Jacob D Estes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche
    Jacob D Estes
    AIDS and Cancer Virus Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD, USA
    Semin Immunol 20:181-6. 2008
  2. ncbi request reprint Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections
    Jacob D Estes
    The AIDS and Cancer Virus Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Fort Detrick Campus, Frederick, MD 21702, USA
    Curr HIV/AIDS Rep 6:29-35. 2009
  3. doi request reprint Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Immunol Rev 254:65-77. 2013
  4. pmc Enhancing immune responses to limit chronic immune activation during SIV
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 122:1611-4. 2012
  5. pmc Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    PLoS Pathog 6:e1001052. 2010
  6. pmc Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection
    Brian Tabb
    AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, SAIC Frederick, Maryland, USA
    J Infect Dis 207:880-92. 2013
  7. pmc Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides
    Christine M Fennessey
    Retroviral Evolution Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Building 535, Rm 408, Frederick, MD, 21702 1201, USA
    Retrovirology 12:49. 2015
  8. pmc Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    Antimicrob Agents Chemother 60:1560-72. 2015
  9. pmc Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
    Levelle D Harris
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 84:7886-91. 2010
  10. pmc Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection
    Xing Pei Hao
    Pathology and Histotechnology Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, BG 539, Post Office Box B, Frederick, Maryland 21702, USA
    Nat Commun 6:8020. 2015

Collaborators

Detail Information

Publications22

  1. pmc The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche
    Jacob D Estes
    AIDS and Cancer Virus Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD, USA
    Semin Immunol 20:181-6. 2008
    ....
  2. ncbi request reprint Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections
    Jacob D Estes
    The AIDS and Cancer Virus Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Fort Detrick Campus, Frederick, MD 21702, USA
    Curr HIV/AIDS Rep 6:29-35. 2009
    ....
  3. doi request reprint Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Immunol Rev 254:65-77. 2013
    ....
  4. pmc Enhancing immune responses to limit chronic immune activation during SIV
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 122:1611-4. 2012
    ....
  5. pmc Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    PLoS Pathog 6:e1001052. 2010
    ..Novel therapeutic approaches to inhibit microbial translocation and/or attenuate chronic immune activation in HIV-infected individuals may complement treatments aimed at direct suppression of viral replication...
  6. pmc Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection
    Brian Tabb
    AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, SAIC Frederick, Maryland, USA
    J Infect Dis 207:880-92. 2013
    ....
  7. pmc Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides
    Christine M Fennessey
    Retroviral Evolution Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Building 535, Rm 408, Frederick, MD, 21702 1201, USA
    Retrovirology 12:49. 2015
    ....
  8. pmc Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    Antimicrob Agents Chemother 60:1560-72. 2015
    ..These findings suggest that HDACi drugs, such as RMD, can reactivate residual virus in the presence of suppressive antiviral therapy and may be a valuable component of a comprehensive HIV functional cure/eradication strategy. ..
  9. pmc Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
    Levelle D Harris
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 84:7886-91. 2010
    ..In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques...
  10. pmc Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection
    Xing Pei Hao
    Pathology and Histotechnology Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, BG 539, Post Office Box B, Frederick, Maryland 21702, USA
    Nat Commun 6:8020. 2015
    ..Together these results support the hypothesis that GI tract damage leading to local and systemic microbial translocation, and associated immune activation, are important determinants of AIDS pathogenesis. ..
  11. pmc Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection
    Jacob T Minang
    AIDS and Cancer Virus Program, SAIC Frederick, Frederick, MD 21702, USA
    J Immunol 184:315-26. 2010
    ....
  12. pmc Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory, Frederick, MD 21702, USA
    Cell Host Microbe 16:412-8. 2014
    ..One of these SHIVs could be transmitted mucosally. We demonstrate the utility of the SHIVs generated by this method for evaluating neutralizing antibody administration as a protection against mucosal SHIV challenge. ..
  13. pmc Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    Antimicrob Agents Chemother 58:6790-806. 2014
    ....
  14. pmc Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    Nichole R Klatt
    National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 123:903-7. 2013
    ..Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis...
  15. pmc Defining HIV and SIV Reservoirs in Lymphoid Tissues
    Claire Deléage
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702
    Pathog Immun 1:68-106. 2016
    ..These new tools should allow new insights into viral reservoir biology and evaluation of cure strategies...
  16. pmc Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission
    Jeremy Smedley
    Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc, Frederick National Laboratory, Frederick, Maryland, United States of America
    PLoS ONE 9:e92830. 2014
    ..These results provide insights into potential patterns of viral dissemination that can help guide efforts to better elucidate the earliest events of virus transmission and potential intervention strategies...
  17. pmc Impact of early cART in the gut during acute HIV infection
    Claire Deléage
    AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, Maryland, USA
    JCI Insight 1:. 2016
    ....
  18. pmc Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence
    Claire Deléage
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Bg 535, Post Office Box B, Frederick, MD 21702, USA
    Curr Opin Virol 19:77-84. 2016
    ....
  19. pmc Three-dimensional imaging of HIV-1 virological synapses reveals membrane architectures involved in virus transmission
    Thao Do
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:10327-39. 2014
    ..Mechanisms that selectively disrupt the polarization and formation of such membrane extensions could thus represent a possible target for reducing viral spread...
  20. pmc Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    J Virol 88:8077-90. 2014
    ..This approach provides a novel nonhuman primate challenge system for the study of viral transmission, evaluation of vaccines and other prevention approaches, and characterization of viral reservoirs and strategies to target them...
  21. pmc Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, National Cancer Institute, Frederick, Maryland, USA
    J Virol 86:3152-66. 2012
    ..Given that human APOBEC proteins restrict XMRV infection in vitro, human XMRV infection, if it occurred, would be expected to be characterized by similarly limited viral replication and spread...
  22. pmc Barriers to mucosal transmission of immunodeficiency viruses
    Brandon F Keele
    AIDS and Cancer Virus Program, SAIC Frederick Inc, National Cancer Institute, Frederick, MD, USA
    Blood 118:839-46. 2011
    ..Understanding the initial events of infection, before systemic spread, could provide insights into strategies for reducing acquisition or ameliorating clinical outcome...