Thomas A Fleisher

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor
    M Margarida Souto-Carneiro
    Centro de Neurociencias e Biologia Celular, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Arthritis Res Ther 11:R84. 2009
  2. doi request reprint The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis
    Thomas A Fleisher
    Clinical Center, NIH, DHHS, Bethesda, MD 20892 1508, USA
    Immunol Res 40:87-92. 2008
  3. pmc Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy
    Claude Sportes
    Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1203, USA
    Clin Cancer Res 16:727-35. 2010
  4. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
  5. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
  6. pmc Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Blood 121:3117-25. 2013
  7. pmc Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 124:1152-60.e12. 2009
  8. ncbi request reprint Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation
    Mindy Anderson-Cohen
    Laboratory of Host Defenses, NIAID, Department of Laboratory Medicine, Bethesda, MD, USA
    Clin Immunol 109:308-17. 2003
  9. pmc NRAS mutation causes a human autoimmune lymphoproliferative syndrome
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8953-8. 2007
  10. pmc Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    Claude Sportes
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 205:1701-14. 2008

Detail Information

Publications57

  1. pmc Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor
    M Margarida Souto-Carneiro
    Centro de Neurociencias e Biologia Celular, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Arthritis Res Ther 11:R84. 2009
    ..Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in RA is still unclear...
  2. doi request reprint The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis
    Thomas A Fleisher
    Clinical Center, NIH, DHHS, Bethesda, MD 20892 1508, USA
    Immunol Res 40:87-92. 2008
    ..There remain patients with a diagnosis of ALPS but without a defined genetic defect and current investigations are focusing on fully characterizing this patient subgroup...
  3. pmc Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy
    Claude Sportes
    Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1203, USA
    Clin Cancer Res 16:727-35. 2010
    ..We report here on the toxicity and biological activity of recombinant human IL-7 (rhIL-7) in humans...
  4. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
    ....
  5. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
    ..We suggest the use of the term RAS-associated autoimmune leukoproliferative disease to differentiate this disorder from autoimmune lymphoproliferative syndrome...
  6. pmc Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Blood 121:3117-25. 2013
    ..In summary, homozygous PRKCD mutation results in B-cell hyperproliferation and defective apoptosis with consequent lymphocyte accumulation and autoantibody production in humans, and disrupts natural killer cell function...
  7. pmc Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 124:1152-60.e12. 2009
    ..Finally, we discuss the role of high-quality databases in treatment of PIDs and HCT as an element of the infrastructure that will be needed for productive multicenter clinical trials in these rare diseases...
  8. ncbi request reprint Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation
    Mindy Anderson-Cohen
    Laboratory of Host Defenses, NIAID, Department of Laboratory Medicine, Bethesda, MD, USA
    Clin Immunol 109:308-17. 2003
    ..Our conclusion: A presumed autosomal form of CGD has been excluded. Instead, a spontaneous mutation in gp91-phox coinciding with an extreme X chromosome inactivation ratio resulted in X-linked CGD in this young woman...
  9. pmc NRAS mutation causes a human autoimmune lymphoproliferative syndrome
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8953-8. 2007
    ..Our observations on the effects of NRAS activation indicate that RAS-inactivating drugs, such as farnesyltransferase inhibitors should be examined in human autoimmune and lymphocyte homeostasis disorders...
  10. pmc Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    Claude Sportes
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 205:1701-14. 2008
    ....
  11. ncbi request reprint Autoimmune lymphoproliferative syndrome
    Thomas A Fleisher
    Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, DHHS, Bethesda, MD, USA
    Isr Med Assoc J 7:758-61. 2005
  12. pmc FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 186:6035-43. 2011
    ..The apoptosis defect could be corrected by FAS overexpression in vitro. Our findings define haploinsufficiency as a common disease mechanism in ALPS patients with extracellular FAS mutations...
  13. doi request reprint Applications of flow cytometry for the study of primary immune deficiencies
    Joao B Oliveira
    Immunology Service, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
    Curr Opin Allergy Clin Immunol 8:499-509. 2008
    ..This review focuses on the current applications of flow cytometry for the diagnosis and evaluation of primary immune deficiencies (PIDs)...
  14. ncbi request reprint Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/lpr-/- mice or in patients with autoimmune lymphoproliferative syndrome
    V Koneti Rao
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Hematol 82:1049-55. 2007
    ..We conclude that these drugs do not warrant further use empirically or as part of clinical trials in ALPS Type Ia as a lympholytic agent...
  15. pmc Congenital B cell lymphocytosis explained by novel germline CARD11 mutations
    Andrew L Snow
    Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 209:2247-61. 2012
    ....
  16. pmc Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
    Kennichi C Dowdell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Blood 115:5164-9. 2010
    ..These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children...
  17. pmc Laboratory evaluation of primary immunodeficiencies
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, USA
    J Allergy Clin Immunol 125:S297-305. 2010
    ..In this article the authors describe a general approach for the investigation of the most common primary immunodeficiencies, outlining the typical clinical symptoms and most appropriate laboratory investigations...
  18. pmc Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1)
    Gulbu Uzel
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 111:209-18. 2008
    ..The discovery of 3 cases of reversion mutations in LAD-1 at one center suggests that this may be a relatively common event in this rare disease...
  19. pmc Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis
    Amanda Rudman Spergel
    ALPS Unit, LI NIAID, National Institutes of Health, DHHS, Room 12C106, Building 10, 10 Center Dr, Bethesda, MD 20892 1899
    Pediatrics 132:e1440-4. 2013
    ....
  20. ncbi request reprint A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy
    John C Morris
    Metabolism Branch, Laboratory of Pathology, Department of Laboratory Medicine, National Eye Institute, Bethesda, MD 20892 1457, USA
    Clin Cancer Res 13:958-64. 2007
    ..The primary end point was to determine drug toxicity. Tumor response, tumor-specific CD8+ T-cell immune responses, and modulation of CD4+ CD25+ FoxP3+ regulatory T-cell (Treg) numbers were secondary end points...
  21. pmc Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia
    John C Morris
    Metabolism Branch, Center for Cancer Research, and Office of Cancer Complementary and Alternative Medicine, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:401-6. 2006
    ....
  22. pmc Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand
    Ashish Jain
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 118:3811-7. 2011
    ..This clinical study showed that rCD40L is capable of improving T cell-immune function in patients with XHM...
  23. pmc Mutation analysis in primary immunodeficiency diseases: case studies
    Amy P Hsu
    Laboratory of Clinical Infectious Disease, NIAID, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Allergy Clin Immunol 9:517-24. 2009
    ....
  24. ncbi request reprint Evaluation of suspected immunodeficiency
    Thomas A Fleisher
    Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, DHHS, Bethesda, MD, USA
    Adv Exp Med Biol 601:291-300. 2007
    ..This chapter summarizes screening methods and more sophisticated approaches to assess the immune system when there is a suspicion of an immune deficiency...
  25. pmc Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade
    Silvia Stojanov
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:7148-53. 2011
    ..IL-1 inhibition may thus be beneficial for treatment of PFAPA attacks, with IP-10/CXCL10 serving as a potential biomarker...
  26. ncbi request reprint Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome
    Jack J H Bleesing
    The Immunology Service, Department of Laboratory Medicine, Clinical Center and Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 120:93-6. 2003
    ..Altered O-glycosylation of the extracellular domains of CD45 may have consequences for this tyrosine phosphatase as a regulator of cell proliferation and survival...
  27. ncbi request reprint Back to basics: primary immune deficiencies: windows into the immune system
    Thomas A Fleisher
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Pediatr Rev 27:363-72. 2006
  28. pmc Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
    Thomas A Waldmann
    Center for Cancer Research, National Cancer Institute, Frederick, MD, USA
    Blood 117:4787-95. 2011
    ....
  29. ncbi request reprint Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial
    Linda Mesler Muul
    Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:2563-9. 2003
    ..This long-term follow-up has also provided unique evidence supporting the safety of retroviral-mediated gene transfer and illustrates clear examples of both the potential and the pitfalls of gene therapy in humans...
  30. pmc Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma
    Jonathan L Berkowitz
    Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Immunol 155:176-87. 2014
    ..g., multiple sclerosis) since high-dose daclizumab is required to saturate IL-2R alpha in extravascular sites...
  31. pmc Integrating pharmacogenetic information and clinical decision support into the electronic health record
    Barry R Goldspiel
    Pharmacy Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA
    J Am Med Inform Assoc 21:522-8. 2014
    ..Prescribers have adapted to using the CDS and have ordered PG testing as a direct result of the implementation. ..
  32. pmc The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:4957-62. 2011
    ..This study is registered at http://www.clinicaltrials.gov as NCT00967785...
  33. pmc Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia
    Thomas A Waldmann
    Metabolism Branch, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 121:476-84. 2013
    ....
  34. doi request reprint Monogenic defects in lymphocyte apoptosis
    Thomas A Fleisher
    NIH Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
    Curr Opin Allergy Clin Immunol 12:609-15. 2012
    ..The recognition that apoptosis - programmed cell death - is an important mechanism in immune homeostasis has led to the identification of human disorders associated with defects in the critical control mechanism...
  35. ncbi request reprint Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B-cell marker CD27
    Jack J H Bleesing
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Cytometry B Clin Cytom 51:1-8. 2003
    ..B cells in mice are identified with the pan-B-cell-specific CD45 isoform, B220. In initial studies in humans, it appeared that B220 expression did not include all B cells. This study was performed to expand on those preliminary findings...
  36. doi request reprint Molecular- and flow cytometry-based diagnosis of primary immunodeficiency disorders
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:460-7. 2010
    ..We discuss here advances in flow cytometry and molecular techniques applied to the study of primary immunodeficiencies...
  37. pmc Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:e35-40. 2010
    ..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas...
  38. ncbi request reprint Functional and molecular evaluation of lymphocytes
    Thomas A Fleisher
    Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Department of Health and Human ServicBethesda, MD 20892, USA
    J Allergy Clin Immunol 114:227-34; quiz 235. 2004
    ....
  39. pmc Increased effector-target cell conjugate formation due to HLA restricted specific antigen recognition
    Ching Y Voss
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Immunol Res 45:13-24. 2009
    ..Since conjugate formation analysis does not require knowledge of the target antigen, this assay could potentially be used for enrichment of CTL directed against novel antigens...
  40. ncbi request reprint Single nucleotide polymorphisms in the apoptosis receptor gene TNFRSF6
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD, USA
    Mol Cell Probes 20:21-6. 2006
    ..Four TNFRSF6 SNP pairs were found to be in strong LD. The TNRFSF6 SNPs are useful for linkage and loss of heterozygosity studies probing the role of Fas-mediated apoptosis in autoimmune diseases and malignancies...
  41. pmc Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls
    Adriana Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Clin Vaccine Immunol 16:1249-50. 2009
    ..We performed immunophenotyping in 9 individuals with post-Lyme disease syndrome, 12 who recovered from Lyme disease, and 9 healthy volunteers. The number of natural killer cells was not significantly different between the groups...
  42. pmc Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    J Allergy Clin Immunol 122:1087-96. 2008
    ..Participation of immunologists and HCT physicians having interest in PID and experts in laboratory methods, clinical outcomes assessment, databases, and analysis will be required for the success of these studies...
  43. pmc B-cell activating factor (BAFF) is elevated in chronic granulomatous disease
    Kabir Matharu
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Immunol 148:258-64. 2013
    ..47) and increased rapidly in healthy subjects following intravenous endotoxin administration. These findings suggest that elevated BAFF in CGD subjects and healthy donors is a consequence of acute and chronic inflammation...
  44. ncbi request reprint A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T Cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome
    Jack J H Bleesing
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Clin Immunol 104:21-30. 2002
    ....
  45. pmc Application of Flow Cytometry in the Evaluation of Primary Immunodeficiencies
    Thomas A Fleisher
    Department of Laboratory Medicine, NIH Clinical Center, Building 10, Room 2C306, 10 Center Drive, MSC1508, Bethesda, MD, USA
    Indian J Pediatr 83:444-9. 2016
    ..Thus, the focus of this article is on the application of flow cytometry in the diagnosis and/or evaluation of PIDDs. ..
  46. pmc Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    Elise M N Ferre
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    JCI Insight 1:. 2016
    ..Incorporation of these new manifestations into American diagnostic criteria would accelerate diagnosis by approximately 4 years and potentially prevent life-threatening endocrine complications...
  47. pmc Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 345:1623-7. 2014
    ..Inherited human CTLA4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis. ..
  48. ncbi request reprint Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    Hua Zhang
    Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 11:1238-43. 2005
    ..These studies suggest that IL-2 and lymphopenia are primary modulators of CD4(+)CD25(+) T(reg) cell homeostasis...
  49. ncbi request reprint Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay
    Orathai Jirapongsananuruk
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C 306, 10 Center Drive, MSC 1508, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 111:374-9. 2003
    ..However, some male patients with X-CGD have DHR patterns that overlap the AR-CGD pattern...
  50. ncbi request reprint Evaluation of suspected immunodeficiency
    Thomas A Fleisher
    Department of Laboratory Medicine at the Warren G Magnuson Clinical Center of the National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    MLO Med Lab Obs 35:10-4, 19; quiz 20-1. 2003
  51. doi request reprint Interpretation of flow cytometry in primary immunodeficiency disorders
    Vivian P Hernandez-Trujillo
    Division of Allergy and Clinical Immunology, Miami Children s Hospital, Miami, Florida 33155, USA
    Ann Allergy Asthma Immunol 100:612-5. 2008
  52. ncbi request reprint Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia
    Jordan S Orange
    Division of Immunology, Children s Hospital of Philadelphia, PA, USA
    J Allergy Clin Immunol 114:650-6. 2004
    ..Male subjects with these mutant NEMO molecules have an X-linked syndrome known as ectodermal dysplasia with immunodeficiency, which is characterized by severe infections, with herpesviruses, bacteria, and mycobacterial susceptibility...
  53. ncbi request reprint Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment
    Jack J Bleesing
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 176:7096-103. 2006
    ..These results suggest a role for NADPH in the process of memory B cell formation, inviting further exploration of secondary Ab responses in CGD patients...
  54. ncbi request reprint Immune thrombocytopenic purpura
    Jack J H Bleesing
    N Engl J Med 347:449-50; author reply 449-50. 2002
  55. ncbi request reprint Adolescents and young adults successfully restore lymphocyte homeostasis after intensive T-cell depleting therapy for cancer
    Jessica C Shand
    Br J Haematol 135:270-1. 2006
  56. ncbi request reprint What does it take to call it a pathogenic mutation?
    Thomas A Fleisher
    Clin Immunol 128:285-6. 2008
  57. ncbi request reprint CYBB mutation analysis in X-linked chronic granulomatous disease
    Orathai Jirapongsananuruk
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethsda, MD 20892, USA
    Clin Immunol 104:73-6. 2002
    ..We analyzed DNA from two unusual X-CGD patients and established the genetic basis for their phenotype. We also sequenced 100 normal X chromosomes to establish wild-type consensus sequences and identify polymorphisms...