Robert L Hanson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Quantitative trait linkage studies of diabetes-related traits
    Robert L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E Indian School Road, Phoenix, AZ 85014, USA
    Curr Diab Rep 3:176-83. 2003
  2. pmc Role of Established Type 2 Diabetes-Susceptibility Genetic Variants in a High Prevalence American Indian Population
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 64:2646-57. 2015
  3. pmc Secular trends in treatment and control of type 2 diabetes in an American Indian population: a 30-year longitudinal study
    Helen C Looker
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes Care 33:2383-9. 2010
  4. pmc Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 62:2984-91. 2013
  5. pmc Exploration of non-hierarchical classification methods combined with linkage analysis to identify loci influencing clusters of co-regulated transcripts
    Alka Malhotra
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, Arizona 85004, USA
    BMC Proc 1:S48. 2007
  6. pmc Assessment of parent-of-origin effects in linkage analysis of quantitative traits
    R L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
    Am J Hum Genet 68:951-62. 2001
  7. ncbi request reprint Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: sample size and power calculations
    R L Hanson
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona, 85014, USA
    Ann Hum Genet 70:332-49. 2006
  8. ncbi request reprint Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians
    R L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E Indian School Road, Phoenix, AZ 85014, USA
    Diabetes Metab Res Rev 17:296-303. 2001
  9. ncbi request reprint Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: assessment of the extent to which an association can account for the linkage
    R L Hanson
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona 85014, USA
    Ann Hum Genet 72:126-39. 2008
  10. ncbi request reprint A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 550 E Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 56:3045-52. 2007

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint Quantitative trait linkage studies of diabetes-related traits
    Robert L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E Indian School Road, Phoenix, AZ 85014, USA
    Curr Diab Rep 3:176-83. 2003
    ....
  2. pmc Role of Established Type 2 Diabetes-Susceptibility Genetic Variants in a High Prevalence American Indian Population
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 64:2646-57. 2015
    ..However, differences in allele frequencies do not account for the high population prevalence of T2DM. ..
  3. pmc Secular trends in treatment and control of type 2 diabetes in an American Indian population: a 30-year longitudinal study
    Helen C Looker
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes Care 33:2383-9. 2010
    ..Treatment guidelines for diabetes have become increasingly stringent as most research shows that more aggressive intervention reduces the risks for complications. Community data on the effect of these interventions are lacking...
  4. pmc Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 62:2984-91. 2013
    ..In Pima Indians, the effect of maternally derived KCNQ1 variants appears to be mediated through decreased insulin secretion and is particularly strong, accounting for 4% of the variance in liability to diabetes. ..
  5. pmc Exploration of non-hierarchical classification methods combined with linkage analysis to identify loci influencing clusters of co-regulated transcripts
    Alka Malhotra
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, Arizona 85004, USA
    BMC Proc 1:S48. 2007
    ....
  6. pmc Assessment of parent-of-origin effects in linkage analysis of quantitative traits
    R L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
    Am J Hum Genet 68:951-62. 2001
    ..1 when these effects were ignored. The ability to include parent-of-origin effects within linkage analysis of quantitative traits will facilitate genetic dissection of complex traits...
  7. ncbi request reprint Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: sample size and power calculations
    R L Hanson
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona, 85014, USA
    Ann Hum Genet 70:332-49. 2006
    ..These methods may be useful in the analysis and interpretation of fine-mapping studies...
  8. ncbi request reprint Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians
    R L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E Indian School Road, Phoenix, AZ 85014, USA
    Diabetes Metab Res Rev 17:296-303. 2001
    ....
  9. ncbi request reprint Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: assessment of the extent to which an association can account for the linkage
    R L Hanson
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona 85014, USA
    Ann Hum Genet 72:126-39. 2008
    ..These methods can help determine which association results are likely due to strong linkage disequilibrium with functional alleles and, thus, can facilitate the selection of small chromosomal regions for more extensive study...
  10. ncbi request reprint A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 550 E Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 56:3045-52. 2007
    ..To identify genetic variants in linkage disequilibrium with those conferring diabetes susceptibility, a genome-wide association study for young-onset diabetes was conducted in an American-Indian population...
  11. pmc An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
    R L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Am J Hum Genet 63:1130-8. 1998
    ..Sib-pair analyses suggest additional potential diabetes-susceptibility loci on chromosomes 1q and 7q...
  12. ncbi request reprint Components of the "metabolic syndrome" and incidence of type 2 diabetes
    Robert L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014, USA
    Diabetes 51:3120-7. 2002
    ....
  13. ncbi request reprint Analytic strategies to detect linkage to a common disorder with genetically determined age of onset: diabetes mellitus in Pima Indians
    R L Hanson
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014, USA
    Genet Epidemiol 15:299-315. 1998
    ..The method of age adjustment in linkage analysis may depend on whether one anticipates a genetic effect primarily on age of onset or on ultimate susceptibility...
  14. ncbi request reprint Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians
    Barbora Vozarova de Courten
    Translational Genomics Research Institute, Diabetes Research Unit, NIDDK, NIH, 400 North 5th St, Phoenix, Arizona, USA
    Diabetes 54:284-9. 2005
    ..Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population...
  15. ncbi request reprint The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 52:3005-9. 2003
    ....
  16. ncbi request reprint Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes
    Helen C Looker
    National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014, USA
    J Clin Endocrinol Metab 89:4010-7. 2004
    ..0001). Serum adiponectin is lowest in the presence of impaired glucose regulation and early diabetes. In the presence of diabetes, serum adiponectin is positively associated with abnormal renal function and diabetes duration...
  17. pmc Common variation in SIM1 is reproducibly associated with BMI in Pima Indians
    Michael Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Phoenix, AZ, USA
    Diabetes 58:1682-9. 2009
    ..Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity...
  18. ncbi request reprint Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian
    Jonathan Krakoff
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 26:1745-51. 2003
    ....
  19. pmc Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant
    Jonathan Krakoff
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA
    Diabetes 57:3267-72. 2008
    ..Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure...
  20. ncbi request reprint Genome-wide linkage analysis of serum adiponectin in the Pima Indian population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes 52:2419-25. 2003
    ..Our data suggest that quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population...
  21. ncbi request reprint Plasma glucose regulation and mortality in pima Indians
    Nan Hee Kim
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014 4972, USA
    Diabetes Care 31:488-92. 2008
    ....
  22. pmc Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetes 54:3035-9. 2005
    ..We conclude that variants in HNF4alpha do not appear to be major determinants for type 2 diabetes in Pima Indians; however, HNF4alpha may have a minor role in type 2 diabetes susceptibility within this Native American population...
  23. ncbi request reprint TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals
    Tingwei Guo
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 56:3082-8. 2007
    ..S. populations. We investigated whether TCF7L2 also has a role in type 2 diabetes susceptibility in Pima Indians...
  24. ncbi request reprint Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
    Hypertension 44:681-8. 2004
    ..These data demonstrate association between genetic variability at 11betaHSD1 with hypertension, but these effects are modified by environmental factors...
  25. pmc Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men
    Lijun Ma
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St, Phoenix, AZ 85016, USA
    Diabetes 54:1598-602. 2005
    ..001 and P = 0.002, respectively). Our data suggest that the PYY-Y2R pathway may influence body weight through a sex-specific mechanism, but this finding requires confirmation in other populations...
  26. pmc Childhood obesity, other cardiovascular risk factors, and premature death
    Paul W Franks
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    N Engl J Med 362:485-93. 2010
    ..The effect of childhood risk factors for cardiovascular disease on adult mortality is poorly understood...
  27. ncbi request reprint A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo
    Peter Kovacs
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA
    Diabetes 55:1497-503. 2006
    ..05). We propose that the Tyr1306Cys substitution in LARG, through its differential activation of RhoA, increases insulin sensitivity in nondiabetic Pima Indians...
  28. pmc Predictive value of albuminuria in American Indian youth with or without type 2 diabetes
    Nan Hee Kim
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Pediatrics 125:e844-51. 2010
    ..To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes...
  29. pmc Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans
    Michael T Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Obesity (Silver Spring) 21:193-202. 2013
    ..Therefore LPGAT1 was analyzed as a candidate gene for obesity in Pima Indians...
  30. pmc Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians
    Michael T Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Phoenix, Phoenix, Arizona, USA
    Obesity (Silver Spring) 20:2426-30. 2012
    ..0007 adjusted for age, sex, fat mass, fat-free mass, activity, and family membership). We conclude that common noncoding variation in the LEPR gene is associated with higher BMI and lower energy expenditure in Native Americans...
  31. pmc Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death
    Abeba M Berhane
    Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Clin J Am Soc Nephrol 6:2444-51. 2011
    ..We investigated predictive value of albuminuria and estimated GFR (eGFR) for ESRD in Pima Indians with type 2 diabetes...
  32. pmc Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85004, USA
    J Clin Endocrinol Metab 93:3644-9. 2008
    ....
  33. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  34. ncbi request reprint Childhood predictors of young-onset type 2 diabetes
    Paul W Franks
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 56:2964-72. 2007
    ..Optimal prevention of young-onset type 2 diabetes requires identification of the early-life modifiable risk factors. We aimed to do this using longitudinal data in 1,604 5- to 19-year-old initially nondiabetic American Indians...
  35. ncbi request reprint Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 455 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 56:3089-94. 2007
    ..CACNA1E encodes the voltage-dependent calcium channel Ca(v)2.3 Ca(2+), and mice lacking this channel exhibit impaired glucose tolerance and insulin secretion. Therefore, CACNA1E was investigated as a positional candidate gene...
  36. ncbi request reprint Habitual physical activity in children: the role of genes and the environment
    Paul W Franks
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
    Am J Clin Nutr 82:901-8. 2005
    ..Understanding the factors that contribute to physical inactivity in children is important because sedentary behavior strongly relates to metabolic disorders such as obesity and diabetes...
  37. pmc Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    Rong Rong
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 58:478-88. 2009
    ..We investigated the association of these single nucleotide polymorphisms (SNPs) and some additional tag SNPs with type 2 diabetes and related quantitative traits in Pima Indians...
  38. pmc A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 63:369-76. 2014
    ..Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. ..
  39. pmc MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation
    Li Bian
    Diabetes Molecular Genetics Section and Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85004, USA
    Hum Mol Genet 22:4438-49. 2013
    ..We conclude that MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation. ..
  40. pmc Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians
    Li Bian
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes 59:1276-82. 2010
    ..Genetic variants in or near ASK1 were analyzed to assess the role of this gene in insulin action and type 2 diabetes...
  41. doi request reprint A genome-wide association study of BMI in American Indians
    Alka Malhotra
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Obesity (Silver Spring) 19:2102-6. 2011
    ..53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity...
  42. ncbi request reprint Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes
    Helen C Looker
    National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA
    Diabetes Metab Res Rev 23:193-201. 2007
    ..To assess the role of homocysteine as a risk factor for mortality in diabetic subjects...
  43. ncbi request reprint Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study
    Robert L Hanson
    Translational Genomics Research Institute, 445 North Fifth St, Phoenix, AZ 85004, USA
    Diabetes 56:975-83. 2007
    ..01. The strongest evidence for association was found for rs2648875 (P = 0.0000018; 2.97 [1.90-4.65]), which maps to intron 8 of PVT1. Together, these results suggest that PVT1 may contribute to ESRD susceptibility in diabetes...
  44. ncbi request reprint Do measures of body fat distribution provide information on the risk of type 2 diabetes in addition to measures of general obesity? Comparison of anthropometric predictors of type 2 diabetes in Pima Indians
    Marshall K Tulloch-Reid
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, NIDDK National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:2556-61. 2003
    ....
  45. pmc PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians
    Lijun Ma
    Department of Health and HumanServices, Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and KidneyDiseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 57:3156-60. 2008
    ..PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes...
  46. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010
    ..On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity...
  47. pmc Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
    Yunhua L Muller
    Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2080-5. 2010
    ..To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes...
  48. ncbi request reprint Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85004, USA
    Diabetes 56:1454-9. 2007
    ..01). These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance...
  49. pmc Predictive power of sequential measures of albuminuria for progression to ESRD or death in Pima Indians with type 2 diabetes
    Meda E Pavkov
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
    Am J Kidney Dis 51:759-66. 2008
    ....
  50. ncbi request reprint Genome-wide linkage analyses to identify Loci for diabetic retinopathy
    Helen C Looker
    PECRB, NIDDK, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 56:1160-6. 2007
    ..2 cM), whereas with multipoint analysis the peak LOD was 2.58 at 35 cM. No other areas of suggestive linkage were found. We propose that an area on chromosome 1 may harbor a gene or genes conferring susceptibility to diabetic retinopathy...
  51. pmc Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes
    Yunhua L Muller
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85004, USA
    Hum Genet 132:697-707. 2013
    ..Alternatively, TREH variants may be tagging a nearby T2D locus...
  52. ncbi request reprint Hematocrit and the incidence of type 2 diabetes in the pima indians
    Marshall K Tulloch-Reid
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes Care 27:2245-6. 2004
  53. ncbi request reprint The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes 52:187-93. 2003
    ..Significant linkage disequilibrium was found between -23Hph1 and birth weight but not type 2 diabetes, an observation that supports a potential functional role of INS polymorphisms in the regulation of birth weight...
  54. ncbi request reprint Electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetes
    Aida Jimenez-Corona
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
    Am Heart J 151:1080-6. 2006
    ....
  55. pmc Changing course of diabetic nephropathy in the Pima Indians
    Robert G Nelson
    Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
    Diabetes Res Clin Pract 82:S10-4. 2008
    ..A continued increase in the incidence of type 2 diabetes in youth, however, threatens to reverse this trend...
  56. ncbi request reprint Periodontal disease and mortality in type 2 diabetes
    Aramesh Saremi
    National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, Arizona, USA
    Diabetes Care 28:27-32. 2005
    ..Periodontal disease may contribute to the increased mortality associated with diabetes...
  57. ncbi request reprint Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians
    Alexander R Red Eagle
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, 85014, USA
    Hum Genet 118:12-22. 2005
    ..These results could be explained by functional effects of one or more of these SNPs or by linkage disequilibrium with a nearby functional locus...
  58. ncbi request reprint Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
    Diabetes 55:460-5. 2006
    ..Thus, prevention of offspring type 2 diabetes may require strategies that focus on improving gestational glucose tolerance even within the normal range...
  59. ncbi request reprint Weight, adiposity, and physical activity as determinants of an insulin sensitivity index in pima Indian children
    Joy C Bunt
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes Care 26:2524-30. 2003
    ..To determine whether measures of physical activity are related to an insulin sensitivity index ([ISI] 10(4)/fasting insulin x glucose) independent of weight or adiposity in children...
  60. pmc Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians
    Harini A Chakkera
    Divisions of Nephrology and Transplantation, Mayo Clinic, Phoenix, AZ 85054, USA
    Mol Genet Metab 103:185-90. 2011
    ..04; 18.8ml/min per copy of the C allele; p=0.03; and -13.4ml/min per copy of the C allele; p=0.001, respectively). These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease...
  61. ncbi request reprint Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in pima indians
    Helen C Looker
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes Care 26:320-6. 2003
    ..To examine incidence and progression of retinopathy using retinal photographs in Pima Indians and to compare the results with those obtained when retinopathy is assessed by direct ophthalmoscopy...
  62. ncbi request reprint A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 53:1915-9. 2004
    ..Our findings indicate that the Val1483Ile substitution in FAS is protective against obesity in Pima Indians, an effect possibly explained by the role of this gene in the regulation of substrate oxidation...
  63. ncbi request reprint Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetes
    Jonathan Krakoff
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 26:76-81. 2003
    ..To examine the risk of retinopathy and nephropathy in participants in whom type 2 diabetes was diagnosed in youth (before 20 years of age) compared with those in whom type 2 diabetes was diagnosed at older ages...
  64. pmc Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children
    Yunhua L Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA
    Hum Genet 133:1431-41. 2014
    ..2 %, p = 0.002), increased food intake (β = 676 kcal/day, p = 0.007) and decreased energy expenditure (β = -53.4 kcal/day, p = 0.054). Common and rare variation in MC4R contributes to obesity in American Indians...
  65. pmc Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
    Marie S Thearle
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 61:250-7. 2012
    ..The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood...
  66. ncbi request reprint Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans
    Marshall K Tulloch-Reid
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Pheonix, AZ, USA
    Obes Res 12:1352-9. 2004
    ..The aim of this study was to determine whether both VAT and SAT contribute to insulin resistance in African Americans and to examine the effects of sex on this relationship...
  67. pmc Higher energy expenditure in humans predicts natural mortality
    Reiner Jumpertz
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 96:E972-6. 2011
    ..Higher metabolic rates increase free radical formation, which may accelerate aging and lead to early mortality...
  68. pmc Diabetic nephropathy in American Indians, with a special emphasis on the Pima Indians
    Meda E Pavkov
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
    Curr Diab Rep 8:486-93. 2008
    ..We also review therapeutic strategies for managing diabetic kidney disease...
  69. ncbi request reprint Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weight
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
    Hum Genet 110:503-9. 2002
    ..An imprinted gene on chromosome 11 may influence birth weight in the Pima population. This chromosome contains one of the two major known clusters of imprinted genes in the human genome, lending biological plausibility to our findings...
  70. ncbi request reprint Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:97-103. 2001
    ..Our results indicate that variants in KCNJ9 are associated with diabetes in Pimas but do not account for the linkage of 1q with diabetes in this population...
  71. ncbi request reprint Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians
    J K Wolford
    Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetologia 44:779-82. 2001
    ..Because obesity is a strongly predisposing factor for Type II diabetes, we hypothesized that the LMNA 3408C/T variant could be associated with diabetes and body mass index in Pima Indians...
  72. pmc Pilot study: association of traditional and genetic risk factors and new-onset diabetes mellitus following kidney transplantation
    H A Chakkera
    Division of Transplantation Medicine, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85259, Arizona, USA
    Transplant Proc 41:4172-7. 2009
    ..Several genetic polymorphisms have been shown to be associated with T2DM. We hypothesized that transplant recipients who carry risk alleles for T2DM are "tipped over" to develop diabetes mellitus in the posttransplant milieu...
  73. ncbi request reprint Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:231-8. 2001
    ..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population...
  74. pmc Bimodal distribution of RNA expression levels in human skeletal muscle tissue
    Clinton C Mason
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E, Indian School Rd, Phoenix, AZ 85014, USA
    BMC Genomics 12:98. 2011
    ....
  75. doi request reprint ELMO1 variants and susceptibility to diabetic nephropathy in American Indians
    Robert L Hanson
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
    Mol Genet Metab 101:383-90. 2010
    ....
  76. ncbi request reprint The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 112:409-13. 2003
    ..001). These findings are consistent with a role for genetic determinants of inflammation in the development of T2DM in both Native Americans and Caucasians...
  77. ncbi request reprint Changing patterns of type 2 diabetes incidence among Pima Indians
    Meda E Pavkov
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd, Phoenix, AZ 85014 4972, USA
    Diabetes Care 30:1758-63. 2007
    ..We examined trends in the incidence rate of type 2 diabetes among Pima Indians between 1965 and 2003...
  78. ncbi request reprint A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 78:136-44. 2003
    ..However, these findings suggest that variation within the CRP locus may play a role in diabetes susceptibility in Pima Indians...
  79. pmc Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians
    L Bian
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th Street, Suite 210, Phoenix, AZ 85004, USA
    Diabetologia 53:1349-53. 2010
    ..Therefore, ACAD10 was analysed as a positional and biological candidate for type 2 diabetes...
  80. ncbi request reprint Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians
    M Traurig
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabetologia 50:985-9. 2007
    ..In this study, we determined whether SNPs in PTPN1 also have a role in type 2 diabetes susceptibility in Pima Indians, a population with the world's highest reported prevalence and incidence rates of this disease...
  81. ncbi request reprint Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians
    J K Wolford
    Translational Genomics Research Institute, Diabetes Research Unit, Phoenix, AZ 85004, USA
    Diabet Med 23:367-76. 2006
    ..As AKR1B1 is located on 7q35, where we have previously reported linkage to diabetic nephropathy in Pima Indians, this study examined the association of AKR1B1 variants with diabetic nephropathy in this population...
  82. ncbi request reprint Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
    K Walder
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA
    Hum Mol Genet 7:1431-5. 1998
    ..In conclusion, these results suggest a contribution from UCP2 (or UCP3) to variation in metabolic rate in young Pima Indians which may contribute to overall body fat content later in life...
  83. ncbi request reprint Adiponectin and development of type 2 diabetes in the Pima Indian population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
    Lancet 360:57-8. 2002
    ..01) and individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (incidence rate ratio 0.63 [95% CI 0.43-0.92]; p=0.02)...
  84. ncbi request reprint Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians
    Vidya S Farook
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:3342-6. 2002
    ..1 to 2.9. We conclude that these variants in KCNJ10 are unlikely to be the cause of linkage of type 2 diabetes with 1q in Pima Indians...
  85. pmc Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes
    Meda E Pavkov
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:2396-8. 2010
    ..We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes...
  86. ncbi request reprint Early excess weight gain of children in the Pima Indian population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Pediatrics 109:E33. 2002
    ..To determine the period of childhood in which weight relative to height increases in Pima Indian children and young adults in comparison with the general US population...
  87. ncbi request reprint Higher prevalence of type 2 diabetes, metabolic syndrome and cardiovascular diseases in gypsies than in non-gypsies in Slovakia
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N, 16th Street, Rm 5 41, Phoenix, AZ 85016, USA
    Diabetes Res Clin Pract 62:95-103. 2003
    ..Our aim was to determine the prevalence of type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular diseases in Gypsies and non-Gypsies living in the same region of southern Slovakia...
  88. ncbi request reprint Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle
    Leslie J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 53:1181-6. 2004
  89. ncbi request reprint Alcohol consumption predicts hypertension but not diabetes
    Aramesh Saremi
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    J Stud Alcohol 65:184-90. 2004
    ..This study examines the associations between alcohol consumption, Type 2 diabetes and hypertension in a native American population...
  90. ncbi request reprint Progression to type 2 diabetes characterized by moderate then rapid glucose increases
    Clinton C Mason
    Diabetes Epidemiology and Clinical Research Section, National Institutes of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014 4972, USA
    Diabetes 56:2054-61. 2007
    ..We sought to determine whether a general pattern of glucose change exists in most individuals who become diabetic...
  91. ncbi request reprint Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    J C Long
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA jeff
    Am J Med Genet 81:216-21. 1998
    ..8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis...
  92. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
    ..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated...
  93. ncbi request reprint Serum cholesterol and mortality rates in a Native American population with low cholesterol concentrations: a U-shaped association
    A Fagot-Campagna
    National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Ariz 85014, USA
    Circulation 96:1408-15. 1997
    ..The present report evaluates whether low cholesterol is likely to be a causal factor for mortality from all causes or from specific causes...
  94. ncbi request reprint Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women
    A Fagot-Campagna
    National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014, USA
    Atherosclerosis 128:113-9. 1997
    ..8 mmol/1) or impaired (7.8 mmol/l < or = 2-h glucose < 11.1 mmol/l) glucose tolerance at baseline. These results indicate that lipoprotein disorders are an early accompaniment of the abnormalities that lead to NIDDM...
  95. ncbi request reprint Survival during renal replacement therapy for diabetic end-stage renal disease in Pima Indians
    R G Nelson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85014, USA
    Diabetes Care 19:1333-7. 1996
    ..To examine survival in Pima Indians receiving renal replacement therapy for end-stage renal disease attributed to NIDDM...
  96. ncbi request reprint Gamma globulin levels predict type 2 diabetes in the Pima Indian population
    R S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 50:1598-603. 2001
    ..04 [0.90-1.20]; P = 0.6). Thus, gamma globulin levels predict increased risk of diabetes in the Pima population. We suggest that immune function or activation may play a role in the development of type 2 diabetes...
  97. ncbi request reprint Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothers
    R S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 23:1249-54. 2000
    ..We hypothesized that, in light of the historical improvements in the management of diabetes during pregnancy, these late consequences of the early environment might be diminishing with time...
  98. ncbi request reprint Comparison of the effect of plasma glucose concentrations on microvascular disease between Pima Indian youths and adults
    J Krakoff
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Road, Phoenix, AZ 85014, USA
    Diabetes Care 24:1023-8. 2001
    ..To examine whether the current adult guidelines for diagnosis of diabetes are applicable to youth (age <20 years)...
  99. ncbi request reprint The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima Indians
    D E Williams
    Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, Arizona 85014, USA
    Diabetes Care 24:811-6. 2001
    ..We examined the long-term effects of a self-assessed traditional or nontraditional dietary pattern on the development of type 2 diabetes in 165 nondiabetic Pima Indians...
  100. ncbi request reprint The relationship of menstrual irregularity to type 2 diabetes in Pima Indian women
    J Roumain
    Diabetes and Arthritis Epidemiology, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, AZ 85014 USA
    Diabetes Care 21:346-9. 1998
    ..In this population-based study, we determined the relationship of menstrual irregularity to type 2 diabetes in Pima Indian women...
  101. pmc A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85016, USA
    J Clin Invest 106:R69-73. 2000
    ..A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons...