Amrie C Grammer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus
    Amrie C Grammer
    National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 6D47A, Bethesda, MD 20892, USA
    Arthritis Rheum 46:1417-29. 2002
  2. ncbi request reprint TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation
    Liusheng He
    Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    J Biol Chem 279:55855-65. 2004
  3. pmc Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals
    Amrie C Grammer
    B Cell Biology Group in the National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arthritis Res Ther 6:28-38. 2004
  4. pmc Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    Amrie C Grammer
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:1506-20. 2003
  5. pmc B cell abnormalities in systemic lupus erythematosus
    Amrie C Grammer
    Autoimmunity Branch of the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 5:S22-7. 2003
  6. pmc Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
    Nancy S Longo
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
    Blood 113:3706-15. 2009
  7. pmc Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus
    Patricia L Lugar
    National Institutes of Health, Autoimmunity Branch, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44362. 2012
  8. ncbi request reprint IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:2872-82. 2007
  9. pmc Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells
    Jacob M van Laar
    B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Pathol 171:917-27. 2007
  10. pmc T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue
    David R Withers
    B Cell Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 109:4856-64. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus
    Amrie C Grammer
    National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 6D47A, Bethesda, MD 20892, USA
    Arthritis Rheum 46:1417-29. 2002
  2. ncbi request reprint TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation
    Liusheng He
    Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    J Biol Chem 279:55855-65. 2004
    ..Together, these results reveal a novel association between TRAF2 and TRAF3 that is mediated by unique portions of each protein and that specifically regulates activation of NF-kappaB, but not AP-1...
  3. pmc Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals
    Amrie C Grammer
    B Cell Biology Group in the National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arthritis Res Ther 6:28-38. 2004
    ....
  4. pmc Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    Amrie C Grammer
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:1506-20. 2003
    ....
  5. pmc B cell abnormalities in systemic lupus erythematosus
    Amrie C Grammer
    Autoimmunity Branch of the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 5:S22-7. 2003
    ....
  6. pmc Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
    Nancy S Longo
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
    Blood 113:3706-15. 2009
    ....
  7. pmc Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus
    Patricia L Lugar
    National Institutes of Health, Autoimmunity Branch, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44362. 2012
    ..These data indicate that SLE PC are a unique population of Ig secreting cells with a gene expression profile indicative of a mature, but not fully differentiated phenotype...
  8. ncbi request reprint IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:2872-82. 2007
    ....
  9. pmc Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells
    Jacob M van Laar
    B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Pathol 171:917-27. 2007
    ..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion...
  10. pmc T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue
    David R Withers
    B Cell Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 109:4856-64. 2007
    ..In addition, an important role for contact-dependent interactions with T cells in human plasma cell survival within secondary lymphoid tissue was identified...
  11. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  12. ncbi request reprint Flow cytometric measurement of fluorescence (Förster) resonance energy transfer from cyan fluorescent protein to yellow fluorescent protein using single-laser excitation at 458 nm
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 9N228, Bethesda, MD 20892, USA
    Cytometry A 53:39-54. 2003
    ....
  13. ncbi request reprint Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus
    Hermann J Girschick
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arthritis Rheum 46:1255-63. 2002
    ....
  14. ncbi request reprint Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms
    Akif S Yavuz
    Department of Internal Medicine and Harold C Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, 20892, USA
    Mol Immunol 39:485-93. 2002
    ..Moreover, a comparable mutational frequency of p53 was noted in tonsillar B and T cells. Hence, mutations in p53 do not appear to be the result of the B-cell hypermutational mechanism...
  15. ncbi request reprint The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases
    Marlyn J Mayo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9151, USA
    Liver Int 26:187-96. 2006
    ..CD154 is a member of the tumor necrosis factor superfamily, which is primarily expressed by activated T cells...
  16. pmc The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
    George A Lemieux
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, California 94143, USA
    J Biol Chem 282:14836-44. 2007
    ..ADAM10 contributes to CD23 shedding and thus could be considered a potential therapeutic target for the treatment of allergic disease...