Affiliation: National Institutes of Health
- The frontal cortex of the rat and visual attentional performance: dissociable functions of distinct medial prefrontal subregionsFilippo Passetti
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Cereb Cortex 12:1254-68. 2002..Circuits centred on Cg1 are critical for the temporal organization of behaviour, while networks involving the ventral mPFC are important for maintaining behavioural flexibility...
- Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortexYogita Chudasama
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 29:1628-36. 2004..These data provide the first demonstration that dopamine D1 receptor stimulation sufficient to improve attentional accuracy, can also disrupt, and facilitate short-term working memory performance in a delay-dependent manner...
- Rhesus monkeys with orbital prefrontal cortex lesions can learn to inhibit prepotent responses in the reversed reward contingency taskY Chudasama
Laboratories of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 USA
Cereb Cortex 17:1154-9. 2007..Surprisingly, monkeys with PFo lesions learned as quickly as unoperated controls. Thus, PFo lesions do not yield a deficit in all tests that require the inhibition of a prepotent response...
- Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humansY Chudasama
Laboratory of Neuropsychology, National Institute of Mental Health, Convent Drive, Building 49, Room 1B80, Bethesda, MD 20892, USA
Biol Psychol 73:19-38. 2006....
- D-Amphetamine remediates attentional performance in rats with dorsal prefrontal lesionsY Chudasama
Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, UK
Behav Brain Res 158:97-107. 2005....
- Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophreniaY Chudasama
National Institute of Mental Health, Building 49, Room 1B80, Convent Drive, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 174:86-98. 2004..In schizophrenia, attentional disturbance is a core feature which may not only accompany the disorder, but may precede the onset of psychiatric symptoms...
- Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamineYogita Chudasama
Cambridge University, Department of Experimental Psychology, Cambridge CB2 3EB, UK
Learn Mem 11:78-86. 2004..Together, these findings implicate the nBM cortical cholinergic system in both attentional and mnemonic processing...
- Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivityY Chudasama
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Behav Brain Res 146:105-19. 2003..Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function...
- Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortexY Chudasama
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom CB2 3EB
J Neurosci 23:8771-80. 2003..In contrast, the ILC lesion had no effect on response inhibitory control in either of these settings. The findings are discussed in the context of dissociable executive functions in ventral sectors of the rat prefrontal cortex...
- Functional disconnection of the medial prefrontal cortex and subthalamic nucleus in attentional performance: evidence for corticosubthalamic interactionYogita Chudasama
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 23:5477-85. 2003..This study provides direct evidence that performance in tasks that require optimal attentional and executive control relies on a corticosubthalamic interaction within the neural circuitry of the basal ganglia...
- Distinct contributions of the amygdala and hippocampus to fear expressionYogita Chudasama
Neurobiology of Learning and Memory Section, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Eur J Neurosci 30:2327-37. 2009..These data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses...
- Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortexJeffrey W Dalley
Department of Experimental Psychology, University of Cambridge, Downing St, CB2 3EB, UK
Cereb Cortex 14:922-32. 2004..These findings are consistent with an important modulatory influence of PFC function by BF cholinergic neurons, particularly during increased attentional demand...
- Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbensJeffrey W Dalley
Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, United Kingdom
Proc Natl Acad Sci U S A 102:6189-94. 2005..These findings provide the most direct demonstration to date that D1 and NMDA receptors in the NAc contribute to, and are necessary for, the early consolidation of appetitive Pavlovian learning...
- Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in ratsCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, UK
Psychopharmacology (Berl) 167:304-14. 2003..However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour...
- Hippocampal lesions in rhesus monkeys disrupt emotional responses but not reinforcer devaluation effectsYogita Chudasama
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 63:1084-91. 2008..Although the role of the hippocampus in emotional behavior has long been recognized, the extent to which the hippocampus plays a role in the regulation and expression of emotion in rhesus monkeys has not been systematically explored...
- Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administrationJeffrey W Dalley
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Psychopharmacology (Berl) 161:425-33. 2002..Although dopaminergic mechanisms have been implicated in incentive motivational processes, their role in appetitive conditioning remains poorly understood...
- The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in Learning a Bayesian Prior Belief on ReversalsAnthony I Jang
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415
J Neurosci 35:11751-60. 2015..Thus, by taking a Bayesian approach we find that variability in reversal-learning performance attributable to different neural systems is primarily driven by different prior beliefs about reversals that each group brings to the task...
- Bilateral high-frequency stimulation of the subthalamic nucleus on attentional performance: transient deleterious effects and enhanced motivation in both intact and parkinsonian ratsChristelle Baunez
Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique, UMR6155 CNRS Université de Provence, Pole 3C, Case C, 3 Place Victor Hugo, 13331 Marseille Cedex 03, France
Eur J Neurosci 25:1187-94. 2007..These results are in line with the hypothesis that STN HFS only partially mimics inactivation of STN produced by lesioning and confirm the motivational exacerbation induced by STN inactivation...