Levy Kopelovich

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The epigenome as a target for cancer chemoprevention
    Levy Kopelovich
    Chemopreventive Agent Development Research Group, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1747-57. 2003
  2. pmc Identification of microbial DNA in human cancer
    Christopher G Duncan
    Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Med Genomics 2:22. 2009
  3. pmc Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
    Mohammad Athar
    Department of Dermatology, Skin Diseases Research Center and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Prev Res (Phila) 4:957-61. 2011
  4. ncbi request reprint The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1330-40. 2007
  5. ncbi request reprint Can animal models help us select specific compounds for cancer prevention trials?
    Ernest T Hawk
    GI and Other Cancers Research Group, National Cancer Institute, Suite 2141, 6130 Executive Boulevard, Bethesda, MD 20892 7317, USA
    Recent Results Cancer Res 166:71-87. 2005
  6. ncbi request reprint 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Carcinogenesis 26:571-8. 2005
  7. pmc Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers
    Vernon E Steele
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 2:951-6. 2009
  8. pmc Heritable one-hit events defining cancer prevention?
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 12:2553-7. 2013
  9. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  10. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY, USA
    Int J Cancer 116:495-9. 2005

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The epigenome as a target for cancer chemoprevention
    Levy Kopelovich
    Chemopreventive Agent Development Research Group, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1747-57. 2003
    ....
  2. pmc Identification of microbial DNA in human cancer
    Christopher G Duncan
    Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Med Genomics 2:22. 2009
    ..CONCLUSION: DK-MICROBE can identify previously unknown infectious agents in human tumors, and is now available for further applications for the identification of pathogen DNA in human cancer and other diseases...
  3. pmc Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
    Mohammad Athar
    Department of Dermatology, Skin Diseases Research Center and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Prev Res (Phila) 4:957-61. 2011
    ....
  4. ncbi request reprint The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1330-40. 2007
    ..These findings, together with the intriguing possibility that mTOR suppression may be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may be an important target for chemopreventive drugs...
  5. ncbi request reprint Can animal models help us select specific compounds for cancer prevention trials?
    Ernest T Hawk
    GI and Other Cancers Research Group, National Cancer Institute, Suite 2141, 6130 Executive Boulevard, Bethesda, MD 20892 7317, USA
    Recent Results Cancer Res 166:71-87. 2005
    ....
  6. ncbi request reprint 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Carcinogenesis 26:571-8. 2005
    ..The anti-apoptotic protein survivin was not expressed in normal bladder epithelium, but was variably expressed in cancers. FHIT and survivin expressions were similar in cancers from indomethacin-treated and non-treated mice...
  7. pmc Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers
    Vernon E Steele
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 2:951-6. 2009
    ..These data show that both naproxen and NO-naproxen are effective agents against urinary bladder and colon, but not mammary, carcinogenesis...
  8. pmc Heritable one-hit events defining cancer prevention?
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 12:2553-7. 2013
    ..Indeed, studies to date essentially uniformly show that cancer is a genetic disease...
  9. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  10. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY, USA
    Int J Cancer 116:495-9. 2005
    ..This observation indicates that preexisting mutational events are not necessary for induction of colonic tumors by activated PPAR-gamma in vivo...
  11. ncbi request reprint Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents
    Jeffrey H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Anticancer Res 27:1-16. 2007
    ....
  12. ncbi request reprint RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival
    Yuchen Chien
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 127:157-70. 2006
    ..These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling...
  13. ncbi request reprint Hedgehog signalling in skin development and cancer
    Mohammad Athar
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:667-77. 2006
    ..This review therefore provides a current understanding of the role of the Shh pathway in skin development and neoplasia. It also provides a basis for the molecular target-based chemoprevention and therapeutic management of skin cancer...
  14. ncbi request reprint Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice
    Malisetty V Swamy
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 66:7370-7. 2006
    ..These observations show that atorvastatin inhibits intestinal tumorigenesis and that, importantly, when given together with low doses of celecoxib, it significantly increases the chemopreventive efficacy in an APC(min) mice...
  15. ncbi request reprint Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line
    Jeffrey H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Anticancer Res 26:4177-83. 2006
    ..The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported...
  16. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  17. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  18. ncbi request reprint The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells
    Seiji Adachi
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New Yourk, NY 10032 2704, USA
    Cancer Res 67:6493-501. 2007
    ..These effects may also explain the ability of EGCG to inhibit activation of other membrane-associated RTKs, and they may play a critical role in the anticancer effects of this and related compounds...
  19. ncbi request reprint Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065, USA
    J Nutr 138:1658-63. 2008
    ....
  20. pmc Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats
    Chinthalapally V Rao
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 33:799-805. 2008
    ..These findings may have practical utility for the administration of NO-ASA to humans...
  21. pmc Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
    Rebecca J Leary
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:16224-9. 2008
    ..These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy...
  22. ncbi request reprint Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets
    Chinthalapally V Rao
    Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 5:1530-8. 2006
    ..These results pave the way for the rational design of human clinical trials...
  23. ncbi request reprint Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats
    Bandaru S Reddy
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 66:4542-6. 2006
    ..These observations are of clinical significance because this can pave the way for the use of combinations of these agents in small doses against colon cancer...
  24. ncbi request reprint Efficacy of chemopreventive agents for growth inhibition of Apc [+/-] 1638NCOL colonic epithelial cells
    Meena Katdare
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
    Int J Mol Med 10:427-32. 2002
    ....
  25. ncbi request reprint Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents
    Levy Kopelovich
    CCS Associates, Mountain View, California 94043, USA
    Mol Cancer Ther 1:357-63. 2002
    ..This review presents a rationale for using PPAR modulators as cancer chemopreventive drugs...
  26. ncbi request reprint Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors
    Zhilan Hu
    The Cooperative Human Tissue Network, University of Alabama, Birmingham, AL 35294, USA
    Cancer Res 63:923-8. 2003
    ....
  27. ncbi request reprint Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Carcinogenesis 24:605-11. 2003
    ..These findings thus suggest involvement of Bax and apoptosis in tumors developing after sulindac treatment in this mouse model...
  28. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cancer Res 63:1914-9. 2003
    ....
  29. ncbi request reprint Establishment and characterization of sublines of LNCaP human prostate cancer cells
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19083, USA
    Oncol Rep 10:1569-75. 2003
    ....
  30. ncbi request reprint In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells
    X Steven Wan
    University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Oncol Rep 10:2009-14. 2003
    ....
  31. ncbi request reprint NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice
    Jennie L Williams
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 06595, USA
    Biochem Biophys Res Commun 313:784-8. 2004
    ..Our findings establish the strong inhibitory effect of NO-ASA in intestinal carcinogenesis in the Min mouse and suggest that this agent merits further evaluation as a chemopreventive agent against colon cancer...
  32. ncbi request reprint Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004
    ....
  33. pmc Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein
    Annika Vogt
    Department of Dermatology, University of California San Francisco, 94143, USA
    J Exp Med 199:753-61. 2004
    ....
  34. ncbi request reprint Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation
    Po Lin So
    Department of Dermatology, University of California, San Francisco, California, USA
    Cancer Res 64:4385-9. 2004
    ..The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans...
  35. ncbi request reprint Tobacco smoke induces CYP1B1 in the aerodigestive tract
    Jeffrey L Port
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 25:2275-81. 2004
    ..05). Taken together, these results support a role for CYP1B1 in TS-induced carcinogenesis in the aerodigestive tract...
  36. ncbi request reprint Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis
    Yuzhi Yin
    Department of Oncology, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 65:3950-7. 2005
    ..These results indicate that PPARdelta and PPARgamma agonists produce diverse, yet profound effects on mammary tumorigenesis that give rise to distinctive histopathologic patterns of tumor differentiation and tumor development...
  37. ncbi request reprint Targeting epigenetic regulatory mechanisms in cancer chemoprevention
    Judith R Fay
    CCS Associates, 2005 Landings Dr, Mountain View, CA 94043, USA
    Expert Opin Ther Targets 9:315-28. 2005
    ..This review discusses the potential for restoring epigenetic balance as a means to prevent cancer...
  38. ncbi request reprint Characterization of medroxyprogesterone and DMBA-induced multilineage mammary tumors by gene expression profiling
    Yuzhi Yin
    Department of Oncology, and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Mol Carcinog 44:42-50. 2005
    ....
  39. ncbi request reprint Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model
    Nengtai Ouyang
    Division of Cancer Prevention, State University of New York at Stony Brook, Stony Brook, New York 11794 5200, USA
    Cancer Res 66:4503-11. 2006
    ..NO-ASA merits further evaluation as a chemopreventive agent against pancreatic cancer...
  40. pmc A mouse model of human oral-esophageal cancer
    Oliver G Opitz
    Division of Gastroenterology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 110:761-9. 2002
    ..These data demonstrate that L2D1(+)/p53(+/-) mice provide a well-defined, novel, and faithful model of oral-esophageal cancer, which allows for the testing of novel chemopreventive, diagnostic, and therapeutic approaches...