Courtney Holmes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
  2. pmc Dopamine contamination of infused tyramine
    Courtney Holmes
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:1733-5. 2005
  3. pmc Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observations
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Auton Neurosci 146:18-21. 2009
  4. ncbi request reprint Neurocirculatory abnormalities in chronic orthostatic intolerance
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Circulation 111:839-45. 2005
  5. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
  6. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
  7. ncbi request reprint Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 46:1333-9. 2005
  8. ncbi request reprint Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003
  9. pmc Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 14:600-7. 2008
  10. pmc Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Clin Pharmacol 51:66-74. 2011

Detail Information

Publications60

  1. ncbi request reprint Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
    ..We therefore examined sympathoadrenal function in patients with pseudopheochromocytoma compared with age-matched control subjects in whom there was no suspicion of pheochromocytoma...
  2. pmc Dopamine contamination of infused tyramine
    Courtney Holmes
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:1733-5. 2005
  3. pmc Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observations
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Auton Neurosci 146:18-21. 2009
    ..PAF entails cardiac sympathetic denervation, whereas cardiac sympathetic neuroimaging by thoracic 6-[(18)F]fluorodopamine scanning indicates intact myocardial sympathetic innervation in AAG...
  4. ncbi request reprint Neurocirculatory abnormalities in chronic orthostatic intolerance
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Circulation 111:839-45. 2005
    ..This study addressed whether patients with COI and POTS or NCS have neurocirculatory abnormalities during supine rest...
  5. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
    ..We studied the impact of such denervation on cardiac chronotropic and inotropic function...
  6. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
    ..In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH...
  7. ncbi request reprint Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 46:1333-9. 2005
    ..Parkinson disease with orthostatic hypotension features reflexive cardiovagal and sympathoneural failure and cardiac and partial extracardiac sympathetic denervation, independent of levodopa treatment...
  8. ncbi request reprint Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003
    ..The finding of lower plasma NE levels in patients with than without supine hypertension suggests involvement of pressor mechanisms independent of the sympathetic nervous system...
  9. pmc Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 14:600-7. 2008
    ..This study compared neuroimaging, neurochemical, and olfactory potential biomarkers to detect central dopamine (DA) deficiency and distinguish PD from multiple system atrophy (MSA)...
  10. pmc Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Clin Pharmacol 51:66-74. 2011
    ....
  11. pmc Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervation
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1148:486-9. 2008
    ..05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release...
  12. ncbi request reprint Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Neuropharmacol 29:97-105. 2006
    ....
  13. pmc Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:57-61. 2012
    ..In this case, neuroimaging evidence of cardiac noradrenergic denervation and subsequent progressive striatal dopaminergic denervation fit with Braak staging...
  14. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  15. ncbi request reprint Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication
    Amanda Singleton
    Parkinson s Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Brain 127:768-72. 2004
    ..These results indicate that both parkinsonism and cardiac sympathetic denervation can result from an excess of normal synuclein...
  16. ncbi request reprint Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning
    Sheng Ting Li
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 44:1599-603. 2003
    ..This study examined the effects of normal human aging on cardiac sympathetic innervation and function, including the neuronal uptake of catecholamines (uptake 1) via the cell membrane norepinephrine transporter...
  17. pmc Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disordersand Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Brain 135:1900-13. 2012
    ..Parkinson's disease and pure autonomic failure involve differential dopaminergic versus noradrenergic lesions. Cerebrospinal fluid dihydroxyphenylacetic acid seems to provide a sensitive means to identify even early Parkinson's disease...
  18. ncbi request reprint Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma
    Basil A Eldadah
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Hypertension 43:1227-32. 2004
    ..The results call for caution in drawing quantitative conclusions about uptake-1 in the setting of high circulating concentrations of endogenous norepinephrine...
  19. doi request reprint Central dopamine deficiency in pure autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 18:58-65. 2008
    ..A patient with PAF and another with PD had rapid postmortem striatal, nigral, and sympathetic ganglion sampling, with assays of catechols and tyrosine hydroxylase activity...
  20. ncbi request reprint Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, USA
    Circulation 106:2358-65. 2002
    ..Whether these conditions involve abnormal cardiac sympathetic innervation or function has been unclear...
  21. pmc Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    J Neurochem 126:591-603. 2013
    ..Elevated DOPAL levels in PD putamen reflect a combination of decreased vesicular uptake of cytosolic DA and decreased DOPAL detoxification by ALDH...
  22. pmc Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 1620, USA
    J Clin Invest 121:3320-30. 2011
    ..Vesicular uptake may constitute a novel target for diagnosis, treatment, and prevention...
  23. pmc Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivity
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:1479-82. 2009
    ..Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake...
  24. pmc Neuronal source of plasma dopamine
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 54:1864-71. 2008
    ..We tested in humans whether DA enters the plasma after corelease with NE during exocytosis from sympathetic noradrenergic nerves...
  25. pmc Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Clin Auton Res 19:259-62. 2009
    ....
  26. pmc Temporary elimination of orthostatic hypotension by norepinephrine infusion
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:303-6. 2012
    ..v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH...
  27. ncbi request reprint Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, U S A
    Clin Sci (Lond) 104:649-54. 2003
    ..41+/-1.77 nmol/l respectively; P =0.006). The findings are consistent with central noradrenergic deficiency in both MSA+OH and PAF. In MSA, central noradrenergic deficiency seems to relate specifically to OH...
  28. ncbi request reprint Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 14:363-8. 2004
    ....
  29. ncbi request reprint Sympathoadrenal imbalance before neurocardiogenic syncope
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Am J Cardiol 91:53-8. 2003
    ..Sympathoadrenal imbalance may contribute to hemodynamic derangements precipitating neurocardiogenic syncope...
  30. pmc Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde
    Courtney Holmes
    Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Chem 56:832-8. 2010
    ....
  31. pmc Plasma catechols in familial dysautonomia: a long-term follow-up study
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10 Room 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Neurochem Res 33:1889-93. 2008
    ..In FD, plasma catechol profiles are sufficiently stable, at least over a decade, to be used as a biomarker of disease involvement. An increasing DOPA:DHPG ratio suggests slight but consistent, progressive loss of noradrenergic neurons...
  32. pmc Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA
    J Neurochem 123:932-43. 2012
    ....
  33. ncbi request reprint Autoimmunity-associated autonomic failure with sympathetic denervation
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike MSC 1620, Building 10 Room 5N220, Bethesda, MD, 20892 1620, USA
    Clin Auton Res . 2016
    ..Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years...
  34. pmc Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA Electronic address
    Parkinsonism Relat Disord 31:79-86. 2016
    ..We examined whether an elevated Cys-DA/DOPAC ratio provides a specific biomarker of parkinsonism in synucleinopathy patients...
  35. pmc Deficient vesicular storage: A common theme in catecholaminergic neurodegeneration
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA Electronic address
    Parkinsonism Relat Disord 21:1013-22. 2015
    ..Thus, across neurodegenerative diseases, loss of catecholaminergic neurons seems to be associated with decreased vesicular storage in the residual neurons...
  36. pmc Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neuroscience Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland D S G, Y J, P S, C H, I J K and Hypertension Unit, Chaim Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel Y S
    J Pharmacol Exp Ther 356:483-92. 2016
    ....
  37. pmc 3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, 9000 Rockville Pike, Bldg 10 Rm 5N220, Bethesda, MD, 20892 1620, USA
    Neurochem Res 41:2173-8. 2016
    ..Hydroxytyrosol therefore inhibits both enzymatic and spontaneous oxidation of endogenous dopamine and mitigates the increase in spontaneous oxidation during MAO inhibition. ..
  38. doi request reprint Determinants of denervation-independent depletion of putamen dopamine in Parkinson's disease and multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA Electronic address
    Parkinsonism Relat Disord . 2016
    ..5-S-Cysteinyldopa (Cys-DOPA) is produced from spontaneous oxidation of DOPA and 5-S-cysteinyldopamine (Cys-DA) from spontaneous oxidation of DA...
  39. pmc Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA Electronic address
    Parkinsonism Relat Disord 21:567-72. 2015
    ..In this study we asked whether MSA entails a similar abnormal neurochemical pattern...
  40. pmc A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, Maryland, USA
    J Neurochem 131:219-28. 2014
    ..This shift may be part of a final common pathogenetic pathway in the loss of catecholaminergic neurons that characterizes PD. ..
  41. ncbi request reprint Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor
    David S Goldstein
    Building 10, Room 6N252, Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Clin Auton Res 12:281-5. 2002
    ..The findings in this case support the concept that circulating antibodies to this receptor can interfere with ganglionic neurotransmission and produce autoimmune autonomic neuropathy...
  42. ncbi request reprint Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Pharmacol Exp Ther 306:855-60. 2003
    ....
  43. doi request reprint Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA
    Cleve Clin J Med 76:S51-9. 2009
    ..Alternatively, LF power might reflect baro reflexive modulation of autonomic outflows...
  44. ncbi request reprint Baroreflex failure as a late sequela of neck irradiation
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:110-6. 2003
    ..Splinting of carotid sinus mechanoreceptors in rigidified arterial walls would impede detection of alterations in blood pressure and thereby disrupt baroreflex regulation of cardiovagal and sympathetic outflows...
  45. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  46. pmc Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA
    Heart Rhythm 4:1523-9. 2007
    ..Alternatively, LF power might reflect baroreflexive modulation of autonomic outflows...
  47. pmc Association of anosmia with autonomic failure in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD 20892 1620, USA
    Neurology 74:245-51. 2010
    ..This observational study assessed whether in PD anosmia and autonomic failure are related to each other or to neuroimaging evidence of striatal dopamine deficiency...
  48. pmc Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health NINDS, NIH, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD, 20892 1620, USA
    Clin Auton Res 25:61-7. 2015
    ..We assessed whether plasma biomarkers of a vesicular storage defect can separate PD + OH from MSA-P...
  49. ncbi request reprint Tyrosinase: a developmentally specific major determinant of peripheral dopamine
    Graeme Eisenhofer
    Section on Clinical Neurocardiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr MSC 1620, Bethesda, MD 20892 1620, USA
    FASEB J 17:1248-55. 2003
    ..The transient nature of this source of dopamine reflects a developmental switch in tyrosinase-dependent production of dopamine to production of melanin...
  50. pmc Survival in synucleinopathies: A prospective cohort study
    David S Goldstein
    From the Clinical Neurocardiology Section D S G, C H and Office of the Clinical Director T W, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD and Hypertension Unit Y S, Chaim Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
    Neurology 85:1554-61. 2015
    ..Approximately 40% of patients with PD, most patients with MSA, and all patients with PAF have neurogenic orthostatic hypotension (OH). This study compared long-term survival in these synucleinopathies...
  51. ncbi request reprint Progressive loss of cardiac sympathetic innervation in Parkinson's disease
    Sheng Ting Li
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Ann Neurol 52:220-3. 2002
    ..In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism...
  52. ncbi request reprint Local sympathetic denervation in painful diabetic neuropathy
    Cees J Tack
    Division of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Diabetes 51:3545-53. 2002
    ..The results provide neurochemical and neuroimaging evidence for regionally selective sympathetic denervation in the painful feet of patients with diabetic neuropathy...
  53. ncbi request reprint Partial cardiac sympathetic denervation after bilateral thoracic sympathectomy in humans
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA moakj ninds nih gov
    Heart Rhythm 2:602-9. 2005
    ..Sympathetic nerve fibers emanating from thoracic ganglia innervate the heart. Whether unilateral or bilateral upper thoracic sympathectomy affects cardiac sympathetic innervation in humans in vivo has been unclear...
  54. ncbi request reprint Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure
    Jill M Wecht
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Physiol Heart Circ Physiol 294:H190-7. 2008
    ....
  55. ncbi request reprint Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia
    Alfredo Gamboa
    Clinical Pharmacology, Vanderbilt University Medical Center, 1161 21st Avenue South, Suite AA3228, Nashville, TN 37232, USA
    Clin Auton Res 16:40-5. 2006
    ..05); red cell volume was higher in HA only in the CMS group. The results indicate sympathetic nervous stimulation by chronic ambient hypoxia at altitude in Andean natives, independent of maladaptation to their native environment...
  56. ncbi request reprint Vasodilation during systemic tyramine administration response
    David S Goldstein
    Circulation 109:E17-8. 2004
  57. pmc Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral corr
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, West Roxbury, MA 02132, USA
    Hum Gene Ther 15:1177-96. 2004
    ....
  58. ncbi request reprint Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model
    Jon E Sprague
    Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH, USA
    Crit Care Med 33:1311-6. 2005
    ..Using a rat model of MDMA hyperthermia, we evaluated the acute drug-induced changes in plasma catecholamines and used these results as a basis for the selection of drugs that could potentially reverse this hyperthermia...
  59. ncbi request reprint Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
    ..In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture...
  60. pmc Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Hum Gene Ther 14:415-24. 2003
    ..This improved system efficiently corrects the rat model of PD...