A S Kimes
Affiliation: National Institutes of Health
- Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleusA S Kimes
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res 814:1-12. 1998..The present data support the view that LC is a major substrate of opioid withdrawal in the brain, and they suggest that LC plays an important role in changing rCMRglc during opioid withdrawal induced by systemic naloxone administration...
- 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humansAlane S Kimes
NIDA Intramural Research Program Baltimore, Maryland 21224, USA
FASEB J 17:1331-3. 2003..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
- 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modelingA O Koren
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 41:3690-8. 1998..The new ligands with high affinity for nAChRs may be of interest as pharmacological probes, potential medications, and candidates for developing radiohalogenated tracers to study nAChRs...
- Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptorsA G Horti
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224
J Med Chem 41:4199-206. 1998..2.1]heptane ([18F]FPH), which are highly specific nAChR probes. The initial brain uptake of the 11C analogues and the acute toxicity of the corresponding authentic nonlabeled compounds appeared to be related to their lipophilicity...
- Dose-dependent effects of D-N-allylnormetazocine on regional cerebral metabolic rates for glucoseA Della Puppa
Neuroimaging and Drug Action Section, National Institute on Drug Abuse, Baltimore, MD 21224
Brain Res 603:38-46. 1993....
- Effects of triazolam on brain activity during episodic memory encoding: a PET studyM Z Mintzer
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropsychopharmacology 25:744-56. 2001..Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes...
- Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomographyL L Brown
Brain Imaging Center, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Bioorg Med Chem 9:3055-8. 2001..An efficient radiochemical synthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine (1c), a potential tracer for the study of nAChR by positron emission tomography, has been developed...
- Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacyD B Vaupel
Brain Imaging Section, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Eur J Pharmacol 324:11-20. 1997..These data suggest that constitutive isoforms, but not the inducible isoform of NO synthase, have a primary role in NO-mediated processes that modulate the opioid withdrawal syndrome in the rat...
- Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making taskK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 19:1085-94. 2003..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...