Genomes and Genes
Barry J Make
Affiliation: National Jewish Medical and Research Center
- Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional studyNicholas D Giardino
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Respir Res 11:29. 2010..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...
- Is exercise important in chronic obstructive pulmonary disease?Barry Make
Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado, USA
COPD 4:185-9. 2007..These concepts were explored in a conference sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Pfizer Inc and reviewed in the articles generated from the symposium in this issue of COPD...
- How can we assess outcomes of clinical trials: the MCID approachBarry Make
Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
COPD 4:191-4. 2007..For newer tools such as activity monitors and questionnaires and measures not widely employed such as laboratory-based exercise tests, minimal clinically important differences remain to be determined...
- Assessment of patients with chronic obstructive pulmonary diseaseBarry J Make
National Jewish Health, 1400 Jackson Street, K729, Denver, CO 80206, USA
Proc Am Thorac Soc 5:884-90. 2008..There are outcome measures that have been successfully incorporated in large clinical trials, and the design and outcomes of these trials can be used to plan future clinical investigations in COPD...
- The efficacy and safety of inhaled fluticasone propionate/salmeterol and ipratropium/albuterol for the treatment of chronic obstructive pulmonary disease: an eight-week, multicenter, randomized, double-blind, double-dummy, parallel-group studyBarry Make
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Clin Ther 27:531-42. 2005..The pathology of chronic obstructive pulmonary disease (COPD) includes both obstructive and inflammatory components...
- Chronic obstructive pulmonary disease: developing comprehensive managementBarry J Make
Emphysema Center, Pulmonary Rehavilitation and Respiratory Care, National Jewish Medical and Research Center, Denver, Colorado 80206 2762, USA
Respir Care 48:1225-34; discussion 1234-7. 2003..Disease management programs may be useful in assisting health care practitioners and patients in managing chronic obstructive pulmonary disease...
- Differences in adjustment between individuals with alpha-1 antitrypsin deficiency (AATD)-associated COPD and non-AATD COPDKristen E Holm
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
COPD 10:226-34. 2013..Resources available to persons with AATD-associated COPD, such as being in a serious relationship and having higher education, may offset the effect of age when considering symptoms of depression and anxiety in patients with COPD...
- Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumoniaTasha E Fingerlin
Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA
BMC Genet 17:74. 2016..Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
- Family relationship quality is associated with psychological distress, dyspnea, and quality of life in COPDKristen E Holm
Department of Medicine, National Jewish Health, Denver, Colorado, 80206, USA
COPD 6:359-68. 2009....
- Survival of individuals receiving long-term mechanical ventilationEsther L Langmack
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Respir Care Clin N Am 8:355-77. 2002..In addition to survival, other important outcomes, such as patient satisfaction, quality of life, and costs associated with LTMV, should be assessed in future long-term studies...
- A double-blind crossover study comparing the safety and efficacy of three weeks of Flu/Sal 250/50 bid plus albuterol 180 ug prn q4 hours to Flu/Sal 250/50 bid plus albuterol/Ipratropium bromide 2 puffs prn q4 hours in patients with chronic obstructive pulRon Balkissoon
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
COPD 5:221-7. 2008..SABA and combination SABA/Ipratropium bromide are equally safe and efficacious as rescue inhalers for patients on combination Fluticasone 500 microg/Salmeterol 50 microg...
- Neurobehavioral improvement after brief rehabilitation in patients with chronic obstructive pulmonary diseaseElizabeth Kozora
National Jewish Medical and Research Center, Denver, Colo 80206, USA
J Cardiopulm Rehabil 22:426-30. 2002..Depressive symptoms, physiologic function, and cognition were examined in patients with chronic obstructive pulmonary disease (COPD) after 3 weeks of rehabilitation...
- Improved neurobehavioral functioning in emphysema patients following lung volume reduction surgery compared with medical therapyElizabeth Kozora
National Jewish Medical and Research Center, 1400 Jackson St, A111, Denver, CO 80206, USA
Chest 128:2653-63. 2005..The goal of this study was to evaluate the neuropsychological and psychological functioning of emphysema patients following lung volume reduction surgery (LVRS) compared with patients receiving only medical therapy (MT)...
- Right ventricular diastolic function and exercise capacity in COPDBrett E Fenster
National Jewish Health, Division of Cardiology, Denver, CO, United States Electronic address
Respir Med 109:1287-92. 2015..We evaluated the extent to which right ventricular diastolic function (RVDF) is associated with exercise capacity in COPD...
- A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluationR Graham Barr
Division of Radiology, National Jewish Health, Denver, CO 80206, USA
COPD 9:151-9. 2012....
- Family factors are associated with psychological distress and smoking status in chronic obstructive pulmonary diseaseKristen E Holm
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
Gen Hosp Psychiatry 32:492-8. 2010....
- Oxygen therapy in advanced COPD: in whom does it work?Barry Make
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver Colorado, USA
Semin Respir Crit Care Med 31:334-42. 2010..With the knowledge that studies in patients with advanced COPD and less severe hypoxemia are limited, recommendations are provided on oxygen use in these groups of patients...
- Predictors of rehospitalization and death after a severe exacerbation of COPDRyan McGhan
Denver Health and Hospital Authority, Denver, CO, USA
Chest 132:1748-55. 2007..Patients who survive a severe exacerbation of COPD are at high risk of rehospitalization for COPD and death. The objective of this study was to determine predictors of these events in a large cohort of Veterans Affairs (VA) patients...
- Winter air pollution and disease parameters in advanced chronic obstructive pulmonary disease panels residing in Denver, ColoradoPhilip E Silkoff
Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 115:337-44. 2005..Ambient pollution might worsen chronic obstructive pulmonary disease (COPD)...
- Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisTasha E Fingerlin
University of Colorado Denver, School of Public Health, Denver, Colorado, USA
Nat Genet 45:613-20. 2013..Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs...
- Cognitive and psychological issues in emphysemaElizabeth Kozora
National Jewish Medical and Research Center, Denver, CO 80206, USA
Proc Am Thorac Soc 5:556-60. 2008..Overall, studies suggest that psychological and cognitive improvements occur subsequent to a variety of medical and behavioral treatment therapeutic approaches, and that LVRS appears to have an advantage for some patients with emphysema...
- Pulmonary rehabilitation in idiopathic pulmonary fibrosis: a call for continued investigationJeffrey J Swigris
Autoimmune Lung Center, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Respir Med 102:1675-80. 2008..Pulmonary rehabilitation helps to accomplish many of these goals in patients with chronic obstructive pulmonary disease, and emerging data suggest that it may do the same for patients with IPF...
- Maximum exercise as an outcome in COPD: minimal clinically important differenceE Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson St, J217, Denver, Colorado 80206, USA
COPD 2:137-41. 2005..Further investigation is needed to develop and validate estimates of MCID for maximum exercise capacity and other key clinical outcomes in COPD...
- Complement activation in a model of chronic fatigue syndromeBristol Sorensen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
J Allergy Clin Immunol 112:397-403. 2003..A need exists to identify biological markers in chronic fatigue syndrome (CFS)...
- Genetic epidemiology of COPD (COPDGene) study designElizabeth A Regan
National Jewish Health, Denver, Colorado, USA
COPD 7:32-43. 2010..Finally, subtypes of COPD based on these phenotypes will be used in a comprehensive genome-wide study to identify COPD susceptibility genes...
- Physiologic variables and functional status independently predict COPD hospitalizations and emergency department visits in patients with severe COPDVincent S Fan
Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98108 1597, USA
COPD 4:29-39. 2007..08, 1.02-1.14) independently predicted exacerbations (AUC for full model 0.68). Combining physiologic variables, dyspnea, prior exacerbations and co-morbidity may be useful in identifying patients at high risk for COPD exacerbations...
- The effects of pulmonary rehabilitation in the national emphysema treatment trialAndrew L Ries
UCSD Medical Center, 200 W Arbor Dr, No 8377, San Diego, CA 92103 8377, USA
Chest 128:3799-809. 2005..The National Emphysema Treatment Trial (NETT) provided an opportunity to evaluate pulmonary rehabilitation in a large cohort of patients who were treated in centers throughout the United States...
- Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathologyJames C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007..COPD is associated with reduced life expectancy...
- The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbationsGeorge R Washko
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 177:164-9. 2008..The effect of LVRS on COPD exacerbations has not been as extensively studied, and whether improvement in postoperative lung function alters the risk of disease exacerbations is not known...
- Pulmonary rehabilitation in emphysemaAndrew L Ries
University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0602, USA
Proc Am Thorac Soc 5:524-9. 2008....
- Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment TrialMichael B Drummond
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Chest 134:497-506. 2008..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
- Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary diseaseBipen D Patel
Department of Medicine, University of Cambridge, Cambridge, UK
Am J Respir Crit Care Med 178:500-5. 2008..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families...
- Comorbidities in chronic obstructive pulmonary diseaseWissam M Chatila
Division of Pulmonary and Critical Care Division, Temple University School of Medicine, 3401 N Broad Street, Philadelphia PA, 19140, USA
Proc Am Thorac Soc 5:549-55. 2008....
- Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanicsGeorge R Washko
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, Massachusetts 02115, USA
COPD 5:177-86. 2008..The CT based quantification of emphysema may augment pulmonary function testing in the characterization of COPD by providing complementary phenotypic information...
- Sex, depression, and risk of hospitalization and mortality in chronic obstructive pulmonary diseaseVincent S Fan
Health Services Research and Development Center of Excellence, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108 1597, USA
Arch Intern Med 167:2345-53. 2007....
- Wildfire smoke and respiratory symptoms in patients with chronic obstructive pulmonary diseaseE Rand Sutherland
J Allergy Clin Immunol 115:420-2. 2005
- Editorial: the Journal of COPD--new directions in disease understanding and managementJames D Crapo
COPD 1:1-3. 2004
- Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary diseaseFrank C Sciurba
Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
Proc Am Thorac Soc 3:533-4. 2006