Joao B Oliveira

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes
    João Bosco Oliveira
    Pediatrics Department, Medical Institute Prof Fernando Figueira IMIP, Recife, PE, Brazil
    Methods Mol Biol 979:25-31. 2013
  2. doi request reprint Molecular- and flow cytometry-based diagnosis of primary immunodeficiency disorders
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:460-7. 2010
  3. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
  4. pmc Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:e35-40. 2010
  5. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
  6. ncbi request reprint Autoimmune lymphoproliferative syndrome
    Thomas A Fleisher
    Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, DHHS, Bethesda, MD, USA
    Isr Med Assoc J 7:758-61. 2005
  7. pmc FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 186:6035-43. 2011
  8. pmc Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
  9. doi request reprint Applications of flow cytometry for the study of primary immune deficiencies
    Joao B Oliveira
    Immunology Service, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
    Curr Opin Allergy Clin Immunol 8:499-509. 2008
  10. pmc Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings
    Julie Niemela
    Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, USA
    J Clin Immunol 35:348-55. 2015

Collaborators

Detail Information

Publications20

  1. doi request reprint Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes
    João Bosco Oliveira
    Pediatrics Department, Medical Institute Prof Fernando Figueira IMIP, Recife, PE, Brazil
    Methods Mol Biol 979:25-31. 2013
    ..We describe here how to evaluate the integrity of the intrinsic pathway of lymphocyte apoptosis triggered by starvation for IL-2 or other survival cytokines...
  2. doi request reprint Molecular- and flow cytometry-based diagnosis of primary immunodeficiency disorders
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:460-7. 2010
    ..We discuss here advances in flow cytometry and molecular techniques applied to the study of primary immunodeficiencies...
  3. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
    ..We suggest the use of the term RAS-associated autoimmune leukoproliferative disease to differentiate this disorder from autoimmune lymphoproliferative syndrome...
  4. pmc Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:e35-40. 2010
    ..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas...
  5. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
    ....
  6. ncbi request reprint Autoimmune lymphoproliferative syndrome
    Thomas A Fleisher
    Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, DHHS, Bethesda, MD, USA
    Isr Med Assoc J 7:758-61. 2005
  7. pmc FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 186:6035-43. 2011
    ..The apoptosis defect could be corrected by FAS overexpression in vitro. Our findings define haploinsufficiency as a common disease mechanism in ALPS patients with extracellular FAS mutations...
  8. pmc Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
    ..Notably, treatment with rapamycin to inhibit mTOR activity in vivo partially restored the abundance of naive T cells, largely 'rescued' the in vitro T cell defects and improved the clinical course. ..
  9. doi request reprint Applications of flow cytometry for the study of primary immune deficiencies
    Joao B Oliveira
    Immunology Service, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
    Curr Opin Allergy Clin Immunol 8:499-509. 2008
    ..This review focuses on the current applications of flow cytometry for the diagnosis and evaluation of primary immune deficiencies (PIDs)...
  10. pmc Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings
    Julie Niemela
    Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, USA
    J Clin Immunol 35:348-55. 2015
    ..This phenotype broadens the clinical spectrum of manifestations associated with this disease and warrants the search of CASP8 mutations in other cohorts of patients. ..
  11. pmc Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 345:1623-7. 2014
    ..Inherited human CTLA4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis. ..
  12. pmc Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Blood 121:3117-25. 2013
    ..In summary, homozygous PRKCD mutation results in B-cell hyperproliferation and defective apoptosis with consequent lymphocyte accumulation and autoantibody production in humans, and disrupts natural killer cell function...
  13. ncbi request reprint Autoimmune lymphoproliferative syndrome
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 4:497-503. 2004
    ..In this review we summarize current information regarding the diagnosis, management and underlying molecular basis of the syndrome...
  14. pmc Laboratory evaluation of primary immunodeficiencies
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, USA
    J Allergy Clin Immunol 125:S297-305. 2010
    ..In this article the authors describe a general approach for the investigation of the most common primary immunodeficiencies, outlining the typical clinical symptoms and most appropriate laboratory investigations...
  15. doi request reprint Autoimmunity in hyper-IgM syndrome
    Adriana A Jesus
    Pediatric Rheumatology Unit, Pediatrics Department, Universidade de Sao Paulo, Av Dr Enéas Carvalho de Aguiar 500 IMT Bldg II 3rd floor, Sao Paulo, Sao Paulo 054030 000, Brazil
    J Clin Immunol 28:S62-6. 2008
    ..HIGM can thus be associated with an impairment of both B-cell and T-cell activation...
  16. pmc CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome
    Xiying Fan
    Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Clin Immunol 143:152-61. 2012
    ..This study demonstrates that CP-870,893 suppressed oocysts shedding in XHM patients with biliary cryptosporidiosis. The continued study of CD40 agonists in XHM is warranted...
  17. doi request reprint TNF receptor-associated periodic syndrome (TRAPS): description of a novel TNFRSF1A mutation and response to etanercept
    Adriana A Jesus
    Pediatric Rheumatology Unit, Pediatrics Department, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar, 647, 05403 900, Sao Paulo, SP, Brazil
    Eur J Pediatr 167:1421-5. 2008
    ....
  18. pmc Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia
    Peter D Burbelo
    Neurobiology and Pain Therapeutics, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Blood 116:4848-58. 2010
    ..This study was registered at http://clinicaltrials.gov as NCT00001355...
  19. pmc NRAS mutation causes a human autoimmune lymphoproliferative syndrome
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8953-8. 2007
    ..Our observations on the effects of NRAS activation indicate that RAS-inactivating drugs, such as farnesyltransferase inhibitors should be examined in human autoimmune and lymphocyte homeostasis disorders...
  20. pmc ALPS-ten lessons from an international workshop on a genetic disease of apoptosis
    Michael J Lenardo
    Molecular Development Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:291-5. 2010
    ..Their discussions yielded ten broad messages applicable to genetic and immunological investigations of human disease...