R J Havlik
Affiliation: National Institutes of Health
- APOE-epsilon4 predicts incident AD in Japanese-American men: the honolulu-asia aging studyR J Havlik
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Neurology 54:1526-9. 2000..Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia...
- High-density lipoprotein cholesterol and vascular stiffness at baseline in the activity counseling trialR J Havlik
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
Am J Cardiol 87:104-7, A9. 2001..High-density lipoprotein cholesterol may be an indirect indicator of aerobic capacity or of less atherosclerosis, suggesting mechanisms for preserving vascular integrity...
- Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia Aging studyRichard J Havlik
Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Stroke 33:26-30. 2002..Besides the associations with advanced age and high blood pressure (BP), variability in systolic BP (SBP) and the resulting changes in blood flow to the deep arteries of the brain may be contributing factors...
- Midlife blood pressure and dementia: the Honolulu-Asia aging studyL J Launer
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
Neurobiol Aging 21:49-55. 2000..This study suggests elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication...
- Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging studyR Peila
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Stroke 32:2882-9. 2001..The aim of this study was to explore the joint effect of the APOE epsilon4 allele and midlife systolic blood pressure (SBP) on the risk for poor cognitive function in late life...
- Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the ElderlyK G Losonczy
Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD 20892 9205, USA
Am J Clin Nutr 64:190-6. 1996..These findings are consistent with those for younger persons and suggest protective effects of vitamin E supplements in the elderly...
- Apolipoprotein E epsilon 2 allele and risk of stroke in the older populationL Ferrucci
Geriatric Department, I Fraticini, National Research Institute INRCA, Florence, Italy USA
Stroke 28:2410-6. 1997..We estimated the risk of stroke associated with different apoE genotypes in older persons...
- Chronically depressed mood and cancer risk in older personsB W Penninx
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
J Natl Cancer Inst 90:1888-93. 1998..We examined whether a high level of depressive symptoms, present for a long time, is associated with increased risk of cancer in the elderly...
- Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and olderR Yancik
Cancer Section, Geriatrics Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
JAMA 285:885-92. 2001..Postmenopausal women aged 55 years and older have 66% of incident breast tumors and experience 77% of breast cancer mortality, but other age-related health problems may affect tumor prognosis and treatment decisions...
- Predictors of hypertension. Population studiesR J Havlik
National Institute on Aging, National Institutes of Health, Bethesda, MD
Am J Hypertens 4:586S-589S. 1991..It should be emphasized that any genetic predictive factor will be affected by environmental factors. This interaction provides the opportunity for possible modification or prevention of hypertension by hygienic means...
- Relation of heart rate at rest and mortality in the Women's Health and Aging StudyMilan Chang
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Cardiol 92:1294-9. 2003..In patients with and without heart disease, further investigation of cardiovascular status may be warranted if their HR is >/=90 beats/min...
- Walking may be related to less vascular stiffness in the Activity Counseling Trial (ACT)Richard J Havlik
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA
Am Heart J 150:270-5. 2005..The effects of the interventions, as well as the impact of walking and correlates such as older age and maximal oxygen uptake (VO2max), on APWV were assessed...
- Head injury in early adulthood and the lifetime risk of depressionTracey Holsinger
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Arch Gen Psychiatry 59:17-22. 2002..Head injury can also have long-term cognitive effects, but little is known about the long-term risk of depression associated with head injury. We investigated the lifetime rates of depressive illness 50 years after closed head injury...
- Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from HawaiiIlija P Kovac
Department of Psychiatry, McGill University, Alan Memorial Institute, R and T Building, 1033 Pine Avenue West, Montreal H3A 1A1, Quebec, Canada
Diabetes 56:537-40. 2007..2 cM. The present study was limited by relatively small sample size. Nevertheless, these results corroborate earlier studies, suggesting that further research is warranted in the candidate region approximately 30 cM on chromosome 14...