Affiliation: National Institutes of Health
- Presence of immunoreactive adrenomedullin in human and bovine milkR Pio
Department of Cell and Cancer Biology, National Cancer Institute, NIH, Building 10 Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892, USA
Peptides 21:1859-63. 2000..5 +/- 3.8 pg/mL. Bovine milk products had AM levels similar to those found in fresh bovine milk. Human milk had growth promoting activity on the human intestinal cell line Int-407 that could be partially blocked with an anti-AM antibody...
- Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partnersR Pio
Department of Cell and Cancer Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:12292-300. 2001..In summary, we report on a potentially new regulatory mechanism of AM biology, the influence of factor H on radioimmunoassay quantification of AM, and the possible involvement of AM as a regulator of the complement cascade...
- Is adrenomedullin a causal agent in some cases of type 2 diabetes?A Martinez
Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Peptides 20:1471-8. 1999..AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals...
- Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretionA Martinez
Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Endocrinol 170:503-11. 2001..The expression of factor H in the pancreas may play other important roles such as protection against complement-mediated cell lysis...
- Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesisM Garayoa
Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892, USA
Mol Endocrinol 14:848-62. 2000....