indicate that kinin peptides can serve as danger signals that trigger dendritic cells to produce IL-12 through activation of B(2) bradykinin receptors...
  42. pmc Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway
    Kevin Shenderov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:2029-33. 2014
    ..Instead, both caspase activation and IL-1β production require the alternative TLR4 adaptor TRIF. This pathway may contribute to IL-1-driven tissue pathology in certain disease settings. ..
  43. ncbi request reprint Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii
    Hana Golding
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A, Rm 1A21, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Blood 102:3280-6. 2003
    ..These data support the further development of C-18 derivatives as HIV-1 inhibitors for preventing HIV-1 transmission and for postexposure prophylaxis...
  44. pmc Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells
    Romina S Goldszmid
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:399-410. 2009
    ..Collectively, these findings demonstrate that pathogen-driven hER-PV interaction can serve as an important mechanism for Ag entry into the MHC class I pathway and CD8(+) T cell cross-priming...
  45. pmc IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2485-94. 2006
    ....
  46. pmc Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:807-19. 2011
    ..Our results provide new insights into the regulation of host-protective functions, especially how antigen availability influences T cell dynamics and, in turn, effector T cell function during chronic infection...
  47. ncbi request reprint TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
    Marika C Kullberg
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 35:2886-95. 2005
    ....
  48. ncbi request reprint Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:305-10. 2003
    ..Together these results demonstrate that ICSBP is critically required for the in vivo differentiation of CD8alpha(+) DCs and may also influence the functional maturation of the CD8alpha(-) subsets...
  49. ncbi request reprint Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo
    Sylvie Bertholet
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 177:3525-33. 2006
    ....
  50. pmc Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases LPD, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nature 511:99-103. 2014
    ..Our findings establish proof of concept for host-directed treatment strategies that manipulate the host eicosanoid network and represent feasible alternatives to conventional chemotherapy. ..
  51. pmc Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:1023-34. 2011
    ....
  52. pmc The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments
    Carmen M Collazo
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 70:6933-9. 2002
    ..In contrast, in latent infection, hematopoietically derived cells mediate resistance by means of a largely NO-dependent pathway...
  53. pmc Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
    Autophagy 5:232-4. 2009
    ..We propose that Irgm1 plays a major role in maintaining T lymphocyte homeostasis during host IFN gamma responses by protecting these cells from autophagy-dependent cell death...
  54. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    ..These data underscore the role of Tpl2 as a regulator of T helper cell lineage decisions and demonstrate that Tpl2 has an important functional role in the regulation of Th1 responses...
  55. pmc Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1253-62. 2002
    ..Together, these findings demonstrate a new pathway involving the induction of host LXs for the in vivo regulation of proinflammatory responses during microbial infection...
  56. pmc Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Exp Med 196:505-15. 2002
    ..The induction of such cells in response to gut flora may be a mechanism protecting normal individuals against inflammatory bowel disease...
  57. pmc CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
    David G Kugler
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases 2 Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute and 3 The Johns Hopkins University National Institutes of Health Graduate Partnership Program National Institutes of Health, Bethesda, MD 20892
    J Exp Med 210:1919-27. 2013
    ..In the case of T. gondii infection, this self-regulatory pathway is critical for preventing collateral tissue damage and promoting host survival. ..
  58. pmc Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease
    Bruno B Andrade
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e62618. 2013
    ..In addition, we assess correlations between plasma levels of HO-1 and cytokines closely associated with the immunopathogenesis of TB...
  59. pmc Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi
    Antonio Gigliotti Rothfuchs
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e47835. 2012
    ..These observations point to a previously unappreciated role for MBL in regulating host resistance and cardiac inflammation during infection with a major human pathogen...
  60. pmc Selective expansion of polyfunctional pathogen-specific CD4(+) T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome
    Yolanda D Mahnke
    Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 119:3105-12. 2012
    ..These studies were registered at www.clinical-trials.gov as NCT00557570 and NCT00286767...
  61. pmc Mycobacterium abscessus and M. avium trigger Toll-like receptor 2 and distinct cytokine response in human cells
    Elizabeth P Sampaio
    Laboratory of Clinical Infectious Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1684, USA
    Am J Respir Cell Mol Biol 39:431-9. 2008
    ..We concluded that MAB signals human cells through MAPK and TLR2 pathways and triggers more pronounced pro-inflammatory cytokines and chemokines than MAV...
  62. pmc Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 70:6672-9. 2002
    ..Together, these data indicate that APC-derived IL-10 can exert a major inhibitory effect on control of mycobacterial infection by a mechanism involving the suppression of macrophage effector function and apoptosis...
  63. pmc Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages
    Aleksey Novikov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:2540-7. 2011
    ..tuberculosis infection the induction of type I IFNs is a major mechanism used for this purpose...
  64. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
    ..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation...
  65. ncbi request reprint CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18
    Hana Golding
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 280:29570-7. 2005
    ..The elucidation of the functional C-18-binding mechanism may help in the rational design of novel antiviral agents against HIV...
  66. ncbi request reprint Toll-like receptor recognition of Toxoplasma gondii
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 50, Rm 6144, 50 South Drive MSC 8003, Bethesda, MD 20892 8003, USA
    Int J Parasitol 36:255-9. 2006
    ..Finally, we review the evidence for involvement of other TLR and TLR ligands in host resistance to T. gondii and discuss how such receptors might synergise with TLR11 in the innate response to the parasite...
  67. ncbi request reprint A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  68. ncbi request reprint ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 101:961-9. 2003
    ..Taken together, this study identifies ICSBP as a factor critical for both early differentiation and final maturation of DCs...
  69. pmc Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus
    Even Walseng
    Experimental Immunology Branch, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:41749-54. 2010
    ....
  70. pmc CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:1598-607. 2011
    ..Thus, in the absence of the PD-1 pathway, M. tuberculosis benefits from CD4 T cell responses, and host resistance requires inhibition by PD-1 to prevent T cell-driven exacerbation of the infection...
  71. ncbi request reprint Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbes Infect 4:991-7. 2002
    ..Recent data on the inductive and regulatory pathways involved and their role in governing host resistance to parasite infection in vivo will be discussed...
  72. ncbi request reprint Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    Damien Chaussabel
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:672-81. 2003
    ..The association of characteristic functional clusters with each infectious agent is consistent with the concept that antigen-presenting cells have prewired signaling patterns for use in the response to different pathogens...
  73. ncbi request reprint In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
    Marco L Schito
    Chemical Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 19:91-101. 2003
    ..Thus, these thioesters may provide an effective means for inhibiting the expression of human immunodeficiency virus from integrated viral reservoirs...
  74. ncbi request reprint Cooperation of Toll-like receptor signals in innate immune defence
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 31 93, Frederick, Maryland 21702 1201, USA
    Nat Rev Immunol 7:179-90. 2007
    ..This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies...
  75. ncbi request reprint Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Rm 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Immunol 172:7229-34. 2004
    ..Therefore, TLR-pathogen interactions could play an indirect role in regulating HIV-associated disease. In this review, we summarize emerging evidence for the influence of TLR recognition on HIV gene activation and AIDS progression...
  76. ncbi request reprint Evasion of innate immunity by parasitic protozoa
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:1041-7. 2002
    ..In addition, there is growing evidence that protozoan pathogens modify the antigen-presenting and immunoregulatory functions of dendritic cells, a process that facilitates their evasion of both innate and adaptive immunity...
  77. ncbi request reprint In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:429-39. 2002
    ....
  78. pmc Mining microarray expression data by literature profiling
    Damien Chaussabel
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 3:RESEARCH0055. 2002
    ..Nevertheless, the lack of efficient techniques for assessing the biological implications of gene-expression data remains an important obstacle in exploiting this information...
  79. pmc Processing and presentation of antigens derived from intracellular protozoan parasites
    Romina S Goldszmid
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:118-23. 2010
    ..Elucidating the mechanisms governing antigen processing and presentation of intracellular protozoa may provide important insights needed for the rational design of effective vaccines...
  80. pmc Parasites paralyze cellular host defense system to promote virulence
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 8:463-4. 2010
    ..show that Toxoplasma gondii evades intracellular killing by deploying a virulence determinant, ROP18, which acts by directly phosphorylating and disabling an IFN-γ-inducible immunity-related GTPase involved in pathogen clearance...
  81. ncbi request reprint Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection
    George S Yap
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Microbes Infect 8:1174-8. 2006
    ....
  82. pmc p47 GTPases regulate Toxoplasma gondii survival in activated macrophages
    Barbara A Butcher
    Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Infect Immun 73:3278-86. 2005
    ..gondii. These results suggest that IGTP and LRG-47 are able to regulate host resistance to acute T. gondii infections through their ability to inhibit parasite growth within the macrophage...
  83. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch...
  84. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
    ..These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation...
  85. ncbi request reprint Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering
    Alexander D Edwards
    Immunobiology Laboratory, Cancer Research U K, London Research Institute, London, United Kingdom
    J Immunol 169:3652-60. 2002
    ..These results show that T cell feedback amplifies innate signals for cytokine production by DC and suggest that pattern recognition rather than ontogeny determines the production of cytokines by individual DC subsets...
  86. ncbi request reprint Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
    Julio Aliberti
    Department of Immunology, Duke University School of Medicine, Durham, NC, USA
    Immunol Rev 201:26-34. 2004
    ..In addition, we discuss recent findings concerning the pathways responsible for endogenous regulation of DC IL-12 production during T. gondii infection...
  87. ncbi request reprint Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases)
    Gregory A Taylor
    Department of Medicine, Division of Geriatrics, Center for the Study of Aging and Human Development, Duke University Medical Center, NC 27705, USA
    Microbes Infect 9:1644-51. 2007
    ..Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection...
  88. ncbi request reprint Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc
    Michal Alter-Koltunoff
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 283:2724-33. 2008
    ..Thus, interplay between repression and activation state of the Nramp1 promoter mediated by IRF-8 provides the molecular basis by which macrophages resist intraphagosomal pathogens at early stage after infection...
  89. ncbi request reprint Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication
    Ozlem Equils
    Division of Pediatric Infectious Diseases, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 170:5159-64. 2003
    ....
  90. doi request reprint Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response
    Fabienne Plattner
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Cell Host Microbe 3:77-87. 2008
    ..Thus, profilin is an essential element of two aspects of T. gondii infection. Like bacterial flagellin, profilin plays a role in motility while serving as a microbial ligand recognized by the host innate immune system...
  91. ncbi request reprint Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors
    Laura Del Rio
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Immunol 172:6954-60. 2004
    ..gondii possesses multiple molecules triggering distinct MyD88-dependent signaling cascades, that these pathways are independently regulated, and that they lead to distinct profiles of cytokine production...
  92. pmc Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis
    Nicholas P West
    Mycobacterial Research Program, Centenary Institute of Cancer Medicine and Cell Biology Locked Bag 6, Newtown, NSW 2042, Australia
    Vaccine 26:3853-9. 2008
    ..Finally, following delivery of DNA vaccines, Clp1, 2 and 6, conferred a moderate yet reproducible and significant level of protection in a murine aerosol model of M. tuberculosis infection...
  93. ncbi request reprint Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns
    Alexander D Edwards
    Immunobiology Laboratory and Computational Genome Analysis Laboratory, Cancer Research UK, London Research Institute, London, UK
    J Immunol 171:47-60. 2003
    ..Such associations offer clues to possible unique functions of the CD11c(high) DC subsets that to date have been difficult to define as rigid distinctions...