Jie Liu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
  2. ncbi request reprint The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Hepatology 37:324-33. 2003
  3. pmc Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 326:363-8. 2008
  4. ncbi request reprint Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
  5. pmc Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials?
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Exp Biol Med (Maywood) 233:810-7. 2008
  6. pmc Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 220:284-91. 2007
  7. ncbi request reprint Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
  8. ncbi request reprint Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
  9. ncbi request reprint Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 216:407-15. 2006
  10. ncbi request reprint Hybridization buffer systems impact the quality of filter array data
    Jie Liu
    Inorganic Carcinogenesis Section, LCC, NCI at NIEHS, 111 Alexander Drive, RTP, NC 27709, USA
    J Pharmacol Toxicol Methods 50:67-71. 2004

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. pmc Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
    ....
  2. ncbi request reprint The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Hepatology 37:324-33. 2003
    ..This protection may involve the reduction of oxidative stress, the inhibition of apoptosis, and possibly the maintenance of hepatic vasculature to prevent congestion...
  3. pmc Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 326:363-8. 2008
    ..Arsenic speciation, bioavailability, and toxicity/benefit should be considered in evaluation of mineral arsenical-containing traditional medicines...
  4. ncbi request reprint Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
    ..A briefly commentary is attempted here for their research perspectives...
  5. pmc Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials?
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Exp Biol Med (Maywood) 233:810-7. 2008
    ..In risk assessment, cinnabar is less toxic than many other forms of mercury, but the rationale for its inclusion in traditional Chinese medicines remains to be fully justified...
  6. pmc Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 220:284-91. 2007
    ..These alterations could disrupt genetic programming at the very early life stage, which could impact tumor formation much later in adulthood...
  7. ncbi request reprint Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
    ....
  8. ncbi request reprint Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
  9. ncbi request reprint Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 216:407-15. 2006
    ..Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation...
  10. ncbi request reprint Hybridization buffer systems impact the quality of filter array data
    Jie Liu
    Inorganic Carcinogenesis Section, LCC, NCI at NIEHS, 111 Alexander Drive, RTP, NC 27709, USA
    J Pharmacol Toxicol Methods 50:67-71. 2004
    ..A clean hybridization with minimal background is critical for successful microarray analysis and is highly desired. However, clean hybridization alone is not enough; verification is needed...
  11. ncbi request reprint Fas-mediated signaling pathway in ethanol-induced liver apoptosis: inhibition by zinc
    Jie Liu
    Inorganic Carcinogenesis, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Exp Biol Med (Maywood) 229:365-6. 2004
  12. ncbi request reprint Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity
    J Liu
    University of Kansas Medical Center, Kansas City, USA
    J Pharmacol Exp Ther 289:580-6. 1999
    ..The increased sensitivity does not appear to be due to increased acetaminophen activation, glutathione depletion, or covalent binding, but appears to be associated with the antioxidant role of MT...
  13. ncbi request reprint Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 70:144-51. 2005
    ..Thus, the liver-selective NO donor, V-PYRRO/NO, was partially protective against ANIT-induced liver injury, without affecting ANIT-induced cholestasis and cholestasis-related gene expression...
  14. ncbi request reprint O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays
    Jie Liu
    Inorganic Carcinogenesis Section, National Cancer Institute at National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 300:18-25. 2002
    ....
  15. ncbi request reprint Focal adhesion kinase as a potential target in arsenic toxicity
    Jie Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 84:212-3. 2005
  16. ncbi request reprint Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, 111, Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 170:55-62. 2002
    ....
  17. ncbi request reprint Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice
    Jie Liu
    Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 32:525-35. 2002
    ..Thus, the mechanism of acute cadmium toxicity involves multiple facets including oxidative damage and aberrant gene expression, and absence of MT exacerbates Cd-induced aberrant gene expression...
  18. pmc Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, USA
    Genomics 94:32-8. 2009
    ..Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug...
  19. pmc Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
    ..Adaptation to chronic Cd exposure reduces ROS production, but acquired Cd tolerance with aberrant gene expression plays important roles in chronic Cd toxicity and carcinogenesis...
  20. ncbi request reprint Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 208:289-97. 2005
    ....
  21. ncbi request reprint Stress-related gene expression in mice treated with inorganic arsenicals
    J Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 61:314-20. 2001
    ..In summary, this study profiled the gene expression pattern in mice treated with inorganic arsenicals, which adds to our understanding of acute arsenic poisoning and toxicity...
  22. pmc Arsenic-induced aberrant gene expression in fetal mouse primary liver-cell cultures
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA
    Ann N Y Acad Sci 1140:368-75. 2008
    ....
  23. pmc Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, NC 27713, USA
    Environ Health Perspect 110:119-22. 2002
    ..The Chinese government and international organizations are attempting to improve the house conditions and the coal source, and thereby protect human health in this area...
  24. pmc The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Lett 256:238-45. 2007
    ..The role of NO in reducing the hepatotoxicity of arsenical chemotherapeutics in vivo deserves additional study...
  25. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  26. pmc Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:404-11. 2006
    ..These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis...
  27. pmc Transplacental arsenic carcinogenesis in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 222:271-80. 2007
    ..Transplacental carcinogenesis clearly occurs with other agents in humans and investigating a potential transplacental component of the human carcinogenic response to arsenic should be a research priority...
  28. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  29. pmc Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC 27709, United States
    Toxicology 236:7-15. 2007
    ..Thus, transplacental exposure to arsenic at a hepatocarcinogenic dose induces alterations in DNA methylation and a complex set of aberrant gene expressions in the newborn liver, a target of arsenic carcinogenesis...
  30. ncbi request reprint Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis
    Hua Chen
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Carcinogenesis 25:1779-86. 2004
    ....
  31. pmc Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia
    Zhengqin Yang
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 98:488-94. 2007
    ..In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons...
  32. ncbi request reprint Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Int J Cancer 116:20-6. 2005
    ..The observation that As-TL cells show no lessening of UV-induced genotoxicity supports this possibility...
  33. ncbi request reprint Genomic analysis of the rat lung following elemental mercury vapor exposure
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:174-81. 2003
    ..In summary, genomic analysis revealed an array of gene alterations in response to Hg0 vapor exposure, which could be important for the development of pulmonary adaptation to Hg during Hg0 vapor inhalation...
  34. pmc V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Sci 100:382-8. 2009
    ....
  35. pmc Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis
    Yang Sun
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA
    Toxicology 262:162-70. 2009
    ....
  36. ncbi request reprint Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell Biochem 255:11-8. 2004
    ..In summary, this study shows that chronic arsenic toxicity, including liver pathology and oxidative stress, is enhanced in mdr1a/1b(-/-) mice, possibly due to enhanced accumulation of arsenic as a result of transport system deficiency...
  37. pmc Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure
    Jun Shen
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 95:313-20. 2007
    ..These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood...
  38. ncbi request reprint Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 96:466-74. 2004
    ....
  39. ncbi request reprint Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:295-305. 2006
    ..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
  40. ncbi request reprint Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 66:1337-45. 2006
    ..Thus, arsenic acts with estrogens to enhance production of female mouse urogenital cancers...
  41. ncbi request reprint Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 198:377-84. 2004
    ..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
  42. ncbi request reprint Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice
    Chengxiu Li
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Lett 144:397-406. 2003
    ..Thus, only a combination of gene array analysis with functional studies allows valid conclusions regarding mechanisms of cell injury...
  43. ncbi request reprint Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 114:346-55. 2005
    ....
  44. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  45. ncbi request reprint Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Int J Toxicol 24:215-20. 2005
    ..Overall, MT-null mice appear no more sensitive to the carcinogenic effects of nickel than WT mice. Thus, poor MT production does not appear to be a predisposing factor for nickel carcinogenesis...
  46. doi request reprint Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR
    Mitchell B Rosen
    NHEERL ORD, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 103:46-56. 2008
    ..These results indicate that PFOA alters most genes in wild-type mouse liver through PPAR alpha, but that a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse...
  47. ncbi request reprint Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 119:28-32. 2006
    ..Our results indicate that MT-null mice are hypersusceptible to the hepatocarcinogenic effects of cisplatin, and poor MT expression may be a predisposing factor for cisplatin-induced secondary tumors after chemotherapy...
  48. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008
    ....
  49. ncbi request reprint The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice
    Chengxiu Li
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27706, USA
    Toxicology 189:173-80. 2003
    ..The protection is probably due to multiple mechanisms involving attenuation of APAP-induced congestion and lipid peroxidation in the kidney...
  50. ncbi request reprint Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, MD F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 198:31-8. 2004
    ..In addition, it appears gestational arsenic can act as a tumor initiator in the female mouse liver, inducing liver lesions that can be promoted by TPA...
  51. ncbi request reprint Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cancer Ther 3:709-14. 2004
    ....
  52. pmc Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1255-63. 2004
    ..These effects may play a role in arsenic-induced hepatotoxicity and carcinogenesis and may be of particular toxicologic relevance...
  53. ncbi request reprint Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27703, USA
    Cancer Res 64:7766-72. 2004
    ..Poor production of metallothionein may predispose human populations to lead carcinogenicity...
  54. ncbi request reprint Protective effect of dextromethorphan against endotoxic shock in mice
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NCI, National Institute of Environmental Health Sciences, National Institutes of Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 69:233-40. 2005
    ..This study not only extends neuroprotective effect of DM, but also suggests that DM may be a novel compound for the therapeutic intervention for sepsis...
  55. ncbi request reprint Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Prostate 67:135-45. 2007
    ..Lethal prostate cancers often become androgen-independent due to androgen receptor (AR) overexpression. The role of cadmium in prostate tumor progression was determined...
  56. ncbi request reprint Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA
    Exp Biol Med (Maywood) 231:1535-41. 2006
    ..The dramatic induction of metallothionein and heme oxygenase-1 with Maotai could be important adaptive responses to reduce alcoholic liver injury...
  57. ncbi request reprint The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Nitric Oxide 12:114-20. 2005
    ..Thus, the prodrug, V-PYRRO/NO, protects against the adverse effects of cadmium directly within rat liver cells apparently through generation of NO and, at least in part, by facilitation of cadmium-induced MT synthesis...
  58. ncbi request reprint The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Instititue of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 310:18-24. 2004
    ..This protection is not mediated through altered distribution of Cd but may be related to reduced hepatic inflammation, reduced acute phase responses, and the suppression of cell-death-related components...
  59. ncbi request reprint Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45034-9. 2003
    ..We conclude that AEA and 2-AG synthesis are differentially regulated in macrophages, and AEA rather than 2-AG is a major contributor to LPS-induced hypotension...
  60. ncbi request reprint Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity
    Cathleen Cover
    Liver Research Institute, University of Arizona, Tucson, AZ 85724, USA
    Toxicol Appl Pharmacol 216:98-107. 2006
    ..Together, these data do not support the hypothesis that neutrophils aggravate liver injury induced by AAP overdose...
  61. pmc Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:475-81. 2008
    ..This is the first study to show Cd generation of reactive oxygen- and carbon-centered radical species by involvement of both iron mediation through iron-catalyzed reactions and activation of Kupffer cells, the resident liver macrophages...
  62. pmc Liver is a target of arsenic carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:24-32. 2008
    ..Some of these mechanisms may be liver specific/selective. Overall, accumulating evidence clearly indicates that the liver could be an important target of arsenic carcinogenesis...
  63. ncbi request reprint Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice
    Anja J Stauber
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 67:681-94. 2005
    ..These results indicate that some of the beneficial effects associated with the dwarf phenotype may be caused by constitutive activation of PPARalpha and regulated genes...
  64. pmc Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite
    Vicenta Devesa
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Toxicology 224:147-55. 2006
    ..Tissue concentration-dependent processes could affect kinetics of transfer of inorganic arsenic or its metabolites from mother to fetus...
  65. doi request reprint Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC 27709, United States
    Chem Biol Interact 182:253-8. 2009
    ..Functional studies, such as changes in circulating steroids, would greatly support this hypothesis, and are planned...
  66. ncbi request reprint Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 186:7-17. 2003
    ..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
  67. pmc Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:1797-806. 2007
    ..In contrast, Nrf2-118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response...
  68. pmc Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1101-6. 2007
    ..Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity...
  69. pmc Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
    Lei Wang
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1393-8. 2003
    ....
  70. ncbi request reprint Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect
    Yajun Chen
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    J Pharm Pharmacol 57:259-64. 2005
    ....
  71. doi request reprint Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  72. ncbi request reprint Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity
    Kartik Shankar
    Department of Toxicology, School of Pharmacy, College of Health Sciences, The University of Louisiana at Monroe, Louisiana 71209 0495, USA
    FASEB J 17:1748-50. 2003
    ..Gel shift assays revealed higher activation of nuclear factor-kappaB in WT-DB mice after APAP treatment. These findings suggest PPAR-alpha activation as a hepatoprotective adaptive response mediating protection against APAP in diabetes...
  73. ncbi request reprint The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:52390-8. 2004
    ....
  74. pmc Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo
    Xiaohua Li
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, 17 Changlexilu, Shaanxi Province, Xi an 710032, People s Republic of China
    Carcinogenesis 29:1587-93. 2008
    ..These results suggest that knock down of CIAPIN1 by adenovirus-delivered siRNA may be a potential therapeutic strategy for treatment of HCC in which CIAPIN1 is overexpressed...
  75. ncbi request reprint Cadmium at a non-toxic dose alters gene expression in mouse testes
    Tong Zhou
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:191-200. 2004
    ..These results indicate that changes in gene expression occur well before overt effects of Cd-induced testicular toxicity and carcinogenicity are apparent...
  76. pmc The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 160:1047-56. 2002
    ..This study reveals important roles for MT in chronic lead toxicity, lead accumulation, and inclusion body formation...
  77. doi request reprint New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction
    Jie Liu
    Zunyi Medical College, Key Laboratory of Pharmacology, 201 Dalian Road, Zunyi 563000, China
    Biochem Pharmacol 76:922-8. 2008
    ..These gene expression changes, particularly the dramatic induction of MT and the Nrf2 signaling, occur with hepatoprotection doses of OA, and likely are important in the generalized protective effects of OA against hepatotoxicants...
  78. pmc Current status and prevention strategy for coal-arsenic poisoning in Guizhou, China
    Dasheng Li
    Center for Disease Control of Guizhou, Guiyang, China
    J Health Popul Nutr 24:273-6. 2006
    ..Strategies include the installation of vented stoves, the use of marsh gas to replace coal, health education, the improvement of nutritional status, and the use of various therapies to treat arsenic-induced skin and liver diseases...
  79. pmc Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
    Sandor Batkai
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
    Circulation 110:1996-2002. 2004
    ..Endocannabinoids are novel lipid mediators with hypotensive and cardiodepressor activity. Here, we examined the possible role of the endocannabinergic system in cardiovascular regulation in hypertension...
  80. ncbi request reprint Human S15a expression is upregulated by hepatitis B virus X protein
    Zhaorui Lian
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6749, USA
    Mol Carcinog 40:34-46. 2004
    ..Hence, HBxAg upregulated the expression of S15a, the latter of which participates in the development of HCC, perhaps by altering the integrity of translation...
  81. pmc Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival
    N Lale Satiroglu Tufan
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107 6799, USA
    Neoplasia 4:355-68. 2002
    ..Hence, URG4 may be a natural effector of HBxAg that contributes importantly to multistep hepatocarcinogenesis...
  82. pmc Changes in hepatic gene expression in response to hepatoprotective levels of zinc
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC
    Liver Int 29:1222-9. 2009
    ..Zinc (Zn) administration at non-toxic doses protects against the hepatotoxicity produced by many agents, but the underlying mechanisms remain elusive...
  83. ncbi request reprint Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha
    Kenneth A Voss
    Toxicology and Mycotoxin Research Unit, USDA Agricultural Research Service, Athens, Georgia 30604 5677, USA
    Toxicol Sci 89:108-19. 2006
    ..Together, these findings demonstrate that FB1- and CM-induced hepatotoxicity in mice does not require PPARalpha...
  84. ncbi request reprint Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis
    Zhaorui Lian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Hepatology 45:1390-9. 2007
    ..In conclusion, HBxAg may short circuit VEGFR-3(S) signaling in liver cancer. Blocking VEGFR-3(S) signaling may be effective in preventing tumor development and/or prolonging survival in tumor bearing patients...
  85. ncbi request reprint The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B
    Jie Liu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:4336-41. 2003
    ..This study provides further evidence for tissue-specific imprinting of G(s)alpha in humans and provides a potential mechanism for mild to moderate TSH resistance in PHP1A and borderline resistance in some patients with PHP1B...
  86. ncbi request reprint Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D
    Michael T Collins
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
    J Bone Miner Res 20:1944-50. 2005
    ..In addition, the phosphaturic effect of FGF-23 may be diminished in the absence of PTH action on the kidney...
  87. pmc Endocannabinoids and the control of energy homeostasis
    George Kunos
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 283:33021-5. 2008
    ..Recent work indicates that activation of peripheral CB1 receptors by ECBs plays a key role in the hormonal/metabolic changes associated with obesity/metabolic syndrome and may be targeted for its pharmacotherapy...
  88. ncbi request reprint Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats
    Eduardo Brambila
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Environ Health A 65:1273-88. 2002
    ..Activation of these genes could be part of a defensive response directed at decreasing renal mercury toxicity, and may help divert the metal away from the fetus...
  89. pmc A biosynthetic pathway for anandamide
    Jie Liu
    Laboratories of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:13345-50. 2006
    ..Both PTPN22 and endocannabinoids have been implicated in autoimmune diseases, suggesting that the PLC/phosphatase pathway of anandamide synthesis may be a pharmacotherapeutic target...
  90. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008
    ..Chromatin immunoprecipitation experiments confirmed the binding of STAT5A/B to these sites. We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription...
  91. pmc Multiple pathways involved in the biosynthesis of anandamide
    Jie Liu
    Laboratory of Physiologic Studies, NIAAA NIH, 5625 Fishers Lane, MS 9413, Bethesda, MD 20892 9413, USA
    Neuropharmacology 54:1-7. 2008
    ..In macrophages, the endotoxin-induced synthesis of anandamide proceeds uniquely through the phospholipase C/phosphatase pathway...
  92. ncbi request reprint Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, Inorganic Carcinogenesis Section, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 153:357-64. 2004
    ..A nickel dose-related trend for increased lung tumors occurred in MT-transgenic mice but not in WT mice. Thus, the over-expression of MT did not significantly mitigate the carcinogenic response to nickel...
  93. ncbi request reprint Gs(alpha) mutations and imprinting defects in human disease
    Lee S Weinstein
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 968:173-97. 2002
    ..This GNAS1 imprinting defect is predicted to decrease Gs(alpha) expression in tissues where Gs(alpha) is normally imprinted and therefore to lead to renal parathyroid hormone resistance...
  94. pmc Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase
    Pal Pacher
    National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane MSC 9413, Rm 2S24, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 289:H533-41. 2005
    ....
  95. pmc A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    Liu Cao
    Translational Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 35:534-41. 2009
    ..These observations may have important implications for Brca1-mediated tumor formation as well as for the molecular pathway leading from genomic instability to organismal aging...
  96. ncbi request reprint Purine nucleoside phosphorylase: a fortuitous cytosolic arsenate reductase?
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Sci 70:1-3. 2002
  97. pmc The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels
    Grzegorz Godlewski
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
    J Pharmacol Exp Ther 328:351-61. 2009
    ..3) Direct BK(Ca) channel activation probably contributes to the endothelium-independent component of ARA-S-induced mesenteric vasorelaxation. 4) O-1918 is a BK(Ca) channel inhibitor...
  98. ncbi request reprint The quest for a vascular endothelial cannabinoid receptor
    George Kunos
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive MSC 8115, Bethesda, MD 20892 8115, USA
    Chem Phys Lipids 121:45-56. 2002
    ..Since vasodilation is often associated with hypotension, mechanisms involved in the hypotensive actions of cannabinoids, including the endocannabinoids anandamide and 2-arachidonoylglycerol, are also briefly reviewed...
  99. ncbi request reprint 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
    FASEB J 19:395-7. 2005
    ..In view of the well-documented very low toxicity of DM and its analogs, this report may provide an important new direction for the development of therapeutic interventions for inflammation-related diseases such as PD...
  100. pmc Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma
    Bani Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 285:19002-11. 2010
    ..We conclude that RARgamma regulates CB(1)R expression and is thus involved in the control of hepatic fat metabolism by endocannabinoids...
  101. ncbi request reprint The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats
    Chengxiu Li
    Department of Pharmacology, Guiyang Medical College, China
    Life Sci 72:1563-71. 2003
    ..In conclusion, HDGL can effectively reverse chemically induced liver fibrosis, and this appears to be due, at least in part, to the stimulation of hepatic collagenolysis, resulting in a resolution of hepatic fibrosis...