J A Nick

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Allergen-specific early neutrophil infiltration after allergen challenge in a murine model
    Christian Taube
    Departments of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:410S-1S. 2003
  2. ncbi request reprint Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:837-43. 2004
  3. ncbi request reprint Nontuberculous mycobacteria in cystic fibrosis
    Jerry A Nick
    Division of Pulmonary Science and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Semin Respir Crit Care Med 24:693-702. 2003
  4. pmc Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
    J A Nick
    Department of Medicine, Program in Molecular Signal Transduction, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 103:851-8. 1999
  5. ncbi request reprint Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
    J A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 164:2151-9. 2000
  6. ncbi request reprint Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, D202, 1400 Jackson St, Denver, CO 80206, USA
    Blood 104:3878-85. 2004
  7. ncbi request reprint Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5260-9. 2002
  8. ncbi request reprint Manifestations of cystic fibrosis diagnosed in adulthood
    Jerry A Nick
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pulm Med 11:513-8. 2005
  9. ncbi request reprint Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis
    N J Avdi
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado 80206, USA
    J Biol Chem 276:2189-99. 2001
  10. ncbi request reprint p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
    S C Frasch
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 273:8389-97. 1998

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Allergen-specific early neutrophil infiltration after allergen challenge in a murine model
    Christian Taube
    Departments of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:410S-1S. 2003
  2. ncbi request reprint Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:837-43. 2004
    ..The effects of inhibiting p38 MAPK in decreasing AHR indicate activities independent of its prevention of neutrophil accumulation...
  3. ncbi request reprint Nontuberculous mycobacteria in cystic fibrosis
    Jerry A Nick
    Division of Pulmonary Science and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Semin Respir Crit Care Med 24:693-702. 2003
    ..Hence, patients offered antimycobacterial treatment must be selected carefully. An initial approach to treatment of CF patients is based on guidelines developed for the general population...
  4. pmc Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
    J A Nick
    Department of Medicine, Program in Molecular Signal Transduction, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 103:851-8. 1999
    ....
  5. ncbi request reprint Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
    J A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 164:2151-9. 2000
    ....
  6. ncbi request reprint Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, D202, 1400 Jackson St, Denver, CO 80206, USA
    Blood 104:3878-85. 2004
    ..These rhAPC-induced effects on neutrophil function may represent a mechanism by which rhAPC improves survival in patients with sepsis...
  7. ncbi request reprint Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5260-9. 2002
    ..These findings support the feasibility of p38 MAPK inhibition as a selective intervention to reduce neutrophilic inflammation...
  8. ncbi request reprint Manifestations of cystic fibrosis diagnosed in adulthood
    Jerry A Nick
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pulm Med 11:513-8. 2005
    ..This review highlights the phenotypic features that lead to the diagnosis of cystic fibrosis in adults, and the prognosis of these patients...
  9. ncbi request reprint Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis
    N J Avdi
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado 80206, USA
    J Biol Chem 276:2189-99. 2001
    ....
  10. ncbi request reprint p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
    S C Frasch
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 273:8389-97. 1998
    ..We propose the presence of at least two pathways leading to apoptosis in human neutrophils, a stress-activated pathway that is dependent on p38 MAPK activation and an anti-FAS/spontaneous pathway that is p38 MAPK-independent...
  11. ncbi request reprint Neutrophil maturation and activation determine anatomic site of clearance from circulation
    B T Suratt
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 281:L913-21. 2001
    ..Furthermore, models for circulating neutrophil homeostasis should consider that the site of retention is governed by the maturation and activation states of the cell...
  12. ncbi request reprint Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils
    C Knall
    Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    J Biol Chem 271:2832-8. 1996
    ..These findings demonstrate the control of Raf kinases, the MAPK pathway and specific neutrophil functions by phosphatidylinositol 3-kinase enzymes...
  13. ncbi request reprint Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways
    Patrick G Arndt
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 177:7233-41. 2006
    ....
  14. ncbi request reprint By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Cell 115:13-23. 2003
    ..However, interaction of these heads with PAMPs on foreign organisms or damaged cells and presentation of the collagenous tails in an aggregated state to calreticulin/CD91, stimulates phagocytosis and proinflammatory responses...
  15. pmc Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils
    Travis S Walker
    National Jewish Medical and Research Center, D202, 1400 Jackson Street, Denver, CO 80206, USA
    Infect Immun 73:3693-701. 2005
    ..When the host fails to eradicate the infection, cellular components from necrotic neutrophils can serve as a biological matrix to facilitate P. aeruginosa biofilm formation...
  16. pmc Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 38:679-88. 2008
    ....
  17. pmc Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy
    Quinn M Parks
    Department of Medicine, National Jewish Health, 1400 Jackson, Denver, CO, USA
    J Med Microbiol 58:492-502. 2009
    ..aeruginosa. Neutrophil F-actin represents a potential new therapeutic target for disruption of pathogenic biofilms...
  18. doi request reprint Cystic fibrosis pulmonary guidelines: pulmonary complications: hemoptysis and pneumothorax
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 182:298-306. 2010
    ..There may be intermittent pulmonary exacerbations or acute worsening of infection and obstruction, which require more intensive therapies. Hemoptysis and pneumothorax are complications commonly reported in patients with cystic fibrosis...
  19. pmc Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 178:929-38. 2008
    ..Although the standard assessment of pulmonary treatment response is FEV(1), a measure of airflow limitation, the lack of systemic markers to reflect changes in lung inflammation critically limits the testing of proposed therapeutics...
  20. ncbi request reprint Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx
    Patrick G Arndt
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:978-86. 2005
    ....
  21. ncbi request reprint A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005
    ..No studies to date, however, have addressed whether statins modulate pulmonary inflammation triggered by aerogenic stimuli or whether they affect host defense...
  22. ncbi request reprint A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils
    Natalie J Avdi
    Department of Medicine, Division of Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, D403, Denver, CO 80206, USA
    J Biol Chem 277:40687-96. 2002
    ..Thus, in neutrophils, p38 MAPK, through a PP2A-mediated mechanism, regulates the JNK pathway, thus determining the extent and nature of subsequent responses such as apoptosis...
  23. ncbi request reprint Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:39989-98. 2004
    ..In sum, these findings provide evidence for an important regulatory role of cholesterol in both transmission of the lipopolysaccharide signal and the inflammatory phenotype of the human neutrophil...
  24. pmc Glucose >200 mg/dL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes
    J L Taylor-Cousar
    Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    J Diabetes Res 2016:1527932. 2016
    ..03); CGM indicated a greater level of glucose impairment than OGTT. Glucose >200 mg/dL by CGM predicted development of CFRD (p = 0.0002)...
  25. ncbi request reprint Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Immunol 176:7753-60. 2006
    ..049 for TNFRII. These results demonstrate that stable patterns in the response of peripheral blood neutrophils to LPS exist in the human population and correlate with inflammatory response following direct exposure to LPS in the lung...
  26. ncbi request reprint Functional and genomic changes induced by alveolar transmigration in human neutrophils
    Christopher D Coldren
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1267-76. 2006
    ..These results suggest that neutrophils sequestered in the lung become fundamentally different from those resident in the circulation, and this difference is distinct from in vitro activation with endotoxin...
  27. doi request reprint Blood mRNA biomarkers for detection of treatment response in acute pulmonary exacerbations of cystic fibrosis
    J A Nick
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Thorax 68:929-37. 2013
    ..Acute pulmonary exacerbations accelerate pulmonary decline in cystic fibrosis (CF). There is a critical need for better predictors of treatment response...
  28. ncbi request reprint Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and Fc gamma III receptors
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 170:4301-9. 2003
    ..These results demonstrate that neutrophil influx after allergen challenge requires prior sensitization, is allergen-specific, is mediated through FcgammaRIII, and is dependent on the presence of Ab...
  29. pmc Dual role for RhoA in suppression and induction of cytokines in the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Blood 109:1248-56. 2007
    ..The p65 subunit of NF-kappaB coprecipitates with RhoA in a manner sensitive to the RhoA activation state. Our findings suggest a new, 2-faced role for RhoA as a checkpoint in innate immunity...
  30. ncbi request reprint Late diagnosis defines a unique population of long-term survivors of cystic fibrosis
    David M Rodman
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 171:621-6. 2005
    ..This is the largest cohort of older patients with CF described to date, and our findings indicate that patients diagnosed as adults differ distinctly from survivors of long-term CF diagnosed as children...
  31. pmc Effects of gender and age at diagnosis on disease progression in long-term survivors of cystic fibrosis
    Jerry A Nick
    Adult Cystic Fibrosis Program, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 182:614-26. 2010
    ..Little is known concerning disease progression and outcomes in these cohorts...
  32. pmc Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
    Kathleen Smoak
    Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 180:3305-12. 2008
    ..Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung...
  33. ncbi request reprint Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
    Benjamin T Suratt
    University of Vermont College of Medicine, 149 Beaumont Ave, Burlington, VT 05405, USA
    Blood 104:565-71. 2004
    ....
  34. ncbi request reprint HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil
    Intensive Care Med 33:1829-39. 2007
    ..In the present study we evaluated gene expression and activation of major intracellular signaling pathways in peripheral blood neutrophils obtained from patients with sepsis-induced acute lung injury after culture with HMGB1 or LPS...
  35. pmc Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans
    Tom van der Poll
    Department of Medicine, Academic Medical Center, Room G2 130, Meibergdreef 9, 1105AZ Amsterdam, Netherlands
    Am J Respir Crit Care Med 171:1125-8. 2005
    ..Activated protein C (APC) has systemic anticoagulant effects in patients with sepsis...