J J Letterio

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Murine models define the role of TGF-beta as a master regulator of immune cell function
    J J Letterio
    Laboratory of Cell Regulation and Carcinogenesis, The National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
    Cytokine Growth Factor Rev 11:81-7. 2000
  2. pmc Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism
    Tania Fernandez
    Laboratory of Cell Regulation and Carcinogenesis, The National Cancer Institute, The National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 195:1247-55. 2002
  3. ncbi request reprint Disruption of the TGF-beta pathway and modeling human cancer in mice
    John J Letterio
    Laboratary of Cell Regulation and Carcinogenesis, The Center for Cancer Research, NCI, NIH, Bethesda, MD 20892 5055, USA
    Mutat Res 576:120-31. 2005
  4. ncbi request reprint TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia
    John J Letterio
    The Laboratory of Cell Regulation and Carcinogenesis, The Center for Cancer Research, The National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Oncogene 24:5701-12. 2005
  5. pmc Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression
    J J Letterio
    The Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Clin Invest 98:2109-19. 1996
  6. ncbi request reprint Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse
    S Kobayashi
    Functional Genomics Unit, Gene Targeting Facility, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 163:4013-9. 1999
  7. pmc Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    X Yang
    Genetics of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:1280-91. 1999
  8. pmc A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 100:575-81. 1997
  9. pmc Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse
    Y Vodovotz
    Laboratory of Chemoprevention, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 183:2337-42. 1996
  10. ncbi request reprint The liver in transforming growth factor-Beta-1 (TGF-beta 1) null mutant mice
    A O Williams
    Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Ultrastruct Pathol 20:477-90. 1996

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Murine models define the role of TGF-beta as a master regulator of immune cell function
    J J Letterio
    Laboratory of Cell Regulation and Carcinogenesis, The National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
    Cytokine Growth Factor Rev 11:81-7. 2000
    ....
  2. pmc Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism
    Tania Fernandez
    Laboratory of Cell Regulation and Carcinogenesis, The National Cancer Institute, The National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 195:1247-55. 2002
    ..These data are the first to demonstrate the formation of an intracellular TGF-beta-receptor complex, and define a novel mechanism for modulating the TGF-beta signaling pathway...
  3. ncbi request reprint Disruption of the TGF-beta pathway and modeling human cancer in mice
    John J Letterio
    Laboratary of Cell Regulation and Carcinogenesis, The Center for Cancer Research, NCI, NIH, Bethesda, MD 20892 5055, USA
    Mutat Res 576:120-31. 2005
    ..Here, we consider highlights from a number of in vivo murine model systems and relate a few of the significant observations to what we know about TGF-beta signaling in human cancer...
  4. ncbi request reprint TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia
    John J Letterio
    The Laboratory of Cell Regulation and Carcinogenesis, The Center for Cancer Research, The National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Oncogene 24:5701-12. 2005
    ..These studies are increasing our awareness of the many complex mechanisms through which TGF-beta signaling controls the pathogenesis of cancer...
  5. pmc Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression
    J J Letterio
    The Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Clin Invest 98:2109-19. 1996
    ..Thus, MHC class II antigens are essential for the expression of autoimmunity in TGF-beta1-deficient mice, and normally may cooperate with TGF-beta1 to regulate hematopoiesis...
  6. ncbi request reprint Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse
    S Kobayashi
    Functional Genomics Unit, Gene Targeting Facility, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 163:4013-9. 1999
    ..Our data thus indicate that MHC class I molecules influence the development of the autoimmunity and the inflammation seen in TGF-beta 1-/- mice and CD8+ T cells may have a contribution to the inflammation in TGF-beta 1-/- mice...
  7. pmc Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    X Yang
    Genetics of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:1280-91. 1999
    ....
  8. pmc A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 100:575-81. 1997
    ....
  9. pmc Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse
    Y Vodovotz
    Laboratory of Chemoprevention, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 183:2337-42. 1996
    ..These findings demonstrate that TGF-beta 1 negatively regulates iNOS expression in vivo, as had been inferred from mechanistic studies on the control of iNOS expression by TGF-beta 1 in vitro...
  10. ncbi request reprint The liver in transforming growth factor-Beta-1 (TGF-beta 1) null mutant mice
    A O Williams
    Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Ultrastruct Pathol 20:477-90. 1996
    ..The data suggest that TGF-beta 1 may be required for normal development and regulation of subcellular organelles in hepatocytes and may be essential for physiological functions involving mitochondria and Golgi complex...
  11. ncbi request reprint TGF-beta knockout and dominant-negative receptor transgenic mice
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Miner Electrolyte Metab 24:161-7. 1998
    ..New approaches to tissue- and cell-restricted disruption of TGF-beta signaling pathways in transgenic mice carrying dominant-negative mutant TGF-beta receptors will be discussed...
  12. ncbi request reprint Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
    R A Seder
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:5719-28. 1998
    ..Finally, the addition of exogenous TGF-beta to priming cultures significantly enhanced the production of TGF-beta upon restimulation, demonstrating that TGF-beta has a role in self-regulating its own production...
  13. ncbi request reprint Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
    B Tang
    Laboratory of Cell Regulation and Carcinogenesis formerly Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    Nat Med 4:802-7. 1998
    ....
  14. ncbi request reprint TGF-beta: a critical modulator of immune cell function
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland, 20892 5055, USA
    Clin Immunol Immunopathol 84:244-50. 1997
  15. pmc Invasive candidiasis stimulates hepatocyte and monocyte production of active transforming growth factor beta
    J J Letterio
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:5115-20. 2001
    ..albicans infection that most probably contributes to disease progression in the immunocompromised host...
  16. ncbi request reprint Maternal rescue of transforming growth factor-beta 1 null mice
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 264:1936-8. 1994
    ..These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus...
  17. pmc A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    T A Borkowski
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Exp Med 184:2417-22. 1996
    ..We conclude that endogenous TGF-beta 1 is essential for normal murine LC development or epidermal localization...
  18. pmc Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype
    A G Geiser
    Laboratory of Chemoprevention, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:9944-8. 1993
    ..These results suggest potential applications for TGF-beta in the management of autoimmune disease, allograft rejection, and other problems associated with altered MHC expression...
  19. ncbi request reprint Loss of Smad3 in acute T-cell lymphoblastic leukemia
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 351:552-9. 2004
    ..The role of one of these intermediates--Smad3--in the pathogenesis of lymphoid neoplasia is unknown...
  20. ncbi request reprint p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:3093-102. 2004
    ....
  21. ncbi request reprint IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent
    Mallika Kaviratne
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:4020-9. 2004
    ..Together, these studies provide unequivocal evidence of a pathway of fibrogenesis that is IL-13 dependent but TGF-beta1 independent, illustrating the importance of targeting IL-13 directly in the treatment of infection-induced fibrosis...
  22. ncbi request reprint Cutting edge: p27Kip1 deficiency reduces the requirement for CD28-mediated costimulation in naive CD8+ but not CD4+ T lymphocytes
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2481-4. 2005
    ..These data highlight a previously unappreciated difference in the way CD28 signaling is coupled to the core cell cycle machinery in these two T cell subsets...
  23. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005
    ..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo...
  24. ncbi request reprint TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
    Marika C Kullberg
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 35:2886-95. 2005
    ....
  25. ncbi request reprint Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    Byung Gyu Kim
    Laboratory of Cell Regulation and Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 441:1015-9. 2006
    ....
  26. ncbi request reprint CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1
    Mizuko Mamura
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg 41, 41 Library Drive MSC 5055, Bethesda, MD 20892 5055, USA
    Blood 103:4594-601. 2004
    ....
  27. ncbi request reprint Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells
    Zhouhong Cao
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 101:498-507. 2003
    ....
  28. ncbi request reprint Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 293:175-83. 2004
    ..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression...
  29. pmc Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence
    Masaki Terabe
    Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1741-52. 2003
    ....
  30. ncbi request reprint Concentration-dependent bifunctional effect of TGF-beta 1 on immunoglobulin production: a role for Smad3 in IgA production in vitro
    Susan C McKarns
    Department of Pharmacology and Toxicology, 315 National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Int Immunopharmacol 3:1761-74. 2003
    ..Our results suggest that the effects of TGF-beta(1) on humoral immune responses fundamentally differ in a concentration-dependent manner and are mediated, in part, through Smad3 signaling...
  31. pmc Differential regulation of mouse B cell development by transforming growth factor beta1
    Denise A Kaminski
    Department of Microbiology, 378 Wallace Tumor Institute, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Immunol 9:85-95. 2002
    ..These results indicate that TGFbeta1 is important for normal B cell development in vivo, and that B cell progenitors are differentially affected by the cytokine according to their stage of differentiation...
  32. pmc Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
    Yu An Yang
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1607-15. 2002
    ..Thus this soluble TGF-beta antagonist has potential for long-term clinical use in the prevention of metastasis...
  33. pmc Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Exp Med 196:505-15. 2002
    ..The induction of such cells in response to gut flora may be a mechanism protecting normal individuals against inflammatory bowel disease...
  34. ncbi request reprint Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice
    Ashok B Kulkarni
    Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Mol Med 2:303-27. 2002
    ....
  35. pmc CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    Ciriaco A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    J Exp Med 196:237-46. 2002
    ..Collectively, these results demonstrate that CD4(+)CD25(+) suppressor function can occur independently of TGF-beta1...
  36. ncbi request reprint Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally
    Elena Bodegas
    Oncology Division, Center for Applied Medical Research, Department of Histology and Pathology, University of Navarra, Spain
    Int J Dev Biol 48:67-70. 2004
    ..The elevated expression of adrenomedullin which occurs postnatally in the TGF-beta1 null mouse may be a cause or a consequence of the multifocal wasting syndrome which is characteristic of postnatal TGF-beta1 null mice...
  37. pmc Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    Ying Wei Lin
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 8901 Wisconsin Ave, Bethesda, MD 20889 5105, USA
    Blood 107:2540-3. 2006
    ..Taken together, these findings indicate that Notch1 mutations are very frequent events that are acquired relatively early in the process of leukemic transformation and are important for leukemic cell growth...
  38. ncbi request reprint TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1
    Il Kyoo Park
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:5666-74. 2005
    ..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1...
  39. ncbi request reprint Development and application of fully functional epitope-tagged forms of transforming growth factor-beta
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, The National Cancer Institute, National Institutes of Health, Room C629, Building 41, 41 Library Drive, MSC 5055, Bethesda, MD 20892 5055, USA
    J Immunol Methods 266:7-18. 2002
    ..The design of these fully functional epitope-tagged TGF-beta proteins should facilitate studies such as the evaluation of in vivo peptide pharmacodynamics and trafficking of TGF-beta ligand-receptor complexes...
  40. pmc TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent
    Il Kyoo Park
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Mol Immunol 44:3283-90. 2007
    ..Thus, TGF-beta1's inhibition of IFN-gamma signaling in T cells is mediated through a highly specific Smad3 independent, MEK/ERK-dependent signaling pathway...