Laura E Kwako

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders
    Laura E Kwako
    Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Psychiatry 80:179-89. 2016
  2. pmc The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study
    Laura E Kwako
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, 1 3330, Bethesda, MD, 20892 1108, USA
    Psychopharmacology (Berl) 232:295-304. 2015
  3. doi request reprint Traumatic brain injury in intimate partner violence: a critical review of outcomes and mechanisms
    Laura E Kwako
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    Trauma Violence Abuse 12:115-26. 2011
  4. doi request reprint Major depressive disorder in persons exposed to trauma: relationship between emotional intelligence and social support
    Laura E Kwako
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    J Am Psychiatr Nurses Assoc 17:237-45. 2011
  5. pmc The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 41:2818-2829. 2016
  6. pmc Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences
    Joanna R Sells
    Section on Human Psychopharmacology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA Laboratory of Cognitive Interventions, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA Electronic address
    Drug Alcohol Depend 163:242-6. 2016
  7. doi request reprint FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence
    Primavera A Spagnolo
    Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland
    Alcohol Clin Exp Res 40:2426-2434. 2016
  8. pmc Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes
    Laura E Kwako
    Laboratory for Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Addict Biol 20:733-46. 2015
  9. pmc The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study
    Laura E Kwako
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 40:1053-63. 2015

Collaborators

Detail Information

Publications9

  1. pmc Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders
    Laura E Kwako
    Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Psychiatry 80:179-89. 2016
    ..Neuroclinical assessment is key to reconceptualizing the nosology of ADs on the basis of process and etiology, an advance that can lead to improved prevention and treatment. ..
  2. pmc The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study
    Laura E Kwako
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, 1 3330, Bethesda, MD, 20892 1108, USA
    Psychopharmacology (Berl) 232:295-304. 2015
    ..The NK1 antagonist aprepitant, clinically available as a treatment for chemotherapy-induced nausea, offers a tool to probe a potential role of the SP/NK1 system in comorbid PTSD and alcoholism...
  3. doi request reprint Traumatic brain injury in intimate partner violence: a critical review of outcomes and mechanisms
    Laura E Kwako
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    Trauma Violence Abuse 12:115-26. 2011
    ....
  4. doi request reprint Major depressive disorder in persons exposed to trauma: relationship between emotional intelligence and social support
    Laura E Kwako
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    J Am Psychiatr Nurses Assoc 17:237-45. 2011
    ....
  5. pmc The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 41:2818-2829. 2016
    ..The findings do not support a clinical efficacy of CRF1 blockade in stress-induced alcohol craving and relapse...
  6. pmc Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences
    Joanna R Sells
    Section on Human Psychopharmacology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA Laboratory of Cognitive Interventions, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA Electronic address
    Drug Alcohol Depend 163:242-6. 2016
    ..We hypothesized that those with AD and PTSD would have higher levels of: (1) alcohol use and AD severity; (2) anxiety and mood disorders; (3) neuroticism...
  7. doi request reprint FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence
    Primavera A Spagnolo
    Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland
    Alcohol Clin Exp Res 40:2426-2434. 2016
    ..We evaluated the effects of C385A variation on behavioral and biochemical biomarkers of distress responses...
  8. pmc Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes
    Laura E Kwako
    Laboratory for Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Addict Biol 20:733-46. 2015
    ..Further research is warranted to better understand the mechanisms behind craving induced by stress versus alcohol cues, as well as to understand the impact of co-morbid PTSD and AD on craving. ..
  9. pmc The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study
    Laura E Kwako
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 40:1053-63. 2015
    ..Our results may indicate that antagonists with slow offset are required for therapeutic efficacy. Alternatively, the extensive preclinical data on CRH1 antagonism as a mechanism to suppress alcohol seeking may not translate to humans. ..