Pierre A Henkart

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
  2. pmc Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice
    E K Haddad
    Experimental Immunology Branch, National Cancer Institute, and
    J Cell Biol 152:835-42. 2001
  3. ncbi request reprint IL-15 is a growth factor and an activator of CD8 memory T cells
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 975:46-56. 2002
  4. pmc TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Immunology 125:70-9. 2008
  5. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
  6. ncbi request reprint Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 20:219-30. 2004
  7. ncbi request reprint CD8+ effector cells
    Pierre A Henkart
    National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    Adv Immunol 83:233-52. 2004
  8. ncbi request reprint Perforin and the granule exocytosis cytotoxicity pathway
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892 1360, USA
    Curr Opin Immunol 15:522-7. 2003
  9. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
  10. pmc Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 108:3363-70. 2006

Collaborators

Detail Information

Publications12

  1. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
    ..These experiments support a model in which granule-derived surface cathepsin B provides self-protection for degranulating cytotoxic lymphocytes...
  2. pmc Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice
    E K Haddad
    Experimental Immunology Branch, National Cancer Institute, and
    J Cell Biol 152:835-42. 2001
    ....
  3. ncbi request reprint IL-15 is a growth factor and an activator of CD8 memory T cells
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 975:46-56. 2002
    ..These findings indicate that IL-15 is not only a growth factor but also an antigen-independent activator for CD8 memory T cells...
  4. pmc TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Immunology 125:70-9. 2008
    ..These results demonstrate that fast delivery of mediators by the regulated secretory pathway in CD4+ T cells can be used to perform other functions that are not involved in cytotoxic function but that can influence/regulate other cells...
  5. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
    ..This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity...
  6. ncbi request reprint Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 20:219-30. 2004
    ..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function...
  7. ncbi request reprint CD8+ effector cells
    Pierre A Henkart
    National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    Adv Immunol 83:233-52. 2004
  8. ncbi request reprint Perforin and the granule exocytosis cytotoxicity pathway
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892 1360, USA
    Curr Opin Immunol 15:522-7. 2003
    ..Selfprotection of cytotoxic lymphocytes after degranulation can be explained by surface expression of the granule protease cathepsin B, as shown by suicidal degranulation in the presence of specific inhibitors...
  9. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
    ..Thus, IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8(+) memory T cells...
  10. pmc Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 108:3363-70. 2006
    ..Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8(+) T-cell response...
  11. ncbi request reprint Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin
    Eun Joo Chung
    Medical Oncology Clinical Research Unit and Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 100:982-90. 2002
    ..Fas-mediated apoptosis was potentiated by inhibition of beta-catenin nuclear signaling. The data suggest that beta-catenin can play a significant role in promoting leukemic cell proliferation, adhesion, and survival...