Paul E Love

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Ldb1 complexes: the new master regulators of erythroid gene transcription
    Paul E Love
    Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Trends Genet 30:1-9. 2014
  2. pmc Signal integration and crosstalk during thymocyte migration and emigration
    Paul E Love
    Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Rev Immunol 11:469-77. 2011
  3. pmc ITAM-mediated signaling by the T-cell antigen receptor
    Paul E Love
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cold Spring Harb Perspect Biol 2:a002485. 2010
  4. pmc Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:1125-34. 2005
  5. pmc Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
    Renaud Lesourne
    Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 189:1154-61. 2012
  6. pmc Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
    Sujin Hwang
    Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:1781-95. 2012
  7. pmc Deconstructing Ras signaling in the thymus
    Robert L Kortum
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:2748-59. 2012
  8. ncbi request reprint LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Bioessays 26:61-7. 2004
  9. pmc Themis, a T cell-specific protein important for late thymocyte development
    Renaud Lesourne
    Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Immunol 10:840-7. 2009
  10. pmc Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:129-36. 2011

Collaborators

Detail Information

Publications40

  1. pmc Ldb1 complexes: the new master regulators of erythroid gene transcription
    Paul E Love
    Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Trends Genet 30:1-9. 2014
    ..Together with new data demonstrating that Ldb1 can mediate long-range promoter-enhancer interactions, these findings provide a foundation for the first comprehensive models of the global regulation of erythroid gene transcription. ..
  2. pmc Signal integration and crosstalk during thymocyte migration and emigration
    Paul E Love
    Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Rev Immunol 11:469-77. 2011
    ..These advances are the subject of this Review, with a particular focus on the role of reciprocal cooperative and regulatory interactions between TCR- and chemokine receptor-mediated signalling...
  3. pmc ITAM-mediated signaling by the T-cell antigen receptor
    Paul E Love
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cold Spring Harb Perspect Biol 2:a002485. 2010
    ..Here, we summarize data generated during the past two decades and discuss how these findings have in some cases resolved, and in others complicated, outstanding questions relating to the function of TCR ITAMs...
  4. pmc Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:1125-34. 2005
    ....
  5. pmc Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
    Renaud Lesourne
    Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 189:1154-61. 2012
    ..These results suggest that conserved molecular features of the Themis1 and Themis2 proteins are important for their biological activity and predict that Themis1 and Themis2 may perform similar functions in T and B cells, respectively...
  6. pmc Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
    Sujin Hwang
    Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:1781-95. 2012
    ..These results identify a potential compensatory pathway for the enforcement of immune tolerance in response to defective negative selection caused by reduced TCR signaling capability...
  7. pmc Deconstructing Ras signaling in the thymus
    Robert L Kortum
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:2748-59. 2012
    ..This functional redundancy in RasGEFs during negative selection may act as a failsafe mechanism ensuring appropriate central tolerance...
  8. ncbi request reprint LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Bioessays 26:61-7. 2004
    ..These studies suggest that similar levels of control may be found in other systems where adapter molecules are known to have important functions...
  9. pmc Themis, a T cell-specific protein important for late thymocyte development
    Renaud Lesourne
    Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Immunol 10:840-7. 2009
    ..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation...
  10. pmc Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:129-36. 2011
    ..Our results identify a central role for Ldb1 in regulating the transcriptional program responsible for the maintenance of HSCs...
  11. ncbi request reprint Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model
    Batu Erman
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 177:6613-25. 2006
    ....
  12. ncbi request reprint Premature expression of chemokine receptor CCR9 impairs T cell development
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Immunol 176:75-84. 2006
    ..Together, these results suggest that regulated expression of CCR9 is critical for normal development of immature thymocytes, but that down-regulation of CCR9 is not a prerequisite for thymocyte emigration...
  13. pmc Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 121:4575-85. 2013
    ..Together, these results provide a foundation for defining the mechanism and scope of Ldb1 complex activity during erythropoiesis...
  14. doi request reprint Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892 4259, MD, USA
    Eur J Immunol 43:918-28. 2013
    ..Thus, in addition to its previously documented role in promoting CD4-lineage gene-expression, Gata3 represses CD8-lineage gene expression. These findings identify Gata3 as a critical pivot of CD4-CD8 lineage differentiation...
  15. pmc Bam32: a novel mediator of Erk activation in T cells
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int Immunol 20:811-8. 2008
    ..These results indicate a novel pathway to Erk activation in T cells involving the adapter protein Bam32...
  16. ncbi request reprint A LAT mutation that inhibits T cell development yet induces lymphoproliferation
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:2040-3. 2002
    ..In contrast, TCR-induced Erk activation was intact. These results identify a critical role for integrated PLC-gamma1 and Ras-Erk signaling through LAT in T cell development and homeostasis...
  17. ncbi request reprint TCR signal strength influences alphabeta/gammadelta lineage fate
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Immunity 22:583-93. 2005
    ..These results support a model in which the strength of the TCR signal is a critical determinant in the lineage fate decision...
  18. ncbi request reprint A role for CCR9 in T lymphocyte development and migration
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 168:2811-9. 2002
    ..Thus, CCR9 plays an important, although not indispensable, role in regulating the development and/or migration of both alphabeta(-) and gammadelta(-) T lymphocytes...
  19. ncbi request reprint Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes
    Kenneth J Woodside
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 2B 210, 9000 Rockville Pike, Bethesda, MD 20892 2780, USA
    Gene Expr Patterns 4:315-20. 2004
    ....
  20. pmc Targeted Sos1 deletion reveals its critical role in early T-cell development
    Robert L Kortum
    National Cancer Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:12407-12. 2011
    ..These data reveal that Sos1 is uniquely positioned to affect signal transduction early in thymocyte development...
  21. pmc A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells
    Melanie S Vacchio
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 15:947-56. 2014
    ..As such, the ThPOK-LRF transcriptional module was essential for CD4(+) T cell integrity and responses. ..
  22. ncbi request reprint Distinct structure and signaling potential of the gamma delta TCR complex
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:827-38. 2002
    ..These results reveal fundamental differences in the primary structure and signaling potential of the alpha beta- and gamma delta TCR complexes...
  23. pmc Stoichiometry of the murine gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:47-52. 2006
    ..Our results support a model of murine gammadeltaTCR stoichiometry in which there are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer...
  24. pmc A requirement for Lim domain binding protein 1 in erythropoiesis
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2543-50. 2010
    ..These results represent the first unequivocal demonstration of a role for Ldb1 in erythropoiesis in vivo and establish a critical function for Ldb1-nucleated complexes in regulating the erythroid/megakaryocyte transcriptional program...
  25. pmc Activation-induced modification in the CD3 complex of the gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 196:1355-61. 2002
    ....
  26. ncbi request reprint Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice
    Susana M Cerritelli
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 11:807-15. 2003
    ..These findings also have important implications for therapy of mitochondrial dysfunctions and drug development for the structurally related RNase H of HIV...
  27. ncbi request reprint CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain
    Avinash Bhandoola
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Immunol 32:1811-7. 2002
    ..We now report that CD5 mediated down-regulation of TCR signaling during thymocyte development does not require the CD5 extracellular domain and, consequently, does not involve CD5 binding of an extracellular ligand in the thymus...
  28. pmc LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth
    Itai Tzchori
    Section on Mammalian Molecular Genetics, Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Development 136:1375-85. 2009
    ....
  29. pmc The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells
    Jung Min Park
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, 31 Center Drive, Bldg 31, Rm 2A25, Bethesda, MD 20892 2426, USA
    Mol Cell Biol 26:1445-51. 2006
    ..The results indicate that in contrast to the situation in yeasts, La is essential in mammals and is one of a limited number of genes required as early as the development of the ICM...
  30. ncbi request reprint Imprint control element-mediated secondary methylation imprints at the Igf2/H19 locus
    Madhulika Srivastava
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:5977-83. 2003
    ..Finally, we analyzed the dependence of the methylation of Igf2DMR1 region on the primary methylation imprint about 90 kilobases away...
  31. pmc TCR ITAM multiplicity is required for the generation of follicular helper T-cells
    Sujin Hwang
    Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Room 2B 210, Building 6B, Bethesda, Maryland 20892, USA
    Nat Commun 6:6982. 2015
    ....
  32. pmc In vivo functional mapping of the conserved protein domains within murine Themis1
    Ekaterina Zvezdova
    Section on Cellular and Developmental Biology, Program on Genomics of Differentiation, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Immunol Cell Biol 92:721-8. 2014
    ..The results demonstrate an essential requirement for the PRR and NLS motifs but not the conserved CABIT cysteines for Themis1 function. ..
  33. ncbi request reprint Strength of signal: a fundamental mechanism for cell fate specification
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Immunol Rev 209:170-5. 2006
    ..In this review, we compare the alphabeta/gammadelta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification...
  34. pmc CCR6 is required for IL-23-induced psoriasis-like inflammation in mice
    Michael N Hedrick
    Inflammation Biology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 119:2317-29. 2009
    ..These findings reveal an expanded role for CCR6 in IL-23-related responses and identify CCR6 as a potential therapeutic target in psoriasis...
  35. ncbi request reprint Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR
    Hugh I McFarland
    Division of Therapeutics Proteins, Center for Biologics Evaluation and Research, Food and Drug Admnistration, Bethesda, MD, USA
    Blood 101:4520-8. 2003
    ..Lacking TCRs, these veto cells are unlikely to mediate graft-versus-host disease (GVHD) and thus may be useful as a cellular therapy for therapeutic deletion of alloreactive T cells in the settings of graft rejection and GVHD...
  36. ncbi request reprint Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells
    Ipsita Dey-Guha
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, HHS, Bethesda, Maryland 20892, USA
    J Cell Biochem 103:1856-65. 2008
    ..We propose that phosphorylation involving N-terminal tyrosine residues of Ssdp1 is a means of regulating its nuclear localization and subsequent transcriptional activation of LIM-HD complexes...
  37. ncbi request reprint Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunol 168:134-42. 2002
    ..These findings suggest that CCR9 may play an important role in the development and trafficking of both alphabetaTCR+ and gammadeltaTCR+ T cells...
  38. ncbi request reprint Regulation of thymocyte development: only the meek survive
    Paul E Love
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 15:199-203. 2003
    ..These studies indicate the importance of the strength and duration of signals activated through PLC and PKC pathways in shaping the mature TCR repertoire...
  39. ncbi request reprint An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 191:28-37. 2003
    ....
  40. ncbi request reprint A potential role for CD69 in thymocyte emigration
    Chiguang Feng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Int Immunol 14:535-44. 2002
    ..These results identify a potential role for CD69 in controlling thymocyte export, and suggest that the transient expression of CD69 on thymocytes and T cells may function to regulate thymocyte and T cell trafficking...