C J Portier

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The forest for the trees: a systems approach to human health research
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 115:1261-3. 2007
  2. pmc Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta
    Hiroyoshi Toyoshiba
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1217-24. 2004
  3. pmc Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure
    Reuben Thomas
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    Genome Biol 10:R44. 2009
  4. pmc Genetic and environmental pathways to complex diseases
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 3:46. 2009
  5. pmc Characterization of the proneural gene regulatory network during mouse telencephalon development
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    BMC Biol 6:15. 2008
  6. pmc Absolute estimation of initial concentrations of amplicon in a real-time RT-PCR process
    Marjo V Smith
    Constella Group, Suite 200, 2605 Meridian Pky, Durham, NC, USA
    BMC Bioinformatics 8:409. 2007
  7. pmc The NIEHS and the National Toxicology Program: an integrated scientific vision
    Christopher J Portier
    Environ Health Perspect 113:A440. 2005
  8. ncbi request reprint Comments on the International Symposium on Light, Endocrine Systems and Cancer
    Christopher J Portier
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neuro Endocrinol Lett 23:79-81. 2002
  9. ncbi request reprint Endocrine dismodulation and cancer
    Christopher J Portier
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neuro Endocrinol Lett 23:43-7. 2002
  10. ncbi request reprint Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD
    C Portier
    National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Analysis, Research Triangle Park, NC 27709, USA
    Food Addit Contam 17:335-46. 2000

Detail Information

Publications39

  1. pmc The forest for the trees: a systems approach to human health research
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 115:1261-3. 2007
    ....
  2. pmc Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta
    Hiroyoshi Toyoshiba
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1217-24. 2004
    ..Simulation studies demonstrated the method works well, even for small samples...
  3. pmc Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure
    Reuben Thomas
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    Genome Biol 10:R44. 2009
    ..The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results...
  4. pmc Genetic and environmental pathways to complex diseases
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 3:46. 2009
    ....
  5. pmc Characterization of the proneural gene regulatory network during mouse telencephalon development
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    BMC Biol 6:15. 2008
    ..The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors...
  6. pmc Absolute estimation of initial concentrations of amplicon in a real-time RT-PCR process
    Marjo V Smith
    Constella Group, Suite 200, 2605 Meridian Pky, Durham, NC, USA
    BMC Bioinformatics 8:409. 2007
    ..The more elaborate mechanistic models require many more parameters than can be fit from a single amplification, while the empirical models provide little insight and are difficult to tailor to specific reactants...
  7. pmc The NIEHS and the National Toxicology Program: an integrated scientific vision
    Christopher J Portier
    Environ Health Perspect 113:A440. 2005
  8. ncbi request reprint Comments on the International Symposium on Light, Endocrine Systems and Cancer
    Christopher J Portier
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neuro Endocrinol Lett 23:79-81. 2002
    ..This overview of the conference is intended to summarize some of the key elements of the conference and to indicate both conclusions and research gaps identified by this reviewer...
  9. ncbi request reprint Endocrine dismodulation and cancer
    Christopher J Portier
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neuro Endocrinol Lett 23:43-7. 2002
    ..This manuscript summarizes cancer mechanisms linked to changes in endocrine function and discusses tools for analyzing and understanding the associated data...
  10. ncbi request reprint Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD
    C Portier
    National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Analysis, Research Triangle Park, NC 27709, USA
    Food Addit Contam 17:335-46. 2000
    ..The paper also evaluates the adequacy of linear and non-linear models for fitting these data and concludes that the assumption of a threshold dose-response is not fully supported by these data...
  11. ncbi request reprint Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    N J Walker
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Appl Pharmacol 154:279-86. 1999
    ....
  12. ncbi request reprint A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice
    B A Willems
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 176:81-91. 2001
    ..However, conclusions regarding which metabolite(s) may be responsible for the lung toxicity could not be reached...
  13. pmc AhR-mediated gene expression in the developing mouse telencephalon
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    Reprod Toxicol 28:321-8. 2009
    ....
  14. ncbi request reprint A physiologically based pharmacokinetic model of p,p'-dichlorodiphenylsulfone
    Fred M Parham
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 181:153-63. 2002
    ..Because the data from mice are limited compared to those from rats, there is more confidence in the model's description of DDS kinetics in rats than in its description of kinetics in mice...
  15. ncbi request reprint Toxicogenomics: the new frontier in risk analysis
    P Trinia Simmons
    National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Analysis, MD A3 06, Research Triangle Park, NC 27709, USA
    Carcinogenesis 23:903-5. 2002
    ..This paper briefly discusses these technologies and how each is being employed for more scientifically sound risk assessments...
  16. ncbi request reprint Gene interaction network analysis suggests differences between high and low doses of acetaminophen
    Hiroyoshi Toyoshiba
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:306-16. 2006
    ..The approaches shown here could provide predictive information to understand high- versus low-dose mechanisms of toxicity...
  17. ncbi request reprint Development of a biologically-based controlled growth and differentiation model for developmental toxicology
    Shree Y Whitaker
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Bldg 101, MD A3 06, Research Triangle Park, North Carolina 27709, USA
    J Math Biol 46:1-16. 2003
    ..Comparisons between the Leroux et al. (1996) model and the controlled growth and differentiation (CGD) model as developed in this paper are also discussed...
  18. pmc Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver
    Petra J M Koken
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1312-7. 2003
    ....
  19. ncbi request reprint Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat
    Michael C Kohn
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Sciences, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Dispos 30:676-83. 2002
    ..Replacement of the V(max) of methemoglobin reductase with a value representative of humans predicted a 10% methemoglobinemia following an intravenous dose of 5.8 mg/kg, in close agreement with an observed value of 5.7 mg/kg for humans...
  20. ncbi request reprint Variation in the hepatic gene expression in individual male Fischer rats
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:102-10. 2005
    ..The level of hepatic gene expression under carefully controlled study conditions is less than 1.5-fold for most genes. The impact of individual animal variability on microarray data can be minimized through experimental design...
  21. pmc Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds"
    Nigel J Walker
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27705, USA
    Environ Health Perspect 113:43-8. 2005
    ..These data support the use of the TEF approach for dioxin cancer risk assessments...
  22. ncbi request reprint Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    N J Walker
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 54:330-7. 2000
    ....
  23. pmc The TAO-Gen algorithm for identifying gene interaction networks with application to SOS repair in E. coli
    Takeharu Yamanaka
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 112:1614-21. 2004
    ..The method is used to evaluate interactions between genes in the SOS signaling pathway in Escherichia coli using gene expression data where each gene in the network is over-expressed using plasmids inserts...
  24. ncbi request reprint Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay
    K W Gaido
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 143:205-12. 1997
    ....
  25. ncbi request reprint Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice
    R L Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:867-78. 1999
    ..Cancer potency of chloroprene is greater in the mouse lung than in the rat lung, but greater in the rat kidney than in the mouse kidney and nearly equivalent in the mammary gland of each species...
  26. ncbi request reprint Physiological modeling of a proposed mechanism of enzyme induction by TCDD
    M C Kohn
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 162:193-208. 2001
    ..Predicted induction at low doses was found to vary widely with the assumptions used in the construction of a model. More detailed descriptions of biological processes might provide more reliable predictions of enzyme induction...
  27. pmc Effects of temperature and air pollutants on cardiovascular and respiratory diseases for males and females older than 65 years of age in Tokyo, July and August 1980-1995
    F Ye
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 109:355-9. 2001
    ..For angina and acute bronchitis, there were no differences for the expected daily numbers of emergency transports per million between males and females...
  28. pmc The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population
    Jung Wan Koo
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 110:405-10. 2002
    ..Our findings suggest that there may be significant demographic variations in exposure and/or metabolism of phthalates and that health-risk assessments for phthalate exposure in humans should consider different potential risk groups...
  29. ncbi request reprint Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds
    Hiroyoshi Toyoshiba
    National Institute of Environmental Health Sciences, 27709, Durham, NC, USA
    Toxicol Appl Pharmacol 194:156-68. 2004
    ..These results indicate that for some biological responses, the use of a single relative potency factor (RPF) is not appropriate for the comparison of the dose response behavior of different dioxin-like congeners...
  30. ncbi request reprint Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice
    H A el-Masri
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 26:585-94. 1998
    ..This result was in agreement with a recently finished National Toxicology Program (NTP) carcinogenicity study of primidone in rats and mice...
  31. pmc Temperature and air pollution as risk factors for heat stroke in Tokyo, July and August 1980-1995
    W T Piver
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 107:911-6. 1999
    ....
  32. pmc Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development
    Windy A Boyd
    Biomoleclular Screening Branch, National Toxicology Program, Research Triangle Park, North Carolina, USA
    PLoS ONE 4:e7024. 2009
    ..Chlorpyrifos, an organophosphate pesticide known to cause developmental delays and malformations in mammals, was used as a model toxicant to test the applicability of the growth model for in vivo toxicological testing...
  33. ncbi request reprint Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation
    Hugh A Barton
    US EPA, ORD, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:395-402. 2007
    ....
  34. pmc Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: identification of key issues
    Ravi P Subramaniam
    NCEA, ORD, U S Environmental Protection Agency, Pennsylvania Ave NW, Washington, DC 20460, USA
    Risk Anal 28:907-23. 2008
    ..The authors of the CIIT modeling endeavor characterized their human risk estimates as "conservative in the face of modeling uncertainties." The uncertainties discussed in this article indicate that such a claim is premature...
  35. pmc Compound cytotoxicity profiling using quantitative high-throughput screening
    Menghang Xia
    NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3370, USA
    Environ Health Perspect 116:284-91. 2008
    ..Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects...
  36. ncbi request reprint Report of an ISRTP workshop: progress and barriers to incorporating alternative toxicological methods in the U.S
    Richard A Becker
    American Chemistry Council, Arlington, VA, USA
    Regul Toxicol Pharmacol 46:18-22. 2006
    ....
  37. pmc MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies
    Grace E Kissling
    Regul Toxicol Pharmacol 50:428-9. 2008
  38. ncbi request reprint Impact of physiologically based pharmacokinetic modeling on benchmark dose calculations for TCDD-induced biochemical responses
    Amy H Kim
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, 509 Mary Ellen Jones Building, CB 7270, 27599, USA
    Regul Toxicol Pharmacol 36:287-96. 2002
    ..BB(01) and BB(10) values from both methods were within two orders of magnitude of current human general population exposure to all dioxin-like compounds...