J D Lifson

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc Antiretroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in rectal mucosa during acute simian immunodeficiency virus infection
    Muhamuda Kader
    Department of Microbiology and Immunology, Uniformed Services University, Room B4068, Bethesda, MD 20814, USA
    J Virol 82:11467-71. 2008
  2. pmc Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
  3. ncbi request reprint Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins
    Jeffrey D Lifson
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    AIDS Res Hum Retroviruses 20:772-87. 2004
  4. ncbi request reprint Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    J Med Primatol 32:201-10. 2003
  5. ncbi request reprint Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo
    R J Gorelick
    AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
    Virology 253:259-70. 1999
  6. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
  7. pmc Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:2584-93. 2000
  8. pmc The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 71:9508-14. 1997
  9. ncbi request reprint Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, MD 21702, USA
    J Med Primatol 31:205-16. 2002
  10. ncbi request reprint Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences
    R J Gorelick
    SAIC Frederick, National Cancer Institute, Frederick, Maryland, 21702 1201
    Virology 256:92-104. 1999

Detail Information

Publications70

  1. pmc Antiretroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in rectal mucosa during acute simian immunodeficiency virus infection
    Muhamuda Kader
    Department of Microbiology and Immunology, Uniformed Services University, Room B4068, Bethesda, MD 20814, USA
    J Virol 82:11467-71. 2008
    ..Although early ART was of limited value in protecting the CD4 T cells in the rectal mucosa, the significant preservation of peripheral CD4 T cells could contribute to maintaining immune competence, leading to a better long-term outcome...
  2. pmc Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
    ..Since few KIR remain orthologous between species, with only one of them, KIR2DL4, shown to be common to human, apes and monkeys, the evolution of the KIR gene family in primates remains unclear...
  3. ncbi request reprint Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins
    Jeffrey D Lifson
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    AIDS Res Hum Retroviruses 20:772-87. 2004
    ..With further optimization, AT-2-inactivated viral particles may be a useful class of immunogen in the development of a vaccine to prevent AIDS...
  4. ncbi request reprint Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    J Med Primatol 32:201-10. 2003
    ..Comparative analysis of virologic and immunologic parameters in this model system may provide important insights for understanding the basis of effective immunologic control of SIV infection...
  5. ncbi request reprint Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo
    R J Gorelick
    AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
    Virology 253:259-70. 1999
    ..NC mutations can therefore be used to generate replication defective virions for candidate vaccines in the SIV macaque model for primate lentiviral diseases...
  6. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
    ..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
  7. pmc Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:2584-93. 2000
    ..These findings may be particularly important in relation to prospects for control of primate lentiviruses in the settings of both prophylactic and therapeutic vaccination for prevention of AIDS...
  8. pmc The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 71:9508-14. 1997
    ....
  9. ncbi request reprint Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, MD 21702, USA
    J Med Primatol 31:205-16. 2002
    ..Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls...
  10. ncbi request reprint Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences
    R J Gorelick
    SAIC Frederick, National Cancer Institute, Frederick, Maryland, 21702 1201
    Virology 256:92-104. 1999
    ..The evolutionary pressure to maintain CCHC NC Zn2+ fingers depends mainly on its function in infection processes, in addition to its function in genome packaging...
  11. pmc Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1
    M T Esser
    AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
    J Virol 75:1152-64. 2001
    ..The results suggest that the immunopathogenesis of HIV infection may not depend solely on direct cytopathic effects of HIV replication, but that effects due to noninfectious HIV-1 virions may also contribute importantly...
  12. ncbi request reprint Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection
    Jacob D Estes
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 195:551-61. 2007
    ....
  13. ncbi request reprint Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
    Jonah B Sacha
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
    J Immunol 178:2746-54. 2007
    ..0017) in SIV-infected rhesus macaques. These results suggest that HIV vaccines should focus CD8(+) T cell responses on Gag...
  14. pmc Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection
    Marie Claire Gauduin
    Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, and Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Boston 02115, USA
    J Exp Med 203:2661-72. 2006
    ..The ability of SIVDeltanef to induce a high frequency virus-specific CD4+ T cell response with direct effector function may play a key role in protective immunity produced by vaccination with attenuated SIV strains...
  15. ncbi request reprint Generation of simian-tropic HIV-1 by restriction factor evasion
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 314:95. 2006
    ....
  16. ncbi request reprint A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum
    Christiane Stahl-Hennig
    German Primate Center, D 37077 Gottingen, Germany
    Front Biosci 12:2107-23. 2007
    ..Therefore, tonsillar application of attenuated SIV induces protection in some animals against a superinfection with wild-type SIV distant at a distant mucosal site...
  17. pmc Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro
    Geoffrey W Stone
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0679, USA
    Clin Vaccine Immunol 13:1223-30. 2006
    ..These molecular adjuvants provide new tools for vaccine development in the simian immunodeficiency virus system and other macaque models...
  18. pmc Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus
    Amitinder Kaur
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Virology 357:199-214. 2007
    ..05) and peak neutralizing antibody titers pre-challenge (P value 0.06). These findings support continued study of recombinant herpesviruses as a vaccine approach for AIDS...
  19. pmc Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
    Elena Chertova
    AIDS Vaccine Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Virol 80:9039-52. 2006
    ..MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages...
  20. pmc IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    Louis J Picker
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Clin Invest 116:1514-24. 2006
    ....
  21. pmc The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication
    Levi J Yant
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
    J Virol 80:5074-7. 2006
    ..001). Mamu-B(*)17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control...
  22. ncbi request reprint Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection
    Jacob D Estes
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
    J Infect Dis 193:703-12. 2006
    ..We conclude that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared...
  23. ncbi request reprint Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics
    Eugene V Barsov
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    Immunol Lett 105:26-37. 2006
    ..This approach provides a convenient, reproducible means for generating a stable, continuously renewable source of antigen-specific T lymphocytes for a variety of studies of T cell biology...
  24. ncbi request reprint Transduction with human telomerase reverse transcriptase immortalizes a rhesus macaque CD8+ T cell clone with maintenance of surface marker phenotype and function
    Hanne Andersen
    AIDS Vaccine Program, SAIC Frederick NCI Frederick, Frederick, Maryland 21702, USA
    AIDS Res Hum Retroviruses 23:456-65. 2007
    ..Such immortalized T cells may be useful as a source of consistent controls for in vitro assays of cellular immune function, and as a potentially important reagent for autologous adoptive cellular immunotherapy studies in macaques...
  25. pmc Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry
    Rachid Sougrat
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 3:e63. 2007
    ..Determination of the molecular composition and structure of the entry claw may facilitate the identification of improved drugs for the inhibition of HIV-1 entry...
  26. pmc Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo
    Shuji Sato
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 82:9739-52. 2008
    ....
  27. pmc Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Virol 82:6591-9. 2008
    ..These results highlight the unpredictability of antiviral compounds as topical microbicides and suggest that repeated exposures to candidate treatments should be considered for in vivo evaluation...
  28. pmc Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana 70433, USA
    J Virol 82:5618-30. 2008
    ..These results reemphasize that SIV-specific CD8(+) T-cell responses are absolutely critical to initiate at least partial control of SIV infection...
  29. pmc Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys
    Eun Young Kim
    Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Suite 200, Chicago, IL 60611, USA
    J Virol 82:5631-5. 2008
    ..These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation...
  30. pmc Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery
    Keith Mansfield
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    J Virol 82:4135-48. 2008
    ....
  31. ncbi request reprint Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones
    Jacob T Minang
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Virology 372:430-41. 2008
    ..The use of hTERT immortalized effector and target cells for such assays preserves relevant functional properties while providing a convenient, reproducible means of conducting studies over time...
  32. pmc The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers
    Juan P Giraldo-Vela
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
    J Virol 82:859-70. 2008
    ..0001). The study of MHC-II alleles in macaques that control viral replication could improve our understanding of the role of CD4(+) T cells in suppressing HIV/SIV replication and further our understanding of HIV vaccine design...
  33. pmc Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism
    M Quinn DeGottardi
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 82:321-34. 2008
    ..These studies reveal differences in the peaks and durations of a single round of productive infection that reflect envelope-specific differences in infectivity, chemokine receptor specificity, and cellular tropism...
  34. pmc Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Building 535, Room 123, Frederick, MD 21702, USA
    J Virol 81:12145-55. 2007
    ..By contrast, ART effectively suppressed RT-SHIV in 5/6 animals. These data indicate that suboptimal therapy facilitates HIV-1 drug resistance and suggest that this model can be used to investigate persisting viral reservoirs...
  35. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
    ....
  36. pmc Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation
    Jonah B Sacha
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
    J Virol 81:11703-12. 2007
    ..Finally, Pol-specific CD8+ T cells eliminated infected cells as early as 6 h postinfection, well before MHC-I downregulation, suggesting a previously underappreciated antiviral role for Pol-specific CD8+ T cells...
  37. pmc Mamu-B*08-positive macaques control simian immunodeficiency virus replication
    John T Loffredo
    Wisconsin National Primate Research Center, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
    J Virol 81:8827-32. 2007
    ..002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers...
  38. pmc Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate
    Patricia L Earl
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 33, Room 1E19, 33 North Drive, MSC 3210, Bethesda, MD 20892, USA
    Virology 366:84-97. 2007
    ..These non-human primate studies support the clinical testing of recombinant MVA as an HIV vaccine and further demonstrate that MVA can provide long-term poxvirus immunity, essential for use as an alternative smallpox vaccine...
  39. pmc Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions
    Rui Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Blood 107:1989-95. 2006
    ..HIV-mediated blunted CD154 expression may thus play an important role in the suppression of cell-mediated immunity seen in HIV infection...
  40. ncbi request reprint Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection
    Qingsheng Li
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 192:1269-76. 2005
    ....
  41. ncbi request reprint HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensi
    Mark K Louder
    Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Virology 339:226-38. 2005
    ..Replication competent HIV-1 and isogenic envelope pseudoviruses have similar neutralization characteristics, but passage into PBMC is associated with decreased sensitivity to neutralization...
  42. ncbi request reprint Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses
    Ines Frank
    Center for Biomedical Research, Population Council, New York, New York 10021, USA
    J Acquir Immune Defic Syndr 34:7-19. 2003
    ..Further studies using AT-2 inactivated virus may help to define better the details of the virus-DC interactions critical for infection versus induction of antiviral immune responses...
  43. ncbi request reprint Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    J Med Primatol 32:194-200. 2003
    ..These data suggest that while high CTL responses develop at a similar rate, and magnitude in both peripheral and mucosal lymphoid tissues in primary SIV infection, mucosal CTL responses may predominate later in the course of the disease...
  44. pmc Simian immunodeficiency virus infection in neonatal macaques
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Virol 77:8783-92. 2003
    ....
  45. pmc Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 77:5749-58. 2003
    ..The underlying mechanism may be a dysfunction of memory B and CD8(+) T lymphocytes associated with SIV-induced impairment of CMV-specific CD4(+) T-cell help...
  46. ncbi request reprint CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection
    Daniela Verthelyi
    Section of Retroviral Immunology and Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 170:4717-23. 2003
    ..These findings support the clinical development of CpG ODNs as immunoprotective agents in normal and HIV-infected patients...
  47. pmc Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system
    David T Evans
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 77:2400-9. 2003
    ..Nevertheless, this study demonstrates the potential of mucosal priming by the Salmonella type III secretion system to direct SIV-specific cellular immune responses to the gastrointestinal mucosa in a primate model...
  48. pmc Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    Jörn E Schmitz
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2165-73. 2003
    ..However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication...
  49. pmc Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles
    Ronald L Willey
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:1163-74. 2003
    ..These results indicate that despite the protection from SHIV-induced disease, the vaccinated animals still harbored replication-competent and pathogenic virus...
  50. pmc Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    J Virol 76:10507-11. 2002
    ..By themselves, these strong CTL responses failed to control SIVmac239 replication...
  51. ncbi request reprint The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection
    Janice E Clements
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Infect Dis 186:905-13. 2002
    ..Latent virus in the brain must be considered in therapeutic strategies to eliminate HIV from infected persons...
  52. ncbi request reprint SIV(mac) pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans
    Binhua Ling
    Tulane University Health Sciences Center, Department of Tropical Medicine and the Tulane Regional Primate Research Center, Covington, Louisiana 70433, USA
    AIDS 16:1489-96. 2002
    ..To develop a SIV-rhesus macaque (Rh) model of AIDS that more closely approximates HIV pathogenesis in humans...
  53. pmc Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus
    Elena Chertova
    AIDS Vaccine Program, SAIC Frederick, Maryland 21702 1201, USA
    J Virol 76:5315-25. 2002
    ..These findings suggest that incorporation of SU-TM complexes into the viral membrane may be the primary factor determining the quantity of SU associated with SIV and HIV-1 virions, rather than shedding of SU from mature virions...
  54. pmc Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis
    Stephanie J Bissel
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 160:927-41. 2002
    ..These data suggest that presynaptic damage occurs independent of pathological changes associated with SIVE, whereas postsynaptic damage is more tightly linked to regional presence of both activated and infected macrophages...
  55. pmc Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection
    Ronald S Veazey
    Joan and Sanford I Weill Medical College of Cornell University, Dept of Microbiology and Immunology, 1300 York Ave, W 805, New York, NY 10021, USA
    J Exp Med 198:1551-62. 2003
    ..These findings support the development of small molecule CCR5 inhibitors as antiviral therapies, and possibly as components of a topical microbicide to prevent HIV-1 sexual transmission...
  56. ncbi request reprint Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
    Stuart G Turville
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Blood 103:2170-9. 2004
    ..Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time...
  57. ncbi request reprint Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge
    Marc Busch
    California National Primate Research Center, University California Davis, County Road 98, Hutchison Drive, Davis, CA 95616, USA
    Vaccine 23:4036-47. 2005
    ..These results suggest that the delay in systemic infection resulting from delivery of SHIV 89.6 as a plasmid decreased the effectiveness of this live attenuated vaccine...
  58. pmc Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
    J Virol 79:8131-41. 2005
    ....
  59. pmc Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239
    David T Evans
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102
    J Virol 79:7707-20. 2005
    ..Given the extraordinary difficulty in protecting against SIV(mac)239, these results are encouraging and support further evaluation of lentiviruses that are limited to a single cycle of infection as a preclinical AIDS vaccine approach...
  60. pmc Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac23
    Eun Young Kim
    Division of Infectious Diseases, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    J Virol 79:4886-95. 2005
    ..These findings show that recombination can occur readily in vivo after mucosal SIV exposure and thus contributes to the generation of viral genetic diversity and enhancement of viral fitness...
  61. pmc Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins
    David R Morcock
    AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Building 535, 5th Floor, PO Box B, Frederick, MD 21702, USA
    J Virol 79:1533-42. 2005
    ....
  62. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, 9000 Rockville Pike, Bethesda, MD, USA
    Blood 105:2458-64. 2005
    ..The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS...
  63. pmc Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection
    Louis J Picker
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, West Campus, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Exp Med 200:1299-314. 2004
    ....
  64. ncbi request reprint Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA
    Science 306:485-7. 2004
    ..These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention...
  65. ncbi request reprint CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells
    Natalia Teleshova
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    J Immunol 173:1647-57. 2004
    ....
  66. ncbi request reprint Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques
    Marie Claire Gauduin
    New England Primate Research Center, Harvard Medical School, Division of Immunology, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Immunol Methods 288:61-79. 2004
    ..The use of more sensitive techniques such as ICS permits delineation of antigen-specific cells at the single cell level and should provide new insights into pathogen-specific immune responses in the rhesus macaque model...
  67. ncbi request reprint CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques
    Daniela Verthelyi
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    AIDS 18:1003-8. 2004
    ..Although HBV vaccination is recommended to all HIV-positive patients, its efficacy in these patients is reduced...
  68. ncbi request reprint Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection
    Simone E Gloster
    Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 18:749-55. 2004
    ..To investigate whether there are differences in the virus-specific CD4 T cell response during primary HIV-1 infection in patients who naturally (without antiretroviral intervention) control viral replication with differing efficiencies...
  69. pmc Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
    Zhi qiang Zhang
    Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 101:5640-5. 2004
    ....
  70. ncbi request reprint Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses
    Erin Mehlhop
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Immunol Methods 260:219-34. 2002
    ..Thus, the cocktail represents a particularly potent and useful stimulus for the generation of efficacious immunostimulatory macaque DCs...