David S Goldstein

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Sympathoadrenal imbalance before neurocardiogenic syncope
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Am J Cardiol 91:53-8. 2003
  2. ncbi request reprint Dysautonomia in Parkinson's disease: neurocardiological abnormalities
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Lancet Neurol 2:669-76. 2003
  3. pmc Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivity
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:1479-82. 2009
  4. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
  5. ncbi request reprint Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
  6. pmc Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observations
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Auton Neurosci 146:18-21. 2009
  7. ncbi request reprint Neurocirculatory abnormalities in chronic orthostatic intolerance
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Circulation 111:839-45. 2005
  8. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
  9. pmc Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Clin Pharmacol 51:66-74. 2011
  10. pmc Neonatal diagnosis and treatment of Menkes disease
    Stephen G Kaler
    Unit on Pediatric Genetics, Program in Molecular Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Rm 5 2571, 10 Center Dr, MSC 1832, Bethesda, MD 20892 1832
    N Engl J Med 358:605-14. 2008

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Sympathoadrenal imbalance before neurocardiogenic syncope
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Am J Cardiol 91:53-8. 2003
    ..Sympathoadrenal imbalance may contribute to hemodynamic derangements precipitating neurocardiogenic syncope...
  2. ncbi request reprint Dysautonomia in Parkinson's disease: neurocardiological abnormalities
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Lancet Neurol 2:669-76. 2003
    ....
  3. pmc Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivity
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:1479-82. 2009
    ..Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake...
  4. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
    ..In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH...
  5. ncbi request reprint Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
    ..We therefore examined sympathoadrenal function in patients with pseudopheochromocytoma compared with age-matched control subjects in whom there was no suspicion of pheochromocytoma...
  6. pmc Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observations
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Auton Neurosci 146:18-21. 2009
    ..PAF entails cardiac sympathetic denervation, whereas cardiac sympathetic neuroimaging by thoracic 6-[(18)F]fluorodopamine scanning indicates intact myocardial sympathetic innervation in AAG...
  7. ncbi request reprint Neurocirculatory abnormalities in chronic orthostatic intolerance
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Circulation 111:839-45. 2005
    ..This study addressed whether patients with COI and POTS or NCS have neurocirculatory abnormalities during supine rest...
  8. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
    ..We studied the impact of such denervation on cardiac chronotropic and inotropic function...
  9. pmc Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Clin Pharmacol 51:66-74. 2011
    ....
  10. pmc Neonatal diagnosis and treatment of Menkes disease
    Stephen G Kaler
    Unit on Pediatric Genetics, Program in Molecular Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Rm 5 2571, 10 Center Dr, MSC 1832, Bethesda, MD 20892 1832
    N Engl J Med 358:605-14. 2008
    ....
  11. ncbi request reprint Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, USA
    Circulation 106:2358-65. 2002
    ..Whether these conditions involve abnormal cardiac sympathetic innervation or function has been unclear...
  12. pmc Cardiac sympathetic hypo-innervation in familial dysautonomia
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 6N252, Bethesda, MD 20892 1620, USA
    Clin Auton Res 18:115-9. 2008
    ..Whether such loss extends to sympathetic innervation of the heart has been unknown. This study used 6-[(18)F]fluorodopamine neuroimaging to assess cardiac sympathetic innervation and function in FD...
  13. ncbi request reprint Diagnosis and localization of pheochromocytoma
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 43:907-10. 2004
    ..It also confirms that functional imaging by 6-[18F]fluorodopamine or 123I-metaiodobenzylguanidine scanning can localize pheochromocytoma in difficult cases in which other imaging tests are not diagnostic...
  14. ncbi request reprint Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 46:1333-9. 2005
    ..Parkinson disease with orthostatic hypotension features reflexive cardiovagal and sympathoneural failure and cardiac and partial extracardiac sympathetic denervation, independent of levodopa treatment...
  15. pmc Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 14:600-7. 2008
    ..This study compared neuroimaging, neurochemical, and olfactory potential biomarkers to detect central dopamine (DA) deficiency and distinguish PD from multiple system atrophy (MSA)...
  16. ncbi request reprint Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Neuropharmacol 29:97-105. 2006
    ....
  17. ncbi request reprint Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome
    Susannah Cleary
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Endocrinol 193:225-33. 2007
    ....
  18. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  19. pmc Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:57-61. 2012
    ..In this case, neuroimaging evidence of cardiac noradrenergic denervation and subsequent progressive striatal dopaminergic denervation fit with Braak staging...
  20. ncbi request reprint Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma
    Basil A Eldadah
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Hypertension 43:1227-32. 2004
    ..The results call for caution in drawing quantitative conclusions about uptake-1 in the setting of high circulating concentrations of endogenous norepinephrine...
  21. ncbi request reprint Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning
    Sheng Ting Li
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 44:1599-603. 2003
    ..This study examined the effects of normal human aging on cardiac sympathetic innervation and function, including the neuronal uptake of catecholamines (uptake 1) via the cell membrane norepinephrine transporter...
  22. ncbi request reprint Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:735-44. 2005
    ..Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors...
  23. ncbi request reprint Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003
    ..The finding of lower plasma NE levels in patients with than without supine hypertension suggests involvement of pressor mechanisms independent of the sympathetic nervous system...
  24. pmc Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervation
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1148:486-9. 2008
    ..05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release...
  25. pmc Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disordersand Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Brain 135:1900-13. 2012
    ..Parkinson's disease and pure autonomic failure involve differential dopaminergic versus noradrenergic lesions. Cerebrospinal fluid dihydroxyphenylacetic acid seems to provide a sensitive means to identify even early Parkinson's disease...
  26. ncbi request reprint Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication
    Amanda Singleton
    Parkinson s Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Brain 127:768-72. 2004
    ..These results indicate that both parkinsonism and cardiac sympathetic denervation can result from an excess of normal synuclein...
  27. pmc Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 1620, USA
    J Clin Invest 121:3320-30. 2011
    ..Vesicular uptake may constitute a novel target for diagnosis, treatment, and prevention...
  28. pmc Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Faisal Rahman
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Clin Auton Res 21:133-41. 2011
    ..In this study we attempted to replicate our findings in additional subject cohorts, taking into account possible influences of respiration and using different methods to measure baroreflex-cardiovagal gain (BCG)...
  29. pmc Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Exp Physiol 96:1255-61. 2011
    ..Manipulations and drugs that change LF power or LF:HF may do so not by affecting cardiac autonomic outflows directly but by affecting modulation of those outflows by baroreflexes...
  30. pmc ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease mouse model
    Anthony Donsante
    Unit on Human Copper Metabolism, Molecular Medicine Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1853, USA
    Mol Ther 19:2114-23. 2011
    ..Our findings provide the first definitive evidence that gene therapy may have clinical utility in the treatment of Menkes disease...
  31. pmc Relative efficiencies of plasma catechol levels and ratios for neonatal diagnosis of menkes disease
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Neurochem Res 34:1464-8. 2009
    ..The relative diagnostic efficiencies of levels of catechol analytes, alone or in combination, in neonates at genetic risk of Menkes disease have been unknown...
  32. ncbi request reprint Clinical catecholamine neurochemistry: a legacy of Julius Axelrod
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Cell Mol Neurobiol 26:695-702. 2006
    ..2. Here, we provide examples of this aspect of Axelrod's scientific legacy...
  33. ncbi request reprint Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2
    Thanh Truc Huynh
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Ann N Y Acad Sci 1073:241-52. 2006
    ..Microarray analysis, however, did indicate differences in expression of genes involved in neural crest cell lineage and chromaffin cell development, consistent with differential survival of PNMT-expressing cells in the two syndromes...
  34. pmc Neuronal source of plasma dopamine
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 54:1864-71. 2008
    ..We tested in humans whether DA enters the plasma after corelease with NE during exocytosis from sympathetic noradrenergic nerves...
  35. doi request reprint Central dopamine deficiency in pure autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 18:58-65. 2008
    ..A patient with PAF and another with PD had rapid postmortem striatal, nigral, and sympathetic ganglion sampling, with assays of catechols and tyrosine hydroxylase activity...
  36. pmc Neuroscience and heart-brain medicine: the year in review
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892 1620, USA
    Cleve Clin J Med 77:S34-9. 2010
    ..Lack of correlation between commonly used indices from power spectral analysis of heart rate variability and cardiac norepinephrine spillover casts doubt on the validity of power spectral analysis to indicate cardiac sympathetic tone...
  37. pmc Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    J Neurochem 126:591-603. 2013
    ..Elevated DOPAL levels in PD putamen reflect a combination of decreased vesicular uptake of cytosolic DA and decreased DOPAL detoxification by ALDH...
  38. pmc Temporary elimination of orthostatic hypotension by norepinephrine infusion
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:303-6. 2012
    ..v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH...
  39. ncbi request reprint Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, U S A
    Clin Sci (Lond) 104:649-54. 2003
    ..41+/-1.77 nmol/l respectively; P =0.006). The findings are consistent with central noradrenergic deficiency in both MSA+OH and PAF. In MSA, central noradrenergic deficiency seems to relate specifically to OH...
  40. doi request reprint Cardiac ectopy in chronic autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD 20892 1620, USA
    Clin Auton Res 20:85-92. 2010
    ..This study assessed whether CAF is associated with an increased prevalence of cardiac ectopy...
  41. ncbi request reprint Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysis
    Simon Bruce
    NINDS, NIH, Bethesda, Maryland 20892 1620, USA
    Clin Auton Res 12:13-9. 2002
    ..This study examined the validity of microdialysis and measurements of microdialysate concentrations of catechols, to assess local sympathetic function in skeletal muscle and adipose tissue in humans...
  42. pmc In utero copper treatment for Menkes disease associated with a severe ATP7A mutation
    Marie Reine Haddad
    Unit on Human Copper Metabolism, Molecular Medicine Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1853, USA
    Mol Genet Metab 107:222-8. 2012
    ....
  43. doi request reprint Autonomic dysfunction in PD: a window to early detection?
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Neurol Sci 310:118-22. 2011
    ..In elderly patients with unexplained OH or other evidence of autonomic failure, it is reasonable for clinicians to look for subtle signs of parkinsonism, such as masked facies, cogwheel rigidity, and shuffling gate...
  44. pmc Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 15:516-20. 2009
    ....
  45. pmc Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Clin Auton Res 19:259-62. 2009
    ....
  46. ncbi request reprint Sources and significance of plasma levels of catechols and their metabolites in humans
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620
    J Pharmacol Exp Ther 305:800-11. 2003
    ..This article provides an update about plasma levels of catechols and their metabolites and the relevance of those levels to some issues in human health and disease...
  47. ncbi request reprint Orthostatic hypotension as an early finding in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892, USA
    Clin Auton Res 16:46-54. 2006
    ..In PD, OH can occur early in the disease, occasionally preceding or overshadowing the movement disorder...
  48. ncbi request reprint Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure
    Dnyanesh N Tipre
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 46:1775-81. 2005
    ..In this study, we examined whether 6-(18)F-fluorodopamine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation...
  49. ncbi request reprint Evolution of concepts of stress
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Stress 10:109-20. 2007
    ..This systems concept of stress yields predictions that observation or experimentation can test and that are applicable to normal physiology and to a variety of acute and chronic disorders...
  50. pmc Plasma catechols in familial dysautonomia: a long-term follow-up study
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10 Room 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Neurochem Res 33:1889-93. 2008
    ..In FD, plasma catechol profiles are sufficiently stable, at least over a decade, to be used as a biomarker of disease involvement. An increasing DOPA:DHPG ratio suggests slight but consistent, progressive loss of noradrenergic neurons...
  51. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  52. ncbi request reprint Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine
    Graeme Eisenhofer
    Clinical Neurocardiology Section, Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, Maryland 20892 1620, USA
    J Clin Endocrinol Metab 90:2068-75. 2005
    ....
  53. ncbi request reprint Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 14:363-8. 2004
    ....
  54. pmc Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2
    Thanh Truc Huynh
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 153:551-63. 2005
    ....
  55. ncbi request reprint Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor
    David S Goldstein
    Building 10, Room 6N252, Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Clin Auton Res 12:281-5. 2002
    ..The findings in this case support the concept that circulating antibodies to this receptor can interfere with ganglionic neurotransmission and produce autoimmune autonomic neuropathy...
  56. pmc Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA
    J Neurochem 123:932-43. 2012
    ....
  57. pmc Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Neurol Sci 310:123-8. 2011
    ..Future research is needed to understand better and attenuate blood pressure fluctuations through manipulations that improve baroreflex function...
  58. ncbi request reprint Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Endocr Regul 42:111-9. 2008
    ..Here we report results of a meta-analysis of the literature, examining inter-relationships among AHS, HPA, and SNS responses to stressors, as measured by plasma epinephrine (EPI), corticotrophin (ACTH), and norepinephrine (NE) levels...
  59. ncbi request reprint Baroreflex failure as a late sequela of neck irradiation
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:110-6. 2003
    ..Splinting of carotid sinus mechanoreceptors in rigidified arterial walls would impede detection of alterations in blood pressure and thereby disrupt baroreflex regulation of cardiovagal and sympathetic outflows...
  60. pmc Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 17:118-21. 2007
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  61. pmc Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde
    Courtney Holmes
    Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Chem 56:832-8. 2010
    ....
  62. doi request reprint Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC 1620, Building 10, Room 6N252, Bethesda, MD 20892 1620, USA
    Cleve Clin J Med 76:S47-50. 2009
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  63. ncbi request reprint Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:2656-66. 2003
    ..Patterns of biochemical test results and responses of plasma normetanephrine to clonidine can then help distinguish true- from false-positive results...
  64. ncbi request reprint Failure of propranolol to prevent tilt-evoked systemic vasodilatation, adrenaline release and neurocardiogenic syncope
    Basil A Eldadah
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Sci (Lond) 111:209-16. 2006
    ..In this small, but tightly controlled, study, propranolol did not prevent tilt-induced vasodilatation, syncope or elevated plasma adrenaline...
  65. ncbi request reprint Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:170-6. 2002
    ..In this report we provide an update regarding nuclear imaging of primary and metastatic pheochromocytoma, particularly using 6-[(18)F]fluorodopamine positron emission tomographic scanning...
  66. ncbi request reprint Pheochromocytoma: rediscovery as a catecholamine-metabolizing tumor
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Endocr Pathol 14:193-212. 2003
    ..This review provides an update on the diagnosis of pheochromocytoma, with emphasis on identifying and correcting relevant misconceptions about catecholamine metabolism...
  67. pmc Computer models of stress, allostasis, and acute and chronic diseases
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Ann N Y Acad Sci 1148:223-31. 2008
    ..These models can be used to predict effects of environmental and genetic alterations on allostatic load and therefore on the development of multisystem disorders and failures...
  68. pmc Association of anosmia with autonomic failure in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD 20892 1620, USA
    Neurology 74:245-51. 2010
    ..This observational study assessed whether in PD anosmia and autonomic failure are related to each other or to neuroimaging evidence of striatal dopamine deficiency...
  69. ncbi request reprint Dysautonomias: clinical disorders of the autonomic nervous system
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Ann Intern Med 137:753-63. 2002
    ..Dysautonomias are an important subject in clinical neurocardiology...
  70. ncbi request reprint Progressive loss of cardiac sympathetic innervation in Parkinson's disease
    Sheng Ting Li
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Ann Neurol 52:220-3. 2002
    ..In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism...
  71. ncbi request reprint Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Pharmacol Exp Ther 306:855-60. 2003
    ....
  72. pmc Dopamine contamination of infused tyramine
    Courtney Holmes
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:1733-5. 2005
  73. ncbi request reprint Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene
    Olga A Tjurmina
    Laboratory of Clinical Science, National Institute of Mental Health, and Clinical Neurocardiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:4520-6. 2002
    ..Exaggerated adrenomedullary responses seem to be an autonomic correlate of the anxiety-like behaviors in 5-HTT knockout mice...
  74. ncbi request reprint Prevalence of anti-locus coeruleus immunoreactivity in CSF of patients with autonomic failure
    Richard Imrich
    Clinical Neurocardiology Section, NINDS NIH, Building 10, Room 6N252, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Auton Res 16:401-5. 2006
    ..The results failed to confirm the previously reported high prevalence of immune binding to rat LC in CSF from patients with MSA...
  75. ncbi request reprint Leaky catecholamine stores: undue waste or a stress response coping mechanism?
    Graeme Eisenhofer
    Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Ann N Y Acad Sci 1018:224-30. 2004
    ....
  76. pmc Catecholamines 101
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, 9000 Rockville Pike, Bldg 10 Rm 5N220, Bethesda, MD 20892, USA
    Clin Auton Res 20:331-52. 2010
    ....
  77. pmc Adrenal responses to stress
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N220, 9000 Rockville Pike, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Cell Mol Neurobiol 30:1433-40. 2010
    ..Instead, adrenomedullary responses to stressors are more closely tied to adrenocortical than to sympathetic noradrenergic responses. Distress involves concurrent activation of the HPA and adrenomedullary neuroendocrine systems...
  78. ncbi request reprint Catecholamine metabolism: a contemporary view with implications for physiology and medicine
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, MSC 1620, Bethesda, MD 20892 1620, USA
    Pharmacol Rev 56:331-49. 2004
    ....
  79. ncbi request reprint Painful sweating
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurologic Disorders and Stroke, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Neurology 63:1471-5. 2004
    ..The authors report a case of spontaneous and gustatory facial pain and sweating...
  80. ncbi request reprint Kinetic model for the fate of 6-[18F]fluorodopamine in the human heart: a novel means to examine cardiac sympathetic neuronal function
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Naunyn Schmiedebergs Arch Pharmacol 365:38-49. 2002
    ..The model seems useful in predicting effects of altered cardiac sympathetic function on time-activity curves for myocardial 6-[18F]fluorodopamine-derived radioactivity in humans...
  81. ncbi request reprint Imaging of the autonomic nervous system: focus on cardiac sympathetic innervation
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Semin Neurol 23:423-33. 2003
    ..As new ligands are developed, one may predict further discoveries of involvement of components of the autonomic nervous system in neurological diseases...
  82. pmc Pioneer Award Address: ignorance isn't biased: comments on receiving the Pioneer Award
    David S Goldstein
    Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Cleve Clin J Med 76:S31-6. 2009
    ..Patient-oriented research is a strength of heart-brain medicine. Patients are a unique scientific resource because they tell us the truth. We experience the joy and thrill of a "sparkle of insight" when we realize what they teach...
  83. ncbi request reprint Catecholamines and stress
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Endocr Regul 37:69-80. 2003
  84. pmc Cardiac sympathetic neuroimaging: summary of the First International Symposium
    David S Goldstein
    Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Bethesda, MA 20892 1620, USA
    Clin Auton Res 19:137-48. 2009
    ..Here, we review the background for the Symposium, provide an annotated summary of the lectures and posters, discuss some of the take-home points from the roundtable discussion, and propose a plan of action for the future...
  85. pmc Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA
    Heart Rhythm 4:1523-9. 2007
    ..Alternatively, LF power might reflect baroreflexive modulation of autonomic outflows...
  86. ncbi request reprint Allostasis, homeostats, and the nature of stress
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Stress 5:55-8. 2002
    ..Applying these notions can aid in understanding how acute and chronic stress can exert adverse health consequences via allostatic load...
  87. ncbi request reprint Partial cardiac sympathetic denervation after bilateral thoracic sympathectomy in humans
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA moakj ninds nih gov
    Heart Rhythm 2:602-9. 2005
    ..Sympathetic nerve fibers emanating from thoracic ganglia innervate the heart. Whether unilateral or bilateral upper thoracic sympathectomy affects cardiac sympathetic innervation in humans in vivo has been unclear...
  88. ncbi request reprint Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
    ..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
  89. ncbi request reprint L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
    Cardiovasc Drug Rev 24:189-203. 2006
    ..L-DOPS holds promise for treating other much more common conditions involving decreased DBH activity or NE deficiency, such as a variety of syndromes associated with neurogenic orthostatic hypotension...
  90. ncbi request reprint Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
    ..In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture...
  91. ncbi request reprint Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Charité Campus Buch and Helio Klinikum, Berlin, Germany
    Clin Pharmacol Ther 76:480-9. 2004
    ..St John's wort (Hypericum perforatum) is a popular over-the-counter antidepressant. Its antidepressive effect has been attributed in part to inhibition of monoamine transporters and monoamine oxidase, on the basis of in vitro studies...
  92. pmc Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral corr
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, West Roxbury, MA 02132, USA
    Hum Gene Ther 15:1177-96. 2004
    ....
  93. ncbi request reprint Case 27-2004: multiple-system atrophy
    David S Goldstein
    N Engl J Med 351:2881-3; author reply 2881-3. 2004
  94. ncbi request reprint Increased myocardial perfusion and sympathoadrenal activation during mild core hypothermia in awake humans
    Steven M Frank
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Sci (Lond) 104:503-8. 2003
    ..In conclusion, core hypothermia triggers beta-adrenoceptor-mediated increased cardiac work, sympathoadrenal activation and increased myocardial perfusion. There is no evidence for hypothermia-induced coronary vasoconstriction...
  95. pmc Genotype and vascular phenotype linked by catecholamine systems
    David S Goldstein
    Circulation 117:458-61. 2008
  96. ncbi request reprint Threshold for adrenomedullary activation and increased cardiac work during mild core hypothermia
    Steven M Frank
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Carnegie 280, 600 N Wolfe Street, Baltimore, MD 21287, U S A
    Clin Sci (Lond) 102:119-25. 2002
    ..Mild core hypothermia therefore constitutes a catecholamine-mediated cardiovascular "stress test"...
  97. ncbi request reprint Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:369-75. 2004
    ..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function...
  98. ncbi request reprint Local sympathetic denervation in painful diabetic neuropathy
    Cees J Tack
    Division of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Diabetes 51:3545-53. 2002
    ..The results provide neurochemical and neuroimaging evidence for regionally selective sympathetic denervation in the painful feet of patients with diabetic neuropathy...
  99. ncbi request reprint Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure
    Jill M Wecht
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Physiol Heart Circ Physiol 294:H190-7. 2008
    ....
  100. ncbi request reprint Functional neuroimaging of sympathetic innervation of the heart
    David S Goldstein
    Building 10, Room 6N252, NINDS, NIH, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Ann N Y Acad Sci 1018:231-43. 2004
    ..Analogous abnormalities might help explain increased cardiovascular risk in psychiatric disorders such as melancholic depression...
  101. ncbi request reprint Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia
    Alfredo Gamboa
    Clinical Pharmacology, Vanderbilt University Medical Center, 1161 21st Avenue South, Suite AA3228, Nashville, TN 37232, USA
    Clin Auton Res 16:40-5. 2006
    ..05); red cell volume was higher in HA only in the CMS group. The results indicate sympathetic nervous stimulation by chronic ambient hypoxia at altitude in Andean natives, independent of maladaptation to their native environment...