Christina M Van Itallie

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892
    Mol Biol Cell . 2016
  2. pmc A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Mol Biol Cell 26:2769-87. 2015
  3. pmc Architecture of tight junctions and principles of molecular composition
    Christina M Van Itallie
    The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA Electronic address
    Semin Cell Dev Biol 36:157-65. 2014
  4. pmc The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 288:13775-88. 2013
  5. pmc Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
    Christina M Van Itallie
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 125:4902-12. 2012
  6. doi request reprint SUMOylation of claudin-2
    Christina M Van Itallie
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1258:60-4. 2012
  7. pmc Claudin-2 forms homodimers and is a component of a high molecular weight protein complex
    Christina M Van Itallie
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:3442-50. 2011
  8. doi request reprint Caveolin binds independently to claudin-2 and occludin
    Christina M Van Itallie
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1257:103-7. 2012

Collaborators

  • James Melvin Anderson
  • Christina M Van Itallie
  • Amber Jean Tietgens
  • Marjan Gucek
  • Angel Aponte
  • Laura L Mitic
  • Evan Krystofiak
  • Bechara Kachar
  • Karin Fredriksson
  • Kirsten Logrande

Detail Information

Publications9

  1. pmc Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892
    Mol Biol Cell . 2016
    ..We speculate that intermittent tethering of claudins to actin may allow for accommodation of the paracellular seal to physiologic or pathologic alterations in cell shape or movement...
  2. pmc A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Mol Biol Cell 26:2769-87. 2015
    ..Identification of the ZO-1/TOCA-1 complex provides novel insights into the underappreciated dependence of the barrier on the dynamic nature of cell-to-cell contacts and perijunctional actin. ..
  3. pmc Architecture of tight junctions and principles of molecular composition
    Christina M Van Itallie
    The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA Electronic address
    Semin Cell Dev Biol 36:157-65. 2014
    ....
  4. pmc The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks
    Christina M Van Itallie
    Laboratory of Tight Junction Structure and Function, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 288:13775-88. 2013
    ..Biotin ligase tagging with ZO-1 was applied to identify a more complete tight junction proteome...
  5. pmc Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
    Christina M Van Itallie
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 125:4902-12. 2012
    ..Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane...
  6. doi request reprint SUMOylation of claudin-2
    Christina M Van Itallie
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1258:60-4. 2012
    ..We conclude that the cellular levels of claudin-2 may be modulated by SUMOylation, warranting further investigation of cellular pathways that regulate this modification in vivo...
  7. pmc Claudin-2 forms homodimers and is a component of a high molecular weight protein complex
    Christina M Van Itallie
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:3442-50. 2011
    ..Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure...
  8. doi request reprint Caveolin binds independently to claudin-2 and occludin
    Christina M Van Itallie
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1257:103-7. 2012
    ..The finding that caveolin-1 interacts with claudin-2 and occludin, but not with claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components...