Suresh Cuddapah

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Epigenomics of T cell activation, differentiation, and memory
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:341-7. 2010
  2. pmc Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:24-32. 2009
  3. pmc Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 31:700-9. 2011
  4. doi request reprint Dynamic regulation of nucleosome positioning in the human genome
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 132:887-98. 2008
  5. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
  6. pmc Chromatin poises miRNA- and protein-coding genes for expression
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1742-51. 2009
  7. pmc Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 17:629-34. 2010
  8. ncbi request reprint High-resolution profiling of histone methylations in the human genome
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 129:823-37. 2007
  9. pmc The genomic landscape of histone modifications in human T cells
    Tae Young Roh
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:15782-7. 2006
  10. pmc Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data
    Raja Jothi
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 36:5221-31. 2008

Collaborators

Detail Information

Publications14

  1. pmc Epigenomics of T cell activation, differentiation, and memory
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:341-7. 2010
    ..On the other hand, memory T cells are poised and do not require epigenetic changes for short-term activation...
  2. pmc Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:24-32. 2009
    ..Our data indicate that CTCF may play important roles in the barrier activity of insulators, and this study provides a resource for further investigation of the CTCF function in organizing chromatin in the human genome...
  3. pmc Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 31:700-9. 2011
    ..Our results suggest that HMGN1 is part of the cellular machinery that modulates transcriptional fidelity by generating, maintaining, or preferentially interacting with specific sites in chromatin...
  4. doi request reprint Dynamic regulation of nucleosome positioning in the human genome
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 132:887-98. 2008
    ..Our results suggest that H2A.Z-containing and modified nucleosomes are preferentially lost from the -1 nucleosome position. Our data provide a comprehensive view of the nucleosome landscape and its dynamic regulation in the human genome...
  5. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
    ..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation...
  6. pmc Chromatin poises miRNA- and protein-coding genes for expression
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1742-51. 2009
    ..Our data suggest that miRNA- and protein-coding genes share similar mechanisms of regulation by chromatin modifications, which poise inducible genes for activation in response to environmental stimuli...
  7. pmc Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 17:629-34. 2010
    ..Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III...
  8. ncbi request reprint High-resolution profiling of histone methylations in the human genome
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 129:823-37. 2007
    ..Our data provide new insights into the function of histone methylation and chromatin organization in genome function...
  9. pmc The genomic landscape of histone modifications in human T cells
    Tae Young Roh
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:15782-7. 2006
    ..Therefore, these regions have a distinctive chromatin modification pattern and thus may represent a distinct class of chromatin domains...
  10. pmc Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data
    Raja Jothi
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 36:5221-31. 2008
    ..Using tag density as an indicator of DNA-binding affinity, we have identified core residues within the NRSF and CTCF binding sites that are critical for a stronger DNA binding...
  11. pmc Native chromatin preparation and illumina/solexa library construction
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    CSH Protoc 2009:pdb.prot5237. 2009
    ....
  12. pmc Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRGl
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    FEBS Lett 582:391-7. 2008
    ..The regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes...
  13. pmc Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping
    Tae Young Roh
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 19:542-52. 2005
    ..TCR signaling induces 4045 new acetylation loci that may mediate the global chromatin remodeling and gene activation. We propose that the acetylation islands are epigenetic marks that allow prediction of functional regulatory elements...
  14. pmc Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape
    Joseph G Crompton
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 13:502-13. 2016
    ..These findings have major implications for our understanding of peripheral T-cell ontogeny and the formation of immunological memory...