J Moss

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADP-Ribose) Polymerase-1 Response to Oxidative Stress
    Masato Mashimo
    Rm 6D05, Bldg 10, MSC 1590, National Institutes of Health, Bethesda, MD 20892 1590 USA
    Curr Protein Pept Sci 17:633-640. 2016
  2. ncbi request reprint Prevalence and clinical characteristics of lymphangioleiomyomatosis (LAM) in patients with tuberous sclerosis complex
    J Moss
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, Diagnostic Radiology Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Am J Respir Crit Care Med 164:669-71. 2001
  3. ncbi request reprint Meningiomas in lymphangioleiomyomatosis
    J Moss
    Room 6D05, Bldg 10, MSC 1590, National Institutes of Health, Bethesda, MD 20892 1590, USA
    JAMA 286:1879-81. 2001
  4. ncbi request reprint Lymphangioleiomyomatosis (LAM): a review of clinical and morphological features
    V J Ferrans
    Pathology Section, National Heart, Lung, and Blood Institute, NIH, Behtesda, MD 20892 1518, USA
    J Nippon Med Sch 67:311-29. 2000
  5. ncbi request reprint Pulmonary lymphangioleiomyomatosis: correlation of ventilation-perfusion scintigraphy, chest radiography, and CT with pulmonary function tests
    N A Avila
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1182, USA
    Radiology 214:441-6. 2000
  6. ncbi request reprint Hyperplasia of type II pneumocytes in pulmonary lymphangioleiomyomatosis
    K Matsui
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1518, USA
    Arch Pathol Lab Med 124:1642-8. 2000
  7. ncbi request reprint Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
    J Marks-Konczalik
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 273:22201-8. 1998
  8. ncbi request reprint Lymphangioleiomyomatosis: CT of diurnal variation of lymphangioleiomyomas
    N A Avila
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Rm 1C 660, 10 Center Dr MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 221:415-21. 2001
  9. ncbi request reprint Prognostic significance of pulmonary lymphangioleiomyomatosis histologic score
    K Matsui
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Surg Pathol 25:479-84. 2001
  10. ncbi request reprint Immunohistochemical analysis of proteins of the Bcl-2 family in pulmonary lymphangioleiomyomatosis: association of Bcl-2 expression with hormone receptor status
    J Usuki
    Pathology Section, Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1518, USA
    Arch Pathol Lab Med 122:895-902. 1998

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADP-Ribose) Polymerase-1 Response to Oxidative Stress
    Masato Mashimo
    Rm 6D05, Bldg 10, MSC 1590, National Institutes of Health, Bethesda, MD 20892 1590 USA
    Curr Protein Pept Sci 17:633-640. 2016
    ..In addition, we describe the current knowledge of poly-ADP-ribosylation and cell death pathways regulated PARP1, PARG, and ARH3...
  2. ncbi request reprint Prevalence and clinical characteristics of lymphangioleiomyomatosis (LAM) in patients with tuberous sclerosis complex
    J Moss
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, Diagnostic Radiology Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Am J Respir Crit Care Med 164:669-71. 2001
    ..The prevalence of LAM in women with TSC was 34%, approximately 10-fold that previously reported, consistent with a large hitherto unrecognized subclinical population of patients at risk for pulmonary complications...
  3. ncbi request reprint Meningiomas in lymphangioleiomyomatosis
    J Moss
    Room 6D05, Bldg 10, MSC 1590, National Institutes of Health, Bethesda, MD 20892 1590, USA
    JAMA 286:1879-81. 2001
    ..Since 30% to 40% of patients with tuberous sclerosis complex (TSC) have LAM, we routinely screen patients with LAM for brain lesions found in TSC...
  4. ncbi request reprint Lymphangioleiomyomatosis (LAM): a review of clinical and morphological features
    V J Ferrans
    Pathology Section, National Heart, Lung, and Blood Institute, NIH, Behtesda, MD 20892 1518, USA
    J Nippon Med Sch 67:311-29. 2000
    ..Types of treatment used for LAM include oophorectomy, administration of Lupron or progesterone and in very severe cases, pulmonary transplantation (following the onset of respiratory insufficiency, not relieved by O(2))...
  5. ncbi request reprint Pulmonary lymphangioleiomyomatosis: correlation of ventilation-perfusion scintigraphy, chest radiography, and CT with pulmonary function tests
    N A Avila
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1182, USA
    Radiology 214:441-6. 2000
    ..To determine the findings on ventilation-perfusion (V-P) scintigrams, computed tomographic (CT) scans, and chest radiographs and correlate them with pulmonary function test results in patients with lymphangioleiomyomatosis...
  6. ncbi request reprint Hyperplasia of type II pneumocytes in pulmonary lymphangioleiomyomatosis
    K Matsui
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1518, USA
    Arch Pathol Lab Med 124:1642-8. 2000
    ..Little is known of the morphology of the pneumocytes lining the parenchymal cysts in lymphangioleiomyomatosis (LAM)...
  7. ncbi request reprint Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
    J Marks-Konczalik
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 273:22201-8. 1998
    ..Thus, AP-1 and NF-kappaB are important cis-elements for induction of hiNOS gene transcription...
  8. ncbi request reprint Lymphangioleiomyomatosis: CT of diurnal variation of lymphangioleiomyomas
    N A Avila
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Rm 1C 660, 10 Center Dr MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 221:415-21. 2001
    ..To evaluate the imaging and clinical features of lymphangioleiomyomas and to describe the phenomenon of diurnal variation in the size of lymphangioleiomyomas in patients with lymphangioleiomyomatosis...
  9. ncbi request reprint Prognostic significance of pulmonary lymphangioleiomyomatosis histologic score
    K Matsui
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Surg Pathol 25:479-84. 2001
    ..029) and a worse prognosis (p = 0.0012). Thus, the current study suggests that the LHS may provide a basis for determining the prognosis of LAM...
  10. ncbi request reprint Immunohistochemical analysis of proteins of the Bcl-2 family in pulmonary lymphangioleiomyomatosis: association of Bcl-2 expression with hormone receptor status
    J Usuki
    Pathology Section, Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1518, USA
    Arch Pathol Lab Med 122:895-902. 1998
    ....
  11. ncbi request reprint Lymphangioleiomyomatosis: abdominopelvic CT and US findings
    N A Avila
    Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Rm 1C 660, Bethesda, MD 20892 1182, USA
    Radiology 216:147-53. 2000
    ..To describe the abdominal computed tomographic (CT) and ultrasonographic (US) findings in patients with thoracic lymphangioleiomyomatosis (LAM) and to relate the prevalence of the findings to the severity of pulmonary disease...
  12. ncbi request reprint Distribution and mRNA expression of insulin-like growth factor system in pulmonary lymphangioleiomyomatosis
    J C Valencia
    Pathology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1518, USA
    J Investig Med 49:421-33. 2001
    ..Thus, the patterns of localization and expression of components of the IGF system in LAM strongly suggest that these agents are involved in the proliferation of LAM cells...
  13. pmc Effects of site-directed mutagenesis of Escherichia coli heat-labile enterotoxin on ADP-ribosyltransferase activity and interaction with ADP-ribosylation factors
    L A Stevens
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    Infect Immun 67:259-65. 1999
    ..Based on these data, it appears that ARF-binding and catalytic sites are not identical and that a region outside the NAD cleft may participate in the LTA-ARF interaction...
  14. ncbi request reprint Lymphangioleiomyomatosis
    J Kelly
    Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Med Sci 321:17-25. 2001
    ..Although the efficacy of these therapies has not been established, the clinical course is more favorable in recent studies compared with earlier reports...
  15. ncbi request reprint Association of lymphangioleiomyomatosis (LAM) with endosalpingiosis in the retroperitoneal lymph nodes: report of two cases
    K Matsui
    Pathology Section, National Heart, Lung and Blood Institute, Bldg. 10/2N240, National Institutes of Health, 10 Center Dr. MSC-1518, Bethesda, MD 20892-1518, USA
    Int J Surg Pathol 9:155-62. 2001
    ....
  16. ncbi request reprint Reversible airflow obstruction, proliferation of abnormal smooth muscle cells, and impairment of gas exchange as predictors of outcome in lymphangioleiomyomatosis
    A M Taveira-DaSilva
    Pulmonary-Critical Care Medicine Branch, Office of Biostatistics Research, and Pathology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590, USA
    Am J Respir Crit Care Med 164:1072-6. 2001
    ..Impairment of DL(CO) correlates with LHS, a predictor of survival and time to lung transplantation...
  17. pmc Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors
    M Sata
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:2752-7. 1999
    ..As predicted, the double C-1Sec7 mutant with S199D and P209M was BFA-sensitive, demonstrating that Asp965 and Met975 in ySec7d are major molecular determinants of BFA sensitivity...
  18. pmc Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis
    M K Park
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Sarcoidosis Vasc Diffuse Lung Dis 26:121-31. 2009
    ..Agents that target pro-inflammatory cytokines may be useful in pulmonary sarcoidosis...
  19. pmc Cloning and characterization of human inducible nitric oxide synthase splice variants: a domain, encoded by exons 8 and 9, is critical for dimerization
    N T Eissa
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Proc Natl Acad Sci U S A 95:7625-30. 1998
    ..This region could be a potential target for therapeutic interventions aimed at inhibiting iNOS dimerization and hence NO synthesis...
  20. ncbi request reprint Rapid, reliable ligation-independent cloning of PCR products using modified plasmid vectors
    R S Haun
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Biotechniques 13:515-8. 1992
  21. pmc Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298
    M Tesauro
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Proc Natl Acad Sci U S A 97:2832-5. 2000
    ....
  22. ncbi request reprint Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases
    P Konczalik
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 274:16736-40. 1999
    ..These data clearly show that the conserved vicinal aspartates 60 and 61 in rat ADP-ribosylarginine hydrolase are critical for catalytic activity, but not for high affinity binding of the substrate analogue, ADP-ribose...
  23. ncbi request reprint Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation
    A S Kristof
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 276:8445-52. 2001
    ..Thus, p38- and ERK-dependent pathways, through effects on the AP-1 complex, activate the hiNOS promoter in cells stimulated with CM or LPS/IFN-gamma...
  24. ncbi request reprint Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase
    J Rivera-Nieves
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:19525-31. 1999
    ..This thiol linkage was stable to HgCl2. Thus, linkage of GAPDH to NADH, in contrast to NAD, occurs in the presence of thiol, is independent of NO, and is mediated by superoxide...
  25. pmc Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2
    Yoshihiko Ikeda
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 300:L64-72. 2011
    ..Although the high red cell mass of LAM patients could be related to advanced disease, we propose that EPO, synthesized in response to episodic hypoxia, may increase disease progression by enhancing the proliferation of LAM cells...
  26. pmc Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis
    Xiong Cai
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Respir Crit Care Med 182:1410-8. 2010
    ....
  27. ncbi request reprint Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors
    J Moss
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biochem 193:153-7. 1999
    ..There are now five Sec7 domain proteins known to have GEP activity toward class I ARFs. It remains to be determined whether there are other Sec7 domain proteins that are GEPs for ARFs 4, 5, or 6...
  28. ncbi request reprint Structural elements of ADP-ribosylation factor 1 required for functional interaction with cytohesin-1
    G Pacheco-Rodriguez
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:12438-44. 1999
    ....
  29. ncbi request reprint Molecules in the ARF orbit
    J Moss
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:21431-4. 1998
  30. ncbi request reprint Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors
    A Togawa
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:12308-15. 1999
    ....
  31. ncbi request reprint Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain
    G Pacheco-Rodriguez
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:26543-8. 1998
    ..Data obtained with mutant ARF constructs are all consistent with the conclusion that the ARF N terminus is an important determinant of cytohesin-1 specificity...
  32. pmc beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    R T Premont
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:14082-7. 1998
    ..Moreover, they provide a mechanism for integration of receptor activation and endocytosis through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane...
  33. pmc Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain
    N Morinaga
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 93:12856-60. 1996
    ....
  34. ncbi request reprint Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    Annu Rev Nutr 19:485-509. 1999
    ..ADP-ribosylation can be reversed by ADP-ribosylarginine hydrolases, resulting in the regeneration of free arginine. Thus, an ADP-ribosylation cycle may play a regulatory role in vertebrate tissues...
  35. ncbi request reprint beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis
    A Claing
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:42509-13. 2001
    ....
  36. ncbi request reprint Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein
    T J Kemp
    Division of Biomedical Sciences, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, United Kingdom
    Genomics 66:229-41. 2000
    ..We have named this gene ankyrin-repeat domain 2 (stretch-responsive muscle) (Ankrd2). We hypothesize that Ankrd2 plays an important role in skeletal muscle hypertrophy...
  37. pmc Identification of the probable site of choleragen-catalyzed ADP-ribosylation in a Go alpha-like protein based on cDNA sequence
    C W Angus
    Proc Natl Acad Sci U S A 83:5813-6. 1986
    ..The reported differences in conditions that promote choleragen-catalyzed ADP-ribosylation of Gs alpha vs. Go alpha could be related to differences in amino acid sequence in the region of the acceptor arginine...
  38. ncbi request reprint Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cells
    K Ogushi
    Department of Bacteriology, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan
    J Biol Chem 276:30521-6. 2001
    ..We conclude that S. enteritidis FliC induces hBD-2 expression in Caco-2 cells via NF-kappaB activation and thus plays an important role in up-regulation of the innate immune response...
  39. pmc ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
    A Someya
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:2413-8. 2001
    ..No similar coincidence of ARF-GEP(100) with AP-1, AP-2, catenin, LAMP-1, or 58K was observed. The new human BFA-insensitive GEP may function with ARF6 in specific endocytic processes...
  40. pmc Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1
    N Vitale
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:7342-52. 2000
    ..These results suggest that ARD1 is a multidomain protein with ARF and GAP regions, which contain Golgi and lysosomal localization signals, respectively, that could function in vesicular trafficking...
  41. ncbi request reprint ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli
    C Y Lin
    Institute of Molecular Medicine and Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Biol Chem 275:37815-23. 2000
    ....
  42. ncbi request reprint Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)
    N Vitale
    Pulmonary Critical Care Medicine Branch and the Pathology Section, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:21331-9. 2000
    ..It was concluded that cytohesin-1 is likely to be involved in ARD1 activation, consistent with a role for ARD1 in the regulation of vesicular trafficking...
  43. pmc Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex
    R Yamaji
    Pulmonary Critical Care Medicine Branch and Pathology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:2567-72. 2000
    ..All observations were consistent with the conclusion that significant fractions of BIG1 and BIG2 exist as components of the same macromolecular complexes in bovine brain cytosol and are similarly localized in cultured cells...
  44. ncbi request reprint Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors
    M Ogasawara
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 275:3221-30. 2000
    ..Thus, in gene structure and brefeldin A-insensitive GEP activity, cytohesin-4 resembles other cytohesins, but its tissue distribution differs considerably, consistent with a different specific function...
  45. ncbi request reprint Effect of staurosporine-induced apoptosis on endothelial nitric oxide synthase in transfected COS-7 cells and primary endothelial cells
    M Tesauro
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building10 Room 6D03, Bethesda, MD 20892 1590, USA
    Cell Death Differ 13:597-606. 2006
    ..eNOS, therefore, is both an inhibitor of apoptosis and a target of apoptosis-associated proteolysis...
  46. ncbi request reprint Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2
    T Takada
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:9420-3. 1994
    ..2. These results strongly suggest that the rat T cell alloantigen RT6.2 is a GPI-anchored NAD glycohydrolase...
  47. ncbi request reprint Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha
    S Lavu
    Biological Response Modifiers Program, National Cancer Institute Frederick Cancer Research Facility, MD 21701
    Biochem Biophys Res Commun 150:811-5. 1988
    ..There is 100% identity at the amino acid level for the cholera and pertussis toxin-catalyzed ADP ribosylation sites, the putative guanine nucleotide binding, and the GTP hydrolysis sites...
  48. pmc Guanine nucleotide-binding proteins that enhance choleragen ADP-ribosyltransferase activity: nucleotide and deduced amino acid sequence of an ADP-ribosylation factor cDNA
    S R Price
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:5488-91. 1988
    ..In addition to serving as an ADP-ribose acceptor, ARF interacts with the toxin in a manner that modifies its catalytic properties...
  49. ncbi request reprint Different ARF domains are required for the activation of cholera toxin and phospholipase D
    G F Zhang
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 270:21-4. 1995
    ..It appears that the amino-terminal region of ARF1 is not critical for its action as a GTP-dependent activator of cholera toxin, whereas it is necessary for activation of the putative effector enzyme, PLD...
  50. ncbi request reprint ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin
    C F Welsh
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Mol Cell Biochem 138:157-66. 1994
    ..They have recently been shown to associate with phospholipid and Golgi membranes in a GTP-dependent manner and are involved in regulating vesicular transport...
  51. ncbi request reprint Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases
    I J Okazaki
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 33:12828-36. 1994
    ..These data are consistent with the conclusion that GPI-anchored skeletal and cardiac muscle ADP-ribosyltransferases are conserved across mammalian species...
  52. ncbi request reprint Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae
    F J Lee
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:20931-7. 1994
    ..As yARF3 was not essential for cell viability and was not required for endoplasmic reticulum to Golgi protein transport, it may provide an opportunity to define an ARF function in another kind of vesicular trafficking...
  53. ncbi request reprint Characterization of class II and class III ADP-ribosylation factor genes and proteins in Drosophila melanogaster
    F J Lee
    Laboratory of Cellular Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:21555-60. 1994
    ..These observations are consistent with the conclusion that the three classes of ARFs are present in non-mammalian as well as mammalian species...
  54. pmc Alternative splicing of the guanine nucleotide-binding regulatory protein Go alpha generates four distinct mRNAs
    J J Murtagh
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 22:842-9. 1994
    ....
  55. ncbi request reprint Hydroxylamine-stable covalent linkage of myristic acid in G0 alpha, a guanine nucleotide-binding protein of bovine brain
    A M Schultz
    Biochem Biophys Res Commun 146:1234-9. 1987
    ....
  56. pmc Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins
    K P Van Meurs
    Proc Natl Acad Sci U S A 84:3107-11. 1987
    ..There are also marked similarities of sequence in regions of the G proteins, elongation factors, and the ras p21 gene products that are believed to be involved in guanine nucleotide binding and GTP hydrolysis...
  57. pmc Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin
    D A Bobak
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:6101-5. 1989
    ..Definition of the regulation of ARF mRNAs and of function(s) of recombinant ARF proteins will aid in the elucidation of the physiologic role(s) of ARFs...
  58. ncbi request reprint Regulation of ADP-ribosylation factor (ARF) expression. Cross-species conservation of the developmental and tissue-specific alternative polyadenylation of ARF 4 mRNA
    K Mishima
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:24109-16. 1992
    ..1-kb mRNA was identified primarily in mature sperm, consistent with the developmental studies. Shorter mRNAs, thought to be more stable, may compensate for cessation of transcription at late stages of spermatogenesis...
  59. ncbi request reprint Molecular and immunological characterization of ADP-ribosylarginine hydrolases
    J Moss
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:10481-8. 1992
    ..The immunological and molecular biological data are consistent with partial conservation of hydrolase structure across animal species...
  60. ncbi request reprint Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae
    F J Lee
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:24441-5. 1992
    ..We infer from the impaired growth of these rescued strains that the homologous ARFs may have specific targeting information that does not interact effectively or efficiently with the yeast protein membrane trafficking system...
  61. pmc Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle
    A Zolkiewska
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:11352-6. 1992
    ..The hydrophobic amino and carboxyl termini may represent a signal peptide and a site for a glycosyl-phosphatidylinositol anchor, respectively...
  62. ncbi request reprint Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin
    C M Lee
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:9028-34. 1992
    ..The 5'-flanking region has a high GC content but no TATA or CAAT box, as found in housekeeping genes. In addition, the two human class I ARF genes, ARF 1 and ARF 3, have similar exon/intron organizations and use GC-rich promoters...
  63. ncbi request reprint Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin
    S C Tsai
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 266:23053-9. 1991
    ..The 1.2-kb ARF 3 mRNA is shown to arise by use of an alternative polyadenylation signal (AACAAA) at nucleotide 1091 within the ARF 3 cDNA...
  64. pmc Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin
    L Monaco
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:2206-10. 1990
    ..9-kilobase mRNA for ARF 1 in these tissues. The PCR provides a powerful tool for investigating diversity in this and other multigene families, especially with primers targeted at domains believed to have functional significance...
  65. ncbi request reprint Guanine nucleotide-dependent ADP-ribosylation of soluble rho catalyzed by Clostridium botulinum C3 ADP-ribosyltransferase. Isolation and characterization of a newly recognized form of rhoA
    K C Williamson
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:20807-12. 1990
    ....
  66. ncbi request reprint An RNA-binding protein gene (RBP1) of Saccharomyces cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs
    F J Lee
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:15080-7. 1993
    ..From these observations, we infer that RBP1 may be involved in growth regulation, possibly through its participation in RNA metabolism...
  67. ncbi request reprint Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase
    T Takada
    Laboratory of Cellular Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17837-43. 1993
    ..Human hydrolase and rat C108S were DTT-independent; human S103C was, however, DTT-dependent. These data clearly show that cysteine 108 in rat hydrolase plays a critical role in DTT dependence and may be important in immunoreactivity...
  68. pmc Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor
    E Meacci
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Proc Natl Acad Sci U S A 94:1745-8. 1997
    ..In this regard, it differs from a recently reported BFA-sensitive ARF-GEP that contains a Sec7 domain...
  69. ncbi request reprint Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor domain protein ARD1
    N Vitale
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:25077-82. 1997
    ..It is suggested that, like the amino-terminal segment of ARF, the equivalent region in ARD1, located between the GTPase-activating protein and ARF domains, may act as a GDP dissociation inhibitor...
  70. pmc Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor
    N Morinaga
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Proc Natl Acad Sci U S A 94:12926-31. 1997
    ....
  71. ncbi request reprint Characterization of an ADP-ribosylation factor-like 1 protein in Saccharomyces cerevisiae
    F J Lee
    Institute of Molecular Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Biol Chem 272:30998-1005. 1997
    ..However, yARL1 was not required for endoplasmic reticulum-to-Golgi protein transport, and it may offer an opportunity to define an ARL function in another kind of vesicular trafficking, such as the regulated secretory pathway...
  72. ncbi request reprint Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1)
    N Vitale
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:2553-60. 1998
    ..The GAP domain of ARD1 thus is similar to ARF GAPs but differs from other GAPs in its covalent association with the GTP-binding domain...
  73. pmc Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors
    M Sata
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:4204-8. 1998
    ..These results are consistent with the conclusion that the yeast Sec7 domain itself contains the elements necessary for ARF GEP activity and its inhibition by BFA...
  74. ncbi request reprint Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1)
    J X Hong
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:15872-6. 1998
    ..In vitro, the activities of rARL1 and rARF1 are similar. Rather than being a member of a separate subfamily, hARL1, which activates PLD and CT in a phospholipiddependent manner, appears to be part of a continuum of ARF family proteins...
  75. pmc Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus
    N Vitale
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8613-8. 1998
    ..These observations suggest that the ARF-related protein ARD1 may play a role in the formation or function of lysosomes and in protein trafficking between Golgi and lysosomes...
  76. ncbi request reprint Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities
    S R Price
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biochem 159:15-23. 1996
    ..The unusually high degree of conservation of the untranslated regions is consistent with these regions having important regulatory roles and that individual ARFs contain structurally unique elements required for specific functions...
  77. ncbi request reprint Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Blood 88:915-21. 1996
    ..Thus, we have cloned a novel gene that has properties identical to the transferase detected in CTL, and may be involved in the NAD-dependent regulation of proliferation and cytotoxicity...
  78. ncbi request reprint Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:22052-7. 1996
    ....
  79. ncbi request reprint Characterization of the gene for ADP-ribosylation factor (ARF) 2, a developmentally regulated, selectively expressed member of the ARF family of approximately 20-kDa guanine nucleotide-binding proteins
    I M Serventi
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:4863-72. 1993
    ..Although the pattern of expression of ARF 2 is unique among the ARFs, the structures of the class I ARF genes are conserved among its members and across species...
  80. ncbi request reprint Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter
    R S Haun
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8793-800. 1993
    ..Expression of the promoter containing a mutated palindrome was reduced dramatically, consistent with the conclusion that this region functions in vivo to control expression of the ARF3 gene...
  81. ncbi request reprint ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain
    K Mishima
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8801-7. 1993
    ..In addition, the characteristic features of ARF proteins may be found as domains of larger mammalian proteins...
  82. ncbi request reprint Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster
    J J Murtagh
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 32:6011-8. 1993
    ....
  83. pmc ARD1, a 64-kDa bifunctional protein containing an 18-kDa GTP-binding ADP-ribosylation factor domain and a 46-kDa GTPase-activating domain
    N Vitale
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 93:1941-4. 1996
    ..Thus, like the alpha subunits of heterotrimeric G proteins, ARD1 appears to consist of two domains that interact to regulate the biological activity of the protein...
  84. ncbi request reprint Effects of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ADP-ribosylation factor
    S C Tsai
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 273:20697-701. 1998
    ..These findings indicate that arfaptin acts as an inhibitor of ARF actions in vitro, raising the possibility that it has a similar role in vivo...
  85. ncbi request reprint The alpha 7 integrin as a target protein for cell surface mono-ADP-ribosylation in muscle cells
    A Zolkiewska
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    Adv Exp Med Biol 419:297-303. 1997
    ..Thus, cell surface ADP-ribosylation, in contrast to intracellular ADP-ribosylation, is not readily reversed by the presently known ADP-ribosylarginine hydrolase and seems to operate outside the postulated ADP-ribosylation cycle...
  86. ncbi request reprint GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6
    N Vitale
    INSERM U 338, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
    J Biol Chem 275:13901-6. 2000
    ....
  87. ncbi request reprint Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity
    C Taggart
    Pulmonary Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 275:27258-65. 2000
    ..We suggest that inactivation of alpha(1)-antitrypsin by oxidation of either methionine 351 or 358 provides a mechanism for regulation of its activity at sites of inflammation...
  88. ncbi request reprint Conservation of a 23-kDa human transplantation antigen in mammalian species
    S R Price
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 14:959-64. 1992
    ..abstract truncated at 250 words)..