Jaime M Ross

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:20087-92. 2010
  2. pmc Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Nature 501:412-5. 2013
  3. pmc Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases
    Lin Lin
    Laboratory of Cell Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Cell Res 316:2260-77. 2010
  4. pmc Maternally transmitted mitochondrial DNA mutations can reduce lifespan
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Sci Rep 4:6569. 2014
  5. pmc Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm 171 77, Sweden
    Int J Mol Sci 16:19458-76. 2015

Detail Information

Publications5

  1. pmc High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:20087-92. 2010
    ..The mtDNA mutator mouse allows us to conclude that the increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes...
  2. pmc Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Nature 501:412-5. 2013
    ..Our findings suggest that maternally transmitted mtDNA mutations may have a similar role in aggravating aspects of normal human ageing. ..
  3. pmc Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases
    Lin Lin
    Laboratory of Cell Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Cell Res 316:2260-77. 2010
    ..Our results suggest that TM-agrin regulates actin-based protrusions in large part through interaction of its GAG chains with extracellular or transmembrane proteins, leading to the activation of Cdc42 and Rac1...
  4. pmc Maternally transmitted mitochondrial DNA mutations can reduce lifespan
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Sci Rep 4:6569. 2014
    ..Our data thus demonstrate that low levels of maternally inherited mtDNA mutations when present during development can affect both overall health and lifespan negatively. ..
  5. pmc Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm 171 77, Sweden
    Int J Mol Sci 16:19458-76. 2015
    ..Furthermore, we provide a hypothetical model for the heterogeneity described among individuals during ageing. ..