Genomes and Genes
Christina M Van Itallie
Affiliation: National Institutes of Health
- Architecture of tight junctions and principles of molecular compositionChristina M Van Itallie
The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA Electronic address
Semin Cell Dev Biol 36:157-65. 2014....
- The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networksChristina M Van Itallie
Laboratory of Tight Junction Structure and Function, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 288:13775-88. 2013..Biotin ligase tagging with ZO-1 was applied to identify a more complete tight junction proteome...
- Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomesChristina M Van Itallie
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 125:4902-12. 2012..Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane...
- SUMOylation of claudin-2Christina M Van Itallie
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Ann N Y Acad Sci 1258:60-4. 2012..We conclude that the cellular levels of claudin-2 may be modulated by SUMOylation, warranting further investigation of cellular pathways that regulate this modification in vivo...
- Claudin-2 forms homodimers and is a component of a high molecular weight protein complexChristina M Van Itallie
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 286:3442-50. 2011..Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure...
- Caveolin binds independently to claudin-2 and occludinChristina M Van Itallie
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1257:103-7. 2012..The finding that caveolin-1 interacts with claudin-2 and occludin, but not with claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components...