Shahinaz M Gadalla

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Effect of Recipient Age and Stem Cell Source on the Association between Donor Telomere Length and Survival after Allogeneic Unrelated Hematopoietic Cell Transplantation for Severe Aplastic Anemia
    Shahinaz M Gadalla
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Electronic address
    Biol Blood Marrow Transplant 22:2276-2282. 2016
  2. doi request reprint Telomere biology in hematopoiesis and stem cell transplantation
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Blood Rev 25:261-9. 2011
  3. pmc The relationship between DNA methylation and telomere length in dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging Cell 11:24-8. 2012
  4. pmc Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia
    Shahinaz M Gadalla
    Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland
    JAMA 313:594-602. 2015
  5. pmc Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetic Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Biol Blood Marrow Transplant 19:1238-43. 2013
  6. pmc National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Subsequent Neoplasms Working Group Report
    Lindsay M Morton
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Blood Marrow Transplant 23:367-378. 2017
  7. doi request reprint Diabetes, Abnormal Glucose, Dyslipidemia, Hypertension and Risk of Inflammatory and Other Breast Cancer
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute
    Cancer Epidemiol Biomarkers Prev . 2017
  8. pmc Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 10:e0133382. 2015
  9. doi request reprint Telomeres in molecular epidemiology studies
    Clara Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prog Mol Biol Transl Sci 125:113-31. 2014
  10. pmc Quantifying cancer absolute risk and cancer mortality in the presence of competing events after a myotonic dystrophy diagnosis
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e79851. 2013

Detail Information

Publications12

  1. pmc Effect of Recipient Age and Stem Cell Source on the Association between Donor Telomere Length and Survival after Allogeneic Unrelated Hematopoietic Cell Transplantation for Severe Aplastic Anemia
    Shahinaz M Gadalla
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Electronic address
    Biol Blood Marrow Transplant 22:2276-2282. 2016
    ..A larger study is needed to account for multiple comparisons and to further test the generalizability of our findings...
  2. doi request reprint Telomere biology in hematopoiesis and stem cell transplantation
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Blood Rev 25:261-9. 2011
    ..g., cord blood). Telomere attrition may play a role in, or be a marker of, long term outcome after HSCT, but these data are limited. In this review, we discuss telomere biology in normal and abnormal hematopoiesis, including HSCT...
  3. pmc The relationship between DNA methylation and telomere length in dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging Cell 11:24-8. 2012
    ..17), subtelomeric (r = -0.20) were present in unaffected relatives. This study suggests an interaction between TL and both subtelomeric and LINE-1 methylation, which may be altered based on mutation status of telomere biology genes...
  4. pmc Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia
    Shahinaz M Gadalla
    Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland
    JAMA 313:594-602. 2015
    ..Telomeres protect chromosome ends and are markers of cellular aging and replicative capacity...
  5. pmc Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetic Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Biol Blood Marrow Transplant 19:1238-43. 2013
    ..Late mortality was attributed mainly to pulmonary complications and likely related to the underlying disease. ..
  6. pmc National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Subsequent Neoplasms Working Group Report
    Lindsay M Morton
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Blood Marrow Transplant 23:367-378. 2017
    ....
  7. doi request reprint Diabetes, Abnormal Glucose, Dyslipidemia, Hypertension and Risk of Inflammatory and Other Breast Cancer
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute
    Cancer Epidemiol Biomarkers Prev . 2017
    ....
  8. pmc Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 10:e0133382. 2015
    ..03), and alachlor with longer RTL (p=0.03). Our findings suggest that leukocyte TL may be impacted by cumulative use and recent use of certain pesticides...
  9. doi request reprint Telomeres in molecular epidemiology studies
    Clara Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prog Mol Biol Transl Sci 125:113-31. 2014
    ..This chapter provides an overview of the current telomere epidemiology research and discusses approaches taken in these investigations. We also highlight important methodological considerations that may affect data interpretation. ..
  10. pmc Quantifying cancer absolute risk and cancer mortality in the presence of competing events after a myotonic dystrophy diagnosis
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e79851. 2013
    ..It is important to apply population-appropriate, validated cancer screening strategies in DM patients. ..
  11. pmc LINE-1 methylation is inherited in familial testicular cancer kindreds
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    BMC Med Genet 11:77. 2010
    ..Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck...
  12. pmc Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging (Albany NY) 2:867-74. 2010
    ..66, p=0.002), blood and buccal cells (r=0.74, p<0.0001), and fibroblast and buccal cells (r=0.65, p=0.004). These data suggest that relative TL is tissue-independent in DC and possibly in the other IBMFS...