Jonine D Figueroa

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
  2. pmc Terminal duct lobular unit involution of the normal breast: implications for breast cancer etiology
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics JDF, RMP, DAP, LL, Lab, GLG, XRY, DP, WFA, ZGK, MES, Laboratory of Pathology SH, and Division of Cancer Prevention MES, National Cancer Institute, Bethesda, MD Mayo Clinic Cancer Center, Rochester, MN DV, ACD Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA CM Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL SEC Susan G Komen Tissue Bank at the Indiana University Simon Cancer Center, Indianapolis, IN AMS
    J Natl Cancer Inst 106:. 2014
  3. pmc Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients
    Jonine D Figueroa
    National Cancer Institute, NIH, HHS, Bethesda, MD, USA
    Breast Cancer Res Treat 150:457-66. 2015
  4. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  5. ncbi request reprint Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
  6. pmc Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:361-8. 2009
  7. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
  8. doi request reprint Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors
    Jonine D Figueroa
    Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 19:917-29. 2008
  9. pmc Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Mol Genet 20:4693-706. 2011
  10. ncbi request reprint Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007

Detail Information

Publications61

  1. pmc Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  2. pmc Terminal duct lobular unit involution of the normal breast: implications for breast cancer etiology
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics JDF, RMP, DAP, LL, Lab, GLG, XRY, DP, WFA, ZGK, MES, Laboratory of Pathology SH, and Division of Cancer Prevention MES, National Cancer Institute, Bethesda, MD Mayo Clinic Cancer Center, Rochester, MN DV, ACD Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA CM Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL SEC Susan G Komen Tissue Bank at the Indiana University Simon Cancer Center, Indianapolis, IN AMS
    J Natl Cancer Inst 106:. 2014
    ..Greater degrees of terminal duct lobular unit (TDLU) involution have been linked to lower breast cancer risk; however, factors that influence this process are poorly characterized...
  3. pmc Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients
    Jonine D Figueroa
    National Cancer Institute, NIH, HHS, Bethesda, MD, USA
    Breast Cancer Res Treat 150:457-66. 2015
    ..Prospective assessment of MEI along with other prognostic signatures should be evaluated in future studies...
  4. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  5. ncbi request reprint Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...
  6. pmc Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:361-8. 2009
    ..Further research on these tumors is needed to identify molecular markers associated with variations in the risk factor profiles...
  7. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  8. doi request reprint Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors
    Jonine D Figueroa
    Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 19:917-29. 2008
    ..02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma...
  9. pmc Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Mol Genet 20:4693-706. 2011
    ..Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer...
  10. ncbi request reprint Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations...
  11. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  12. doi request reprint TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
    ..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear...
  13. pmc Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression
    HISANI N HORNE
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Breast Cancer Res Treat 143:181-7. 2014
    ....
  14. pmc Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data
    Summer S Han
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 176:1060-7. 2012
    ..5-fold. The authors illustrate their method by applying it to data from a bladder cancer study...
  15. pmc Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
    Breast Cancer Res Treat 137:837-47. 2013
    ..Analyses of mapped TDLUs may provide information about the sequence of molecular changes occurring in breast carcinogenesis...
  16. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  17. pmc Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue
    Hannah Oh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, Bethesda, MD, 20892, USA
    Breast Cancer Res Treat 158:341-50. 2016
    ..Our data suggest that the loci associated with ages at menarche and menopause may influence TDLU involution, suggesting some shared genetic mechanisms. However, larger studies are needed to confirm the results. ..
  18. pmc Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy
    Hannah Oh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Horm Cancer 7:305-315. 2016
    ..Our data suggest that higher levels of serum EMs are generally associated with lower levels of TDLU involution...
  19. pmc Prolactin receptor expression and breast cancer: relationships with tumor characteristics among pre- and post-menopausal women in a population-based case-control study from Poland
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, 2W 172, Bethesda, MD, 20892, USA
    Horm Cancer 5:42-50. 2014
    ..These data provide new avenues from which to explore the associations of the prolactin/prolactin receptor signaling network with breast tumorigenesis. ..
  20. pmc Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
    ..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years...
  21. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  22. pmc Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer
    Wei Tang
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 21:1918-30. 2012
    ..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer...
  23. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  24. pmc Genome-wide interaction study of smoking and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Institute for Cancer Research, London, UK, Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain, Municipal Institute of Medical Research, Barcelona, Spain, CIBER Epidemiologia y Salud Pública CIBERESP, Barcelona, Spain, National School of Public Health, Athens, Greece, Maine Cancer Registry, Augusta, ME, USA, Spanish National Cancer Research Centre CNIO, Madrid, Spain, Vermont Cancer Registry, Burlington, VT, USA, Center for Genomics Research, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA, Information Management Services, Inc, Rockville, MD, USA, Imperial College London, London, UK, Department of Preventive Medicine and Department of Obstetrics and Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Carcinogenesis 35:1737-44. 2014
    ..Our findings provide additional evidence of gene-environment interactions for tobacco and bladder cancer. ..
  25. pmc Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal women
    Roni T Falk
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 131:287-94. 2012
    ..Measurement of sex hormones in serum and in the microenvironment may help in understanding the hormonal etiology of breast cancer, suggest methods for prevention, and have value in gauging treatment response and prognosis...
  26. pmc Fine mapping of 14q24.1 breast cancer susceptibility locus
    Phoebe Lee
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:479-90. 2012
    ..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation...
  27. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  28. pmc A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 21:231-6. 2011
    ..Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides...
  29. pmc Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 31:827-33. 2010
    ..Associations with variants in other genes have been suggested, but findings have been inconsistent...
  30. pmc Circulating sex hormones and terminal duct lobular unit involution of the normal breast
    Zeina G Khodr
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland
    Cancer Epidemiol Biomarkers Prev 23:2765-73. 2014
    ..We assessed whether circulating hormones, implicated in breast cancer risk, are associated with levels of TDLU involution using data from the Susan G. Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Center (2009-2011)...
  31. pmc Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease
    HISANI N HORNE
    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rm 7 E108, Bethesda, MD, 20892 9774, USA
    Breast Cancer Res 18:24. 2016
    ....
  32. pmc Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1545-50. 2010
    ..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water...
  33. pmc The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    Cancer Res 74:5808-18. 2014
    ..In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the CCNE1 variants could be useful for inclusion into bladder cancer risk prediction models...
  34. pmc Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
    Kelly L Bolton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:992-9. 2010
    ..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)...
  35. pmc Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Breast Cancer Res 13:R42. 2011
    ..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study...
  36. pmc Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland
    Britton Trabert
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E 228, Bethesda, MD, 20892 9774, USA
    Cancer Causes Control 25:1587-93. 2014
    ....
  37. pmc Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 159:163-72. 2016
    ..Visual assessment of TDLU numbers and acini content, which are highly reproducible between pathologists, could help identify women at high risk for subsequent breast cancer among the million women diagnosed annually with BBD in the US. ..
  38. pmc Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus
    HISANI N HORNE
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America
    PLoS ONE 11:e0160316. 2016
    ..Fine-mapping analysis of the 1p11.2 breast cancer susceptibility locus confirms this region to be limited to risk to cancers that are ER-positive. ..
  39. doi request reprint Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors
    Candace D Middlebrooks
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 48:1330-1338. 2016
    ..These findings suggest a tissue-specific role of environmental oncogenic triggers, particularly in individuals with germline APOBEC3 risk variants...
  40. pmc Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    Cancer Prev Res (Phila) 9:149-58. 2016
    ..If confirmed, these results could suggest a prevention paradigm based on enhancing TDLU involution and monitoring efficacy by assessing MD reduction...
  41. pmc Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types
    Joshua N Sampson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD JNS, OP, SIB, QL, CCA, LTA, JDF, MTL, LM, SAS, PRT, KAM, PR, DA, DB, BAB, AB, LBR, WHC, CCC, JSC, JFFJr, NDF, LEBF, MGC, AMG, RNH, NH, WH, PDI, BTJ, CK, Suwon
    J Natl Cancer Inst 107:djv279. 2015
    ..We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites...
  42. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  43. pmc Smoking status, usual adult occupation, and risk of recurrent urothelial bladder carcinoma: data from The Cancer Genome Atlas (TCGA) Project
    Amber N Wilcox
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, USA
    Cancer Causes Control 27:1429-1435. 2016
    ..We evaluated whether smoking status and usual adult occupation are associated with time to UBC recurrence for 406 patients with muscle-invasive bladder cancer submitted to The Cancer Genome Atlas (TCGA) project...
  44. pmc Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
    Mitchell J Machiela
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nat Commun 7:11843. 2016
    ....
  45. pmc Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Usher Institute of Population Health Sciences and Informatics, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Hum Mol Genet 25:1203-14. 2016
    ..02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer. ..
  46. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  47. pmc Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD20852 7244, USA
    Cancer Res 70:4453-9. 2010
    ..0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility...
  48. pmc Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast
    Clara Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
    Int J Cancer . 2016
    ..Our findings suggest breast cancer SNPs may not strongly influence TDLU involution. Agnostic genome-wide association studies of TDLU involution may provide new insights on its biologic underpinnings and breast cancer susceptibility...
  49. pmc 19p13.1 is a triple-negative-specific breast cancer susceptibility locus
    Kristen N Stevens
    Departments of Health Sciences Research and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 72:1795-803. 2012
    ..These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple-negative tumors and other subtypes likely arise through distinct etiologic pathways...
  50. pmc Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients
    Maeve Mullooly
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892, USA
    Breast Cancer Res 19:8. 2017
    ..Accordingly, we examined relationships between CLS and sex-steroid hormones in breast adipose tissue and serum from postmenopausal breast cancer patients...
  51. pmc Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA
    Hum Mol Genet 23:6616-33. 2014
    ..33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. ..
  52. pmc Characterization of large structural genetic mosaicism in human autosomes
    Mitchell J Machiela
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Am J Hum Genet 96:487-97. 2015
    ..Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population...
  53. pmc A robust association test for detecting genetic variants with heterogeneous effects
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20850, USA
    Biostatistics 16:5-16. 2015
    ..We demonstrate the advantage of the new procedure through numeric simulation studies and an application to a breast cancer study. ..
  54. pmc Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New England
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, North Bethesda, MD 20852, USA
    Int J Cancer 132:162-73. 2013
    ..We observed a previously unrecognized risk associated with use of COX-2 inhibitors, which merits further evaluation...
  55. pmc The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center: a unique resource for defining the "molecular histology" of the breast
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA
    Cancer Prev Res (Phila) 5:528-35. 2012
    ..As research projects are completed, results will be posted on the Bank's website...
  56. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  57. pmc Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer
    Xuezheng Sun
    Authors Affiliations Department of Epidemiology Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Department of Biology, Trinity University, San Antonio, Texas Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 19:4972-82. 2013
    ..To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study...
  58. pmc Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
    Jianxin Shi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS Genet 12:e1006493. 2016
    ....
  59. doi request reprint Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States
    Paige Maas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    JAMA Oncol 2:1295-1302. 2016
    ..An improved model for risk stratification can be useful for guiding public health strategies of breast cancer prevention...
  60. pmc Breast cancer in Sub-Saharan Africa: opportunities for prevention
    Louise A Brinton
    National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rm 7E 102, MSC 9774, Bethesda, MD, 20892 9774, USA
    Breast Cancer Res Treat 144:467-78. 2014
    ..It will also be essential to understand reasons why women delay seeking care after the onset of symptoms and for there to be educational campaigns about the importance of early detection. ..
  61. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    ..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...