Steven J Reynolds

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners
    Victor Pena-Cruz
    Department of Medicine, Division of Infectious Diseases, Boston University, Boston, MA, USA
    Retrovirology 10:162. 2013
  2. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
  3. pmc High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, Uganda
    Lara Stabinski
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 16:405-11. 2011
  4. pmc Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    AIDS Res Hum Retroviruses 28:1739-44. 2012
  5. doi request reprint Use of injectable hormonal contraception and women's risk of herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda
    Mary K Grabowski
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet Glob Health 3:e478-86. 2015
  6. pmc A randomized, controlled, trial of short cycle intermittent compared to continuous antiretroviral therapy for the treatment of HIV infection in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e10307. 2010
  7. pmc HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    AIDS 25:473-7. 2011
  8. pmc Effect of daily aciclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 12:441-8. 2012
  9. pmc Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial
    Larry W Chang
    Division of Infectious Diseases, Johns Hopkins School of Medicine, 725 N Wolfe Street, Suite 216, Baltimore, MD, 21205, USA
    AIDS Behav 19:1742-51. 2015
  10. pmc Evolution of drug resistance after virological failure of a first-line highly active antiretroviral therapy regimen in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 14:293-7. 2009

Collaborators

Detail Information

Publications24

  1. pmc HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners
    Victor Pena-Cruz
    Department of Medicine, Division of Infectious Diseases, Boston University, Boston, MA, USA
    Retrovirology 10:162. 2013
    ..We compared HIV-1 envelopes from 9 newly infected subjects and their linked transmitting partner to explore potential mechanisms for selection...
  2. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
    ..We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM)...
  3. pmc High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, Uganda
    Lara Stabinski
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 16:405-11. 2011
    ..Liver disease is a leading cause of mortality among HIV-infected persons in the United States and Europe. However, data regarding the effects of HIV and antiretroviral therapy (ART) on liver disease in Africa are sparse...
  4. pmc Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    AIDS Res Hum Retroviruses 28:1739-44. 2012
    ..PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART...
  5. doi request reprint Use of injectable hormonal contraception and women's risk of herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda
    Mary K Grabowski
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet Glob Health 3:e478-86. 2015
    ..Whether DMPA increases the risk of other sexually transmitted viral infections is unknown. We assessed the association between DMPA use and incident herpes simplex virus type 2 (HSV2) infection in women...
  6. pmc A randomized, controlled, trial of short cycle intermittent compared to continuous antiretroviral therapy for the treatment of HIV infection in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e10307. 2010
    ..Short cycle treatment interruption could reduce toxicity and drug costs and contribute to further expansion of antiretroviral therapy (ART) programs...
  7. pmc HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    AIDS 25:473-7. 2011
    ..To evaluate the impact of antiretroviral therapy (ART) on HIV-1 transmission rates among HIV-1 discordant couples in Rakai, Uganda...
  8. pmc Effect of daily aciclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 12:441-8. 2012
    ..We investigated the effect of daily suppressive aciclovir on HIV-1 disease progression in Rakai, Uganda...
  9. pmc Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial
    Larry W Chang
    Division of Infectious Diseases, Johns Hopkins School of Medicine, 725 N Wolfe Street, Suite 216, Baltimore, MD, 21205, USA
    AIDS Behav 19:1742-51. 2015
    ..35, p = 0.04), and 20 versus 4 % safe water vessel adherence (PRR 5.78, p = 0.017). Peer support may be an effective intervention to facilitate pre-ART care compliance in this important population. ..
  10. pmc Evolution of drug resistance after virological failure of a first-line highly active antiretroviral therapy regimen in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 14:293-7. 2009
    ..This study aimed to determine the extent of viral resistance over time among non-clade B HIV type-1-infected patients in Uganda who were maintained on first-line highly active antiretroviral therapy (HAART) following virological failure...
  11. doi request reprint Decreased monocyte activation with daily acyclovir use in HIV-1/HSV-2 coinfected women
    Andrew D Redd
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Infect 91:485-8. 2015
    ..This study examines if this slowing in clinical progression is a direct cause of the decrease in viral load or an indirect effect of lower immune activation due to lower levels of herpetic reactivation...
  12. pmc Is CD4 monitoring needed among ugandan clients achieving a virologic and immunologic response to treatment?
    Steven J Reynolds
    1 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    AIDS Patient Care STDS 28:575-8. 2014
    ..Thus, ongoing CD4 monitoring could be omitted...
  13. pmc Impact of Patient-Selected Care Buddies on Adherence to HIV Care, Disease Progression, and Conduct of Daily Life Among Pre-antiretroviral HIV-Infected Patients in Rakai, Uganda: A Randomized Controlled Trial
    Gertrude Nakigozi
    Rakai Health Sciences Program, Kalisizo, Uganda School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda
    J Acquir Immune Defic Syndr 70:75-82. 2015
    ..We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among pre-antiretroviral therapy (pre-ART) HIV-infected individuals in Rakai, Uganda...
  14. pmc Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects
    Larry W Chang
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Lancet Infect Dis 13:65-76. 2013
    ..Only through careful consideration of how to implement and operationalise HIV prevention interventions will the HIV community be able to move from clinical trial evidence to population-level effects...
  15. pmc Hepatitis B virus and sexual behavior in Rakai, Uganda
    Lara Stabinski
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Med Virol 83:796-800. 2011
    ..Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority...
  16. pmc Cost analyses of peer health worker and mHealth support interventions for improving AIDS care in Rakai, Uganda
    Larry W Chang
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA
    AIDS Care 25:652-6. 2013
    ..50 patients per year from switching to second-line antiretroviral therapy. Other AIDS care programs may find these intervention costs affordable...
  17. pmc Frequency of long-term nonprogressors in HIV-1 seroconverters From Rakai Uganda
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 52:316-9. 2009
    ..Studies on long-term nonprogressors (LTNP) have been conducted in the USA and Europe. This study examined the frequency of LTNPs and HIV controllers among 637 HIV-1 seroconverters in rural Uganda...
  18. pmc Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1
    Megan Wind-Rotolo
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 199:1301-9. 2009
    ..Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment...
  19. pmc Longitudinal household surveillance for malaria in Rakai, Uganda
    Kevin Newell
    Research Data and Communication Technologies, Inc, Garrett Park, MD, USA
    Malar J 15:77. 2016
    ..HIV and malaria exert co-pathogenic effects. Malaria surveillance data are necessary for public health strategies to reduce the burden of disease in high HIV prevalence settings...
  20. pmc Socioeconomic determinants of mortality in HIV: evidence from a clinical cohort in Uganda
    Matthew D Burkey
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, Johns Hopkins School of Medicine, Baltimore, MD Division of HIV AIDS and Center for AIDS Prevention Studies, University of California, San Francisco, CA The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH Reach Out Mbuya, Kampala, Uganda Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    J Acquir Immune Defic Syndr 66:41-7. 2014
    ..To delineate the association between baseline socioeconomic status (SES) indicators and mortality and lost to follow-up (LTFU) in a cohort of HIV-infected individuals enrolled in antiretroviral therapy (ART) in urban Uganda...
  21. pmc High retention and appropriate use of insecticide-treated nets distributed to HIV-affected households in Rakai, Uganda: results from interviews and home visits
    Lauren Cohee
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Malar J 8:76. 2009
    ..Knowledge about and appropriate use of ITNs among HIV-positive ITN recipients and their household members has not been well characterized...
  22. pmc Setting the stage: current state of affairs and major challenges
    Steven J Reynolds
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Infect Dis 50:S71-6. 2010
    ..The global health community and political leaders will need to overcome these challenges if a long-term effective response to the HIV pandemic is to be achieved...
  23. pmc Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  24. pmc Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    AIDS 23:697-700. 2009
    ..Our objective was to evaluate immunologic failure criteria against gold standard virologic monitoring...