Affiliation: National Institutes of Health
- CREB-binding protein sequestration by expanded polyglutamineA McCampbell
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Room 3B11, Bethesda, MD 20892 1250, USA
Hum Mol Genet 9:2197-202. 2000..Finally, we demonstrate that over-expression of CBP rescues cells from polyglutamine-mediated toxicity in neuronal cell culture. These data support a CBP-sequestration model of polyglutamine expansion disease...
- Histone deacetylase inhibitors reduce polyglutamine toxicityA McCampbell
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3B14, 10 Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:15179-84. 2001..These findings suggest that nuclear accumulation of polyglutamine can lead to altered protein acetylation in neurons and indicate a novel therapeutic strategy for polyglutamine disease...