Affiliation: National Institutes of Health
- Familiality of polarity at illness onset in bipolar affective disorderLayla Kassem
Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
Am J Psychiatry 163:1754-9. 2006..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder...
- Sequence variation in DOCK9 and heterogeneity in bipolar disorderSevilla D Detera-Wadleigh
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
Psychiatr Genet 17:274-86. 2007..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
- Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorderLiping Hou
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
Hum Mol Genet . 2016..The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS...
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literatureStephanie A Cardenas
National Institutes of Health, 10 Center Drive, RM 3D54, MSC 1264, Bethesda, MD 20814 1264, USA Electronic address
Neurosci Biobehav Rev 69:193-215. 2016..In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives...
- Race, genetic ancestry and response to antidepressant treatment for major depressionEleanor Murphy
Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
Neuropsychopharmacology 38:2598-606. 2013..Larger samples would be needed to identify the specific genetic mechanisms that may be involved, but these findings underscore the importance of including more African-American patients in drug trials...
- Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulationMelissa A Brotman
Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 164:1238-41. 2007..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
- Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association studyLiping Hou
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
Lancet 387:1085-93. 2016..Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified...
- Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain peopleLiping Hou
Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
Trends Genet 29:412-8. 2013..We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations...
- Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attemptsVictor A Lopez
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 61:181-6. 2007..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample...
- Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disordersKelly E Gill
Human Genetics Branch, Section on Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health Intramural Research Program, National Institutes of Health, New York City, USA
Int J Bipolar Disord 4:21. 2016..Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course...
- Do participants in genome sequencing studies of psychiatric disorders wish to be informed of their results? A survey studyElise T Bui
Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 9:e101111. 2014..This study provides information on psychiatric research volunteers' attitudes, beliefs, and concerns with respect to participation in DNA sequencing studies and reporting of individual results...
- The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatmentThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Neuropsychobiology 62:72-8. 2010..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
- The bipolar disorder phenome database: a resource for genetic studiesJames B Potash
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:1229-37. 2007..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
- Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypesThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
Am J Psychiatry 162:2101-8. 2005....
- Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...