Affiliation: National Institutes of Health
- Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assayWindy A Boyd
Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
PLoS ONE 2:e1259. 2007..elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative...
- Global transcriptome and deletome profiles of yeast exposed to transition metalsYong Hwan Jin
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, United States of America
PLoS Genet 4:e1000053. 2008....
- Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans developmentWindy A Boyd
Biomoleclular Screening Branch, National Toxicology Program, Research Triangle Park, North Carolina, USA
PLoS ONE 4:e7024. 2009..Chlorpyrifos, an organophosphate pesticide known to cause developmental delays and malformations in mammals, was used as a model toxicant to test the applicability of the growth model for in vivo toxicological testing...
- A discrete time model for the analysis of medium-throughput C. elegans growth dataMarjolein V Smith
SRA International, Durham, North Carolina, USA
PLoS ONE 4:e7018. 2009..The use of this technology requires the development of mathematical and statistical tools to properly analyze the large volumes of biological data...
- Cadmium induces transcription independently of intracellular calcium mobilizationBrooke E Tvermoes
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
PLoS ONE 6:e20542. 2011..This hypothesis is based on several studies that may be technically problematic; including the use of BAPTA chelators, BAPTA-based fluorescent sensors, and cytotoxic concentrations of metal...
- Comparative toxicogenomic responses of mercuric and methyl-mercuryMatthew K McElwee
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, 111 T, W Alexander Drive, Research Triangle Park, P, O, Box 12233, 27709 Durham, NC, USA
BMC Genomics 14:698. 2013..Mercury is a ubiquitous environmental toxicant that exists in multiple chemical forms. A paucity of information exists regarding the differences or similarities by which different mercurials act at the molecular level...
- Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicityYuxia Cui
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
Genome Biol 8:R122. 2007..Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal...