A Martinez

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 141:406-11. 2000
  2. ncbi Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument
    A Martinez
    Cell and Cancer Biology Department, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA
    Endocrinology 138:5597-604. 1997
  3. ncbi Is adrenomedullin a causal agent in some cases of type 2 diabetes?
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD 20892, USA
    Peptides 20:1471-8. 1999
  4. ncbi Regulation of insulin secretion and blood glucose metabolism by adrenomedullin
    A Martinez
    Biomarkers and Prevention Research Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA
    Endocrinology 137:2626-32. 1996
  5. ncbi Expression pattern for adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types
    A Martinez
    Cell and Cancer Biology Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, 9610 Medical Center Drive, Room 300, Rockville, MD 20850, USA
    Cell Tissue Res 293:95-100. 1998
  6. ncbi Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis
    M Garayoa
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892, USA
    Mol Endocrinol 14:848-62. 2000
  7. ncbi Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 170:503-11. 2001
  8. ncbi Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth
    T W Moody
    Cell and Cancer Biology Department, National Cancer Institute, Rockville, Maryland, USA
    Exp Lung Res 24:617-28. 1998
  9. ncbi Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer
    J Zhou
    Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res Treat 66:217-24. 2001
  10. ncbi Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners
    R Pio
    Department of Cell and Cancer Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:12292-300. 2001

Collaborators

Detail Information

Publications36

  1. ncbi Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 141:406-11. 2000
    ..These data further implicate AM and the other components of its peptide family as important regulators of insulin release...
  2. ncbi Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument
    A Martinez
    Cell and Cancer Biology Department, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA
    Endocrinology 138:5597-604. 1997
    ..These results implicate AM as a potential player in skin defense against infectious microorganisms and as a possible autocrine growth factor in normal skin physiology and tumor development...
  3. ncbi Is adrenomedullin a causal agent in some cases of type 2 diabetes?
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD 20892, USA
    Peptides 20:1471-8. 1999
    ..AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals...
  4. ncbi Regulation of insulin secretion and blood glucose metabolism by adrenomedullin
    A Martinez
    Biomarkers and Prevention Research Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA
    Endocrinology 137:2626-32. 1996
    ..These studies implicate AM as a newly defined factor of the insulin regulatory system that could be involved in disorders such as diabetes and obesity...
  5. ncbi Expression pattern for adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types
    A Martinez
    Cell and Cancer Biology Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, 9610 Medical Center Drive, Room 300, Rockville, MD 20850, USA
    Cell Tissue Res 293:95-100. 1998
    ..This sequential and time-dependent expression of adrenomedullin suggests a tight regulation similar to that observed for other modulatory substances responsible for embryonic morphogenesis...
  6. ncbi Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis
    M Garayoa
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892, USA
    Mol Endocrinol 14:848-62. 2000
    ....
  7. ncbi Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion
    A Martinez
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 170:503-11. 2001
    ..The expression of factor H in the pancreas may play other important roles such as protection against complement-mediated cell lysis...
  8. ncbi Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth
    T W Moody
    Cell and Cancer Biology Department, National Cancer Institute, Rockville, Maryland, USA
    Exp Lung Res 24:617-28. 1998
    ..These data indicate that lipoxygenase inhibitors inhibit lung cancer growth and prevent lung carcinogenesis...
  9. ncbi Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer
    J Zhou
    Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res Treat 66:217-24. 2001
    ..Expression of hnRNP-A2/B1 in breast cancer cells was decreased by exposure to retinoids coordinately with decreased cell growth. These results warrant further evaluation of hnRNP-A2/B1 as a marker of breast carcinogenesis...
  10. ncbi Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners
    R Pio
    Department of Cell and Cancer Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:12292-300. 2001
    ..In summary, we report on a potentially new regulatory mechanism of AM biology, the influence of factor H on radioimmunoassay quantification of AM, and the possible involvement of AM as a regulator of the complement cascade...
  11. ncbi Adrenomedullin receptor expression in human lung and in pulmonary tumors
    A Martinez
    Biomarkers and Prevention Research Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850 3300, USA
    J Histochem Cytochem 45:159-64. 1997
    ..The present findings suggest that the AM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis and that new functions for AM remain to be identified...
  12. pmc Expression of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in morphological abnormalities adjacent to pulmonary tumors
    A Martinez
    Biomarkers and Prevention Research Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20850 3300, USA
    Am J Pathol 149:707-16. 1996
    ..These findings suggest that peptide hormone stimulation of mitogenesis is an early event in tumor progression and merits additional investigation as a target for early detection and chemo-intervention of lung carcinogenesis...
  13. ncbi Presence of immunoreactive adrenomedullin in human and bovine milk
    R Pio
    Department of Cell and Cancer Biology, National Cancer Institute, NIH, Building 10 Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Peptides 21:1859-63. 2000
    ..5 +/- 3.8 pg/mL. Bovine milk products had AM levels similar to those found in fresh bovine milk. Human milk had growth promoting activity on the human intestinal cell line Int-407 that could be partially blocked with an anti-AM antibody...
  14. ncbi Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions
    I Avis
    Intervention Section, Department of Cell and Cancer Biology, Division of Clinical Sciences, National Cancer Institute, NIH Clinical Center, 9000 Rockville Pike, Bethesda, MD 20892-1906, USA
    FASEB J 15:2007-9. 2001
    ....
  15. ncbi Adrenomedullin expression and function in the rat carotid body
    A Martinez
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda, Maryland 20892, USA
    J Endocrinol 176:95-102. 2003
    ..All these data suggest that AM is an important autocrine regulator of carotid body function...
  16. ncbi Alternative splicing of the proadrenomedullin gene results in differential expression of gene products
    A Martinez
    Department of Cell and Cancer Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Mol Endocrinol 27:31-41. 2001
    ..Analysis of the sequence of the third intron and the fourth exon of the AM gene found motifs compatible with a highly regulated alternative splicing mechanism...
  17. ncbi Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action
    L M Montuenga
    Biomarkers and Prevention Research Branch, National Cancer Institute, Rockville, Maryland 20850, USA
    Endocrinology 138:440-51. 1997
    ..In several regions of the embryo, the patterns of AM expression correspond to the degree of differentiation. The possible involvement of AM in the control of embryonic invasion, proliferation, and differentiation is discussed...
  18. ncbi Regulation of pancreatic physiology by adrenomedullin and its binding protein
    E Zudaire
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N262, Bethesda, MD 20892, USA
    Regul Pept 112:121-30. 2003
    ..Further investigation focused on the development of blocking agents for AM could result in new treatments for pancreatic AM-related disorders...
  19. ncbi Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily
    L L Ozbun
    Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, 9610 Medical Center Drive, Rockville, MD 20850, USA
    Genomics 73:179-93. 2001
    ..TGF-beta1 does not induce DENTT mRNA expression in TGF-beta1 nonresponsive NSCLC cells. Our data suggest that this novel TGF-beta1 target gene has distinct domains for direction to different subnuclear locations...
  20. ncbi Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development
    L M Montuenga
    Cell and Cancer Biology Department, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Respir Cell Mol Biol 19:554-62. 1998
    ....
  21. ncbi Detection of adrenomedullin, a hypotensive peptide, in amniotic fluid and fetal membranes
    C J Macri
    Department of Obstetrics and Gynecology, Uniformed Services University of Health Sciences, Bethesda, MD 20814 4799, USA
    Am J Obstet Gynecol 175:906-11. 1996
    ....
  22. ncbi Modulation of endometrial steroid receptors and growth regulatory genes by tamoxifen
    J Elkas
    Department of Obstetrics and Gynecology, National Naval Medical Center, Bethesda, Maryland, USA
    Obstet Gynecol 95:697-703. 2000
    ..We investigated tamoxifen's effects on the expression of growth regulatory genes in the endometrium to identify the mechanism by which tamoxifen induces proliferation...
  23. ncbi Evidence for pigment epithelium-derived factor receptors in the neural retina
    M S Aymerich
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Building 6, 6 Center Drive, Bethesda, MD 20892 2740, USA
    Invest Ophthalmol Vis Sci 42:3287-93. 2001
    ..In the present study, the expression of PEDF receptors in native neural retinas from adult steers was examined...
  24. ncbi Adrenomedullin and cancer
    E Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda MD 20892, USA
    Regul Pept 112:175-83. 2003
    ..The collective findings brought together over the last years place AM as a major regulator of carcinogenesis-tumor progression and identifies its autocrine loop as a putative target for developing new strategies against human cancers...
  25. ncbi Moving to the routine management of pre symptomatic lung cancer
    J L Mulshine
    Intervention Section, Center for Cancer Research, NCI, NIH, Bethesda, MD 20850, USA
    Lung Cancer 34:S1-5. 2001
    ..A distillation of this process up to the current time is reviewed in this manuscript...
  26. ncbi A multicenter, randomized, controlled trial of three preparations of low-dose oral alpha-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm(3). Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group
    B Alston
    Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 7624, USA
    J Acquir Immune Defic Syndr 22:348-57. 1999
    ....
  27. ncbi Inhibition of vasopressin V1b receptor translation by upstream open reading frames in the 5'-untranslated region
    C Rabadan-Diehl
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroendocrinol 19:309-19. 2007
    ..The present study shows that uORFs in the 5'-UTR of the V1bR mRNA inhibit V1bR translation, and suggests that translation of a 38-amino acid membrane peptide encoded by uORF1 exerts tonic inhibition of V1bR translation...
  28. doi Stromal gene signatures in large-B-cell lymphomas
    G Lenz
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 359:2313-23. 2008
    ..Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear...
  29. ncbi Peptide-amidating enzymes are expressed in the stellate epithelial cells of the thymic medulla
    A Martinez
    Cell and Cancer Biology Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850 3300, USA
    J Histochem Cytochem 46:661-8. 1998
    ....
  30. ncbi Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat
    J Serrano
    Department of Neuroanatomy and Cell Biology, Instituto Cajal Madrid, Spain
    Neuroscience 109:717-31. 2002
    ..In summary, adrenomedullin expression is elevated after the ischemic insult and seems to be part of CNS response mechanism to hypoxic injury...
  31. ncbi E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles
    C L Lendon
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Hum Mutat 10:186-95. 1997
    ..Previous investigations of the effect of ApoE genotype on the age of onset were confounded by small patient numbers, familial clustering of ApoE genotypes, and combining data from unrelated families with different mutations...
  32. ncbi Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome
    C Eisenbeiss
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    Br J Dermatol 149:850-2. 2003
    ..Despite the fact that reduced skin thickness is one of the dermatological features in patients with EDS, this issue has not been analysed in greater detail...
  33. ncbi Spatio-temporal analysis of feature-based attention
    M A Schoenfeld
    Department of Neurology II and Center for Advanced Imaging, University of Magdeburg, Leipzigerstrasse 44, 39120 Magdeburg, Germany
    Cereb Cortex 17:2468-77. 2007
    ..By combining methods with high spatial and temporal resolution it is possible to analyze the precise time course of feature-selective processing in specialized cortical areas...
  34. ncbi The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology
    C A Lemere
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Med 2:1146-50. 1996
    ....
  35. ncbi Differential kinetic features by tumour topography in cutaneous small-cell neuroendocrine (Merkel cell) carcinomas
    L Pozo
    Department of Dermatology, Homerton University Hospital, London, UK
    J Eur Acad Dermatol Venereol 21:1220-8. 2007
    ..This study analyses proliferation, apoptosis, and DNA ploidy by topography, features that can help planning therapeutic protocols. This study topographically analyses proliferation, apoptosis, and DNA ploidy...
  36. ncbi Cis-regulatory sequences leading to female-specific expression of yolk protein genes 1 and 2 in the fat body of Drosophila melanogaster
    N Abrahamsen
    Developmental Biology Center, University of Edinburgh, Scotland
    Mol Gen Genet 237:41-8. 1993
    ..g. Adh, Actin 5C). We suggest that DSX acts in concert with other proteins to mediate sex- and tissue-specific expression of the yp genes...