A S Fauci

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Guidelines for using antiretroviral agents among HIV-infected adults and adolescents
    Mark Dybul
    National Institutes of Health, Bethesda, Maryland, USA
    Ann Intern Med 137:381-433. 2002
  2. pmc HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:3250-5. 2005
  3. doi request reprint The world must build on three decades of scientific advances to enable a new generation to live free of HIV/AIDS
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Health Aff (Millwood) 31:1529-36. 2012
  4. pmc Benefits and risks of influenza research: lessons learned
    Anthony S Fauci
    National Institutes of Health, Bethesda, MD 20892, USA
    Science 336:1522-3. 2012
  5. pmc Host-based antipoxvirus therapeutic strategies: turning the tables
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 2520, USA
    J Clin Invest 115:231-3. 2005
  6. ncbi request reprint The global challenge of infectious diseases: the evolving role of the National Institutes of Health in basic and clinical research
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nat Immunol 6:743-7. 2005
  7. ncbi request reprint NK cells in HIV infection: paradigm for protection or targets for ambush
    Anthony S Fauci
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, Room 7A04, 31 Center Drive, MSC 2520, Bethesda, Maryland 20892 2520, USA
    Nat Rev Immunol 5:835-43. 2005
  8. ncbi request reprint Emerging and reemerging infectious diseases: the perpetual challenge
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 31, Room 7A03, MSC 2520, 9000 Rockville Pike, Bethesda, MD 20892 2520, USA
    Acad Med 80:1079-85. 2005
  9. pmc Pandemic influenza threat and preparedness
    Anthony S Fauci
    National Institutes of Health, Bethesda, Maryland 20892 2520, USA
    Emerg Infect Dis 12:73-7. 2006
  10. ncbi request reprint Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 124:665-70. 2006

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Guidelines for using antiretroviral agents among HIV-infected adults and adolescents
    Mark Dybul
    National Institutes of Health, Bethesda, Maryland, USA
    Ann Intern Med 137:381-433. 2002
    ..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website ( http://www.hivatis.org )...
  2. pmc HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:3250-5. 2005
    ..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia...
  3. doi request reprint The world must build on three decades of scientific advances to enable a new generation to live free of HIV/AIDS
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Health Aff (Millwood) 31:1529-36. 2012
    ..If these challenges can be met, the world will have a clear path toward an "AIDS-free generation" in which new HIV infections, as well as illness and death due to AIDS, are increasingly rare...
  4. pmc Benefits and risks of influenza research: lessons learned
    Anthony S Fauci
    National Institutes of Health, Bethesda, MD 20892, USA
    Science 336:1522-3. 2012
    ..Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward...
  5. pmc Host-based antipoxvirus therapeutic strategies: turning the tables
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 2520, USA
    J Clin Invest 115:231-3. 2005
    ..Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents...
  6. ncbi request reprint The global challenge of infectious diseases: the evolving role of the National Institutes of Health in basic and clinical research
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nat Immunol 6:743-7. 2005
  7. ncbi request reprint NK cells in HIV infection: paradigm for protection or targets for ambush
    Anthony S Fauci
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, Room 7A04, 31 Center Drive, MSC 2520, Bethesda, Maryland 20892 2520, USA
    Nat Rev Immunol 5:835-43. 2005
    ..This Review focuses on the role of natural killer cells in controlling HIV infection and on the impact of HIV and HIV-viraemia-induced immune activation on natural-killer-cell function...
  8. ncbi request reprint Emerging and reemerging infectious diseases: the perpetual challenge
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 31, Room 7A03, MSC 2520, 9000 Rockville Pike, Bethesda, MD 20892 2520, USA
    Acad Med 80:1079-85. 2005
    ..In this regard, partnerships between government, industry, and academia are necessary as we struggle to maintain and update our armamentarium in the struggle to outwit the microbes that pose a never-ending threat to mankind...
  9. pmc Pandemic influenza threat and preparedness
    Anthony S Fauci
    National Institutes of Health, Bethesda, Maryland 20892 2520, USA
    Emerg Infect Dis 12:73-7. 2006
    ..We describe recent research progress in preparing for pandemic influenza...
  10. ncbi request reprint Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 124:665-70. 2006
    ..The importance of understanding host-pathogen interactions is underscored by the emergence of virulent H5N1 avian influenza viruses and their transmission to humans, and the potential pandemic threat they pose...
  11. ncbi request reprint Lasker Public Service Award. The expanding global health agenda: a welcome development
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 31, Room 7A 03, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:1169-71. 2007
  12. ncbi request reprint 25 years of HIV/AIDS science: reaching the poor with research advances
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 131:429-32. 2007
    ..Although much has been accomplished in HIV/AIDS research, much remains to be done, especially regarding delivery of HIV/AIDS therapies and care and prevention interventions to the poorest countries that need them most...
  13. doi request reprint Pathogenesis of HIV disease: opportunities for new prevention interventions
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 45:S206-12. 2007
    ....
  14. pmc The ASCI, the spring meetings, and growing up in academic medicine: a personal perspective
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 118:1214-7. 2008
    ..The ASCI continues to provide this meeting forum for young investigators who aspire to emulate their idols and mentors just as I did in 1969 when I attended the spring meetings in Atlantic City for the first time...
  15. doi request reprint HIV vaccine research: the way forward
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA
    Science 321:530-2. 2008
    ..This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities...
  16. pmc CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes
    J Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:6418-24. 2000
    ..The data presented here are consistent with this hypothesis and suggest that the differential capacity of viral envelopes to signal through CCR5 may influence their ability to replicate in macrophages...
  17. pmc Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:253-8. 2001
    ....
  18. ncbi request reprint CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness
    M Dybul
    Laboratory of Immunoregulation and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Warren Magneson Clinical Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:1685-91. 2000
    ..They also indicate the potential for CD40LT and IL-12 as immune-based therapies for HIV infection...
  19. ncbi request reprint Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function
    Angela Malaspina
    Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5965-72. 2003
    ....
  20. pmc Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro
    A Oliva
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 102:223-31. 1998
    ..These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms...
  21. ncbi request reprint Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 5:651-5. 1999
    ..These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV...
  22. pmc Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:6430-5. 1999
    ..Our findings suggest that naive CD4(+) T cells may be a significant viral reservoir for HIV, particularly in those patients harboring CXCR4-using viruses...
  23. pmc HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    R T Davey
    National Institute of Allergy and Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:15109-14. 1999
    ..Virologic relapse occurs rapidly in patients who discontinue suppressive drug therapy, even in patients with a markedly diminished pool of resting, latently infected CD4(+) T cells...
  24. ncbi request reprint Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapy
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Infect Dis 181:1273-9. 2000
    ..There was no evidence of development of resistance to either regimen in virus isolated from LNMC. These data support the use of efavirenz as an alternative to a PI in initial HAART regimens...
  25. pmc B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:637-46. 2000
    ..Furthermore, B cells possess the added capability of circulating in peripheral blood and migrating through tissues where they can potentially interact with and pass virus to T cells...
  26. pmc The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:254-8. 1997
    ....
  27. pmc Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
    ..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
  28. ncbi request reprint Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1576, USA
    J Immunol 161:3195-201. 1998
    ..Patients who harbored syncytium-inducing viruses, however, could not be distinguished from those who harbored nonsyncytium-inducing viruses based on the level of CD4+ T cell activation or chemokine receptor expression...
  29. ncbi request reprint Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope
    C Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:420-6. 1999
    ..Activation of this signaling pathway by HIV-1 envelope may be an important pathogenic mechanism of dysregulated cellular activation and trafficking during HIV infection...
  30. ncbi request reprint Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 144:1696-704. 1990
    ..We have shown that a large proportion of CD3+DR+CD25- cells (50 to 80% in the different patients with AIDS analyzed) expressed VLA-2 Ag.(ABSTRACT TRUNCATED AT 400 WORDS)..
  31. pmc Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8869-73. 1998
    ....
  32. pmc Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1
    M Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 102:1540-50. 1998
    ....
  33. ncbi request reprint Induction of HIV-1 replication by allogeneic stimulation
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:7543-8. 1999
    ..These observations suggest that allogeneic stimulation may play a role in the transmission, replication, and phenotypic transition of HIV-1...
  34. ncbi request reprint Neonatal natural killer cells produce chemokines and suppress HIV replication in vitro
    Helene B Bernstein
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20814, USA
    AIDS Res Hum Retroviruses 20:1189-95. 2004
    ..Our results show that nNK cells can inhibit HIV replication via a chemokine-mediated mechanism, and support a potential role for the innate immune system in preventing perinatal transmission of HIV in a noncytolytic manner...
  35. pmc Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:83-91. 1998
    ....
  36. ncbi request reprint Compromised B cell responses to influenza vaccination in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1442-50. 2005
    ..We assessed the impact of HIV disease on B cell responses to influenza vaccination...
  37. pmc Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection
    K N Reitano
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health DHHS, SAIC Frederick, NCI, Frederick, MD 21702, USA
    AIDS Res Hum Retroviruses 25:1029-37. 2009
    ..These findings suggest a novel mechanism by which HIV is capable of suppressing an innate immune function in infected individuals...
  38. pmc Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:9848-53. 1997
    ..These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection...
  39. pmc Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 72:3394-400. 1998
    ....
  40. pmc Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 72:7772-84. 1998
    ..These findings illustrate certain mechanisms whereby antigenic stimulation may influence the dynamics of HIV replication, including the relative expression of different viral variants...
  41. ncbi request reprint Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera
    G Scala
    Laboratory of Immunoregulation, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Immunol 162:6155-61. 1999
    ..These results demonstrate that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection...
  42. pmc HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
    C Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1178-83. 2000
    ..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage...
  43. ncbi request reprint Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 6:757-61. 2000
    ....
  44. ncbi request reprint Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms
    J F McDyer
    Clinical Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:3711-7. 1999
    ..Together, these results show that CD40LT stimulation of DCs suppresses HIV replication and transmission to CD4+ T cells by two potentially different mechanisms...
  45. ncbi request reprint The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:6133-41. 2000
    ..Finally, it was demonstrated that IL-15 produced by CD40LT-stimulated dendritic cells may be an additional mechanism by which CD40LT induces the expansion of memory CTL in CD4(+) T cell-depleted conditions, where IL-2 is lacking...
  46. pmc HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:10362-7. 2001
    ..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease...
  47. pmc Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:15161-6. 2001
    ..In addition, there was a decrease in serum cholesterol and triglyceride levels. Intermittent therapy may be an important strategy to reduce cost and toxicity for HIV-infected individuals...
  48. ncbi request reprint Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremia
    S Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1193-8. 2004
    ....
  49. ncbi request reprint Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donors
    P Rieckmann
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 147:2922-7. 1991
    ....
  50. pmc Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:8855-63. 2002
    ..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes...
  51. ncbi request reprint Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry
    A Rubbert
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 160:3933-41. 1998
    ..Delineation of the spectrum of coreceptor usage on DC may offer new approaches to interfere with the initiation and propagation of HIV infection...
  52. pmc Factors secreted by human T lymphotropic virus type I (HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I-uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1689-97. 1998
    ..Our data suggest that the net effect of HTLV-I coinfection in HIV-infected individuals favors the transition from M- to T-tropic HIV phenotype, which is generally indicative of progressive HIV disease...
  53. pmc CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32
    O J Cohen
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 1876, USA
    J Virol 72:6215-7. 1998
    ..Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals...
  54. pmc Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:6849-55. 2000
    ....
  55. pmc Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals
    Lia Vassena
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:2355-60. 2007
    ..These results provide a further rationale for consideration of IL-7 as an agent of immune reconstitution in HIV-1 infection...
  56. pmc Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy
    Elizabeth Nies-Kraske
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
    J Infect Dis 199:1648-56. 2009
    ..All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells...
  57. ncbi request reprint Host factors in the pathogenesis of HIV disease
    O J Cohen
    National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
    Immunol Rev 159:31-48. 1997
    ..HIV-specific immune responses, including cytotoxic T-lymphocyte (CTL) responses and neutralizing antibody responses, also appear to play salutary roles in protecting against disease progression...
  58. ncbi request reprint Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Immunol 160:3602-9. 1998
    ..These data suggest that T cells from WG patients overproduce IFN-gamma and TNF-alpha, probably due to dysregulated IL-12 secretion, and that IL-10 may therefore have therapeutic implications for this disease...
  59. ncbi request reprint HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:2449-55. 2003
    ....
  60. pmc Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7
    Angela Malaspina
    Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:2262-7. 2006
    ..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events...
  61. ncbi request reprint Fluorodeoxyglucose imaging in healthy subjects with HIV infection: impact of disease stage and therapy on pattern of nodal activation
    Douglas Brust
    National Institute of Allergy and Infectious Disease, and the Nuclear Medicine Department, Warren G Magnuson Clinical Center of the National Institutes of Health, 10 Center Drive, MSC 1180, Bethesda, MD 20892, USA
    AIDS 20:985-93. 2006
    ..We evaluated the utility of fluorodeoxyglucose scanning as a tool to study HIV pathogenesis...
  62. ncbi request reprint Wegener granulomatosis: an analysis of 158 patients
    G S Hoffman
    National Institutes of Health, Bethesda, Maryland
    Ann Intern Med 116:488-98. 1992
    ..To prospectively study the clinical features, pathophysiology, treatment and prognosis of Wegener granulomatosis...
  63. ncbi request reprint Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 389:981-5. 1997
    ..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis...
  64. ncbi request reprint Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV
    M E Ruiz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 161:4169-76. 1998
    ....
  65. pmc Latent reservoirs of HIV: obstacles to the eradication of virus
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:10958-61. 1999
    ..Here we discuss recent developments in studies of the latent reservoir of HIV in patients receiving HAART and implications for the long-term treatment of infected individuals and eradication of the infection...
  66. ncbi request reprint Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis
    A Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 177:88-98. 2000
    ..Finally, the interaction between chemokine receptors and chemokines or HIV envelope has significant effects on cellular functions which likely play a role in HIV pathogenesis...
  67. ncbi request reprint Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV
    Mark Dybul
    National Institutes of Health, Bethesda, Maryland, USA
    MMWR Recomm Rep 51:1-55. 2002
    ..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website (http://www.hivatis.org)...
  68. ncbi request reprint An HIV vaccine--evolving concepts
    Margaret I Johnston
    Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    N Engl J Med 356:2073-81. 2007
  69. doi request reprint 25 years of HIV
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases NIAID at the US National Institutes of Health in Bethesda, Maryland, USA
    Nature 453:289-90. 2008
  70. pmc Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals
    Manuela Fogli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000101. 2008
    ....
  71. ncbi request reprint Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding
    S M Schnittman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    J Immunol 141:4181-6. 1988
    ..This activity may prove to have some value in protection against initial HIV infection and, thus, the assay may be of use in monitoring vaccine trials...
  72. ncbi request reprint Infectious diseases: considerations for the 21st century
    A S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 32:675-85. 2001
    ..Increasingly, infectious disease research will be linked to the development of the medical infrastructure and training needed in developing countries to translate scientific advances into operational reality...
  73. pmc Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1576, USA
    Clin Microbiol Rev 10:358-67. 1997
    ..This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies...
  74. ncbi request reprint Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes
    X Chen
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
    Nat Med 7:1225-31. 2001
    ..These results provide a new approach to the design of broadly protective HIV-1 vaccines...
  75. ncbi request reprint HIV and AIDS: 20 years of science
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nat Med 9:839-43. 2003
  76. ncbi request reprint Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy
    Neil Gupta
    Laboratory of Immunoregulation, NIAID, NIH Bldg 10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
    Virology 332:491-7. 2005
    ..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers...
  77. ncbi request reprint Race against time
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nature 435:423-4. 2005
  78. pmc Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 92:826-30. 1995
    ....
  79. ncbi request reprint Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 158:3483-91. 1997
    ..Thus, NF-kappa B, a potent transcriptional activator of HIV expression, is also involved in the expression of RANTES, a chemokine that blocks infection by macrophage-tropic strains of HIV...
  80. pmc cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions
    G L Wilson
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 173:137-46. 1991
    ..Additionally, both normal tonsil B cells and a B cell line were found to adhere to COS transfected with BL-CAM in the sense but not the antisense direction.(ABSTRACT TRUNCATED AT 400 WORDS)..
  81. ncbi request reprint Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation
    L Butini
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Eur J Immunol 24:2191-5. 1994
    ..These results indicate that the interaction between LFA-1 and ICAM is a critical step in HIV-mediated syncytia formation, and that ICAM-1, ICAM-2 and ICAM-3 are the receptor molecules for the LFA-1-dependent syncytia formation...
  82. ncbi request reprint Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry
    M Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 159:4322-9. 1997
    ....
  83. pmc Human immunodeficiency virus type 1 (HIV-1) non-B subtypes are similar to HIV-1 subtype B in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected ex vivo
    N Malkevich
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:10520-2. 2001
    ..Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4(+) T cells in human lymphoid tissue infected ex vivo...
  84. ncbi request reprint Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies
    James Arthos
    Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:11456-64. 2002
    ..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines...
  85. ncbi request reprint Ethics of clinical research in the developing world
    Jack Killen
    National Institutes of Health, 9000 Rockville Pike, Bethesda, 20892 Maryland, USA
    Nat Rev Immunol 2:210-5. 2002
    ..Using HIV/AIDS research as an example, we show how this 'Uniform Care Requirement' can undermine biomedical research aimed at improving global health, and then we point towards a more rational and balanced approach to ethical assessment...
  86. pmc HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:9380-5. 2002
    ..These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells...
  87. ncbi request reprint Long-cycle structured intermittent versus continuous highly active antiretroviral therapy for the treatment of chronic infection with human immunodeficiency virus: effects on drug toxicity and on immunologic and virologic parameters
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 188:388-96. 2003
    ..There was no clear autoimmunization effect by immunologic or virologic parameters. There was no benefit to long-cycle SIT versus continuous HAART with regard to certain toxicity, immunologic, or virologic parameters...
  88. ncbi request reprint Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
    AIDS Res Hum Retroviruses 19:847-56. 2003
    ..The ability of resting CD4+ T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention...
  89. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
    ..This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients...
  90. pmc Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:2464-9. 2004
    ....
  91. ncbi request reprint A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1974-82. 2004
    ..Adherence to such a regimen may be problematic for certain patients...
  92. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
    ..These in vitro data suggest that CD25(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease...
  93. pmc Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  94. ncbi request reprint Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  95. pmc Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 6A08A, MSC 1576, Bethesda, MD 20814, USA
    Blood 106:1718-25. 2005
    ..This new phenotypic and functional characterization of NKG2A and NKp80 in rhesus and pigtailed macaque NK cells provides a new approach in the analysis of their innate immune system...
  96. ncbi request reprint HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Virology 345:105-14. 2006
    ..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs...
  97. ncbi request reprint Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:1107-14. 2006
    ..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals...
  98. pmc R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3746-51. 2006
    ..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication...
  99. ncbi request reprint Seasonal and pandemic influenza preparedness: science and countermeasures
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 194:S73-6. 2006
    ..Until these approaches are firmly linked, the community will not have optimized its preparedness for a pandemic...
  100. pmc Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3390-5. 2007
    ....