Venkata S Mattay

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neurobiology of cognitive aging: insights from imaging genetics
    Venkata S Mattay
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychol 79:9-22. 2008
  2. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
  3. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
  4. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
  5. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
  6. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
  7. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
  8. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
  9. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
  10. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009

Detail Information

Publications79

  1. pmc Neurobiology of cognitive aging: insights from imaging genetics
    Venkata S Mattay
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychol 79:9-22. 2008
    ..Further, it is likely with early identification of susceptible individuals, early intervention through life-style changes and other methods could increase an individual's resilience to the effects of aging...
  2. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  3. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  4. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
    ....
  5. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
    ..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia...
  6. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  7. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
    ..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand...
  8. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  9. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
    ....
  10. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
    ....
  11. pmc Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:540-8. 2009
    ....
  12. ncbi request reprint Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 63:475-83. 2008
    ..Currently available data on the heritability of these structural changes are inconsistent...
  13. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  14. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
    ..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses...
  15. pmc Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content
    Karen E Munoz
    Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuroimage 50:340-6. 2010
    ..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS...
  16. doi request reprint Altered hippocampal-parahippocampal function during stimulus encoding: a potential indicator of genetic liability for schizophrenia
    Roberta Rasetti
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:236-47. 2014
    ..To elucidate the possible role of genetic risk factors in such findings, it is necessary to study healthy relatives of patients with schizophrenia who carry risk-associated genes but not the confounding factors related to the disorder...
  17. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  18. ncbi request reprint A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    ....
  19. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  20. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    ..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures...
  21. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  22. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
    ..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry...
  23. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  24. doi request reprint Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex
    Devon C Nixon
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:1006-8. 2011
    ....
  25. ncbi request reprint Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    ..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness...
  26. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    ..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia...
  27. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  28. pmc Impact of interacting functional variants in COMT on regional gray matter volume in human brain
    Robyn Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 45:44-51. 2009
    ....
  29. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  30. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  31. pmc Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:2200-8. 2008
    ..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis...
  32. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
    ..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment...
  33. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
    ....
  34. pmc Genetic variation in FGF20 modulates hippocampal biology
    Herve Lemaitre
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:5992-7. 2010
    ..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging...
  35. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  36. doi request reprint Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults
    Lisa M Nichols
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 69:804-13. 2012
    ..Consistent with differential age effects, research in transgenic mice suggests that the ϵ4 allele may particularly affect the aging process...
  37. doi request reprint Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:1207-17. 2011
    ..However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear...
  38. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  39. ncbi request reprint Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Am J Psychiatry 160:2209-15. 2003
    ..The authors' goal was to explore this phenomenon...
  40. ncbi request reprint Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
    Alessandro Tessitore
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1384, USA
    J Neurosci 22:9099-103. 2002
    ..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects...
  41. pmc Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla
    Alexa J Stern
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:856-62. 2008
    ....
  42. pmc Effects of neuregulin 3 genotype on human prefrontal cortex physiology
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 61859 Mannheim, Germany, Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205, Departments of Psychiatry, Neurology, and Neuroscience and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and Departments of Psychiatry and Cell and Developmental Biology, University of Colorado, School of Medicine, Aurora, Colorado 80045
    J Neurosci 34:1051-6. 2014
    ..Our data indicate a complex modulation of brain physiology by rs10748842, which does not fit the simple inefficiency model of risk association in DLPFC and suggests that other neurobiological mechanisms are involved. ..
  43. pmc Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Schizophr Res 149:162-6. 2013
    ....
  44. pmc Hierarchical organization of human cortical networks in health and schizophrenia
    Danielle S Bassett
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:9239-48. 2008
    ....
  45. ncbi request reprint Neural correlates of genetically abnormal social cognition in Williams syndrome
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:991-3. 2005
    ..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior...
  46. ncbi request reprint Neocortical modulation of the amygdala response to fearful stimuli
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:494-501. 2003
    ....
  47. ncbi request reprint Functional changes in the activity of brain regions underlying emotion processing in the elderly
    Alessandro Tessitore
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Room 3C108, Bethesda, MD 20892 1384, USA
    Psychiatry Res 139:9-18. 2005
    ....
  48. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  49. pmc A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:13936-41. 2010
    ..Our findings identify sex-dependent mechanisms impacting the structure and function of hypothalamic-limbic circuits that are of potential clinical and translational significance...
  50. pmc Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers
    Sophia C Magalona
    Clinical Brain Disorders Branch CBDB, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    CNS Drugs 27:663-73. 2013
    ..The dorsal cingulate (dCC) and prefrontal (PFC) cortices play critical roles in attention. Evidence indicates that catechol-O-methyltransferase (COMT) modulates dopaminergic tone in the PFC and dCC...
  51. ncbi request reprint A validated network of effective amygdala connectivity
    Jason L Stein
    Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892 1257, USA
    Neuroimage 36:736-45. 2007
    ..This validated model can be used to study neurocognitive correlates as well as genotype or disease-related alterations of functional interactions in the limbic system...
  52. ncbi request reprint The amygdala response to emotional stimuli: a comparison of faces and scenes
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 17:317-23. 2002
    ..These results suggest that the human amygdala shows a stronger response to affective facial expressions than to scenes, a bias that should be considered in the design of experimental paradigms interested in probing amygdala function...
  53. ncbi request reprint Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
    Am J Psychiatry 160:709-19. 2003
    ..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified...
  54. pmc DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity
    Joseph H Callicott
    Clinical Brain Disorders Branch, Division of Intramural Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1379, USA
    J Clin Invest 123:2961-4. 2013
    ..78)and connectivity (d = 0.57) during a recognition memory task. These data highlight the importance of epistatic models in understanding genetic association with complex brain phenotypes...
  55. pmc Neurophysiological correlates of age-related changes in working memory updating
    Jamie E Podell
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 62:2151-60. 2012
    ..These results are consistent with computational models of executive cognition and dopamine-mediated age-related cognitive decline...
  56. pmc Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?
    Herve Lemaitre
    Clinical Brain Disorder Branch, Gene Cognition and Psychosis program, NIH NIMH, Bethesda, MD 20892, USA
    Neurobiol Aging 33:617.e1-9. 2012
    ....
  57. pmc WWC1 genotype modulates age-related decline in episodic memory function across the adult life span
    John Muse
    Clinical Brain Disorders Branch JM, ME, FS, HL, H YT, QC, BSK, SD, JHC, DRW, VSM, Genes Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda Lieber Institute for Brain Development JM, H YT, QC, DRW, VSM, Johns Hopkins University Medical Campus, Baltimore
    Biol Psychiatry 75:693-700. 2014
    ..In the current study, we explore the effect of this polymorphism on EM-related activity and cognitive performance across the adult life span using fMRI...
  58. ncbi request reprint Dextroamphetamine modulates the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 27:1036-40. 2002
    ..Our results provide the first evidence of a specific neural substrate for the anxiogenic effects of amphetamine and are consistent with animal models of dopaminergic activation of the amygdala...
  59. pmc Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome
    Andreas Meyer-Lindenberg
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
    J Clin Invest 115:1888-95. 2005
    ..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS...
  60. pmc Selective updating of working memory content modulates meso-cortico-striatal activity
    Vishnu P Murty
    Clinical Brain Disorder Branch, Gene Cognition and Psychosis program, NIH NIMH Bethesda, MD 20892, USA
    Neuroimage 57:1264-72. 2011
    ..These findings highlight the role of this meso-cortico-striatal circuitry during the selective updating of working memory in humans, which complements previous research in behavioral neuroscience and computational modeling...
  61. pmc Automated Quality Assessment of Structural Magnetic Resonance Brain Images Based on a Supervised Machine Learning Algorithm
    Ricardo A Pizarro
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of HealthBethesda, MD, USA Department of Biomedical Engineering, UW MadisonMadison, WI, USA
    Front Neuroinform 10:52. 2016
    ..The accuracy for classifying 1457 3D-MRI volumes from our database using the SVM approach is around 80%. These results are promising and illustrate the possibility of using SVM as an automated quality assessment tool for 3D-MRI...
  62. pmc Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics
    Yunxia Tong
    Clinical and Translational Neuroscience Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 11:e0151391. 2016
    ....
  63. ncbi request reprint Neural mechanisms underlying probabilistic category learning in normal aging
    Francesco Fera
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 25:11340-8. 2005
    ....
  64. ncbi request reprint Dysfunctional prefrontal regional specialization and compensation in schizophrenia
    Hao Yang Tan
    Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
    Am J Psychiatry 163:1969-77. 2006
    ....
  65. pmc Altered cerebral response during cognitive control: a potential indicator of genetic liability for schizophrenia
    Fabio Sambataro
    Brain Center for Motor and Social Cognition, Istituto Italiano di Parma, Italy
    Neuropsychopharmacology 38:846-53. 2013
    ..These results suggest that such changes in the neural activity underlying aspects of cognitive control may represent a potential intermediate phenotype for the investigation of the genetic basis of schizophrenia...
  66. ncbi request reprint Imaging genetic influences in human brain function
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20892 1379, USA
    Curr Opin Neurobiol 14:239-47. 2004
    ..The results also show that neuroimaging techniques can elucidate the influence of genes on brain function in relatively small sample populations, sometimes even in the absence of significant differences in behavioral measures...
  67. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....
  68. ncbi request reprint EPI-BOLD fMRI of human motor cortex at 1.5 T and 3.0 T: sensitivity dependence on echo time and acquisition bandwidth
    Francesco Fera
    Clinical Brain Disorder Branch, National Institutes of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Magn Reson Imaging 19:19-26. 2004
    ..To investigate the sensitivity dependence of BOLD functional imaging on MRI acquisition parameters in motor stimulation experiments using a finger tapping paradigm...
  69. ncbi request reprint Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:906-13. 2003
    ..The objective of this study was to assess possible NAA reductions in hippocampus and prefrontal regions in patients with bipolar disorder...
  70. ncbi request reprint Serotonin transporter genetic variation and the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 297:400-3. 2002
    ....
  71. ncbi request reprint Cortical systems associated with covert music rehearsal
    Frederick J P Langheim
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
    Neuroimage 16:901-8. 2002
    ..These data implicate an associative network independent of primary sensorimotor and auditory activity, likely representing the cortical elements most intimately linked to music production...
  72. pmc Bio-swarm-pipeline: a light-weight, extensible batch processing system for efficient biomedical data processing
    Xi Cheng
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health National Institutes of Health Bethesda, MD, USA
    Front Neuroinform 3:35. 2009
    ..Although this model stems from applications in neuroimaging, the system can potentially be adapted to a wide range of bio-medical application scenarios...
  73. ncbi request reprint Dissociating the effects of Sternberg working memory demands in prefrontal cortex
    Mario Altamura
    Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
    Psychiatry Res 154:103-14. 2007
    ..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...
  74. ncbi request reprint Amphetamine modulates human incentive processing
    Brian Knutson
    Department of Psychology, Stanford University, CA 94305, USA
    Neuron 43:261-9. 2004
    ..These findings suggest that therapeutic effects of amphetamine on incentive processing may involve reducing the difference between anticipation of gains and losses...
  75. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
    ..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex...
  76. ncbi request reprint Oxytocin modulates neural circuitry for social cognition and fear in humans
    Peter Kirsch
    Cognitive Neuroscience Group, Center for Psychiatry and Psychotherapy, Justus Liebig University, D 35385 Giessen, Germany
    J Neurosci 25:11489-93. 2005
    ....
  77. ncbi request reprint Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 56:190-7. 2004
    ..The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder...
  78. ncbi request reprint Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    Alessandro Bertolino
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
    Am J Psychiatry 161:1798-805. 2004
    ....
  79. ncbi request reprint Imaging genetics of brain longevity and mental wellness: the next frontier?
    Jeffrey R Petrella
    Alzheimer Imaging Research Laboratory, Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 246:20-32. 2008
    ..Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice...