Layla Kassem

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
  2. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
  3. pmc Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
    Liping Hou
    Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Hum Mol Genet . 2016
  4. pmc Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature
    Stephanie A Cardenas
    National Institutes of Health, 10 Center Drive, RM 3D54, MSC 1264, Bethesda, MD 20814 1264, USA Electronic address
    Neurosci Biobehav Rev 69:193-215. 2016
  5. pmc Race, genetic ancestry and response to antidepressant treatment for major depression
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Neuropsychopharmacology 38:2598-606. 2013
  6. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
  7. pmc Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
    Liping Hou
    Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Lancet 387:1085-93. 2016
  8. pmc Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people
    Liping Hou
    Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
    Trends Genet 29:412-8. 2013
  9. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
  10. pmc Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders
    Kelly E Gill
    Human Genetics Branch, Section on Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health Intramural Research Program, National Institutes of Health, New York City, USA
    Int J Bipolar Disord 4:21. 2016

Detail Information

Publications15

  1. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
    ..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder...
  2. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  3. pmc Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
    Liping Hou
    Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Hum Mol Genet . 2016
    ..The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS...
  4. pmc Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature
    Stephanie A Cardenas
    National Institutes of Health, 10 Center Drive, RM 3D54, MSC 1264, Bethesda, MD 20814 1264, USA Electronic address
    Neurosci Biobehav Rev 69:193-215. 2016
    ..In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives...
  5. pmc Race, genetic ancestry and response to antidepressant treatment for major depression
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Neuropsychopharmacology 38:2598-606. 2013
    ..Larger samples would be needed to identify the specific genetic mechanisms that may be involved, but these findings underscore the importance of including more African-American patients in drug trials...
  6. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  7. pmc Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
    Liping Hou
    Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Lancet 387:1085-93. 2016
    ..Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified...
  8. pmc Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people
    Liping Hou
    Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
    Trends Genet 29:412-8. 2013
    ..We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations...
  9. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
    ..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample...
  10. pmc Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders
    Kelly E Gill
    Human Genetics Branch, Section on Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health Intramural Research Program, National Institutes of Health, New York City, USA
    Int J Bipolar Disord 4:21. 2016
    ..Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course...
  11. pmc Do participants in genome sequencing studies of psychiatric disorders wish to be informed of their results? A survey study
    Elise T Bui
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e101111. 2014
    ..This study provides information on psychiatric research volunteers' attitudes, beliefs, and concerns with respect to participation in DNA sequencing studies and reporting of individual results...
  12. pmc The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuropsychobiology 62:72-8. 2010
    ..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
  13. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  14. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  15. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...