Jack M Guralnik

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Translating research to promote healthy aging: the complementary role of longitudinal studies and clinical trials
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 58:S337-42. 2010
  2. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
  3. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
  4. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
  5. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
  6. pmc The relationship between plasma carotenoids and depressive symptoms in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    World J Biol Psychiatry 13:588-98. 2012
  7. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
  8. pmc Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
    Br J Haematol 145:514-23. 2009
  9. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
  10. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007

Detail Information

Publications63

  1. pmc Translating research to promote healthy aging: the complementary role of longitudinal studies and clinical trials
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 58:S337-42. 2010
    ..Relevant issues are illustrated with examples of unsuccessful and successful trials, with a major emphasis on clinical trials of physical activity in older persons...
  2. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
    ..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts...
  3. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
    ..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation...
  4. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
    ..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin...
  5. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  6. pmc The relationship between plasma carotenoids and depressive symptoms in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    World J Biol Psychiatry 13:588-98. 2012
    ..We examined the cross-sectional and longitudinal relationship between plasma carotenoids and depressive symptoms over a 6-year follow-up in older persons...
  7. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  8. pmc Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
    Br J Haematol 145:514-23. 2009
    ..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans...
  9. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  10. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  11. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  12. ncbi request reprint Frailty, hospitalization, and progression of disability in a cohort of disabled older women
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
    Am J Med 118:1225-31. 2005
    ..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability...
  13. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  14. pmc Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine
    Sandra V Giannelli
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Geriatr Soc 55:816-23. 2007
    ....
  15. pmc Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 64:76-82. 2009
    ..The aim of the present study was to evaluate fatigue and its association with measures of physical function and disability in a representative sample of the older population...
  16. pmc Characteristics of 400-meter walk test performance and subsequent mortality in older adults
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    Rejuvenation Res 12:177-84. 2009
    ..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons...
  17. ncbi request reprint Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Arch Intern Med 165:2222-7. 2005
    ..We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels...
  18. pmc Mediterranean diet and mobility decline in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Exp Gerontol 46:303-8. 2011
    ..High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health...
  19. pmc Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
    Rejuvenation Res 13:3-11. 2010
    ..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength...
  20. ncbi request reprint The origins of age-related proinflammatory state
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
    Blood 105:2294-9. 2005
    ..Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity...
  21. pmc Midlife physical activity and mobility in older age: The InCHIANTI study
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Am J Prev Med 31:217-24. 2006
    ....
  22. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  23. pmc Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti study
    Antonia K Coppin
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Age Ageing 35:619-24. 2006
    ..previous studies have reported an association between cognitive function and physical performance, particularly among older adults...
  24. ncbi request reprint Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  25. pmc Disparities in influenza vaccine coverage in the United States, 2008
    Shauna T Linn
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA
    J Am Geriatr Soc 58:1333-40. 2010
    ..To determine the distribution of influenza vaccine coverage in the United States in 2008...
  26. ncbi request reprint Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  27. ncbi request reprint Incidence of loss of ability to walk 400 meters in a functionally limited older population
    Milan Chang
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 52:2094-8. 2004
    ..To assess the incidence of and factors related to nondisabled but functionally limited older adults aged 75 to 85 years losing the ability to walk 400 m...
  28. pmc Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort
    Kathryn R Martin
    Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20814, USA
    BMC Musculoskelet Disord 14:219. 2013
    ..We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction...
  29. pmc Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Room 3C 309, Bethesda, MD 20892, USA
    Aging Clin Exp Res 21:174-81. 2009
    ..The goal of this study is to investigate the extent to which marital and parental role characteristics are associated with midlife physical function...
  30. pmc Serum 25-hydroxyvitamin D and depressive symptoms in older women and men
    Yuri Milaneschi
    Longitudinal Studies Section, National Institute on Aging, Clinical Research Branch, Harbor Hospital Center, Room NM540, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 95:3225-33. 2010
    ..Hypovitaminosis D and depressive symptoms are common conditions in older adults...
  31. pmc Racial variation in the relationship of anemia with mortality and mobility disability among older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20892, USA
    Blood 109:4663-70. 2007
    ..Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted...
  32. ncbi request reprint Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 96:991-5. 2005
    ..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults...
  33. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  34. ncbi request reprint Childhood socioeconomic status predicts physical functioning a half century later
    Jack M Guralnik
    Laboratory of Epidemiology, Demography aand Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 61:694-701. 2006
    ..Relating childhood socioeconomic environment to midlife functional status provides a life course perspective on childhood factors associated with poor and good health status later in life...
  35. pmc Interleukin-6 in aging and chronic disease: a magnificent pathway
    Marcello Maggio
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:575-84. 2006
    ....
  36. pmc Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial disease
    Mary M McDermott
    Department of Medicine, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 56:724-9. 2008
    ..To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels...
  37. ncbi request reprint Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairments
    Antonia K Coppin
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C 309, Bethesda, MD 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 61:86-91. 2006
    ..The purpose of this study was to determine if SES has an impact on mobility functioning and to explore which physiological impairments are also associated with SES and may explain its relationship with mobility...
  38. ncbi request reprint Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism
    Taina Rantanen
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 51:636-41. 2003
    ....
  39. ncbi request reprint Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging study
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 53:198-203. 2005
    ..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women...
  40. pmc Red blood cell distribution width and the risk of death in middle-aged and older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Ste 3C309, Bethesda, MD 20814, USA
    Arch Intern Med 169:515-23. 2009
    ..In patients with symptomatic cardiovascular disease (CVD), RDW is associated with mortality. However, it has not been demonstrated that RDW is a predictor of mortality independent of nutritional deficiencies or in the general population...
  41. ncbi request reprint Relation of heart rate at rest and mortality in the Women's Health and Aging Study
    Milan Chang
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Cardiol 92:1294-9. 2003
    ..In patients with and without heart disease, further investigation of cardiovascular status may be warranted if their HR is >/=90 beats/min...
  42. pmc Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
    Avner Shahar
    Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA
    Mov Disord 25:1909-15. 2010
    ..Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction...
  43. ncbi request reprint Patterns of functional decline at the end of life
    June R Lunney
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    JAMA 289:2387-92. 2003
    ..Clinicians have observed various patterns of functional decline at the end of life, but few empirical data have tested these patterns in large populations...
  44. pmc Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 57:260-5. 2009
    ..To examine the association between stopping to rest during a 400-m usual-pace walk test (400-MWT) and incident mobility disability in older persons with functional limitations...
  45. ncbi request reprint A flame burning within
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
    Aging Clin Exp Res 16:240-3. 2004
    ..Given that the inflammatory response is a critical age-related process, understanding its regulatory action is essential in avoiding hazardous consequences in old age...
  46. pmc Driving life expectancy of persons aged 70 years and older in the United States
    Daniel J Foley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Public Health 92:1284-9. 2002
    ..We estimated total life expectancy and driving life expectancy of US drivers aged 70 years and older...
  47. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
    ..The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids...
  48. ncbi request reprint Differential effects of premorbid physical and emotional health on recovery from acute events
    Glenn V Ostir
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 50:713-8. 2002
    ..The aim of this study is to determine whether premorbid emotional health is predictive of recovery in functional ability 1 year after reporting a stroke, heart attack, or hip fracture (event)...
  49. pmc Medical and long-term care costs when older persons become more dependent
    Jack M Guralnik
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Public Health 92:1244-5. 2002
  50. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
    ..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease...
  51. ncbi request reprint Assessing the building blocks of function: utilizing measures of functional limitation
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Am J Prev Med 25:112-21. 2003
    ..Functional limitation measures add substantially to our knowledge about older populations, but further work is needed to promote their standardization and use in both clinical and research settings...
  52. pmc Epidemiology of aging
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, MD, USA
    Radiol Clin North Am 46:643-52, v. 2008
    ..We come to this enormous challenge unprepared...
  53. pmc Weight loss and premature death: the 1946 British birth cohort study
    Emiliano Albanese
    Laboratory of Population Science, National Institute on Aging, Bethesda, Maryland, United States of America
    PLoS ONE 9:e86282. 2014
    ..We aimed to study the association between midlife weight change and mortality accounting for health and lifestyle characteristics, and also considering potential bias due to preexisting chronic diseases and smoking status...
  54. ncbi request reprint The frailty syndrome: a critical issue in geriatric oncology
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Crit Rev Oncol Hematol 46:127-37. 2003
    ..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists...
  55. ncbi request reprint Robine and Michel's "Looking forward to a general theory on population aging": population aging across time and cultures: can we move from theory to evidence?
    Jack M Guralnik
    National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    J Gerontol A Biol Sci Med Sci 59:M606-8; author reply M616-20. 2004
  56. ncbi request reprint Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
    Jack M Guralnik
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    Blood 104:2263-8. 2004
    ..The impact of anemia on quality of life, recovery from illness, and functional abilities must be further investigated in older persons...
  57. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  58. pmc Seat belt use among American Indians/Alaska Natives and non-Hispanic whites
    Andrea N Garcia
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    Am J Prev Med 33:200-6. 2007
    ..The purpose of this study was to examine geographic variation and the existence of a seat belt law on seat belt use among AI/AN and non-Hispanic whites (NHW)...
  59. ncbi request reprint Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women's Health and Aging Study
    Stefano Volpato
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Diabetes Care 25:678-83. 2002
    ....
  60. pmc Menopausal characteristics and physical functioning in older adulthood in the National Health and Nutrition Examination Survey III
    Sarah E Tom
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA
    Menopause 19:283-9. 2012
    ..We hypothesized that natural menopause would be related to better physical functioning compared with surgical menopause and that later age at menopause would be related to better physical functioning...
  61. ncbi request reprint Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study
    Stefano Volpato
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 26:70-5. 2003
    ..We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes...
  62. ncbi request reprint Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life
    David Melzer
    Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:60-6. 2003
    ..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life...
  63. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...