Michail S Lionakis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Drosophila and Galleria insect model hosts: new tools for the study of fungal virulence, pharmacology and immunology
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virulence 2:521-7. 2011
  2. pmc New insights into innate immune control of systemic candidiasis
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Med Mycol 52:555-64. 2014
  3. pmc Pharmacological blockade of the chemokine receptor CCR1 protects mice from systemic candidiasis of hematogenous origin
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Antimicrob Agents Chemother . 2016
  4. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
  5. pmc CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Sci Transl Med 8:322ra10. 2016
  6. pmc Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice
    Wuzhou Wan
    Molecular Signaling Section, Laboratory of Molecular Immunology LMI, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Cardiovasc Res 106:478-87. 2015
  7. pmc Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm11N113, Bethesda, MD 20892, USA
    Cardiovasc Res 97:580-8. 2013
  8. pmc Drosophila melanogaster as a model organism for invasive aspergillosis
    Michail S Lionakis
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Methods Mol Biol 845:455-68. 2012
  9. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
  10. pmc Organ-specific innate immune responses in a mouse model of invasive candidiasis
    Michail S Lionakis
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Innate Immun 3:180-99. 2011

Collaborators

Detail Information

Publications22

  1. pmc Drosophila and Galleria insect model hosts: new tools for the study of fungal virulence, pharmacology and immunology
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virulence 2:521-7. 2011
    ..In this review, we discuss how the insects Drosophila melanogaster and Galleria mellonella can be employed for the study of various facets of host-fungal interactions as complementary hosts to conventional vertebrate animal models...
  2. pmc New insights into innate immune control of systemic candidiasis
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Med Mycol 52:555-64. 2014
    ..In this review, the new developments in our understanding of how the mammalian immune system responds to systemic Candida challenge are synthesized and important future research directions are highlighted. ..
  3. pmc Pharmacological blockade of the chemokine receptor CCR1 protects mice from systemic candidiasis of hematogenous origin
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Antimicrob Agents Chemother . 2016
    ..Herein, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases kidney fungal burden and protects from renal tissue injury...
  4. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
    ..Thus, neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ...
  5. pmc CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Sci Transl Med 8:322ra10. 2016
    ....
  6. pmc Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice
    Wuzhou Wan
    Molecular Signaling Section, Laboratory of Molecular Immunology LMI, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Cardiovasc Res 106:478-87. 2015
    ..Here we investigated the role of Ackr1 in chronic inflammation, in particular in the setting of atherogenesis, using the apolipoprotein E-deficient (ApoE(-/-)) mouse model...
  7. pmc Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm11N113, Bethesda, MD 20892, USA
    Cardiovasc Res 97:580-8. 2013
    ..Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis...
  8. pmc Drosophila melanogaster as a model organism for invasive aspergillosis
    Michail S Lionakis
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Methods Mol Biol 845:455-68. 2012
    ..These methods can also be adapted to study pathogenesis and antifungal drug activity against other medically important human fungal pathogens...
  9. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
    ..Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined...
  10. pmc Organ-specific innate immune responses in a mouse model of invasive candidiasis
    Michail S Lionakis
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Innate Immun 3:180-99. 2011
    ..The results delineate immune responses to the same pathogen that are highly idiosyncratic for each organ tested. The work provides novel insights into the balance between effective host defense and immunopathology in IC...
  11. pmc Mechanistic Insights into the Role of C-Type Lectin Receptor/CARD9 Signaling in Human Antifungal Immunity
    Rebecca A Drummond
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD, USA
    Front Cell Infect Microbiol 6:39. 2016
    ....
  12. pmc Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense
    Timothy J Break
    a Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virulence 7:826-35. 2016
    ....
  13. pmc Regulation of motor function and behavior by atypical chemokine receptor 1
    Erich H Schneider
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID NIH, Bethesda, MD, USA
    Behav Genet 44:498-515. 2014
    ..Together, the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1. ..
  14. pmc Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome
    E Liana Falcone
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbiome 4:13. 2016
    ..Almost half of patients with CGD develop inflammatory bowel disease, and the involvement of the intestinal microbiome in relation to this predisposing immunodeficiency has not been explored...
  15. pmc CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System
    Rebecca A Drummond
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases LCID, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS Pathog 11:e1005293. 2015
    ..Taken together, our data highlight the critical role of CARD9-dependent neutrophil trafficking into the CNS and provide novel insight into the CNS fungal susceptibility of CARD9-deficient humans. ..
  16. pmc Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, Bethesda, MD, 20892, USA
    Cell Mol Life Sci 72:2157-75. 2015
    ..Herein, we critically review how a variety of G-protein coupled chemoattractant receptors and their ligands mediate mononuclear phagocyte recruitment and effector function during infection by the most common human fungal pathogens. ..
  17. pmc CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans
    Timothy J Break
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    Infect Immun 83:958-65. 2015
    ....
  18. pmc CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells
    Ian A Myles
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Leukoc Biol 101:307-320. 2017
    ....
  19. pmc The growing promise of Toll-deficient Drosophila melanogaster as a model for studying Aspergillus pathogenesis and treatment
    Michail S Lionakis
    Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD, USA
    Virulence 1:488-99. 2010
    ....
  20. pmc Isolation of Mouse Neutrophils
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    Curr Protoc Immunol 110:3.20.1-3.20.15. 2015
    ....
  21. pmc Characterization of chemokine and chemokine receptor expression during Pneumocystis infection in healthy and immunodeficient mice
    Lisa R Bishop
    Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Microbes Infect 17:638-50. 2015
    ..However, based on the current and prior studies, no single chemokine receptor appears to be critical to the clearance of Pneumocystis. ..