Donald E Mager

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique
    Donald E Mager
    Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
    J Pharmacol Exp Ther 311:830-5. 2004
  2. ncbi request reprint Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
    Donald E Mager
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    FASEB J 20:631-7. 2006
  3. ncbi request reprint Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats
    Marion L Williams
    National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Drug Metab Dispos 32:786-93. 2004
  4. ncbi request reprint HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma
    Danuta Siluk
    Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 859:213-21. 2007
  5. ncbi request reprint Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability
    Donald E Mager
    National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biomed Sci Instrum 40:337-42. 2004
  6. doi request reprint Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus
    Ying Hong
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    J Clin Pharmacol 48:696-707. 2008
  7. ncbi request reprint Use of wavelet and fast Fourier transforms in pharmacodynamics
    Donald E Mager
    Department of Pharmaceutical Sciences, University at Buffalo, the State Universitiy of New York, Buffalo, NY, USA
    J Pharmacol Exp Ther 321:423-30. 2007
  8. ncbi request reprint Integrated QSPR--pharmacodynamic model of genomic effects of several corticosteroids
    Donald E Mager
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Pharm Sci 92:881-9. 2003
  9. ncbi request reprint Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man
    Gerhard Levy
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Pharm Sci 92:985-94. 2003
  10. pmc Integrated cellular bone homeostasis model for denosumab pharmacodynamics in multiple myeloma patients
    Anshu Marathe
    Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 326:555-62. 2008

Detail Information

Publications10

  1. ncbi request reprint Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique
    Donald E Mager
    Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
    J Pharmacol Exp Ther 311:830-5. 2004
    ..Type 2 diabetic subjects demonstrate a significant response to exendin-4, but to a lesser extent than nondiabetic subjects, despite comparable measures of apparent drug exposure and efficacy...
  2. ncbi request reprint Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
    Donald E Mager
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    FASEB J 20:631-7. 2006
    ..These results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans...
  3. ncbi request reprint Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats
    Marion L Williams
    National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Drug Metab Dispos 32:786-93. 2004
    ..005 (DNK1); N.S. (DNK2)], which was in concordance with the decrease in apparent clearance values. These results show that PCM significantly alters the pharmacokinetics of KET and several of its metabolites...
  4. ncbi request reprint HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma
    Danuta Siluk
    Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 859:213-21. 2007
    ..0537+/-0.0073 L/kg min vs. 0.0439+/-0.0086 L/kg min), while the volumes of distribution at steady-state were similar for the hyoscyamine enantiomers (Vss/f=7.82+/-2.66 L/kg vs. 7.73+/-1.39 L/kg)...
  5. ncbi request reprint Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability
    Donald E Mager
    National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biomed Sci Instrum 40:337-42. 2004
    ..of coefficients in the high frequency band (0.15-0.4 Hz). These findings may have clinical significance and the developed algorithm provides an alternative means of analyzing HRV data originating from populations with complex covariates...
  6. doi request reprint Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus
    Ying Hong
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    J Clin Pharmacol 48:696-707. 2008
    ..Simulations suggested that the clinical utility of metformin was maintained over the dose range evaluated with respect to fasting plasma glucose and lactic acid response...
  7. ncbi request reprint Use of wavelet and fast Fourier transforms in pharmacodynamics
    Donald E Mager
    Department of Pharmaceutical Sciences, University at Buffalo, the State Universitiy of New York, Buffalo, NY, USA
    J Pharmacol Exp Ther 321:423-30. 2007
    ..In this review, we discuss specific applications of these transforms in pharmacodynamics and their potential role in ascertaining the dynamics of spatiotemporal properties of complex pharmacological systems...
  8. ncbi request reprint Integrated QSPR--pharmacodynamic model of genomic effects of several corticosteroids
    Donald E Mager
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Pharm Sci 92:881-9. 2003
    ..This study serves as a demonstration of how in vitro pharmacologic data and QSPR modeling results may be incorporated into existing mechanistic PK/PD models to anticipate the effects of other chemically related compounds...
  9. ncbi request reprint Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man
    Gerhard Levy
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Pharm Sci 92:985-94. 2003
    ..Utilization of a model premised on similar target-mediated drug disposition also allowed characterization of data from the literature for racemic warfarin pharmacokinetics in man...
  10. pmc Integrated cellular bone homeostasis model for denosumab pharmacodynamics in multiple myeloma patients
    Anshu Marathe
    Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 326:555-62. 2008
    ....