Emmie de Wit

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 8:e69127. 2013
  2. pmc Nipah virus transmission in a hamster model
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 5:e1432. 2011
  3. pmc Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques
    Emmie de Wit
    Laboratory of Virology, Rocky Mountain Veterinary Branch, and Microscopy Unit, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840
    Proc Natl Acad Sci U S A 110:16598-603. 2013
  4. pmc Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques
    Darryl Falzarano
    Disease Modeling and Transmission Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Nat Med 19:1313-7. 2013
  5. pmc Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route
    Vincent J Munster
    Laboratory of Virology, Microscopy Unit, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Sci Rep 2:736. 2012
  6. pmc Comparison of the pathogenicity of Nipah virus isolates from Bangladesh and Malaysia in the Syrian hamster
    Blair L Debuysscher
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    PLoS Negl Trop Dis 7:e2024. 2013
  7. pmc An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity
    Laura J Baseler
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, Montana Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana
    Am J Pathol 186:630-8. 2016
  8. pmc Foodborne transmission of nipah virus in Syrian hamsters
    Emmie de Wit
    Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 10:e1004001. 2014
  9. pmc Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
    Darryl Falzarano
    Disease Modeling and Transmission Unit, Hamilton, MT, USA
    Sci Rep 3:1686. 2013
  10. pmc Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
    Vincent J Munster
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Sci Rep 6:21878. 2016

Collaborators

Detail Information

Publications16

  1. pmc The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 8:e69127. 2013
    ..Clinical signs of disease, virus replication, histological lesions, cytokine upregulation nor seroconversion were observed in any of the inoculated animals, indicating that MERS-CoV does not replicate in Syrian hamsters. ..
  2. pmc Nipah virus transmission in a hamster model
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 5:e1432. 2011
    ..The data provide new and much-needed insights into the modes and efficiency of Nipah virus transmission and have important public health implications with regards to the risk assessment and management of future Nipah virus outbreaks...
  3. pmc Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques
    Emmie de Wit
    Laboratory of Virology, Rocky Mountain Veterinary Branch, and Microscopy Unit, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840
    Proc Natl Acad Sci U S A 110:16598-603. 2013
    ..This tropism of MERS-CoV for the lower respiratory tract may explain the severity of the disease observed in humans and the, up to now, limited human-to-human transmission. ..
  4. pmc Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques
    Darryl Falzarano
    Disease Modeling and Transmission Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Nat Med 19:1313-7. 2013
    ..As these two drugs are already used in combination in the clinic for other infections, IFN-α2b and ribavirin should be considered for the management of MERS-CoV cases. ..
  5. pmc Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route
    Vincent J Munster
    Laboratory of Virology, Microscopy Unit, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Sci Rep 2:736. 2012
    ..NiV entry into the CNS coincided with the occurrence of respiratory disease, suggesting that the initial entry of NiV into the CNS occurs simultaneously with, rather than as a result of, systemic virus replication...
  6. pmc Comparison of the pathogenicity of Nipah virus isolates from Bangladesh and Malaysia in the Syrian hamster
    Blair L Debuysscher
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    PLoS Negl Trop Dis 7:e2024. 2013
    ..This model can be used to study NiV-B pathogenesis, transmission, and countermeasures that could be used to control outbreaks...
  7. pmc An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity
    Laura J Baseler
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, Montana Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana
    Am J Pathol 186:630-8. 2016
    ..Together, the rhesus macaque and common marmoset models of MERS-CoV span the wide range of disease severity reported in MERS-CoV-infected humans, which will aid in investigating MERS-CoV disease pathogenesis. ..
  8. pmc Foodborne transmission of nipah virus in Syrian hamsters
    Emmie de Wit
    Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 10:e1004001. 2014
    ..Understanding the Nipah virus transmission cycle is essential for preventing and mitigating future outbreaks...
  9. pmc Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
    Darryl Falzarano
    Disease Modeling and Transmission Unit, Hamilton, MT, USA
    Sci Rep 3:1686. 2013
    ..Thus, a combination of interferon-α2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections...
  10. pmc Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
    Vincent J Munster
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Sci Rep 6:21878. 2016
    ..Our results indicate that MERS-CoV maintains the ability to replicate in bats without clinical signs of disease, supporting the general hypothesis of bats as ancestral reservoirs for MERS-CoV. ..
  11. pmc Infection with MERS-CoV causes lethal pneumonia in the common marmoset
    Darryl Falzarano
    Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 10:e1004250. 2014
    ....
  12. pmc The immune response to Nipah virus infection
    Joseph Prescott
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Arch Virol 157:1635-41. 2012
    ..This review summarizes our current understanding of the immune response to Nipah virus infection and emphasizes the need for further research...
  13. pmc Assessment of rodents as animal models for Reston ebolavirus
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S968-72. 2011
    ..Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies...
  14. pmc Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, 903 South 4th Street, MT 59840, USA
    Genome Med 3:5. 2011
    ..Here, we review the current state of Ebolavirus research, with emphasis on prophylactic and therapeutic intervention strategies...
  15. pmc Animal models of disease shed light on Nipah virus pathogenesis and transmission
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA
    J Pathol 235:196-205. 2015
    ..Since data from human cases are sparse, this knowledge is largely based on the results of studies performed in animal models that recapitulate Nipah virus disease in humans...
  16. doi request reprint Birth and pathogenesis of rogue respiratory viruses
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana email
    Annu Rev Pathol 10:449-71. 2015
    ..Our current state of knowledge on the pathogenicity of these three severe, emerging viral infections is discussed. ..