- The molecular pathology of cancerTimothy J R Harris
SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Nat Rev Clin Oncol 7:251-65. 2010..This paradigm shift is occurring first in cancer patient management and is likely to promote the application of these technologies to other diseases...
- Does large scale DNA sequencing of patient and tumor DNA yet provide clinically actionable information?Tim Harris
Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
Discov Med 10:144-50. 2010..The number of clinical options available for patients stratified by molecular diagnostics may actually be limited more by the specific treatments available rather than by the ability to stratify the patients in the first place...
- Long-range enhancers on 8q24 regulate c-MycJose Sotelo
Laboratory of Molecular Technology, National Cancer Institute Frederick, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 107:3001-5. 2010..We also demonstrate that one such enhancer element physically interacts with the Myc promoter via transcription factor Tcf-4 binding and acts in an allele specific manner to regulate Myc expression...