Scott E McNeil

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Analysis of fullerene-based nanomaterial in serum matrix by CE
    King C Chan
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Electrophoresis 28:1518-24. 2007
  2. ncbi request reprint Nanotechnology for the biologist
    Scott E McNeil
    Nanotechnology Characterization Laboratory, 1050 Boyles St, Frederick, MD 21702 1201, USA
    J Leukoc Biol 78:585-94. 2005
  3. pmc Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models
    Pavan P Adiseshaiah
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States
    Cancer Lett 337:254-65. 2013
  4. pmc Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Nanomedicine 5:106-17. 2009
  5. pmc Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory
    Rachael M Crist
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Integr Biol (Camb) 5:66-73. 2013
  6. pmc Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulations
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Nanomedicine (Lond) 5:555-62. 2010
  7. pmc Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, Maryland Electronic address
    Nanomedicine 10:1453-63. 2014
  8. pmc Prediction of nanoparticle prodrug metabolism by pharmacokinetic modeling of biliary excretion
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, Frederick National Lab for Cancer Research, Frederick, 21702, USA Electronic address
    J Control Release 172:558-67. 2013
  9. pmc Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
    Denise N Johnson-Lyles
    Nanotechnology Characterization Lab NCL, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 248:249-58. 2010
  10. pmc Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, United States
    Mol Pharm 9:382-93. 2012

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Analysis of fullerene-based nanomaterial in serum matrix by CE
    King C Chan
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Electrophoresis 28:1518-24. 2007
    ..The quantitation of the nanoparticles was linear from 0-500 microg/mL with detection limits ranging from 0.5 to 6 microg/mL...
  2. ncbi request reprint Nanotechnology for the biologist
    Scott E McNeil
    Nanotechnology Characterization Laboratory, 1050 Boyles St, Frederick, MD 21702 1201, USA
    J Leukoc Biol 78:585-94. 2005
    ..This article presents an overview of nanotechnology for the biologist and discusses "nanotech" strategies and constructs that have already demonstrated in vitro and in vivo efficacy...
  3. pmc Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models
    Pavan P Adiseshaiah
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States
    Cancer Lett 337:254-65. 2013
    ..In conclusion, in vitro and in vivo data support a synergistic antitumor activity of the nanoliposomal C6-ceramide and vinblastine combination, potentially mediated by an autophagy mechanism. ..
  4. pmc Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Nanomedicine 5:106-17. 2009
    ..The difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are also discussed...
  5. pmc Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory
    Rachael M Crist
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Integr Biol (Camb) 5:66-73. 2013
    ..While not exhaustive, this article aims to share some of the most common pitfalls observed by the NCL as they relate to nanoparticle synthesis, purification, characterization and analysis...
  6. pmc Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulations
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Nanomedicine (Lond) 5:555-62. 2010
    ..Here we report that nanoparticles often interfere with these traditional endotoxin detection tests and suggest approaches to detect and overcome such interferences...
  7. pmc Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, Maryland Electronic address
    Nanomedicine 10:1453-63. 2014
    ..The authors suggest that specialized hematological tests must be used to deduce nanoparticle hematotoxicity...
  8. pmc Prediction of nanoparticle prodrug metabolism by pharmacokinetic modeling of biliary excretion
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, Frederick National Lab for Cancer Research, Frederick, 21702, USA Electronic address
    J Control Release 172:558-67. 2013
    ..Uses of such models may include interpretation of preclinical toxicology studies, selection of first in man dosing regimens, and PK/PD model development. ..
  9. pmc Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
    Denise N Johnson-Lyles
    Nanotechnology Characterization Lab NCL, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 248:249-58. 2010
    ..As nanoparticle-induced cytoskeleton disruption, autophagic vacuole accumulation and mitochondrial dysfunction are commonly reported in the literature, the proposed mechanism may be relevant for a variety of nanomaterials...
  10. pmc Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, United States
    Mol Pharm 9:382-93. 2012
    ..Taken in context with previously reported studies, our data suggest that large cationic PAMAM dendrimers induce platelet aggregation through disruption of membrane integrity...
  11. pmc Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
    Parag Aggarwal
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Adv Drug Deliv Rev 61:428-37. 2009
    ..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution...
  12. doi request reprint Analyzing the influence of PEG molecular weight on the separation of PEGylated gold nanoparticles by asymmetric-flow field-flow fractionation
    Matthew Hansen
    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
    Anal Bioanal Chem 407:8661-72. 2015
    ....
  13. pmc Inhibition of phosphoinositol 3 kinase contributes to nanoparticle-mediated exaggeration of endotoxin-induced leukocyte procoagulant activity
    Anna N Ilinskaya
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, 1050 Boyles Street, Building 469, Frederick, MD 21702, USA
    Nanomedicine (Lond) 9:1311-26. 2014
    ..We have previously reported on the exaggeration of endotoxin-induced PCA by cationic dendrimers. Herein, we report an effort to discern the mechanism...
  14. doi request reprint Unique benefits of nanotechnology to drug delivery and diagnostics
    Scott E McNeil
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
    Methods Mol Biol 697:3-8. 2011
    ..The remaining bulk of the volume provides the reader with protocols that have been tested against clinically relevant nanoparticles and describes some of the nuances of nanoparticle types and necessary controls...
  15. pmc Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Toxicol Sci 106:140-52. 2008
    ..These data suggest that QD cytotoxicity is dependent upon properties of the particle as a whole, and not exclusively the metal core materials...
  16. pmc Method for analysis of nanoparticle hemolytic properties in vitro
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Nano Lett 8:2180-7. 2008
    ..We propose alternative methods to avoid misleading results from nanoparticles and discuss the potential relevance of nanoparticle in vitro hemolytic properties to in vivo systems...
  17. pmc Translational considerations for cancer nanomedicine
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, PO Box B, Frederick, MD 21702, USA
    J Control Release 146:164-74. 2010
    ..Where possible, these recommendations are justified using the existing regulatory guidance literature...
  18. pmc Induction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA
    Anna N Ilinskaya
    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA
    Nanomedicine 11:1925-38. 2015
    ....
  19. doi request reprint Choice of method for endotoxin detection depends on nanoformulation
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, 1050 Boyles Street, Frederick, MD 21702, USA
    Nanomedicine (Lond) 9:1847-56. 2014
    ....
  20. pmc Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile duct cannulated rats
    Peng Zou
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, United States
    Mol Pharm 10:1977-87. 2013
    ..Additionally, the remaining encapsulated curcumin fraction following burst release is available for tumor delivery via the enhanced permeation and retention effect commonly observed for nanoparticle formulations...
  21. pmc Stable isotope method to measure drug release from nanomedicines
    Sarah Skoczen
    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, United States
    J Control Release 220:169-74. 2015
    ..98). We believe that this method will have tremendous utility in the development and regulatory evaluation of nanomedicines, and aid in determination of generic bioequivalence. ..
  22. doi request reprint Quantitative analysis of PEG-functionalized colloidal gold nanoparticles using charged aerosol detection
    Mackensie C Smith
    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
    Anal Bioanal Chem 407:3705-16. 2015
    ..This is an important distinction, as differences in the bound and unbound PEG fractions can affect biocompatibility, which would not be detected in techniques that only quantitate the total PEG fraction. ..
  23. doi request reprint Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    J Control Release 172:456-66. 2013
    ....
  24. doi request reprint Nanomaterial standards for efficacy and toxicity assessment
    Pavan P Adiseshaiah
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:99-112. 2010
    ..Finally, we show how knowledge of these properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy...
  25. doi request reprint Immunological properties of engineered nanomaterials
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, 1050 Boyles St, Bldg 469, Frederick, Maryland 21702, USA
    Nat Nanotechnol 2:469-78. 2007
    ..Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery...
  26. pmc Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Mol Pharm 5:487-95. 2008
    ..We will also provide an overview of in vitro methods useful in identifying interactions with components of the immune system and the potential effects of such interaction on particle distribution to tissues...
  27. doi request reprint Rapid distribution of liposomal short-chain ceramide in vitro and in vivo
    Banu S Zolnik
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Drug Metab Dispos 36:1709-15. 2008
    ..Our studies suggest that this nanoscale PEGylated drug delivery system for short-chain ceramide offers rapid tissue distribution without adverse effects for a neoplastic-selective, insoluble agent...
  28. doi request reprint Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
    Marina A Dobrovolskaia
    Principal Scientist, Immunology Section Head, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, P O Box B, Frederick, MD 21702, USA 1 301 8466939 1 301 846 6399
    Expert Opin Drug Deliv 12:1163-75. 2015
    ..However, little attention was given to the immunological and hematological issues associated with nanotechnology reformulation...
  29. doi request reprint Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
    Marina A Dobrovolskaia
    Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Nanotechnology Characterization Laboratory, Cancer Research Technology Program, P O Box B, Frederick, MD 21702, USA 1 301 846 6939 1 301 846 6399
    Expert Opin Biol Ther 15:1023-48. 2015
    ..Immunological and hematological issues are a commonly reported side effect of NAT treatment; however, literature exploring the mechanistic background of these effects is sparse...
  30. ncbi request reprint Nanotechnology safety concerns revisited
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Toxicol Sci 101:4-21. 2008
    ..Until such time as the exposures, hazards, and environmental life cycle of nanomaterials have been more clearly defined, cautious development and implementation of nanotechnology is the most prudent course...
  31. doi request reprint Challenges for nanoparticle characterization
    Scott E McNeil
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
    Methods Mol Biol 697:9-15. 2011
    ..Additionally, we discuss ways to identify, avoid, and resolve such interference, with emphasis on the use of inhibition and enhancement controls...