Chen Feng Qi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC
    Chen Feng Qi
    Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States Electronic address
    Leuk Res 37:1680-9. 2013
  2. pmc Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I, Room 1528, Rockville, MD 20852, USA
    Immunol Res 45:62-74. 2009
  3. pmc Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Pathol 221:106-16. 2010
  4. ncbi request reprint Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Twinbrook I, Room 1421, National Institutes of Health, Rockville, MD, USA
    Leuk Res 30:153-63. 2006
  5. ncbi request reprint Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Res 67:2439-47. 2007
  6. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
  7. ncbi request reprint Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:7544-52. 2007
  8. pmc Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas
    Zhaoyang Li
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS ONE 5:e10755. 2010
  9. pmc Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms
    Chen Feng Qi
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA E Mails Y S K S X Z A A L K J S
    Int J Mol Sci 13:6204-19. 2012
  10. ncbi request reprint B lymphoid neoplasms of mice: characteristics of naturally occurring and engineered diseases and relationships to human disorders
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Adv Immunol 81:97-121. 2003

Collaborators

Detail Information

Publications21

  1. pmc Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC
    Chen Feng Qi
    Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States Electronic address
    Leuk Res 37:1680-9. 2013
    ..These findings indicate that the dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1. ..
  2. pmc Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I, Room 1528, Rockville, MD 20852, USA
    Immunol Res 45:62-74. 2009
    ..These findings demonstrate differential requirements for IRF8 among distinct subsets of B cells, DC, and macrophages...
  3. pmc Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Pathol 221:106-16. 2010
    ..Published in 2010 by John Wiley & Sons, Ltd...
  4. ncbi request reprint Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Twinbrook I, Room 1421, National Institutes of Health, Rockville, MD, USA
    Leuk Res 30:153-63. 2006
    ..Here, p27 was complexed with D-type cyclins 1 and 3 and with the COPS9 protein, JAB1. In addition, we found cytoplasmic sequestration following phosphorylation by activated AKT...
  5. ncbi request reprint Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Res 67:2439-47. 2007
    ..Selecting specific types of mouse plasmacytomas that relate most closely to subtypes of human multiple myeloma may provide new opportunities for preclinical testing of drugs for treatment of the human disease...
  6. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  7. ncbi request reprint Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:7544-52. 2007
    ..Our results support the idea that transitional B cells lose the capacity to edit, but are sensitive to positive and negative selection...
  8. pmc Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas
    Zhaoyang Li
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS ONE 5:e10755. 2010
    ..High-level expression was also a feature of a subset of cell lines developed from mouse PCT and from the human MM...
  9. pmc Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms
    Chen Feng Qi
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA E Mails Y S K S X Z A A L K J S
    Int J Mol Sci 13:6204-19. 2012
    ....
  10. ncbi request reprint B lymphoid neoplasms of mice: characteristics of naturally occurring and engineered diseases and relationships to human disorders
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Adv Immunol 81:97-121. 2003
  11. pmc IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 186:1458-66. 2011
    ..Functional studies showed that IRF8-CKO mice generated normal Ab responses to T-independent and T-dependent Ags. Thus, IRF8 controls the expansion and maturation of MZ and FO B cells but has little effect on B cell function...
  12. pmc AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
    Alexander L Kovalchuk
    Laboratory of Cancer Biology and Genetics, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2989-3001. 2007
    ..In contrast, the second was T(12;15) negative, but had an elevated N-Myc expression caused by a paracentric inversion of chromosome 12. Thus, novel mechanisms juxtapose Ig and Myc-family genes in AID-deficient plasma cell tumors...
  13. pmc Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma
    Zhaoyang Li
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Blood 114:4158-68. 2009
    ..These results suggest that, in addition to constitutive activation of BCL10 in MZ B cells, other genetic factors or environmental influences are required for short latency oncogenic transformation...
  14. ncbi request reprint The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas
    Mitsuo Hori
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, 7 Centre Drive, Room 304, MSC 0760, Bethesda, MD 20892, USA
    Leuk Res 26:739-43. 2002
    ..The mouse Bcl6 locus must be inaccessible to the mutational machinery responsible for somatic mutations of Ig and BCL6 in humans...
  15. ncbi request reprint A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  16. pmc The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Blood 119:465-8. 2012
    ..CXCR7 thus appears to function as a scavenger receptor for CXCL12 on MZ B cells...
  17. pmc IFN regulatory factor 8 regulates MDM2 in germinal center B cells
    Jeff X Zhou
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:3188-94. 2009
    ..These results suggest that by regulating MDM2, IRF8 might allow GC B cells to tolerate physiological DNA breaks that otherwise would trigger apoptosis...
  18. ncbi request reprint Histologic and molecular characterizations of megakaryocytic leukemia in mice
    Xingpei Hao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Leuk Res 30:397-406. 2006
    ..This is the first report of spontaneous MKL in mice, defining VWF as a biomarker for diagnosis and suggesting possible involvement of a series of genes in disease pathogenesis...
  19. pmc CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:633-8. 2003
    ..Rapid activation of CTCF by BCR ligation or treatment with TGF-beta was suppressed by ligation of CD40. These results demonstrate that CTCF is a common determinant to different pathways of death signaling in immature B cells...
  20. pmc Hematopoietic neoplasms in Prkar2a-deficient mice
    Emmanouil Saloustros
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics PDEGEN and Pediatric Endocrinology Inter Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    J Exp Clin Cancer Res 34:143. 2015
    ..Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their susceptibility to any tumors...
  21. pmc p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression
    Linjie Tian
    1 Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA 2
    Nat Commun 5:3146. 2014
    ..In this report we identify the mechanism and role of CD300f in AC phagocytosis and maintenance of immune homeostasis. ..