N A Giese

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury
    J C Yu
    COR Therapeutics, Inc, South San Francisco, California 94080, USA
    J Pharmacol Exp Ther 298:1172-8. 2001
  2. pmc Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Exp Med 186:1535-46. 1997
  3. pmc Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
    L Gabriele
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0760, USA
    J Exp Med 190:411-21. 1999
  4. pmc Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Immunology 87:467-74. 1996
  5. pmc STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:7093-5. 1999
  6. ncbi request reprint Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse
    R A Morawetz
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Braz J Med Biol Res 31:61-7. 1998
  7. pmc Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5819-24. 1994
  8. pmc Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
  9. ncbi request reprint Resistance to murine acquired immunodeficiency syndrome (MAIDS)
    R A Morawetz
    Science 265:264-6; author reply 267. 1994
  10. ncbi request reprint PDGF-D, a new protease-activated growth factor
    W J LaRochelle
    CuraGen Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511, USA
    Nat Cell Biol 3:517-21. 2001

Collaborators

  • H C Morse
  • D M Klinman
  • J K Actor
  • Janet W Hartley
  • Mo Yang
  • R T Gazzinelli
  • I Esposito
  • A Kolb
  • L Gabriele
  • R A Morawetz
  • J C Yu
  • W J LaRochelle
  • N A Lokker
  • K Ozato
  • H Adwan
  • M W Buchler
  • A Guweidhi
  • H Friess
  • M R Berger
  • J Kleeff
  • T Giese
  • S Ide
  • R A Shimkets
  • J Shimkets
  • M Apatira
  • E Tsukuda
  • K Matsuno
  • A Betz
  • J Li
  • R A Chillakuru
  • M Jeffers
  • S Hollenbach
  • C E Burgess
  • B Rittman
  • S Oda
  • Y Nomoto
  • E Fernandes
  • F L Boldog
  • L L Deegler
  • C Vernet
  • D Sedlock
  • H S Lichenstein
  • C Sullivan
  • W F McDonald
  • J M Rothberg
  • D Segal
  • J Fukumoto
  • I M Wang
  • J Phung
  • P Giannakakou
  • I Horak
  • M Connors
  • P Rothman
  • A B Kulkarni
  • K Rajewsky
  • C Y Firestone
  • R Kuhn
  • R Coffman
  • B R Murphy
  • W Muller
  • T M Doherty

Detail Information

Publications11

  1. ncbi request reprint Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury
    J C Yu
    COR Therapeutics, Inc, South San Francisco, California 94080, USA
    J Pharmacol Exp Ther 298:1172-8. 2001
    ..Therefore, PDGFR antagonism by CT52923 could be a viable strategy for the prevention of clinical restenosis or the treatment of other human diseases involving PDGFR signaling...
  2. pmc Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Exp Med 186:1535-46. 1997
    ..This indicates that ICSBP is a deciding factor in Th responses governing humoral and cellular immunity through its role in regulating IL-12 expression...
  3. pmc Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
    L Gabriele
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0760, USA
    J Exp Med 190:411-21. 1999
    ..These data suggest that ICSBP modulates survival of myeloid cells by regulating expression of apoptosis-related genes...
  4. pmc Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Immunology 87:467-74. 1996
    ..These studies suggest that continuing low-level expression of IFN-gamma, stimulated by IL-12 and TNF-alpha, contributes to the susceptibility of B6 mice to MAIDS but is not required for the resistance of BALB/c mice to disease...
  5. pmc STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:7093-5. 1999
    ..In addition, serum IgE levels were indistinguishable in mice of either genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation...
  6. ncbi request reprint Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse
    R A Morawetz
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Braz J Med Biol Res 31:61-7. 1998
    ..ICSBP is thus an important determinant of hematopoietic growth and differentiation as well as a prominent signaling molecule for IFNs...
  7. pmc Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5819-24. 1994
    ..These results indicate that induction of MAIDS by BM5def is antigen driven and is dependent on expression of major histocompatibility complex class II molecules on antigen-presenting cells and the presence of CD4+ T cells...
  8. pmc Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
    ..It is possible that this process played a role in enhanced disease observed in infants and children immunized with FI-RSV...
  9. ncbi request reprint Resistance to murine acquired immunodeficiency syndrome (MAIDS)
    R A Morawetz
    Science 265:264-6; author reply 267. 1994
  10. ncbi request reprint PDGF-D, a new protease-activated growth factor
    W J LaRochelle
    CuraGen Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511, USA
    Nat Cell Biol 3:517-21. 2001
    ..However, in cells expressing both PDGFRs, PDGF-D activates both receptors. This indicates that PDGFR-alpha activation may result from PDGFR-alpha/beta heterodimerization...
  11. ncbi request reprint Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions
    A Kolb
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Biol Ther 4:740-6. 2005
    ..Our results do suggest, however, that blockade of OPN might be useful as a therapeutic approach to inhibit invasion and metastasis of pancreatic cancer cells...