Allison C Nugent

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
  2. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
  3. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
  4. pmc Biomarkers in mood disorders research: developing new and improved therapeutics
    Mark J Niciu
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Rev Psiquiatr Clin 41:131-134. 2014
  5. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
  6. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
  7. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
  8. pmc Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, USA
    J Psychopharmacol 27:894-902. 2013
  9. pmc Baseline mood-state measures as predictors of antidepressant response to scopolamine
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 196:62-7. 2012
  10. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
    ....
  2. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
    ..We conducted the first magnetic resonance imaging analysis of habenula volume in MDD and bipolar disorder (BD)...
  3. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT(1A) receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT(1A) receptor system of individuals with a tendency toward cortisol hypersecretion...
  4. pmc Biomarkers in mood disorders research: developing new and improved therapeutics
    Mark J Niciu
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Rev Psiquiatr Clin 41:131-134. 2014
    ..Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders...
  5. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
    ..Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD...
  6. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
    ..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications...
  7. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  8. pmc Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, USA
    J Psychopharmacol 27:894-902. 2013
    ..These preliminary findings are consistent with the hypothesis that these mood stabilizers enhance 5-HT1A receptor expression in BD, which may underscore an important component of these agents' mechanism of action. ..
  9. pmc Baseline mood-state measures as predictors of antidepressant response to scopolamine
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 196:62-7. 2012
    ..These results indicate that self-report mood-ratings obtained before treatment can predict response outcome to scopolamine, and suggest that a constellation of mood-state features may be related to clinical response...
  10. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  11. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  12. ncbi request reprint Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006
    ..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects...
  13. pmc Neural correlates of suicidal ideation and its reduction in depression
    Elizabeth D Ballard
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland Dr Ballard, Mr Lally, Dr Nugent, Dr Furey, Mr Luckenbaugh, and Dr Zarate Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, UK Mr Lally
    Int J Neuropsychopharmacol 18:. 2014
    ....
  14. pmc Reliability of 7T (1) H-MRS measured human prefrontal cortex glutamate, glutamine, and glutathione signals using an adapted echo time optimized PRESS sequence: A between- and within-sessions investigation
    Níall Lally
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Magn Reson Imaging 43:88-98. 2016
    ..However, the advent of novel pulse sequences and higher field magnetic resonance imaging (MRI) allows more precise resolution of overlapping glutamatergic signals, although the question of signal reliability remains undetermined...
  15. pmc Automated subcortical segmentation using FIRST: test-retest reliability, interscanner reliability, and comparison to manual segmentation
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Brain Mapp 34:2313-29. 2013
    ..In addition, the inclusion of psychiatric patients establishes reliability in subjects exhibiting volumetric abnormalities, validating patient studies...
  16. pmc Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA
    Bipolar Disord 16:119-28. 2014
    ..Evidence supports a role for the glutamatergic system in the pathophysiology of BD. This double-blind, randomized, cross-over study sought to determine cerebral metabolic correlates of antidepressant response to ketamine...
  17. pmc Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls
    Arlener D Turner
    National Institutes of Mental Health Experimental and Pathophysiology Branch, NIMH, CRC, Bethesda, MD 20892, USA
    Neuropsychologia 50:2348-55. 2012
    ..This suggests that larger hippocampal volume is related to better memory recall in depression, but specifically with regard to utilizing an inferior memory strategy...
  18. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..Here, we compare the volume of the habenula in unmedicated patients with post-traumatic stress disorder (PTSD) and healthy controls (HC) using MRI...
  19. pmc Recognition of emotional facial expressions in anxious and nonanxious depression
    Hannah E Berg
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD
    Compr Psychiatry 70:1-8. 2016
    ..Anxiety and depression have each been independently associated with impairments in emotional face recognition. However, little is known about the nature of these impairments when anxiety and depression co-occur...
  20. pmc Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression
    Robin Ortiz
    National Institutes of Health National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Building 10 Clinical Research Center CRC, 10 Center Dr, Room 7 5342, Bethesda, MD 20892, USA
    J Affect Disord 172:307-11. 2015
    ..We hypothesized that elevated baseline plasma Shank3 levels might predict antidepressant response to the NMDA receptor antagonist ketamine...
  21. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
    ....
  22. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  23. pmc Sex differences in the neural correlates of autonomic arousal: a pilot PET study
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH NIH, 9 Memorial Drive, MSC 0940, Bethesda, MD 20892 0940, United States
    Int J Psychophysiol 80:182-91. 2011
    ....
  24. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  25. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  26. doi request reprint Amygdala response to explicit sad face stimuli at baseline predicts antidepressant treatment response to scopolamine in major depressive disorder
    Joanna Szczepanik
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Electronic address
    Psychiatry Res 254:67-73. 2016
    ....
  27. pmc Preliminary differences in resting state MEG functional connectivity pre- and post-ketamine in major depressive disorder
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Electronic address
    Psychiatry Res 254:56-66. 2016
    ..These preliminary findings suggest that sgACC connectivity may be directly related to glutamate levels. ..
  28. pmc Deriving frequency-dependent spatial patterns in MEG-derived resting state sensorimotor network: A novel multiband ICA technique
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Hum Brain Mapp . 2016
    ..The implications of these results on our understanding of sensorimotor function are discussed, as are the potential applications of this technique. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc...
  29. pmc Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
    Marc S Lener
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Psychiatry . 2016
    ....
  30. pmc Safety of research into severe and treatment-resistant mood disorders: analysis of outcome data from 12 years of clinical trials at the US National Institute of Mental Health
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Electronic address
    Lancet Psychiatry 3:436-42. 2016
    ..We aimed to assess the cumulative effects of research in individuals with mood disorders and to provide data to address ethical concerns regarding research in this population...
  31. pmc Group differences in MEG-ICA derived resting state networks: Application to major depressive disorder
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Electronic address
    Neuroimage 118:1-12. 2015
    ..Findings of increased connectivity between the amygdala and cortical nodes further support the role of amygdalar networks in mediated depressive symptomatology...
  32. pmc Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants
    Mark J Niciu
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, Maryland
    Depress Anxiety 31:297-307. 2014
    ..In sum, the combination of target engagement and well-qualified disease-related measures are crucial to improve our pathophysiological understanding, personalize treatment selection, and expand our armamentarium of novel therapeutics...
  33. pmc The relationship between glucose metabolism, resting-state fMRI BOLD signal, and GABAA-binding potential: a preliminary study in healthy subjects and those with temporal lobe epilepsy
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 35:583-91. 2015
    ..TLE may be a disorder of altered long-range connectivity in association with glutamate function...
  34. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  35. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  36. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  37. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  38. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...