Roslyn B Mannon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Polyomavirus nephropathy: what have we learned?
    Roslyn B Mannon
    Transplantation and Autoimmunity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 77:1313-8. 2004
  2. ncbi request reprint Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin
    Allan D Kirk
    Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 80:1051-9. 2005
  3. ncbi request reprint Surgical transplant physical examination: correlation of renal resistance index and biopsy-proven chronic allograft nephropathy
    Eric A Elster
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Am Coll Surg 200:552-6. 2005
  4. ncbi request reprint The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials
    Eric A Elster
    Department of Health and Human Services, Transplantation Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transpl Immunol 13:87-99. 2004
  5. doi request reprint Obesity following kidney transplantation and steroid avoidance immunosuppression
    Eric A Elster
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Transplant 22:354-9. 2008
  6. pmc Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients
    Wai Johnn Sam
    Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 94:971-7. 2012
  7. ncbi request reprint Functionally significant renal allograft rejection is defined by transcriptional criteria
    Steven C Hoffmann
    Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Transplant 5:573-81. 2005
  8. ncbi request reprint Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion
    Jonathan P Pearl
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Transplant 5:465-74. 2005
  9. ncbi request reprint Strategies for minimizing immunosuppression in kidney transplantation
    Allan D Kirk
    Transplantation Branch, Department of Health and Human Services, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Center Drive, Bethesda, MD 20892, USA
    Transpl Int 18:2-14. 2005
  10. pmc Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events
    Yuen Yi Hon
    Pharmacy Department, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Transplant 24:557-63. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Polyomavirus nephropathy: what have we learned?
    Roslyn B Mannon
    Transplantation and Autoimmunity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 77:1313-8. 2004
  2. ncbi request reprint Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin
    Allan D Kirk
    Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 80:1051-9. 2005
    ..We therefore performed a trial to determine if lymphocyte depletion with alemtuzumab combined with DSG would induce tolerance in humans...
  3. ncbi request reprint Surgical transplant physical examination: correlation of renal resistance index and biopsy-proven chronic allograft nephropathy
    Eric A Elster
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Am Coll Surg 200:552-6. 2005
    ..A screening test capable of identifying individuals at high risk for CAN would be a valuable adjunct to patient care, but to be cost effective, should be administered during routine evaluations by transplantation clinicians...
  4. ncbi request reprint The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials
    Eric A Elster
    Department of Health and Human Services, Transplantation Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transpl Immunol 13:87-99. 2004
    ..Seminal preclinical studies will be cited and the results of initial clinical trials will be reviewed. The data to date indicate that while tolerance remains elusive, immunosuppression minimization is a feasible near-term alternative...
  5. doi request reprint Obesity following kidney transplantation and steroid avoidance immunosuppression
    Eric A Elster
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Transplant 22:354-9. 2008
    ..Thus, patients gain weight after renal transplantation regardless of the treatment strategy. Steroid avoidance alone does not reduce risk factors associated with obesity in our patient population...
  6. pmc Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients
    Wai Johnn Sam
    Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 94:971-7. 2012
    ..We further examined to see whether these polymorphisms were also associated with SRL-induced dyslipidemia...
  7. ncbi request reprint Functionally significant renal allograft rejection is defined by transcriptional criteria
    Steven C Hoffmann
    Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Transplant 5:573-81. 2005
    ..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts...
  8. ncbi request reprint Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion
    Jonathan P Pearl
    Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Transplant 5:465-74. 2005
    ..These data demonstrate that therapeutic depletion begets a limited population of functional memory-like T cells that are easily suppressed with certain immunosuppressants, but cannot be considered uniquely pro-tolerant...
  9. ncbi request reprint Strategies for minimizing immunosuppression in kidney transplantation
    Allan D Kirk
    Transplantation Branch, Department of Health and Human Services, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Center Drive, Bethesda, MD 20892, USA
    Transpl Int 18:2-14. 2005
    ..Based on the available data we suggest that most patients can be transplanted with less immunosuppression than is currently standard...
  10. pmc Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events
    Yuen Yi Hon
    Pharmacy Department, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Transplant 24:557-63. 2010
    ..Lower C0 and AUC appeared to be associated with biopsy-proven AR>6 months post-transplant. Further prospective evaluation of TAC AUC and C0 monitoring in a larger cohort of patients is warranted...
  11. pmc Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients
    Wai Johnn Sam
    Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD, USA
    Transplantation 92:1342-7. 2011
    ....
  12. ncbi request reprint The clinical application of monoclonal antibody therapies in renal transplantation
    Kiran K Dhanireddy
    Transplantation Branch, National Institute of Diabets, Digestives and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Expert Opin Emerg Drugs 9:23-37. 2004
    ..It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described...
  13. pmc Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154
    He Xu
    Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Clin Invest 116:769-74. 2006
    ..These data implicate platelets as a proximal component of acquired alloimmunity, providing insight into the mechanisms of allograft rejection and the physiological response to trauma in general...
  14. ncbi request reprint Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H)
    Allan D Kirk
    Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Transplantation 76:120-9. 2003
    ..We therefore performed a study to determine if pretransplant T-cell depletion with alemtuzumab would induce tolerance in human renal allografts and to evaluate the nature of the alloimmune response in the setting of T-cell depletion...
  15. ncbi request reprint Beyond histology: novel tools to diagnose allograft dysfunction
    Roslyn B Mannon
    Transplantation Branch, NIDDK NIH, 10 Center Drive, MSC 1450, CRC 5 5750, Bethesda, MD 20892, USA
    Clin J Am Soc Nephrol 1:358-66. 2006
    ..The future challenge for promising tests is validation in larger patient populations to facilitate their addition to the diagnostic armamentarium...
  16. ncbi request reprint BK virus and SV40 co-infection in polyomavirus nephropathy
    Rui Mei Li
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Transplantation 74:1497-504. 2002
    ..The simian virus (SV) 40 is PV that was likely introduced into the human population through contaminated vaccines. The purpose of this study was to identify and characterize the PV that is associated with PV nephropathy...
  17. ncbi request reprint Successful renal transplantation in a patient with congenital generalized lipodystrophy: a case report
    Michael McNally
    Department of Surgery, National Naval Medical Center, Bethesda, MD, USA
    Am J Transplant 4:447-9. 2004
  18. ncbi request reprint Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury
    Steven C Hoffmann
    National Institute of Diabetes and Digestive and Kidney Diseases and Navy Transplantation and Autoimmunity Branch, Bethesda, MD 20892, USA
    Transplantation 74:916-23. 2002
    ..This gives way to a T-cell dominant milieu even in grafts selected for their stable function and absence of rejection. These data have implications for understanding the fundamental link between I/R injury and alloimmunity...
  19. ncbi request reprint Diagnostic tools for monitoring kidney transplant recipients
    Raffaele Girlanda
    Transplantation Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Semin Nephrol 27:462-78. 2007
    ..Newer studies are presented, along with more mundane assays, to highlight the practical use of studies regardless of their degree of mechanistic sophistication...
  20. doi request reprint Therapeutic management of posttransplant diabetes mellitus
    Roslyn B Mannon
    Transplantation Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Transplant Rev (Orlando) 22:116-24. 2008
    ..As diabetes has a negative impact on patient and graft outcome, the transplant practitioner must be vigilant in screening and managing diabetes after transplantation...
  21. pmc Care of the kidney transplant recipient
    Anil Chandraker
    Transplantation Branch, NIDDK NIH, 10 Center Drive, MSC 1450, CRC 5 5750, Bethesda, MD 20892, USA
    Clin J Am Soc Nephrol 3:S27-8. 2008
  22. pmc Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University School of Medicine, Bethesda, MD, USA
    Proteomics Clin Appl 5:311-21. 2011
    ....
  23. ncbi request reprint Idiopathic intracranial hypertension following kidney transplantation: a case report and review of the literature
    Christine E Chamberlain
    Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Transplant 9:545-50. 2005
    ....
  24. ncbi request reprint Detection and localization of proteinuria by dynamic contrast-enhanced magnetic resonance imaging using MS325
    Yantian Zhang
    Department of Radiology, Warren Grant Magnuson Clinical Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Am Soc Nephrol 16:1752-7. 2005
    ..If this technique can be successfully applied in human patients, it may allow for the localization of proteinuria after kidney transplant and thereby provide a noninvasive way to detect disease affecting the renal allograft...
  25. ncbi request reprint Delayed autotransplantation of a solitary kidney facilitated by pump perfusion preservation
    Linda C Cendales
    Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD 20892, USA
    Surgery 133:438-9. 2003
  26. ncbi request reprint Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay
    Richard J Kowalski
    Cylex Incorporated, Columbia, MD 21045, USA
    Transplantation 82:663-8. 2006
    ..A meta-analysis of 504 solid organ transplant recipients (heart, kidney, kidney-pancreas, liver and small bowel) from 10 U.S. centers was performed using the Cylex ImmuKnow assay...
  27. pmc Late kidney allograft loss: what we know about it, and what we can do about it
    Anthony M Jevnikar
    Department of Medicine, Lawson Health Research Institute and Robarts Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 3:S56-67. 2008
    ..Understanding the basic pathogenesis sufficiently to allow early intervention may finally benefit patients who are at high risk for tubular atrophy and interstitial fibrosis and promote their long-term graft function...
  28. ncbi request reprint Leflunomide therapy in kidney transplantation: ready for prime time?
    Roslyn B Mannon
    Clin J Am Soc Nephrol 3:652-3. 2008
  29. ncbi request reprint Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy
    S John Swanson
    Organ Transplant Service, Walter Reed Army Medical Center, Washington, DC, USA
    Lancet 360:1662-4. 2002
    ..Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression...
  30. ncbi request reprint Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection
    Roslyn B Mannon
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA
    Kidney Int 62:290-300. 2002
    ..Chronic rejection (CR) develops in these long surviving grafts. The pathologic features of CR in this model are similar to CR in human kidney grafts...
  31. ncbi request reprint Inhibition of prolyl-4-hydroxylase ameliorates chronic rejection of mouse kidney allografts
    Nora Franceschini
    Department of Medicine, Division of Nephrology, Duke and Durham VA Medical Centers, Durham, North Carolina, USA
    Am J Transplant 3:396-402. 2003
    ..In conclusion, PHI-treated allografts had improved renal function and reduced the severity of renal injury as a result of CAN. Inhibition of matrix synthesis may be a useful adjunct in ameliorating the development of CAN in humans...